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UniProtKB - Q86X53 (ERIC1_HUMAN)

Entry version 115 (11 Dec 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Glutamate-rich protein 1

Gene

ERICH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutamate-rich protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ERICH1
ORF Names:HSPC319
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000104714.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:27234 ERICH1

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86X53

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		157697

Open Targets

More...OpenTargetsi		ENSG00000104714

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671903

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86X53 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ERICH1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74727771

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000870291 – 443Glutamate-rich protein 1Add BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12N6-acetyllysineCombined sources1
Modified residuei238PhosphoserineCombined sources1
Modified residuei254PhosphoserineCombined sources1
Modified residuei277PhosphothreonineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q86X53

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q86X53

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86X53

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86X53

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86X53

PeptideAtlas

More...PeptideAtlasi		Q86X53

PRoteomics IDEntifications database

More...PRIDEi		Q86X53

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70240

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86X53

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86X53

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000104714 Expressed in 192 organ(s), highest expression level in adult mammalian kidney

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86X53 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86X53 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA003725

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		127615, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q86X53, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000262109

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86X53 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi193 – 328Glu-richAdd BLAST136

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IK3S Eukaryota
ENOG410YSPJ LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005606

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000013042

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86X53

Identification of Orthologs from Complete Genome Data

More...OMAi		LFHYWIT

Database of Orthologous Groups

More...OrthoDBi		1453097at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86X53

TreeFam database of animal gene trees

More...TreeFami		TF335794

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026719 ERICH1

The PANTHER Classification System

More...PANTHERi		PTHR22444 PTHR22444, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q86X53-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAHRKHVFV EKVLQRLFPP VPSGQGKREP QTLAVQNPPK KVTSEKVSQK 
        60         70         80         90        100
HAEPLTDTGS ETPTARRLYT ASGPPEGYVP CWPEPSSCGS PENASSGDDT 
       110        120        130        140        150
EDQDPHDQPK RRRIRKHKSK KKFKNPNNVL IEQAELEKQQ SLLQEKSQRQ 
       160        170        180        190        200
HTDGTTISKN KKRKLKKKQQ IKRKKAAGLA AKAAGVSFMY QPEDSSNEGE 
       210        220        230        240        250
GVGEACEEDG VDTSEEDPTL AGEEDVKDTR EEDGADASEE DLTRARQEEG 
       260        270        280        290        300
ADASEEDPTP AGEEDVKDAR EEDGVDTIEE DLTRAGEEDG KDTREEDGAD 
       310        320        330        340        350
ASEEDPTWAG EEEGADSGEE DGADASEEDD TITNEKAHSI LNFLKSTQEM 
       360        370        380        390        400
YFYDGVSRDA ASAALADAAE ELLDRLASHS MLPSDVSILY HMKTLLLLQD 
       410        420        430        440 
TERLKHALEM FPEHCTMPPD HARVISAFFS YWITHILPEK SSD
Length:443
Mass (Da):48,984
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB343667314588823
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RHA3E5RHA3_HUMAN
Glutamate-rich protein 1
ERICH1
345Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB25H0YB25_HUMAN
Glutamate-rich protein 1
ERICH1
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBT6H0YBT6_HUMAN
Glutamate-rich protein 1
ERICH1
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y8EN93A0A1Y8EN93_HUMAN
Glutamate-rich protein 1
ERICH1
7Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF28997 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3A → Q in AAF28997 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035915365L → F in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs774405503Ensembl.1
Natural variantiVAR_050974403R → S. Corresponds to variant dbSNP:rs1703879Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK290264 mRNA Translation: BAF82953.1
CH471181 Genomic DNA Translation: EAW51467.1
BC046243 mRNA Translation: AAH46243.1
AF161437 mRNA Translation: AAF28997.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5955.1

NCBI Reference Sequences

More...RefSeqi		NP_997215.1, NM_207332.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262109; ENSP00000262109; ENSG00000104714

Database of genes from NCBI RefSeq genomes

More...GeneIDi		157697

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:157697

UCSC genome browser

More...UCSCi		uc003wph.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290264 mRNA Translation: BAF82953.1
CH471181 Genomic DNA Translation: EAW51467.1
BC046243 mRNA Translation: AAH46243.1
AF161437 mRNA Translation: AAF28997.1 Different initiation.
CCDSiCCDS5955.1
RefSeqiNP_997215.1, NM_207332.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi127615, 2 interactors
IntActiQ86X53, 1 interactor
STRINGi9606.ENSP00000262109

PTM databases

iPTMnetiQ86X53
PhosphoSitePlusiQ86X53

Polymorphism and mutation databases

BioMutaiERICH1
DMDMi74727771

Proteomic databases

EPDiQ86X53
jPOSTiQ86X53
MassIVEiQ86X53
MaxQBiQ86X53
PaxDbiQ86X53
PeptideAtlasiQ86X53
PRIDEiQ86X53
ProteomicsDBi70240

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		157697

Genome annotation databases

EnsembliENST00000262109; ENSP00000262109; ENSG00000104714
GeneIDi157697
KEGGihsa:157697
UCSCiuc003wph.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		157697
DisGeNETi157697
EuPathDBiHostDB:ENSG00000104714.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		ERICH1
HGNCiHGNC:27234 ERICH1
HPAiHPA003725
neXtProtiNX_Q86X53
OpenTargetsiENSG00000104714
PharmGKBiPA142671903

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IK3S Eukaryota
ENOG410YSPJ LUCA
GeneTreeiENSGT00390000005606
HOGENOMiHOG000013042
InParanoidiQ86X53
OMAiLFHYWIT
OrthoDBi1453097at2759
PhylomeDBiQ86X53
TreeFamiTF335794

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ERICH1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		157697
PharosiQ86X53 Tdark

Protein Ontology

More...PROi		PR:Q86X53
RNActiQ86X53 protein

Gene expression databases

BgeeiENSG00000104714 Expressed in 192 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiQ86X53 baseline and differential
GenevisibleiQ86X53 HS

Family and domain databases

InterProiView protein in InterPro
IPR026719 ERICH1
PANTHERiPTHR22444 PTHR22444, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERIC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86X53
Secondary accession number(s): A8K2J9, Q9P063
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 1, 2003
Last modified: December 11, 2019
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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