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Protein

Glutamate-rich protein 1

Gene

ERICH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-rich protein 1
Gene namesi
Name:ERICH1
ORF Names:HSPC319
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104714.13
HGNCiHGNC:27234 ERICH1
neXtProtiNX_Q86X53

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104714
PharmGKBiPA142671903

Polymorphism and mutation databases

BioMutaiERICH1
DMDMi74727771

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000870291 – 443Glutamate-rich protein 1Add BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12N6-acetyllysineCombined sources1
Modified residuei238PhosphoserineCombined sources1
Modified residuei254PhosphoserineCombined sources1
Modified residuei277PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ86X53
MaxQBiQ86X53
PaxDbiQ86X53
PeptideAtlasiQ86X53
PRIDEiQ86X53
ProteomicsDBi70240

PTM databases

iPTMnetiQ86X53
PhosphoSitePlusiQ86X53

Expressioni

Gene expression databases

BgeeiENSG00000104714 Expressed in 192 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_ERICH1
ExpressionAtlasiQ86X53 baseline and differential
GenevisibleiQ86X53 HS

Organism-specific databases

HPAiHPA003725

Interactioni

Protein-protein interaction databases

BioGridi127615, 1 interactor
IntActiQ86X53, 1 interactor
STRINGi9606.ENSP00000262109

Structurei

3D structure databases

ProteinModelPortaliQ86X53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi193 – 328Glu-richAdd BLAST136

Phylogenomic databases

eggNOGiENOG410IK3S Eukaryota
ENOG410YSPJ LUCA
GeneTreeiENSGT00390000005606
HOGENOMiHOG000013042
HOVERGENiHBG081480
InParanoidiQ86X53
OMAiHDQPKRR
OrthoDBiEOG091G0DLL
PhylomeDBiQ86X53
TreeFamiTF335794

Family and domain databases

InterProiView protein in InterPro
IPR026719 ERICH1
PANTHERiPTHR22444 PTHR22444, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.iShow all

Q86X53-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAHRKHVFV EKVLQRLFPP VPSGQGKREP QTLAVQNPPK KVTSEKVSQK
60 70 80 90 100
HAEPLTDTGS ETPTARRLYT ASGPPEGYVP CWPEPSSCGS PENASSGDDT
110 120 130 140 150
EDQDPHDQPK RRRIRKHKSK KKFKNPNNVL IEQAELEKQQ SLLQEKSQRQ
160 170 180 190 200
HTDGTTISKN KKRKLKKKQQ IKRKKAAGLA AKAAGVSFMY QPEDSSNEGE
210 220 230 240 250
GVGEACEEDG VDTSEEDPTL AGEEDVKDTR EEDGADASEE DLTRARQEEG
260 270 280 290 300
ADASEEDPTP AGEEDVKDAR EEDGVDTIEE DLTRAGEEDG KDTREEDGAD
310 320 330 340 350
ASEEDPTWAG EEEGADSGEE DGADASEEDD TITNEKAHSI LNFLKSTQEM
360 370 380 390 400
YFYDGVSRDA ASAALADAAE ELLDRLASHS MLPSDVSILY HMKTLLLLQD
410 420 430 440
TERLKHALEM FPEHCTMPPD HARVISAFFS YWITHILPEK SSD
Length:443
Mass (Da):48,984
Last modified:June 1, 2003 - v1
Checksum:iB343667314588823
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RHA3E5RHA3_HUMAN
Glutamate-rich protein 1
ERICH1
345Annotation score:
H0YBT6H0YBT6_HUMAN
Glutamate-rich protein 1
ERICH1
124Annotation score:
H0YB25H0YB25_HUMAN
Glutamate-rich protein 1
ERICH1
223Annotation score:
A0A1Y8EN93A0A1Y8EN93_HUMAN
Glutamate-rich protein 1
ERICH1
7Annotation score:

Sequence cautioni

The sequence AAF28997 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3A → Q in AAF28997 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035915365L → F in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs774405503Ensembl.1
Natural variantiVAR_050974403R → S. Corresponds to variant dbSNP:rs1703879Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290264 mRNA Translation: BAF82953.1
CH471181 Genomic DNA Translation: EAW51467.1
BC046243 mRNA Translation: AAH46243.1
AF161437 mRNA Translation: AAF28997.1 Different initiation.
CCDSiCCDS5955.1
RefSeqiNP_997215.1, NM_207332.2
UniGeneiHs.655310
Hs.662526

Genome annotation databases

EnsembliENST00000262109; ENSP00000262109; ENSG00000104714
GeneIDi157697
KEGGihsa:157697
UCSCiuc003wph.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiERIC1_HUMAN
AccessioniPrimary (citable) accession number: Q86X53
Secondary accession number(s): A8K2J9, Q9P063
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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