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Protein

Ral GTPase-activating protein subunit beta

Gene

RALGAPB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.By similarity

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Ral GTPase-activating protein subunit beta
Alternative name(s):
p170
Gene namesi
Name:RALGAPB
Synonyms:KIAA1219
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000170471.14
HGNCiHGNC:29221 RALGAPB
neXtProtiNX_Q86X10

Pathology & Biotechi

Organism-specific databases

DisGeNETi57148
OpenTargetsiENSG00000170471
PharmGKBiPA165392608

Polymorphism and mutation databases

DMDMi45477126

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567561 – 1494Ral GTPase-activating protein subunit betaAdd BLAST1494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei359PhosphoserineCombined sources1
Modified residuei363PhosphothreonineBy similarity1
Modified residuei379PhosphothreonineCombined sources1
Modified residuei421PhosphoserineBy similarity1
Modified residuei720PhosphoserineCombined sources1
Modified residuei734PhosphothreonineCombined sources1
Modified residuei1285PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86X10
MaxQBiQ86X10
PaxDbiQ86X10
PeptideAtlasiQ86X10
PRIDEiQ86X10
ProteomicsDBi70218
70219 [Q86X10-2]
70220 [Q86X10-3]
70221 [Q86X10-4]

PTM databases

iPTMnetiQ86X10
PhosphoSitePlusiQ86X10

Expressioni

Tissue specificityi

Highly expressed in brain, mostly in amygdala.

Gene expression databases

BgeeiENSG00000170471 Expressed in 226 organ(s), highest expression level in forebrain
CleanExiHS_KIAA1219
ExpressionAtlasiQ86X10 baseline and differential
GenevisibleiQ86X10 HS

Organism-specific databases

HPAiHPA051454

Interactioni

Subunit structurei

Component of the heterodimeric RalGAP1 complex with RALGAPA1 and of the heterodimeric RalGAP2 complex with RALGAPA2. Heterodimerization is required for activity (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121405, 17 interactors
IntActiQ86X10, 15 interactors
MINTiQ86X10
STRINGi9606.ENSP00000262879

Structurei

3D structure databases

ProteinModelPortaliQ86X10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1149 – 1392Rap-GAPPROSITE-ProRule annotationAdd BLAST244

Phylogenomic databases

eggNOGiKOG3652 Eukaryota
ENOG411027C LUCA
GeneTreeiENSGT00700000104550
HOGENOMiHOG000230877
HOVERGENiHBG052199
InParanoidiQ86X10
OMAiLESDSYN
OrthoDBiEOG091G0DSB
PhylomeDBiQ86X10
TreeFamiTF324460

