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UniProtKB - Q86XA9 (HTR5A_HUMAN)

Entry version 133 (02 Dec 2020)
Sequence version 2 (04 Dec 2007)
Previous versions | rss
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Protein

HEAT repeat-containing protein 5A

Gene

HEATR5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86XA9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HEAT repeat-containing protein 5A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HEATR5A
Synonyms:C14orf125, KIAA1316
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000129493.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:20276, HEATR5A

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86XA9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		25938

Open Targets

More...OpenTargetsi		ENSG00000129493

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162390632

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86XA9, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HEATR5A

Domain mapping of disease mutations (DMDM)

More...DMDMi		162416245

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003119901 – 2040HEAT repeat-containing protein 5AAdd BLAST2040

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1110PhosphoserineCombined sources1
Modified residuei1115PhosphothreonineCombined sources1
Modified residuei1647PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q86XA9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q86XA9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86XA9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86XA9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86XA9

PeptideAtlas

More...PeptideAtlasi		Q86XA9

PRoteomics IDEntifications database

More...PRIDEi		Q86XA9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70260 [Q86XA9-1]
70261 [Q86XA9-2]
70262 [Q86XA9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86XA9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86XA9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000129493, Expressed in corpus callosum and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86XA9, baseline and differential

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000129493, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117435, 10 interactors

Protein interaction database and analysis system

More...IntActi		Q86XA9, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000437968

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86XA9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati846 – 883HEAT 1Add BLAST38
Repeati1079 – 1116HEAT 2Add BLAST38

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HEATR5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1822, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006205

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86XA9

Database of Orthologous Groups

More...OrthoDBi		71064at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86XA9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR040108, Laa1/Sip1/HEATR5

The PANTHER Classification System

More...PANTHERi		PTHR21663, PTHR21663, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86XA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELAHSLLLN EEAYNQLGEV QKAEFIFEWL RYLEKLLLAT SRNDVREKQK 
        60         70         80         90        100
TLVEQLLSLL NSSPGPPTRK LLAKNLAILY SIGDTFSVHE AIDKCNDLIR 
       110        120        130        140        150
SKDDSPSYLP TKLAAVVCLG SLYKKLGRIL GNTFTDTVGN ILKAMKSAES 
       160        170        180        190        200
QGRYEIMLSL QNILNGLGAA AAPCHRDVYK AARSCLTDRS MAVRCAAAKN 
       210        220        230        240        250
EAIFMWSTDL DSVATLCFKS FEGSNYDVRI SVSKLLGIIL AKAVISKHPG 
       260        270        280        290        300
TAASRQSIRR VSLEEVLELL GTGFLRGSSG FLRASGDMLK GTSSVSRDVR 
       310        320        330        340        350
VGVTQAYVVF VSTLGGAWLE KNFAAFFSHI LSLASPSHPK ATQTQIDAVC 
       360        370        380        390        400
CRRCVSFILR TTIGGLLGEK AQLAAVKDIC QAIWKLKKVM DAVMSDGNLE 
       410        420        430        440        450
TRLGSTDVAA SQHMLVCALQ ELGNLIHNLG TTAAPLLQDS STGLLDSILS 
       460        470        480        490        500
VILHPSISVR LAAAWCLHCI AVALPSYLTP LLDRCLERLT GHKSSPEAVT 
       510        520        530        540        550
GFSFAVAALL GAVKHCPLGI PHGKGKIIMT LAEDLLCSAA QNSRLSAQRT 
       560        570        580        590        600
QAGWLLISAL MTLGPAVVSH HLARVLLLWK CVFPASPKDL ETEKSRGDSF 
       610        620        630        640        650
TWQVTLEGRA GALCAIKSFV SHCGDLLTEE VTQRLLPPLP CAVDLLTQLS 
       660        670        680        690        700
SILKMYGSPL KTPSVVYRQR LYELLILLPP ETYEGNLCAI LRELAADLTA 
       710        720        730        740        750
PDIQVAASTF LLPPLCHQDD LLILSPFLQE TDHRFIEEQL LLGNGVACGS 
       760        770        780        790        800
LEYDPYSIYE KDVEGDSVPK PLPPALSVIS SASKLFGVVC AHVGETQRLL 
       810        820        830        840        850
ILEQLLDSIK HTKGARQQVV QLHVVSSVSS FLKYVAGSKG CLGPEEMKRF 
       860        870        880        890        900
ALTLVMGALE SPNPLLRCAA AESWARLAQV VDDGAFTAGL AQVSFDKLKS 
       910        920        930        940        950
ARDVVTRTGH SLALGSLHRY LGGISSSQHL NSCIGILYTL AQDSTSPDVQ 
       960        970        980        990       1000
TWALHSLSLI IDSAGPLYYV HVEPTLSLII MLLLNVPPTH AEVHQSLGRC 
      1010       1020       1030       1040       1050
LNALITTLGP ELQGNSTSIS TLRTSCLLGC AVMQDNPDCL VQAQAISCLQ 
      1060       1070       1080       1090       1100
QLHMFAPRHV NLSSLVSCLC VNLCSPYLLL RRAVLACLRQ LVQREAAEVS 
      1110       1120       1130       1140       1150
EHAVMLAKDS REELTPDANI REVGLEGALL ILLDKETDER LCHDIKETLN 
      1160       1170       1180       1190       1200
YMLTSMAVEK LSLWLKLCKD VLAASADFTA VTCVDTMQEE EGDKGDDASV 
      1210       1220       1230       1240       1250
LTTRRDEKSH PFTNPRWATR VFAAECVCRI INQCENANSA HFDIALAQEM 
      1260       1270       1280       1290       1300
KKRDSRNDFL VLHLADLIRM AFMAATDHSD QLRLSGLEML LVVIRRFATV 
      1310       1320       1330       1340       1350
PEPEFPGHVI LEQYQANVGA ALRPAFTSET PPDVTAKACQ VCSAWIASGV 
      1360       1370       1380       1390       1400
VSDLNDLRRV HQLLVSSLTK IQAGKEALSH LYNESASTME ILAVLKAWAE 
      1410       1420       1430       1440       1450
VYIIAVQRHK NHRQPLKTTT CLEDGIRNGS CSSDGLLDLV YADLGTLSRL 
      1460       1470       1480       1490       1500
WLAALQDFAL LTLPSEFASQ LPAEGGAFYT AETSENAKLH YYNSWALILH 
      1510       1520       1530       1540       1550
ATALWLTSTG FVVADPDEGA SNLSRPVTPT SMCQGSSSGA TIKSPEDVYT 
      1560       1570       1580       1590       1600
DRFHLILGIS VEFLCSLRSD ATMESITACL HALQALLDVP WPRSKIGSDQ 
      1610       1620       1630       1640       1650
DLGIELLNVL HRVILTRESP SIQLASLEVV RQIICAAQEH VKEKRRSAEV 
      1660       1670       1680       1690       1700
DDGAAEKETL PEFGEGKDTG GLVPGKSLVF ATLELCVCIL VRQLPELNPK 
      1710       1720       1730       1740       1750
LTGSPGVKAT KPQILLEDGS RLVSAALVIL SELPAVCSPE GSISILPTIL 
      1760       1770       1780       1790       1800
YLTIGVLRET AVKLPGGQLS STVAASLQAL KGILSSPMAR AEKSRTAWTD 
      1810       1820       1830       1840       1850
LLRSALTTIL DCWDPVDETH QELDEVSLLT AITVFILSTS PEVTTIPCLQ 
      1860       1870       1880       1890       1900
KRCIDKFKAT LEIKDPVVQI KTYQLLHSIF QYPNPAVSYP YIYSLASCIM 
      1910       1920       1930       1940       1950
EKLQEIDKRK PENTAELEIF QEGIKVLETL VTVAEEHHRA QLVACLLPIL 
      1960       1970       1980       1990       2000
ISFLLDENSL GSATSIMRNL HDFALQNLMQ IGPQYSSVFK SLVASSPALK 
      2010       2020       2030       2040
ARLEAAIKGN QESVKVKIPT SKYTKSPGKN SSIQLKTSFL
Length:2,040
Mass (Da):222,004
Last modified:December 4, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6598AA06A7D51DB
GO
Isoform 2 (identifier: Q86XA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1741-1815: Missing.

Show »
Length:1,965
Mass (Da):214,083
Checksum:iE4589DBD3C413E33
GO
Isoform 3 (identifier: Q86XA9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-2040: Missing.

