UniProtKB - Q86X53 (ERIC1_HUMAN)
Protein
Glutamate-rich protein 1
Gene
ERICH1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Glutamate-rich protein 1 |
Gene namesi | Name:ERICH1 ORF Names:HSPC319 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27234, ERICH1 |
neXtProti | NX_Q86X53 |
VEuPathDBi | HostDB:ENSG00000104714.13 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 157697 |
OpenTargetsi | ENSG00000104714 |
PharmGKBi | PA142671903 |
Miscellaneous databases
Pharosi | Q86X53, Tdark |
Genetic variation databases
BioMutai | ERICH1 |
DMDMi | 74727771 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087029 | 1 – 443 | Glutamate-rich protein 1Add BLAST | 443 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 12 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 238 | PhosphoserineCombined sources | 1 | |
Modified residuei | 254 | PhosphoserineCombined sources | 1 | |
Modified residuei | 277 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q86X53 |
jPOSTi | Q86X53 |
MassIVEi | Q86X53 |
MaxQBi | Q86X53 |
PaxDbi | Q86X53 |
PeptideAtlasi | Q86X53 |
PRIDEi | Q86X53 |
ProteomicsDBi | 70240 |
PTM databases
iPTMneti | Q86X53 |
PhosphoSitePlusi | Q86X53 |
Expressioni
Gene expression databases
Bgeei | ENSG00000104714, Expressed in calcaneal tendon and 207 other tissues |
ExpressionAtlasi | Q86X53, baseline and differential |
Genevisiblei | Q86X53, HS |
Organism-specific databases
HPAi | ENSG00000104714, Low tissue specificity |
Interactioni
Binary interactionsi
Q86X53
With | #Exp. | IntAct |
---|---|---|
MTG1 [Q9BT17] | 3 | EBI-12902263,EBI-2602570 |
Protein-protein interaction databases
BioGRIDi | 127615, 3 interactors |
IntActi | Q86X53, 1 interactor |
STRINGi | 9606.ENSP00000262109 |
Miscellaneous databases
RNActi | Q86X53, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 193 – 328 | Glu-richAdd BLAST | 136 |
Phylogenomic databases
eggNOGi | ENOG502S06A, Eukaryota |
GeneTreei | ENSGT00390000005606 |
HOGENOMi | CLU_041433_0_0_1 |
InParanoidi | Q86X53 |
OMAi | LFHYWIT |
OrthoDBi | 1453097at2759 |
PhylomeDBi | Q86X53 |
TreeFami | TF335794 |
Family and domain databases
InterProi | View protein in InterPro IPR026719, ERICH1 |
PANTHERi | PTHR22444, PTHR22444, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q86X53-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAHRKHVFV EKVLQRLFPP VPSGQGKREP QTLAVQNPPK KVTSEKVSQK
60 70 80 90 100
HAEPLTDTGS ETPTARRLYT ASGPPEGYVP CWPEPSSCGS PENASSGDDT
110 120 130 140 150
EDQDPHDQPK RRRIRKHKSK KKFKNPNNVL IEQAELEKQQ SLLQEKSQRQ
160 170 180 190 200
HTDGTTISKN KKRKLKKKQQ IKRKKAAGLA AKAAGVSFMY QPEDSSNEGE
210 220 230 240 250
GVGEACEEDG VDTSEEDPTL AGEEDVKDTR EEDGADASEE DLTRARQEEG
260 270 280 290 300
ADASEEDPTP AGEEDVKDAR EEDGVDTIEE DLTRAGEEDG KDTREEDGAD
310 320 330 340 350
ASEEDPTWAG EEEGADSGEE DGADASEEDD TITNEKAHSI LNFLKSTQEM
360 370 380 390 400
YFYDGVSRDA ASAALADAAE ELLDRLASHS MLPSDVSILY HMKTLLLLQD
410 420 430 440
TERLKHALEM FPEHCTMPPD HARVISAFFS YWITHILPEK SSD
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YB25 | H0YB25_HUMAN | Glutamate-rich protein 1 | ERICH1 | 223 | Annotation score: | ||
E5RHA3 | E5RHA3_HUMAN | Glutamate-rich protein 1 | ERICH1 | 345 | Annotation score: | ||
H0YBT6 | H0YBT6_HUMAN | Glutamate-rich protein 1 | ERICH1 | 124 | Annotation score: | ||
A0A1Y8EN93 | A0A1Y8EN93_HUMAN | Glutamate-rich protein 1 | ERICH1 | 7 | Annotation score: |
Sequence cautioni
The sequence AAF28997 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | A → Q in AAF28997 (Ref. 4) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035915 | 365 | L → F in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs774405503Ensembl. | 1 | |
Natural variantiVAR_050974 | 403 | R → S. Corresponds to variant dbSNP:rs1703879Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290264 mRNA Translation: BAF82953.1 CH471181 Genomic DNA Translation: EAW51467.1 BC046243 mRNA Translation: AAH46243.1 AF161437 mRNA Translation: AAF28997.1 Different initiation. |
CCDSi | CCDS5955.1 |
RefSeqi | NP_997215.1, NM_207332.2 |
Genome annotation databases
Ensembli | ENST00000262109; ENSP00000262109; ENSG00000104714 |
GeneIDi | 157697 |
KEGGi | hsa:157697 |
UCSCi | uc003wph.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290264 mRNA Translation: BAF82953.1 CH471181 Genomic DNA Translation: EAW51467.1 BC046243 mRNA Translation: AAH46243.1 AF161437 mRNA Translation: AAF28997.1 Different initiation. |
CCDSi | CCDS5955.1 |
RefSeqi | NP_997215.1, NM_207332.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127615, 3 interactors |
IntActi | Q86X53, 1 interactor |
STRINGi | 9606.ENSP00000262109 |
PTM databases
iPTMneti | Q86X53 |
PhosphoSitePlusi | Q86X53 |
Genetic variation databases
BioMutai | ERICH1 |
DMDMi | 74727771 |
Proteomic databases
EPDi | Q86X53 |
jPOSTi | Q86X53 |
MassIVEi | Q86X53 |
MaxQBi | Q86X53 |
PaxDbi | Q86X53 |
PeptideAtlasi | Q86X53 |
PRIDEi | Q86X53 |
ProteomicsDBi | 70240 |
Protocols and materials databases
Antibodypediai | 1007, 22 antibodies |
DNASUi | 157697 |
Genome annotation databases
Ensembli | ENST00000262109; ENSP00000262109; ENSG00000104714 |
GeneIDi | 157697 |
KEGGi | hsa:157697 |
UCSCi | uc003wph.4, human |
Organism-specific databases
CTDi | 157697 |
DisGeNETi | 157697 |
GeneCardsi | ERICH1 |
HGNCi | HGNC:27234, ERICH1 |
HPAi | ENSG00000104714, Low tissue specificity |
neXtProti | NX_Q86X53 |
OpenTargetsi | ENSG00000104714 |
PharmGKBi | PA142671903 |
VEuPathDBi | HostDB:ENSG00000104714.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S06A, Eukaryota |
GeneTreei | ENSGT00390000005606 |
HOGENOMi | CLU_041433_0_0_1 |
InParanoidi | Q86X53 |
OMAi | LFHYWIT |
OrthoDBi | 1453097at2759 |
PhylomeDBi | Q86X53 |
TreeFami | TF335794 |
Enzyme and pathway databases
PathwayCommonsi | Q86X53 |
Miscellaneous databases
BioGRID-ORCSi | 157697, 3 hits in 874 CRISPR screens |
ChiTaRSi | ERICH1, human |
GenomeRNAii | 157697 |
Pharosi | Q86X53, Tdark |
PROi | PR:Q86X53 |
RNActi | Q86X53, protein |
Gene expression databases
Bgeei | ENSG00000104714, Expressed in calcaneal tendon and 207 other tissues |
ExpressionAtlasi | Q86X53, baseline and differential |
Genevisiblei | Q86X53, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026719, ERICH1 |
PANTHERi | PTHR22444, PTHR22444, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ERIC1_HUMAN | |
Accessioni | Q86X53Primary (citable) accession number: Q86X53 Secondary accession number(s): A8K2J9, Q9P063 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2005 |
Last sequence update: | June 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports