UniProtKB - Q86XE0 (SNX32_HUMAN)
Protein
Sorting nexin-32
Gene
SNX32
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in several stages of intracellular trafficking.By similarity
GO - Molecular functioni
- phosphatidylinositol binding Source: InterPro
GO - Biological processi
- protein transport Source: UniProtKB-KW
- regulation of macroautophagy Source: ParkinsonsUK-UCL
- retrograde transport, endosome to Golgi Source: GO_Central
Keywordsi
Biological process | Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Sorting nexin-32Alternative name(s): Sorting nexin-6B |
Gene namesi | Name:SNX32 Synonyms:SNX6B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26423 SNX32 |
neXtProti | NX_Q86XE0 |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000172803 |
PharmGKBi | PA162404314 |
Miscellaneous databases
Pharosi | Q86XE0 |
Polymorphism and mutation databases
BioMutai | SNX32 |
DMDMi | 74727816 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000320707 | 1 – 403 | Sorting nexin-32Add BLAST | 403 |
Proteomic databases
jPOSTi | Q86XE0 |
MassIVEi | Q86XE0 |
MaxQBi | Q86XE0 |
PaxDbi | Q86XE0 |
PeptideAtlasi | Q86XE0 |
PRIDEi | Q86XE0 |
ProteomicsDBi | 70267 [Q86XE0-1] 70268 [Q86XE0-2] |
PTM databases
iPTMneti | Q86XE0 |
PhosphoSitePlusi | Q86XE0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000172803 Expressed in 105 organ(s), highest expression level in right frontal lobe |
Genevisiblei | Q86XE0 HS |
Organism-specific databases
HPAi | HPA041775 |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGridi | 129016, 11 interactors |
IntActi | Q86XE0, 17 interactors |
MINTi | Q86XE0 |
STRINGi | 9606.ENSP00000310620 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q86XE0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 168 | PXPROSITE-ProRule annotationAdd BLAST | 149 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 258 – 335 | Sequence analysisAdd BLAST | 78 |
Sequence similaritiesi
Belongs to the sorting nexin family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG1660 Eukaryota ENOG410XPZY LUCA |
GeneTreei | ENSGT00940000162773 |
HOGENOMi | HOG000231691 |
InParanoidi | Q86XE0 |
KOi | K17920 |
OMAi | ETHQQLC |
OrthoDBi | 1009572at2759 |
PhylomeDBi | Q86XE0 |
TreeFami | TF313698 |
Family and domain databases
Gene3Di | 1.20.1270.60, 1 hit 3.30.1520.10, 1 hit |
InterProi | View protein in InterPro IPR027267 AH/BAR_dom_sf IPR001683 Phox IPR036871 PX_dom_sf IPR014637 SNX5/SNX6/SNX32 IPR015404 Vps5_C |
Pfami | View protein in Pfam PF00787 PX, 1 hit PF09325 Vps5, 1 hit |
PIRSFi | PIRSF036924 Snx5_Snx6, 1 hit |
SUPFAMi | SSF64268 SSF64268, 1 hit |
PROSITEi | View protein in PROSITE PS50195 PX, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q86XE0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
METYAEVGKE GKPSCASVDL QGDSSLQVEI SDAVSERDKV KFTVQTKSCL
60 70 80 90 100
PHFAQTEFSV VRQHEEFIWL HDAYVENEEY AGLIIPPAPP RPDFEASREK
110 120 130 140 150
LQKLGEGDSS VTREEFAKMK QELEAEYLAI FKKTVAMHEV FLQRLAAHPT
160 170 180 190 200
LRRDHNFFVF LEYGQDLSVR GKNRKELLGG FLRNIVKSAD EALITGMSGL
210 220 230 240 250
KEVDDFFEHE RTFLLEYHTR IRDACLRADR VMRAHKCLAD DYIPISAALS
260 270 280 290 300
SLGTQEVNQL RTSFLKLAEL FERLRKLEGR VASDEDLKLS DMLRYYMRDS
310 320 330 340 350
QAAKDLLYRR LRALADYENA NKALDKARTR NREVRPAESH QQLCCQRFER
360 370 380 390 400
LSDSAKQELM DFKSRRVSSF RKNLIELAEL ELKHAKASTL ILRNTLVALK
GEP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 14 | S → P in BAB70935 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039298 | 155 | H → N1 PublicationCorresponds to variant dbSNP:rs17854065Ensembl. | 1 | |
Natural variantiVAR_039299 | 282 | A → V1 PublicationCorresponds to variant dbSNP:rs17855647Ensembl. | 1 | |