Show »
Length:113
Mass (Da):12,903
Checksum:iD2F13A11E214CFD3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H619F5H619_HUMAN
HEAT repeat-containing protein 5A
HEATR5A
2,046Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5W6H7C5W6_HUMAN
HEAT repeat-containing protein 5A
HEATR5A
1,599Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHS5H0YHS5_HUMAN
HEAT repeat-containing protein 5A
HEATR5A
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIW3H0YIW3_HUMAN
HEAT repeat-containing protein 5A
HEATR5A
896Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHE0H0YHE0_HUMAN
HEAT repeat-containing protein 5A
HEATR5A
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQQ6F8VQQ6_HUMAN
HEAT repeat-containing protein 5A
HEATR5A
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91098 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti429L → P in CAH18282 (PubMed:17974005).Curated1
Sequence conflicti880V → M in AAH45764 (PubMed:15489334).Curated1
Sequence conflicti880V → M in CAH18282 (PubMed:17974005).Curated1
Sequence conflicti880V → M in BAA92554 (PubMed:10718198).Curated1
Sequence conflicti1199S → P in BAA91098 (PubMed:14702039).Curated1
Sequence conflicti1257N → T in AAH63867 (PubMed:15489334).Curated1
Sequence conflicti1525R → T in CAH18282 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029685114 – 2040Missing in isoform 3. 1 PublicationAdd BLAST1927
Alternative sequenceiVSP_0296861741 – 1815Missing in isoform 2. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL136418 Genomic DNA No translation available.
AL139353 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65949.1
BC045764 mRNA Translation: AAH45764.1
BC062720 mRNA Translation: AAH62720.1
BC063867 mRNA Translation: AAH63867.1
AL117511 mRNA Translation: CAB55971.1
CR749444 mRNA Translation: CAH18282.1
AB037737 mRNA Translation: BAA92554.1
AK000343 mRNA Translation: BAA91098.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...PIRi		T17281

NCBI Reference Sequences

More...RefSeqi		NP_056288.2, NM_015473.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000382464; ENSP00000371903; ENSG00000129493 [Q86XA9-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25938

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:25938

UCSC genome browser

More...UCSCi		uc001wrh.4, human [Q86XA9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136418 Genomic DNA No translation available.
AL139353 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65949.1
BC045764 mRNA Translation: AAH45764.1
BC062720 mRNA Translation: AAH62720.1
BC063867 mRNA Translation: AAH63867.1
AL117511 mRNA Translation: CAB55971.1
CR749444 mRNA Translation: CAH18282.1
AB037737 mRNA Translation: BAA92554.1
AK000343 mRNA Translation: BAA91098.1 Different initiation.
PIRiT17281
RefSeqiNP_056288.2, NM_015473.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi117435, 10 interactors
IntActiQ86XA9, 5 interactors
STRINGi9606.ENSP00000437968

PTM databases

iPTMnetiQ86XA9
PhosphoSitePlusiQ86XA9

Polymorphism and mutation databases

BioMutaiHEATR5A
DMDMi162416245

Proteomic databases

EPDiQ86XA9
jPOSTiQ86XA9
MassIVEiQ86XA9
MaxQBiQ86XA9
PaxDbiQ86XA9
PeptideAtlasiQ86XA9
PRIDEiQ86XA9
ProteomicsDBi70260 [Q86XA9-1]
70261 [Q86XA9-2]
70262 [Q86XA9-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		63890, 10 antibodies

The DNASU plasmid repository

More...DNASUi		25938

Genome annotation databases

EnsembliENST00000382464; ENSP00000371903; ENSG00000129493 [Q86XA9-3]
GeneIDi25938
KEGGihsa:25938
UCSCiuc001wrh.4, human [Q86XA9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25938
DisGeNETi25938
EuPathDBiHostDB:ENSG00000129493.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		HEATR5A
HGNCiHGNC:20276, HEATR5A
HPAiENSG00000129493, Low tissue specificity
neXtProtiNX_Q86XA9
OpenTargetsiENSG00000129493
PharmGKBiPA162390632

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1822, Eukaryota
GeneTreeiENSGT00390000006205
InParanoidiQ86XA9
OrthoDBi71064at2759
PhylomeDBiQ86XA9

Enzyme and pathway databases

PathwayCommonsiQ86XA9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		25938, 1 hit in 89 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HEATR5A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		25938
PharosiQ86XA9, Tdark

Protein Ontology

More...PROi		PR:Q86XA9
RNActiQ86XA9, protein

Gene expression databases

BgeeiENSG00000129493, Expressed in corpus callosum and 214 other tissues
ExpressionAtlasiQ86XA9, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR040108, Laa1/Sip1/HEATR5
PANTHERiPTHR21663, PTHR21663, 1 hit
SUPFAMiSSF48371, SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHTR5A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86XA9
Secondary accession number(s): Q68DD8
, Q6P3S5, Q6P5R9, Q9H8D7, Q9NXB7, Q9P2N0, Q9UFQ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: December 2, 2020
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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