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Entry version 133 (02 Dec 2020)
Sequence version 2 (04 Dec 2007)
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Protein

HEAT repeat-containing protein 5A

Gene

HEATR5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q86XA9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HEAT repeat-containing protein 5A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HEATR5A
Synonyms:C14orf125, KIAA1316
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000129493.14

Human Gene Nomenclature Database

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HGNCi
HGNC:20276, HEATR5A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86XA9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25938

Open Targets

More...
OpenTargetsi
ENSG00000129493

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162390632

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86XA9, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
HEATR5A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
162416245

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003119901 – 2040HEAT repeat-containing protein 5AAdd BLAST2040

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1110PhosphoserineCombined sources1
Modified residuei1115PhosphothreonineCombined sources1
Modified residuei1647PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q86XA9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q86XA9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86XA9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86XA9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86XA9

PeptideAtlas

More...
PeptideAtlasi
Q86XA9

PRoteomics IDEntifications database

More...
PRIDEi
Q86XA9

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
70260 [Q86XA9-1]
70261 [Q86XA9-2]
70262 [Q86XA9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86XA9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q86XA9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000129493, Expressed in corpus callosum and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q86XA9, baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000129493, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
117435, 10 interactors

Protein interaction database and analysis system

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IntActi
Q86XA9, 5 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000437968

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q86XA9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati846 – 883HEAT 1Add BLAST38
Repeati1079 – 1116HEAT 2Add BLAST38

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HEATR5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1822, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000006205

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q86XA9

Database of Orthologous Groups

More...
OrthoDBi
71064at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86XA9

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR040108, Laa1/Sip1/HEATR5

The PANTHER Classification System

More...
PANTHERi
PTHR21663, PTHR21663, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86XA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELAHSLLLN EEAYNQLGEV QKAEFIFEWL RYLEKLLLAT SRNDVREKQK
60 70 80 90 100
TLVEQLLSLL NSSPGPPTRK LLAKNLAILY SIGDTFSVHE AIDKCNDLIR
110 120 130 140 150
SKDDSPSYLP TKLAAVVCLG SLYKKLGRIL GNTFTDTVGN ILKAMKSAES
160 170 180 190 200
QGRYEIMLSL QNILNGLGAA AAPCHRDVYK AARSCLTDRS MAVRCAAAKN
210 220 230 240 250
EAIFMWSTDL DSVATLCFKS FEGSNYDVRI SVSKLLGIIL AKAVISKHPG
260 270 280 290 300
TAASRQSIRR VSLEEVLELL GTGFLRGSSG FLRASGDMLK GTSSVSRDVR
310 320 330 340 350
VGVTQAYVVF VSTLGGAWLE KNFAAFFSHI LSLASPSHPK ATQTQIDAVC
360 370 380 390 400
CRRCVSFILR TTIGGLLGEK AQLAAVKDIC QAIWKLKKVM DAVMSDGNLE
410 420 430 440 450
TRLGSTDVAA SQHMLVCALQ ELGNLIHNLG TTAAPLLQDS STGLLDSILS
460 470 480 490 500
VILHPSISVR LAAAWCLHCI AVALPSYLTP LLDRCLERLT GHKSSPEAVT
510 520 530 540 550
GFSFAVAALL GAVKHCPLGI PHGKGKIIMT LAEDLLCSAA QNSRLSAQRT
560 570 580 590 600
QAGWLLISAL MTLGPAVVSH HLARVLLLWK CVFPASPKDL ETEKSRGDSF
610 620 630 640 650
TWQVTLEGRA GALCAIKSFV SHCGDLLTEE VTQRLLPPLP CAVDLLTQLS
660 670 680 690 700
SILKMYGSPL KTPSVVYRQR LYELLILLPP ETYEGNLCAI LRELAADLTA
710 720 730 740 750
PDIQVAASTF LLPPLCHQDD LLILSPFLQE TDHRFIEEQL LLGNGVACGS
760 770 780 790 800
LEYDPYSIYE KDVEGDSVPK PLPPALSVIS SASKLFGVVC AHVGETQRLL
810 820 830 840 850
ILEQLLDSIK HTKGARQQVV QLHVVSSVSS FLKYVAGSKG CLGPEEMKRF
860 870 880 890 900
ALTLVMGALE SPNPLLRCAA AESWARLAQV VDDGAFTAGL AQVSFDKLKS
910 920 930 940 950
ARDVVTRTGH SLALGSLHRY LGGISSSQHL NSCIGILYTL AQDSTSPDVQ
960 970 980 990 1000
TWALHSLSLI IDSAGPLYYV HVEPTLSLII MLLLNVPPTH AEVHQSLGRC
1010 1020 1030 1040 1050
LNALITTLGP ELQGNSTSIS TLRTSCLLGC AVMQDNPDCL VQAQAISCLQ
1060 1070 1080 1090 1100
QLHMFAPRHV NLSSLVSCLC VNLCSPYLLL RRAVLACLRQ LVQREAAEVS
1110 1120 1130 1140 1150
EHAVMLAKDS REELTPDANI REVGLEGALL ILLDKETDER LCHDIKETLN
1160 1170 1180 1190 1200
YMLTSMAVEK LSLWLKLCKD VLAASADFTA VTCVDTMQEE EGDKGDDASV
1210 1220 1230 1240 1250
LTTRRDEKSH PFTNPRWATR VFAAECVCRI INQCENANSA HFDIALAQEM
1260 1270 1280 1290 1300
KKRDSRNDFL VLHLADLIRM AFMAATDHSD QLRLSGLEML LVVIRRFATV
1310 1320 1330 1340 1350
PEPEFPGHVI LEQYQANVGA ALRPAFTSET PPDVTAKACQ VCSAWIASGV
1360 1370 1380 1390 1400
VSDLNDLRRV HQLLVSSLTK IQAGKEALSH LYNESASTME ILAVLKAWAE
1410 1420 1430 1440 1450
VYIIAVQRHK NHRQPLKTTT CLEDGIRNGS CSSDGLLDLV YADLGTLSRL
1460 1470 1480 1490 1500
WLAALQDFAL LTLPSEFASQ LPAEGGAFYT AETSENAKLH YYNSWALILH
1510 1520 1530 1540 1550
ATALWLTSTG FVVADPDEGA SNLSRPVTPT SMCQGSSSGA TIKSPEDVYT
1560 1570 1580 1590 1600
DRFHLILGIS VEFLCSLRSD ATMESITACL HALQALLDVP WPRSKIGSDQ
1610 1620 1630 1640 1650
DLGIELLNVL HRVILTRESP SIQLASLEVV RQIICAAQEH VKEKRRSAEV
1660 1670 1680 1690 1700
DDGAAEKETL PEFGEGKDTG GLVPGKSLVF ATLELCVCIL VRQLPELNPK
1710 1720 1730 1740 1750
LTGSPGVKAT KPQILLEDGS RLVSAALVIL SELPAVCSPE GSISILPTIL
1760 1770 1780 1790 1800
YLTIGVLRET AVKLPGGQLS STVAASLQAL KGILSSPMAR AEKSRTAWTD
1810 1820 1830 1840 1850
LLRSALTTIL DCWDPVDETH QELDEVSLLT AITVFILSTS PEVTTIPCLQ
1860 1870 1880 1890 1900
KRCIDKFKAT LEIKDPVVQI KTYQLLHSIF QYPNPAVSYP YIYSLASCIM
1910 1920 1930 1940 1950
EKLQEIDKRK PENTAELEIF QEGIKVLETL VTVAEEHHRA QLVACLLPIL
1960 1970 1980 1990 2000
ISFLLDENSL GSATSIMRNL HDFALQNLMQ IGPQYSSVFK SLVASSPALK
2010 2020 2030 2040
ARLEAAIKGN QESVKVKIPT SKYTKSPGKN SSIQLKTSFL
Length:2,040
Mass (Da):222,004
Last modified:December 4, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6598AA06A7D51DB
GO
Isoform 2 (identifier: Q86XA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1741-1815: Missing.

Show »
Length:1,965
Mass (Da):214,083
Checksum:iE4589DBD3C413E33
GO
Isoform 3 (identifier: Q86XA9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-2040: Missing.

Show »
Length:113
Mass (Da):12,903
Checksum:iD2F13A11E214CFD3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H619F5H619_HUMAN
HEAT repeat-containing protein 5A
HEATR5A
2,046Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5W6H7C5W6_HUMAN
HEAT repeat-containing protein 5A
HEATR5A
1,599Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHS5H0YHS5_HUMAN
HEAT repeat-containing protein 5A
HEATR5A
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIW3H0YIW3_HUMAN
HEAT repeat-containing protein 5A
HEATR5A
896Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHE0H0YHE0_HUMAN
HEAT repeat-containing protein 5A
HEATR5A
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQQ6F8VQQ6_HUMAN
HEAT repeat-containing protein 5A
HEATR5A
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91098 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti429L → P in CAH18282 (PubMed:17974005).Curated1
Sequence conflicti880V → M in AAH45764 (PubMed:15489334).Curated1
Sequence conflicti880V → M in CAH18282 (PubMed:17974005).Curated1
Sequence conflicti880V → M in BAA92554 (PubMed:10718198).Curated1
Sequence conflicti1199S → P in BAA91098 (PubMed:14702039).Curated1
Sequence conflicti1257N → T in AAH63867 (PubMed:15489334).Curated1
Sequence conflicti1525R → T in CAH18282 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029685114 – 2040Missing in isoform 3. 1 PublicationAdd BLAST1927
Alternative sequenceiVSP_0296861741 – 1815Missing in isoform 2. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL136418 Genomic DNA No translation available.
AL139353 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65949.1
BC045764 mRNA Translation: AAH45764.1
BC062720 mRNA Translation: AAH62720.1
BC063867 mRNA Translation: AAH63867.1
AL117511 mRNA Translation: CAB55971.1
CR749444 mRNA Translation: CAH18282.1
AB037737 mRNA Translation: BAA92554.1
AK000343 mRNA Translation: BAA91098.1 Different initiation.

Protein sequence database of the Protein Information Resource

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PIRi
T17281

NCBI Reference Sequences

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RefSeqi
NP_056288.2, NM_015473.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000382464; ENSP00000371903; ENSG00000129493 [Q86XA9-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
25938

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:25938

UCSC genome browser

More...
UCSCi
uc001wrh.4, human [Q86XA9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136418 Genomic DNA No translation available.
AL139353 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65949.1
BC045764 mRNA Translation: AAH45764.1
BC062720 mRNA Translation: AAH62720.1
BC063867 mRNA Translation: AAH63867.1
AL117511 mRNA Translation: CAB55971.1
CR749444 mRNA Translation: CAH18282.1
AB037737 mRNA Translation: BAA92554.1
AK000343 mRNA Translation: BAA91098.1 Different initiation.
PIRiT17281
RefSeqiNP_056288.2, NM_015473.3

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi117435, 10 interactors
IntActiQ86XA9, 5 interactors
STRINGi9606.ENSP00000437968

PTM databases

iPTMnetiQ86XA9
PhosphoSitePlusiQ86XA9

Polymorphism and mutation databases

BioMutaiHEATR5A
DMDMi162416245

Proteomic databases

EPDiQ86XA9
jPOSTiQ86XA9
MassIVEiQ86XA9
MaxQBiQ86XA9
PaxDbiQ86XA9
PeptideAtlasiQ86XA9
PRIDEiQ86XA9
ProteomicsDBi70260 [Q86XA9-1]
70261 [Q86XA9-2]
70262 [Q86XA9-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
63890, 10 antibodies

The DNASU plasmid repository

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DNASUi
25938

Genome annotation databases

EnsembliENST00000382464; ENSP00000371903; ENSG00000129493 [Q86XA9-3]
GeneIDi25938
KEGGihsa:25938
UCSCiuc001wrh.4, human [Q86XA9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
25938
DisGeNETi25938
EuPathDBiHostDB:ENSG00000129493.14

GeneCards: human genes, protein and diseases

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GeneCardsi
HEATR5A
HGNCiHGNC:20276, HEATR5A
HPAiENSG00000129493, Low tissue specificity
neXtProtiNX_Q86XA9
OpenTargetsiENSG00000129493
PharmGKBiPA162390632

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1822, Eukaryota
GeneTreeiENSGT00390000006205
InParanoidiQ86XA9
OrthoDBi71064at2759
PhylomeDBiQ86XA9

Enzyme and pathway databases

PathwayCommonsiQ86XA9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
25938, 1 hit in 89 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HEATR5A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
25938
PharosiQ86XA9, Tdark

Protein Ontology

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PROi
PR:Q86XA9
RNActiQ86XA9, protein

Gene expression databases

BgeeiENSG00000129493, Expressed in corpus callosum and 214 other tissues
ExpressionAtlasiQ86XA9, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR040108, Laa1/Sip1/HEATR5
PANTHERiPTHR21663, PTHR21663, 1 hit
SUPFAMiSSF48371, SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHTR5A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86XA9
Secondary accession number(s): Q68DD8
, Q6P3S5, Q6P5R9, Q9H8D7, Q9NXB7, Q9P2N0, Q9UFQ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: December 2, 2020
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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