Natural variantiVAR_039300 | 354 | S → Y1 PublicationCorresponds to variant dbSNP:rs17857243Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031742 | 238 – 277 | LADDY…RLRKL → TQGPRGPGSPCPSPQRFNSL GERREQGVPCCLSVATSTKA in isoform 2. 1 PublicationAdd BLAST | 40 | |
Alternative sequenceiVSP_031743 | 278 – 403 | Missing in isoform 2. 1 PublicationAdd BLAST | 126 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK055496 mRNA Translation: BAB70935.1 AK289587 mRNA Translation: BAF82276.1 CH471076 Genomic DNA Translation: EAW74441.1 BC040981 mRNA Translation: AAH40981.1 BC045563 mRNA Translation: AAH45563.1 |
CCDSi | CCDS8113.2 [Q86XE0-1] |
RefSeqi | NP_689973.2, NM_152760.2 [Q86XE0-1] |
Genome annotation databases
Ensembli | ENST00000308342; ENSP00000310620; ENSG00000172803 [Q86XE0-1] |
GeneIDi | 254122 |
KEGGi | hsa:254122 |
UCSCi | uc001ofr.4 human [Q86XE0-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK055496 mRNA Translation: BAB70935.1 AK289587 mRNA Translation: BAF82276.1 CH471076 Genomic DNA Translation: EAW74441.1 BC040981 mRNA Translation: AAH40981.1 BC045563 mRNA Translation: AAH45563.1 |
CCDSi | CCDS8113.2 [Q86XE0-1] |
RefSeqi | NP_689973.2, NM_152760.2 [Q86XE0-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6E8R | X-ray | 2.27 | A/B | 17-166 | [»] | |
SMRi | Q86XE0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 129016, 11 interactors |
IntActi | Q86XE0, 17 interactors |
MINTi | Q86XE0 |
STRINGi | 9606.ENSP00000310620 |
PTM databases
iPTMneti | Q86XE0 |
PhosphoSitePlusi | Q86XE0 |
Polymorphism and mutation databases
BioMutai | SNX32 |
DMDMi | 74727816 |
Proteomic databases
jPOSTi | Q86XE0 |
MassIVEi | Q86XE0 |
MaxQBi | Q86XE0 |
PaxDbi | Q86XE0 |
PeptideAtlasi | Q86XE0 |
PRIDEi | Q86XE0 |
ProteomicsDBi | 70267 [Q86XE0-1] 70268 [Q86XE0-2] |
Protocols and materials databases
DNASUi | 254122 |
Genome annotation databases
Ensembli | ENST00000308342; ENSP00000310620; ENSG00000172803 [Q86XE0-1] |
GeneIDi | 254122 |
KEGGi | hsa:254122 |
UCSCi | uc001ofr.4 human [Q86XE0-1] |
Organism-specific databases
CTDi | 254122 |
GeneCardsi | SNX32 |
HGNCi | HGNC:26423 SNX32 |
HPAi | HPA041775 |
neXtProti | NX_Q86XE0 |
OpenTargetsi | ENSG00000172803 |
PharmGKBi | PA162404314 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1660 Eukaryota ENOG410XPZY LUCA |
GeneTreei | ENSGT00940000162773 |
HOGENOMi | HOG000231691 |
InParanoidi | Q86XE0 |
KOi | K17920 |
OMAi | ETHQQLC |
OrthoDBi | 1009572at2759 |
PhylomeDBi | Q86XE0 |
TreeFami | TF313698 |
Miscellaneous databases
ChiTaRSi | SNX32 human |
GenomeRNAii | 254122 |
Pharosi | Q86XE0 |
PROi | PR:Q86XE0 |
Gene expression databases
Bgeei | ENSG00000172803 Expressed in 105 organ(s), highest expression level in right frontal lobe |
Genevisiblei | Q86XE0 HS |
Family and domain databases
Gene3Di | 1.20.1270.60, 1 hit 3.30.1520.10, 1 hit |
InterProi | View protein in InterPro IPR027267 AH/BAR_dom_sf IPR001683 Phox IPR036871 PX_dom_sf IPR014637 SNX5/SNX6/SNX32 IPR015404 Vps5_C |
Pfami | View protein in Pfam PF00787 PX, 1 hit PF09325 Vps5, 1 hit |
PIRSFi | PIRSF036924 Snx5_Snx6, 1 hit |
SUPFAMi | SSF64268 SSF64268, 1 hit |
PROSITEi | View protein in PROSITE PS50195 PX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SNX32_HUMAN | |
Accessioni | Q86XE0Primary (citable) accession number: Q86XE0 Secondary accession number(s): Q8IW53, Q96NG4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | June 1, 2003 | |
Last modified: | October 16, 2019 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - PDB cross-references
Index of Protein Data Bank (PDB) cross-references