UniProtKB - Q86X29 (LSR_HUMAN)
Protein
Lipolysis-stimulated lipoprotein receptor
Gene
LSR
Organism
Homo sapiens (Human)
Status
Functioni
Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity).By similarity
Caution
In contrast to the rodent orthologous protein, it is longer in N-terminus and no signal sequence is detected by any prediction method.Curated
GO - Biological processi
- establishment of blood-brain barrier Source: ARUK-UCL
- establishment of skin barrier Source: ARUK-UCL
- liver development Source: HGNC
- maintenance of blood-brain barrier Source: ARUK-UCL
- protein localization to tricellular tight junction Source: ARUK-UCL
- regulation of lipid metabolic process Source: Ensembl
- tricellular tight junction assembly Source: ARUK-UCL
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | Q86X29 |
Reactomei | R-HSA-8964038, LDL clearance R-HSA-8964046, VLDL clearance |
Names & Taxonomyi
Protein namesi | Recommended name: Lipolysis-stimulated lipoprotein receptor |
Gene namesi | Name:LSR Synonyms:LISCH |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29572, LSR |
MIMi | 616582, gene |
neXtProti | NX_Q86X29 |
VEuPathDBi | HostDB:ENSG00000105699.16 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Single-pass membrane protein Curated
Extracellular region or secreted
- chylomicron Source: UniProtKB-KW
- extracellular exosome Source: UniProtKB
- low-density lipoprotein particle Source: UniProtKB-KW
- very-low-density lipoprotein particle Source: UniProtKB-KW
Plasma Membrane
- plasma membrane Source: HGNC
Other locations
- integral component of membrane Source: UniProtKB-KW
- tricellular tight junction Source: ARUK-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 259 | ExtracellularSequence analysisAdd BLAST | 259 | |
Transmembranei | 260 – 280 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 281 – 649 | CytoplasmicSequence analysisAdd BLAST | 369 |
Keywords - Cellular componenti
Cell membrane, Chylomicron, LDL, Membrane, VLDLPathology & Biotechi
Organism-specific databases
DisGeNETi | 51599 |
OpenTargetsi | ENSG00000105699 |
PharmGKBi | PA142671504 |
Miscellaneous databases
Pharosi | Q86X29, Tbio |
Genetic variation databases
BioMutai | LSR |
DMDMi | 116242622 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000245308 | 1 – 649 | Lipolysis-stimulated lipoprotein receptorAdd BLAST | 649 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 111 ↔ 218 | PROSITE-ProRule annotation | ||
Modified residuei | 336 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 365 | PhosphoserineCombined sources | 1 | |
Modified residuei | 371 | PhosphoserineCombined sources | 1 | |
Modified residuei | 389 | PhosphoserineCombined sources | 1 | |
Modified residuei | 432 | PhosphoserineCombined sources | 1 | |
Modified residuei | 436 | PhosphoserineCombined sources | 1 | |
Modified residuei | 453 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 464 | PhosphoserineCombined sources | 1 | |
Modified residuei | 467 | PhosphoserineCombined sources | 1 | |
Modified residuei | 493 | PhosphoserineCombined sources | 1 | |
Modified residuei | 501 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 528 | PhosphoserineCombined sources | 1 | |
Modified residuei | 530 | PhosphoserineCombined sources | 1 | |
Modified residuei | 535 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 540 | PhosphoserineCombined sources | 1 | |
Modified residuei | 579 | PhosphoserineCombined sources | 1 | |
Modified residuei | 631 | PhosphoserineCombined sources | 1 | |
Modified residuei | 643 | PhosphoserineCombined sources | 1 | |
Modified residuei | 646 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, PhosphoproteinProteomic databases
EPDi | Q86X29 |
jPOSTi | Q86X29 |
MassIVEi | Q86X29 |
MaxQBi | Q86X29 |
PaxDbi | Q86X29 |
PeptideAtlasi | Q86X29 |
PRIDEi | Q86X29 |
ProteomicsDBi | 20511 4469 70230 [Q86X29-1] 70231 [Q86X29-2] 70232 [Q86X29-3] |
PTM databases
GlyGeni | Q86X29, 6 sites, 1 O-linked glycan (3 sites) |
iPTMneti | Q86X29 |
PhosphoSitePlusi | Q86X29 |
SwissPalmi | Q86X29 |
Expressioni
Gene expression databases
Bgeei | ENSG00000105699, Expressed in pigmented layer of retina and 193 other tissues |
ExpressionAtlasi | Q86X29, baseline and differential |
Genevisiblei | Q86X29, HS |
Organism-specific databases
HPAi | ENSG00000105699, Tissue enhanced (liver, pancreas) |
Interactioni
Subunit structurei
Homotrimer or homotetramer.
By similarityProtein-protein interaction databases
BioGRIDi | 119629, 82 interactors |
IntActi | Q86X29, 43 interactors |
MINTi | Q86X29 |
STRINGi | 9606.ENSP00000480821 |
Miscellaneous databases
RNActi | Q86X29, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 86 – 234 | Ig-like V-typeAdd BLAST | 149 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 280 – 304 | Cys-richAdd BLAST | 25 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QWP5, Eukaryota |
GeneTreei | ENSGT00950000183058 |
HOGENOMi | CLU_028969_2_0_1 |
InParanoidi | Q86X29 |
OMAi | DWLFVVM |
OrthoDBi | 457764at2759 |
PhylomeDBi | Q86X29 |
TreeFami | TF330877 |
Family and domain databases
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR003599, Ig_sub IPR008664, LISCH7 |
Pfami | View protein in Pfam PF05624, LSR, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q86X29-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQQDGLGVGT RNGSGKGRSV HPSWPWCAPR PLRYFGRDAR ARRAQTAAMA
60 70 80 90 100
LLAGGLSRGL GSHPAAAGRD AVVFVWLLLS TWCTAPARAI QVTVSNPYHV
110 120 130 140 150
VILFQPVTLP CTYQMTSTPT QPIVIWKYKS FCRDRIADAF SPASVDNQLN
160 170 180 190 200
AQLAAGNPGY NPYVECQDSV RTVRVVATKQ GNAVTLGDYY QGRRITITGN
210 220 230 240 250
ADLTFDQTAW GDSGVYYCSV VSAQDLQGNN EAYAELIVLG RTSGVAELLP
260 270 280 290 300
GFQAGPIEDW LFVVVVCLAA FLIFLLLGIC WCQCCPHTCC CYVRCPCCPD
310 320 330 340 350
KCCCPEALYA AGKAATSGVP SIYAPSTYAH LSPAKTPPPP AMIPMGPAYN
360 370 380 390 400
GYPGGYPGDV DRSSSAGGQG SYVPLLRDTD SSVASEVRSG YRIQASQQDD
410 420 430 440 450
SMRVLYYMEK ELANFDPSRP GPPSGRVERA MSEVTSLHED DWRSRPSRGP
460 470 480 490 500
ALTPIRDEEW GGHSPRSPRG WDQEPAREQA GGGWRARRPR ARSVDALDDL
510 520 530 540 550
TPPSTAESGS RSPTSNGGRS RAYMPPRSRS RDDLYDQDDS RDFPRSRDPH
560 570 580 590 600
YDDFRSRERP PADPRSHHHR TRDPRDNGSR SGDLPYDGRL LEEAVRKKGS
610 620 630 640
EERRRPHKEE EEEAYYPPAP PPYSETDSQA SRERRLKKNL ALSRESLVV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketS4R3V8 | S4R3V8_HUMAN | Lipolysis-stimulated lipoprotein re... | LSR | 601 | Annotation score: | ||
M0R0W1 | M0R0W1_HUMAN | Lipolysis-stimulated lipoprotein re... | LSR | 51 | Annotation score: | ||
M0QZL9 | M0QZL9_HUMAN | Lipolysis-stimulated lipoprotein re... | LSR | 114 | Annotation score: | ||
M0R1W9 | M0R1W9_HUMAN | Lipolysis-stimulated lipoprotein re... | LSR | 139 | Annotation score: |
Sequence cautioni
The sequence AAB51178 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAB58317 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAH04381 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 259 | D → G in AAB51178 (PubMed:15057824).Curated | 1 | |
Sequence conflicti | 308 | L → R in AAB51178 (PubMed:15057824).Curated | 1 | |
Sequence conflicti | 430 | A → G in AAB51178 (PubMed:15057824).Curated | 1 | |
Sequence conflicti | 518 | G → GR in BAC86714 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 518 | G → GR in BAC11614 (PubMed:16303743).Curated | 1 | |
Sequence conflicti | 518 | G → GR in AAH04381 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 639 | N → D in AAB51178 (PubMed:15057824).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049902 | 363 | S → N2 PublicationsCorresponds to variant dbSNP:rs34259399Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057210 | 1 – 48 | Missing in isoform 6. 1 PublicationAdd BLAST | 48 | |
Alternative sequenceiVSP_019691 | 52 – 88 | Missing in isoform 2. 1 PublicationAdd BLAST | 37 | |
Alternative sequenceiVSP_057211 | 200 – 308 | NADLT…CPEAL → M in isoform 6. 1 PublicationAdd BLAST | 109 | |
Alternative sequenceiVSP_046797 | 240 – 308 | GRTSG…CPEAL → V in isoform 5. CuratedAdd BLAST | 69 | |
Alternative sequenceiVSP_019692 | 240 – 258 | Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST | 19 | |
