ERICH1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glutamate-rich protein 1
Gene namesⁱ	Name:ERICH1 ORF Names:HSPC319
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000104714.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:27234 ERICH1
neXtProtⁱ	NX_Q86X53

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000104714
PharmGKBⁱ	PA142671903

Polymorphism and mutation databases

BioMutaⁱ	ERICH1
DMDMⁱ	74727771

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000087029	1 – 443	Glutamate-rich protein 1Add BLAST		443

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	12	N6-acetyllysineCombined sources	1
Modified residueⁱ	238	PhosphoserineCombined sources	1
Modified residueⁱ	254	PhosphoserineCombined sources	1
Modified residueⁱ	277	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q86X53
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q86X53
PaxDbⁱ	Q86X53
PeptideAtlas More...PeptideAtlasⁱ	Q86X53
PRIDEⁱ	Q86X53
ProteomicsDBⁱ	70240

PTM databases

iPTMnetⁱ	Q86X53
PhosphoSitePlusⁱ	Q86X53

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000104714 Expressed in 192 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	HS_ERICH1
ExpressionAtlasⁱ	Q86X53 baseline and differential
Genevisibleⁱ	Q86X53 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003725

HPAⁱ

HPA003725

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	127615, 1 interactor
IntActⁱ	Q86X53, 1 interactor
STRINGⁱ	9606.ENSP00000262109

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q86X53
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	193 – 328	Glu-richAdd BLAST		136

Phylogenomic databases

eggNOGⁱ	ENOG410IK3S Eukaryota ENOG410YSPJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005606
HOGENOMⁱ	HOG000013042
HOVERGENⁱ	HBG081480
InParanoidⁱ	Q86X53
OMAⁱ	HDQPKRR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DLL
PhylomeDBⁱ	Q86X53
TreeFamⁱ	TF335794

Family and domain databases

InterProⁱ	View protein in InterPro IPR026719 ERICH1
PANTHERⁱ	PTHR22444 PTHR22444, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.ⁱShow all

Q86X53-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAAHRKHVFV EKVLQRLFPP VPSGQGKREP QTLAVQNPPK KVTSEKVSQK 
        60         70         80         90        100
HAEPLTDTGS ETPTARRLYT ASGPPEGYVP CWPEPSSCGS PENASSGDDT 
       110        120        130        140        150
EDQDPHDQPK RRRIRKHKSK KKFKNPNNVL IEQAELEKQQ SLLQEKSQRQ 
       160        170        180        190        200
HTDGTTISKN KKRKLKKKQQ IKRKKAAGLA AKAAGVSFMY QPEDSSNEGE 
       210        220        230        240        250
GVGEACEEDG VDTSEEDPTL AGEEDVKDTR EEDGADASEE DLTRARQEEG 
       260        270        280        290        300
ADASEEDPTP AGEEDVKDAR EEDGVDTIEE DLTRAGEEDG KDTREEDGAD 
       310        320        330        340        350
ASEEDPTWAG EEEGADSGEE DGADASEEDD TITNEKAHSI LNFLKSTQEM 
       360        370        380        390        400
YFYDGVSRDA ASAALADAAE ELLDRLASHS MLPSDVSILY HMKTLLLLQD 
       410        420        430        440 
TERLKHALEM FPEHCTMPPD HARVISAFFS YWITHILPEK SSD

Length:443

Mass (Da):48,984

Last modified:June 1, 2003 - v1

Checksum:ⁱB343667314588823

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
E5RHA3	E5RHA3_HUMAN	Glutamate-rich protein 1 Glutamate-rich protein 1	ERICH1	345	Annotation score:
H0YBT6	H0YBT6_HUMAN	Glutamate-rich protein 1 Glutamate-rich protein 1	ERICH1	124	Annotation score:
H0YB25	H0YB25_HUMAN	Glutamate-rich protein 1 Glutamate-rich protein 1	ERICH1	223	Annotation score:
A0A1Y8EN93	A0A1Y8EN93_HUMAN	Glutamate-rich protein 1 Glutamate-rich protein 1	ERICH1	7	Annotation score:

Sequence cautionⁱ

The sequence AAF28997 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	3	A → Q in AAF28997 (Ref. 4) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035915	365	L → F in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs774405503Ensembl.		1
Natural variantⁱVAR_050974	403	R → S. Corresponds to variant dbSNP:rs1703879Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK290264 mRNA Translation: BAF82953.1 CH471181 Genomic DNA Translation: EAW51467.1 BC046243 mRNA Translation: AAH46243.1 AF161437 mRNA Translation: AAF28997.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5955.1
NCBI Reference Sequences More...RefSeqⁱ	NP_997215.1, NM_207332.2
UniGeneⁱ	Hs.655310 Hs.662526

Genome annotation databases

Ensemblⁱ	ENST00000262109; ENSP00000262109; ENSG00000104714
GeneIDⁱ	157697
KEGGⁱ	hsa:157697
UCSC genome browser More...UCSCⁱ	uc003wph.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q86X53	Glutamate rich 1		GORGO		443	UniRef90_Q86X53
cDNA FLJ56027, highly similar to Glutamate-rich protein 1		HUMAN		422
UPI0008F4DB41		GORGO		504
UPI0007DC616B		HUMAN		421

Protein	Similar proteins		Species	Score	Length	Source
Q86X53	Glutamate rich 1		GORGO		443	UniRef50_Q86X53
cDNA FLJ56027, highly similar to Glutamate-rich protein 1		HUMAN		422
Uncharacterized protein		Cebus capucinus imitator		239
Glutamate rich 1		PANPA		408
UPI0008F4DB41		GORGO		504
+3

Entry informationⁱ

Entry nameⁱ	ERIC1_HUMAN
Accessionⁱ	Q86X53Primary (citable) accession number: Q86X53 Secondary accession number(s): A8K2J9, Q9P063
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
	Last sequence update:	June 1, 2003
	Last modified:	September 12, 2018
	This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB - Q86X53 (ERIC1_HUMAN)

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Glutamate-rich protein 1

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Names & Taxonomyⁱ

Organism-specific databases

Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

Expressionⁱ

Gene expression databases

Organism-specific databases

Interactionⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Compositional bias

Phylogenomic databases

Family and domain databases

Sequence (1+)ⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Similar proteinsⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q86X53 (ERIC1_HUMAN)

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Glutamate-rich protein 1

ERICH1

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