UniProtKB - Q86X95 (CIR1_HUMAN)
Corepressor interacting with RBPJ 1
CIR1
Functioni
GO - Molecular functioni
- histone deacetylase binding Source: MGI
- protein-containing complex binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- transcription corepressor activity Source: UniProtKB
GO - Biological processi
- mRNA processing Source: UniProtKB-KW
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: MGI
- RNA splicing Source: UniProtKB-KW
Keywordsi
Molecular function | Repressor |
Biological process | mRNA processing, mRNA splicing, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q86X95 |
SignaLinki | Q86X95 |
SIGNORi | Q86X95 |
Names & Taxonomyi
Protein namesi | Recommended name: Corepressor interacting with RBPJ 1Alternative name(s): CBF1-interacting corepressor Recepin |
Gene namesi | Name:CIR1 Synonyms:CIR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138433.15 |
HGNCi | HGNC:24217, CIR1 |
MIMi | 605228, gene |
neXtProti | NX_Q86X95 |
Subcellular locationi
Cytoskeleton
Nucleus
Note: Colocalizes with NEK6 in the centrosome.
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
Nucleus
- nuclear speck Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB-KW
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9541 |
OpenTargetsi | ENSG00000138433 |
PharmGKBi | PA165696415 |
Miscellaneous databases
Pharosi | Q86X95, Tdark |
Polymorphism and mutation databases
BioMutai | CIR1 |
DMDMi | 74727790 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000247984 | 1 – 450 | Corepressor interacting with RBPJ 1Add BLAST | 450 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 79 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 202 | PhosphoserineCombined sources | 1 | |
Cross-linki | 340 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q86X95 |
jPOSTi | Q86X95 |
MassIVEi | Q86X95 |
MaxQBi | Q86X95 |
PaxDbi | Q86X95 |
PeptideAtlasi | Q86X95 |
PRIDEi | Q86X95 |
ProteomicsDBi | 70256 [Q86X95-1] 70257 [Q86X95-2] |
PTM databases
iPTMneti | Q86X95 |
PhosphoSitePlusi | Q86X95 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000138433, Expressed in tendon of biceps brachii and 235 other tissues |
ExpressionAtlasi | Q86X95, baseline and differential |
Genevisiblei | Q86X95, HS |
Organism-specific databases
HPAi | ENSG00000138433, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with RP9, SNW1, SFRS1, SFRS2,U2AF1, RBPJ, SAP30, HDAC2 NKAP and NEK6.
Interacts with Epstein-Barr virus RPMS1.
Component of the histone deacetylase complex.
Component of the Notch corepressor complex.
Interacts with NKAPL (By similarity).
By similarity5 PublicationsBinary interactionsi
Hide detailsQ86X95
With | #Exp. | IntAct |
---|---|---|
CEP76 [Q8TAP6] | 3 | EBI-627102,EBI-742887 |
SRSF1 [Q07955] | 3 | EBI-627102,EBI-398920 |
SRSF2 [Q01130] | 4 | EBI-627102,EBI-627047 |
U2AF1 [Q01081] | 4 | EBI-627102,EBI-632461 |
Isoform 2 [Q86X95-2]
With | #Exp. | IntAct |
---|---|---|
DPPA4 [Q7L190] | 3 | EBI-12034850,EBI-710457 |
MB21D2 [Q8IYB1] | 3 | EBI-12034850,EBI-11323212 |
GO - Molecular functioni
- histone deacetylase binding Source: MGI
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114916, 27 interactors |
IntActi | Q86X95, 26 interactors |
MINTi | Q86X95 |
STRINGi | 9606.ENSP00000339723 |
Miscellaneous databases
RNActi | Q86X95, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 121 | Interaction with RBPJ1 PublicationAdd BLAST | 121 | |
Regioni | 204 – 232 | Interaction with RP9By similarityAdd BLAST | 29 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 235 – 245 | Nuclear localization signalSequence analysisAdd BLAST | 11 | |
Motifi | 291 – 298 | Nuclear localization signalSequence analysis | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 214 – 368 | Lys/Ser-richAdd BLAST | 155 | |
Compositional biasi | 369 – 450 | Arg/Ser-rich (RS domain)Add BLAST | 82 |
Phylogenomic databases
eggNOGi | KOG3794, Eukaryota |
GeneTreei | ENSGT00730000111135 |
HOGENOMi | CLU_035642_2_0_1 |
InParanoidi | Q86X95 |
OMAi | KHKKHKM |
OrthoDBi | 1604301at2759 |
PhylomeDBi | Q86X95 |
TreeFami | TF317567 |
Family and domain databases
InterProi | View protein in InterPro IPR040014, CIR1 IPR019339, CIR_N_dom |
PANTHERi | PTHR13151, PTHR13151, 1 hit |
Pfami | View protein in Pfam PF10197, Cir_N, 1 hit |
SMARTi | View protein in SMART SM01083, Cir_N, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGKSFANFMC KKDFHPASKS NIKKVWMAEQ KISYDKKKQE ELMQQYLKEQ
60 70 80 90 100
ESYDNRLLMG DERVKNGLNF MYEAPPGAKK ENKEKEETEG ETEYKFEWQK
110 120 130 140 150
GAPREKYAKD DMNIRDQPFG IQVRNVRCIK CHKWGHVNTD RECPLFGLSG
160 170 180 190 200
INASSVPTDG SGPSMHPSEL IAEMRNSGFA LKRNVLGRNL TANDPSQEYV
210 220 230 240 250
ASEGEEDPEV EFLKSLTTKQ KQKLLRKLDR LEKKKKKKDR KKKKFQKSRS
260 270 280 290 300
KHKKHKSSSS SSSSSSSSSS TETSESSSES ESNNKEKKIQ RKKRKKNKCS
310 320 330 340 350
GHNNSDSEEK DKSKKRKLHE ELSSSHHNRE KAKEKPRFLK HESSREDSKW
360 370 380 390 400
SHSDSDKKSR THKHSPEKRG SERKEGSSRS HGREERSRRS RSRSPGSYKQ
410 420 430 440 450
RETRKRAQRN PGEEQSRRND SRSHGTDLYR GEKMYREHPG GTHTKVTQRE
The sequence of this isoform differs from the canonical sequence as follows:
162-202: GPSMHPSELI...NDPSQEYVAS → DAVLQIEGFW...KCTGEKLDRK
203-450: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH3BLY3 | H3BLY3_HUMAN | Corepressor-interacting with RBPJ 1 | CIR1 | 96 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 48 | K → R in AAD05243 (PubMed:9874765).Curated | 1 | |
Sequence conflicti | 113 | N → S in AAD05243 (PubMed:9874765).Curated | 1 | |
Sequence conflicti | 172 | A → G in AAA17853 (Ref. 2) Curated | 1 | |
Sequence conflicti | 325 | S → T in AAD05243 (PubMed:9874765).Curated | 1 | |
Sequence conflicti | 325 | S → T in AAA17853 (Ref. 2) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020091 | 162 – 202 | GPSMH…EYVAS → DAVLQIEGFWAIDAPLGANS GDEKQWVCTETKCTGEKLDR K in isoform 2. 1 PublicationAdd BLAST | 41 | |
Alternative sequenceiVSP_020092 | 203 – 450 | Missing in isoform 2. 1 PublicationAdd BLAST | 248 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF098297 mRNA Translation: AAD05243.1 U03644 mRNA Translation: AAA17853.1 Frameshift. AK292389 mRNA Translation: BAF85078.1 AC018470 Genomic DNA Translation: AAY24216.1 BC015040 mRNA No translation available. BC021175 mRNA Translation: AAH21175.1 Sequence problems. BC038987 mRNA Translation: AAH38987.1 Sequence problems. BC046098 mRNA Translation: AAH46098.1 |