Alternative sequenceiVSP_019693 | 366 – 386 | Missing in isoform 2. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_019694 | 386 | Missing in isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF130366 mRNA Translation: AAD22101.1 AK075426 mRNA Translation: BAC11614.1 AK126834 mRNA Translation: BAC86714.1 AK296618 mRNA Translation: BAG59226.1 AC002128 Genomic DNA Translation: AAB58317.1 Sequence problems. AD000684 Genomic DNA Translation: AAB51178.1 Sequence problems. BC004381 mRNA Translation: AAH04381.2 Different initiation. BC047376 mRNA Translation: AAH47376.2 |
RefSeqi | NP_001247418.1, NM_001260489.1 NP_001247419.1, NM_001260490.1 [Q86X29-6] NP_057009.3, NM_015925.6 NP_991403.1, NM_205834.3 NP_991404.1, NM_205835.3 |
Genome annotation databases
Ensembli | ENST00000347609; ENSP00000262627; ENSG00000105699 [Q86X29-2] ENST00000354900; ENSP00000346976; ENSG00000105699 [Q86X29-4] ENST00000360798; ENSP00000354034; ENSG00000105699 [Q86X29-5] ENST00000361790; ENSP00000354575; ENSG00000105699 [Q86X29-1] ENST00000427250; ENSP00000394479; ENSG00000105699 [Q86X29-6] ENST00000602122; ENSP00000472569; ENSG00000105699 [Q86X29-3] ENST00000621372; ENSP00000480821; ENSG00000105699 [Q86X29-1] |
GeneIDi | 51599 |
KEGGi | hsa:51599 |
UCSCi | uc002nyl.4, human [Q86X29-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF130366 mRNA Translation: AAD22101.1 AK075426 mRNA Translation: BAC11614.1 AK126834 mRNA Translation: BAC86714.1 AK296618 mRNA Translation: BAG59226.1 AC002128 Genomic DNA Translation: AAB58317.1 Sequence problems. AD000684 Genomic DNA Translation: AAB51178.1 Sequence problems. BC004381 mRNA Translation: AAH04381.2 Different initiation. BC047376 mRNA Translation: AAH47376.2 |
RefSeqi | NP_001247418.1, NM_001260489.1 NP_001247419.1, NM_001260490.1 [Q86X29-6] NP_057009.3, NM_015925.6 NP_991403.1, NM_205834.3 NP_991404.1, NM_205835.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119629, 82 interactors |
IntActi | Q86X29, 43 interactors |
MINTi | Q86X29 |
STRINGi | 9606.ENSP00000480821 |
PTM databases
GlyGeni | Q86X29, 6 sites, 1 O-linked glycan (3 sites) |
iPTMneti | Q86X29 |
PhosphoSitePlusi | Q86X29 |
SwissPalmi | Q86X29 |
Genetic variation databases
BioMutai | LSR |
DMDMi | 116242622 |
Proteomic databases
EPDi | Q86X29 |
jPOSTi | Q86X29 |
MassIVEi | Q86X29 |
MaxQBi | Q86X29 |
PaxDbi | Q86X29 |
PeptideAtlasi | Q86X29 |
PRIDEi | Q86X29 |
ProteomicsDBi | 20511 4469 70230 [Q86X29-1] 70231 [Q86X29-2] 70232 [Q86X29-3] |
Protocols and materials databases
Antibodypediai | 1523, 173 antibodies |
DNASUi | 51599 |
Genome annotation databases
Organism-specific databases
CTDi | 51599 |
DisGeNETi | 51599 |
GeneCardsi | LSR |
HGNCi | HGNC:29572, LSR |
HPAi | ENSG00000105699, Tissue enhanced (liver, pancreas) |
MIMi | 616582, gene |
neXtProti | NX_Q86X29 |
OpenTargetsi | ENSG00000105699 |
PharmGKBi | PA142671504 |
VEuPathDBi | HostDB:ENSG00000105699.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWP5, Eukaryota |
GeneTreei | ENSGT00950000183058 |
HOGENOMi | CLU_028969_2_0_1 |
InParanoidi | Q86X29 |
OMAi | DWLFVVM |
OrthoDBi | 457764at2759 |
PhylomeDBi | Q86X29 |
TreeFami | TF330877 |
Enzyme and pathway databases
PathwayCommonsi | Q86X29 |
Reactomei | R-HSA-8964038, LDL clearance R-HSA-8964046, VLDL clearance |
Miscellaneous databases
BioGRID-ORCSi | 51599, 10 hits in 876 CRISPR screens |
ChiTaRSi | LSR, human |
GeneWikii | LSR_(gene) |
GenomeRNAii | 51599 |
Pharosi | Q86X29, Tbio |
PROi | PR:Q86X29 |
RNActi | Q86X29, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105699, Expressed in pigmented layer of retina and 193 other tissues |
ExpressionAtlasi | Q86X29, baseline and differential |
Genevisiblei | Q86X29, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR003599, Ig_sub IPR008664, LISCH7 |
Pfami | View protein in Pfam PF05624, LSR, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LSR_HUMAN | |
Accessioni | Q86X29Primary (citable) accession number: Q86X29 Secondary accession number(s): A6NDW3 Q9UQL3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2006 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 10, 2021 | |
This is version 172 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families