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR039930 RALGAPB
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
PANTHERiPTHR21344 PTHR21344, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
PROSITEiView protein in PROSITE
PS50085 RAPGAP, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86X10-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYSEWRSLHL VIQNDQGHTS VLHSYPESVG REVANAVVRP LGQVLGTPSV
60 70 80 90 100
AGSENLLKTD KEVKWTMEVI CYGLTLPLDG ETVKYCVDVY TDWIMALVLP
110 120 130 140 150
KDSIPLPVIK EPNQYVQTIL KHLQNLFVPR QEQGSSQIRL CLQVLRAIQK
160 170 180 190 200
LARESSLMAR ETWEVLLLFL LQINDILLAP PTVQGGIAEN LAEKLIGVLF
210 220 230 240 250
EVWLLACTRC FPTPPYWKTA KEMVANWRHH PAVVEQWSKV ICALTSRLLR
260 270 280 290 300
FTYGPSFPAF KVPDEDASLI PPEMDNECVA QTWFRFLHML SNPVDLSNPA
310 320 330 340 350
IISSTPKFQE QFLNVSGMPQ ELNQYPCLKH LPQIFFRAMR GISCLVDAFL
360 370 380 390 400
GISRPRSDSA PPTPVNRLSM PQSAAVSTTP PHNRRHRAVT VNKATMKTST
410 420 430 440 450
VSTAHASKVQ HQTSSTSPLS SPNQTSSEPR PLPAPRRPKV NSILNLFGSW
460 470 480 490 500
LFDAAFVHCK LHNGINRDSS MTAITTQASM EFRRKGSQMS TDTMVSNPMF
510 520 530 540 550
DASEFPDNYE AGRAEACGTL CRIFCSKKTG EEILPAYLSR FYMLLIQGLQ
560 570 580 590 600
INDYVCHPVL ASVILNSPPL FCCDLKGIDV VVPYFISALE TILPDRELSK
610 620 630 640 650
FKSYVNPTEL RRSSINILLS LLPLPHHFGT VKSEVVLEGK FSNDDSSSYD
660 670 680 690 700
KPITFLSLKL RLVNILIGAL QTETDPNNTQ MILGAMLNIV QDSALLEAIG
710 720 730 740 750
CQMEMGGGEN NLKSHSRTNS GISSASGGST EPTTPDSERP AQALLRDYAL
760 770 780 790 800
NTDSAAGLLI RSIHLVTQRL NSQWRQDMSI SLAALELLSG LAKVKVMVDS
810 820 830 840 850
GDRKRAISSV CTYIVYQCSR PAPLHSRDLH SMIVAAFQCL CVWLTEHPDM
860 870 880 890 900
LDEKDCLKEV LEIVELGISG SKSKNNEQEV KYKGDKEPNP ASMRVKDAAE
910 920 930 940 950
ATLTCIMQLL GAFPSPSGPA SPCSLVNETT LIKYSRLPTI NKHSFRYFVL
960 970 980 990 1000
DNSVILAMLE QPLGNEQNDF FPSVTVLVRG MSGRLAWAQQ LCLLPRGAKA
1010 1020 1030 1040 1050
NQKLFVPEPR PVPKNDVGFK YSVKHRPFPE EVDKIPFVKA DLSIPDLHEI
1060 1070 1080 1090 1100
VTEELEERHE KLRSGMAQQI AYEIHLEQQS EEELQKRSFP DPVTDCKPPP
1110 1120 1130 1140 1150
PAQEFQTARL FLSHFGFLSL EALKEPANSR LPPHLIALDS TIPGFFDDIG
1160 1170 1180 1190 1200
YLDLLPCRPF DTVFIFYMKP GQKTNQEILK NVESSRTVQP HFLEFLLSLG
1210 1220 1230 1240 1250
WSVDVGRHPG WTGHVSTSWS INCCDDGEGS QQEVISSEDI GASIFNGQKK
1260 1270 1280 1290 1300
VLYYADALTE IAFVVPSPVE SLTDSLESNI SDQDSDSNMD LMPGILKQPS
1310 1320 1330 1340 1350
LTLELFPNHT DNLNSSQRLS PSSRMRKLPQ GRPVPPLGPE TRVSVVWVER
1360 1370 1380 1390 1400
YDDIENFPLS ELMTEISTGV ETTANSSTSL RSTTLEKEVP VIFIHPLNTG
1410 1420 1430 1440 1450
LFRIKIQGAT GKFNMVIPLV DGMIVSRRAL GFLVRQTVIN ICRRKRLESD
1460 1470 1480 1490
SYSPPHVRRK QKITDIVNKY RNKQLEPEFY TSLFQEVGLK NCSS
Length:1,494
Mass (Da):166,799
Last modified:June 1, 2003 - v1
Checksum:i5FEDBB0CB269F8CE
GO
Isoform 2 (identifier: Q86X10-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-222: Missing.
     1233-1233: E → EE

Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Show »
Length:1,273
Mass (Da):141,866
Checksum:i024E924F27623CC2
GO
Isoform 3 (identifier: Q86X10-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     749-752: Missing.
     1233-1233: E → EE

Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Show »
Length:1,491
Mass (Da):166,528
Checksum:i49C23593DB561453
GO
Isoform 4 (identifier: Q86X10-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     943-1473: Missing.

Note: Splicing acceptor site is not canonical. No experimental confirmation available.
Show »
Length:963
Mass (Da):106,838
Checksum:i13AF758962E013A4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A2F0A2A2F0_HUMAN
Ral GTPase-activating protein subun...
RALGAPB
1,323Annotation score:
A0A0J9YW54A0A0J9YW54_HUMAN
Ral GTPase-activating protein subun...
RALGAPB
866Annotation score:

Sequence cautioni

The sequence BAA86533 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC85649 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB61346 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAD39096 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti326P → S in CAD39096 (PubMed:10574462).Curated1
Sequence conflicti1072Y → G in AAH18668 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0096931 – 222Missing in isoform 2. 1 PublicationAdd BLAST222
Alternative sequenceiVSP_009694749 – 752Missing in isoform 3. 1 Publication4
Alternative sequenceiVSP_009695943 – 1473Missing in isoform 4. 1 PublicationAdd BLAST531
Alternative sequenceiVSP_0096961233E → EE in isoform 2 and isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033045 mRNA Translation: BAA86533.3 Different initiation.
AL834436 mRNA Translation: CAD39096.1 Different initiation.
AL132998 mRNA Translation: CAB61346.1 Different initiation.
AL035419 Genomic DNA No translation available.
AL049868 Genomic DNA No translation available.
BC010916 mRNA Translation: AAH10916.2
BC018668 mRNA Translation: AAH18668.1
BC047482 mRNA Translation: AAH47482.1
AK123576 mRNA Translation: BAC85649.1 Different initiation.
CCDSiCCDS13305.1 [Q86X10-1]
CCDS63272.1 [Q86X10-3]
RefSeqiNP_001269846.1, NM_001282917.1 [Q86X10-1]
NP_001269847.1, NM_001282918.1 [Q86X10-3]
NP_065069.1, NM_020336.3 [Q86X10-1]
UniGeneiHs.598850

Genome annotation databases

EnsembliENST00000262879; ENSP00000262879; ENSG00000170471 [Q86X10-1]
ENST00000397040; ENSP00000380233; ENSG00000170471 [Q86X10-1]
ENST00000397042; ENSP00000380235; ENSG00000170471 [Q86X10-3]
GeneIDi57148
KEGGihsa:57148
UCSCiuc002xiw.5 human [Q86X10-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033045 mRNA Translation: BAA86533.3 Different initiation.
AL834436 mRNA Translation: CAD39096.1 Different initiation.
AL132998 mRNA Translation: CAB61346.1 Different initiation.
AL035419 Genomic DNA No translation available.
AL049868 Genomic DNA No translation available.
BC010916 mRNA Translation: AAH10916.2
BC018668 mRNA Translation: AAH18668.1
BC047482 mRNA Translation: AAH47482.1
AK123576 mRNA Translation: BAC85649.1 Different initiation.
CCDSiCCDS13305.1 [Q86X10-1]
CCDS63272.1 [Q86X10-3]
RefSeqiNP_001269846.1, NM_001282917.1 [Q86X10-1]
NP_001269847.1, NM_001282918.1 [Q86X10-3]
NP_065069.1, NM_020336.3 [Q86X10-1]
UniGeneiHs.598850

3D structure databases

ProteinModelPortaliQ86X10
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121405, 17 interactors
IntActiQ86X10, 15 interactors
MINTiQ86X10
STRINGi9606.ENSP00000262879

PTM databases

iPTMnetiQ86X10
PhosphoSitePlusiQ86X10

Polymorphism and mutation databases

DMDMi45477126

Proteomic databases

EPDiQ86X10
MaxQBiQ86X10
PaxDbiQ86X10
PeptideAtlasiQ86X10
PRIDEiQ86X10
ProteomicsDBi70218
70219 [Q86X10-2]
70220 [Q86X10-3]
70221 [Q86X10-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262879; ENSP00000262879; ENSG00000170471 [Q86X10-1]
ENST00000397040; ENSP00000380233; ENSG00000170471 [Q86X10-1]
ENST00000397042; ENSP00000380235; ENSG00000170471 [Q86X10-3]
GeneIDi57148
KEGGihsa:57148
UCSCiuc002xiw.5 human [Q86X10-1]

Organism-specific databases

CTDi57148
DisGeNETi57148
EuPathDBiHostDB:ENSG00000170471.14
GeneCardsiRALGAPB
H-InvDBiHIX0203031
HGNCiHGNC:29221 RALGAPB
HPAiHPA051454
neXtProtiNX_Q86X10
OpenTargetsiENSG00000170471
PharmGKBiPA165392608
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3652 Eukaryota
ENOG411027C LUCA
GeneTreeiENSGT00700000104550
HOGENOMiHOG000230877
HOVERGENiHBG052199
InParanoidiQ86X10
OMAiLESDSYN
OrthoDBiEOG091G0DSB
PhylomeDBiQ86X10
TreeFamiTF324460

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane

Miscellaneous databases

ChiTaRSiRALGAPB human
GeneWikiiKIAA1219
GenomeRNAii57148
PROiPR:Q86X10

Gene expression databases

BgeeiENSG00000170471 Expressed in 226 organ(s), highest expression level in forebrain
CleanExiHS_KIAA1219
ExpressionAtlasiQ86X10 baseline and differential
GenevisibleiQ86X10 HS

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR039930 RALGAPB
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
PANTHERiPTHR21344 PTHR21344, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
PROSITEiView protein in PROSITE
PS50085 RAPGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRLGPB_HUMAN
AccessioniPrimary (citable) accession number: Q86X10
Secondary accession number(s): A2A2E8
, A2A2E9, Q5TG31, Q8N3D1, Q8WWC0, Q9H3X8, Q9UJR1, Q9ULK1, Q9Y3G9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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