CCDSi | CCDS2256.1 [Q86X95-1] |
PIRi | G01227 |
RefSeqi | NP_004873.3, NM_004882.3 [Q86X95-1] |
Genome annotation databases
Ensembli | ENST00000342016; ENSP00000339723; ENSG00000138433 [Q86X95-1] |
GeneIDi | 9541 |
KEGGi | hsa:9541 |
UCSCi | uc002uim.4, human [Q86X95-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF098297 mRNA Translation: AAD05243.1 U03644 mRNA Translation: AAA17853.1 Frameshift. AK292389 mRNA Translation: BAF85078.1 AC018470 Genomic DNA Translation: AAY24216.1 BC015040 mRNA No translation available. BC021175 mRNA Translation: AAH21175.1 Sequence problems. BC038987 mRNA Translation: AAH38987.1 Sequence problems. BC046098 mRNA Translation: AAH46098.1 |
CCDSi | CCDS2256.1 [Q86X95-1] |
PIRi | G01227 |
RefSeqi | NP_004873.3, NM_004882.3 [Q86X95-1] |
3D structure databases
SMRi | Q86X95 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114916, 27 interactors |
IntActi | Q86X95, 26 interactors |
MINTi | Q86X95 |
STRINGi | 9606.ENSP00000339723 |
PTM databases
iPTMneti | Q86X95 |
PhosphoSitePlusi | Q86X95 |
Polymorphism and mutation databases
BioMutai | CIR1 |
DMDMi | 74727790 |
Proteomic databases
EPDi | Q86X95 |
jPOSTi | Q86X95 |
MassIVEi | Q86X95 |
MaxQBi | Q86X95 |
PaxDbi | Q86X95 |
PeptideAtlasi | Q86X95 |
PRIDEi | Q86X95 |
ProteomicsDBi | 70256 [Q86X95-1] 70257 [Q86X95-2] |
Protocols and materials databases
Antibodypediai | 19463, 128 antibodies |
Genome annotation databases
Ensembli | ENST00000342016; ENSP00000339723; ENSG00000138433 [Q86X95-1] |
GeneIDi | 9541 |
KEGGi | hsa:9541 |
UCSCi | uc002uim.4, human [Q86X95-1] |
Organism-specific databases
CTDi | 9541 |
DisGeNETi | 9541 |
EuPathDBi | HostDB:ENSG00000138433.15 |
GeneCardsi | CIR1 |
HGNCi | HGNC:24217, CIR1 |
HPAi | ENSG00000138433, Low tissue specificity |
MIMi | 605228, gene |
neXtProti | NX_Q86X95 |
OpenTargetsi | ENSG00000138433 |
PharmGKBi | PA165696415 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3794, Eukaryota |
GeneTreei | ENSGT00730000111135 |
HOGENOMi | CLU_035642_2_0_1 |
InParanoidi | Q86X95 |
OMAi | KHKKHKM |
OrthoDBi | 1604301at2759 |
PhylomeDBi | Q86X95 |
TreeFami | TF317567 |
Enzyme and pathway databases
PathwayCommonsi | Q86X95 |
SignaLinki | Q86X95 |
SIGNORi | Q86X95 |
Miscellaneous databases
BioGRID-ORCSi | 9541, 74 hits in 826 CRISPR screens |
ChiTaRSi | CIR1, human |
GeneWikii | CIR_(gene) |
GenomeRNAii | 9541 |
Pharosi | Q86X95, Tdark |
PROi | PR:Q86X95 |
RNActi | Q86X95, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138433, Expressed in tendon of biceps brachii and 235 other tissues |
ExpressionAtlasi | Q86X95, baseline and differential |
Genevisiblei | Q86X95, HS |
Family and domain databases
InterProi | View protein in InterPro IPR040014, CIR1 IPR019339, CIR_N_dom |
PANTHERi | PTHR13151, PTHR13151, 1 hit |
Pfami | View protein in Pfam PF10197, Cir_N, 1 hit |
SMARTi | View protein in SMART SM01083, Cir_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CIR1_HUMAN | |
Accessioni | Q86X95Primary (citable) accession number: Q86X95 Secondary accession number(s): A6NFI6 Q8IWI2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2006 |
Last sequence update: | June 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM