UniProtKB - Q86X02 (CDR2L_HUMAN)
Protein
Cerebellar degeneration-related protein 2-like
Gene
CDR2L
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- identical protein binding Source: IntAct
Enzyme and pathway databases
PathwayCommonsi | Q86X02 |
Names & Taxonomyi
Protein namesi | Recommended name: Cerebellar degeneration-related protein 2-likeAlternative name(s): Paraneoplastic 62 kDa antigen |
Gene namesi | Name:CDR2L Synonyms:HUMPPA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29999, CDR2L |
neXtProti | NX_Q86X02 |
VEuPathDBi | HostDB:ENSG00000109089.7 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 30850 |
OpenTargetsi | ENSG00000109089 |
PharmGKBi | PA142672137 |
Miscellaneous databases
Pharosi | Q86X02, Tbio |
Genetic variation databases
BioMutai | CDR2L |
DMDMi | 160017566 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000307234 | 1 – 465 | Cerebellar degeneration-related protein 2-likeAdd BLAST | 465 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 308 | PhosphoserineCombined sources | 1 | |
Modified residuei | 318 | PhosphoserineCombined sources | 1 | |
Modified residuei | 344 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q86X02 |
jPOSTi | Q86X02 |
MassIVEi | Q86X02 |
MaxQBi | Q86X02 |
PaxDbi | Q86X02 |
PeptideAtlasi | Q86X02 |
PRIDEi | Q86X02 |
ProteomicsDBi | 70217 |
PTM databases
iPTMneti | Q86X02 |
PhosphoSitePlusi | Q86X02 |
Expressioni
Gene expression databases
Bgeei | ENSG00000109089, Expressed in cerebellar hemisphere and 217 other tissues |
ExpressionAtlasi | Q86X02, baseline and differential |
Genevisiblei | Q86X02, HS |
Organism-specific databases
HPAi | ENSG00000109089, Tissue enhanced (brain) |
Interactioni
Binary interactionsi
Q86X02
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 119060, 67 interactors |
IntActi | Q86X02, 64 interactors |
STRINGi | 9606.ENSP00000336587 |
Miscellaneous databases
RNActi | Q86X02, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 38 – 143 | Sequence analysisAdd BLAST | 106 | |
Coiled coili | 188 – 265 | Sequence analysisAdd BLAST | 78 | |
Coiled coili | 350 – 377 | Sequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the CDR2 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QRN3, Eukaryota |
GeneTreei | ENSGT00390000018570 |
HOGENOMi | CLU_048751_0_0_1 |
InParanoidi | Q86X02 |
OMAi | RDFRGEG |
OrthoDBi | 1101523at2759 |
PhylomeDBi | Q86X02 |
TreeFami | TF326183 |
Family and domain databases
InterProi | View protein in InterPro IPR026079, CDR2 |
PANTHERi | PTHR19232, PTHR19232, 1 hit |
i Sequence
Sequence statusi: Complete.
Q86X02-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRRAAGMEDF SAEEEESWYD QQDLEQDLHL AAELGKTLLE RNKELEGSLQ
60 70 80 90 100
QMYSTNEEQV QEIEYLTKQL DTLRHVNEQH AKVYEQLDLT ARDLELTNHR
110 120 130 140 150
LVLESKAAQQ KIHGLTETIE RLQAQVEELQ AQVEQLRGLE QLRVLREKRE
160 170 180 190 200
RRRTIHTFPC LKELCTSPRC KDAFRLHSSS LELGPRPLEQ ENERLQTLVG
210 220 230 240 250
ALRSQVSQER QRKERAEREY TAVLQEYSEL ERQLCEMEAC RLRVQELEAE
260 270 280 290 300
LLELQQMKQA KTYLLGPDDH LAEALLAPLT QAPEADDPQP GRGDDLGAQD
310 320 330 340 350
GVSSPAASPG HVVRKSCSDT ALNAIVAKDP ASRHAGNLTL HANSVRKRGM
360 370 380 390 400
SILREVDEQY HALLEKYEEL LSKCRQHGAG VRHAGVQTSR PISRDSSWRD
410 420 430 440 450
LRGGEEGQGE VKAGEKSLSQ HVEAVDKRLE QSQPEYKALF KEIFSRIQKT
460
KADINATKVK THSSK
Sequence cautioni
The sequence AAA91850 differs from that shown. Reason: Frameshift.Curated
The sequence AAH47534 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 383 | H → D in AAA91850 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035384 | 300 | D → E. Corresponds to variant dbSNP:rs36057512Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L02867 mRNA Translation: AAA91850.1 Frameshift. AK294006 mRNA Translation: BAG57368.1 CH471099 Genomic DNA Translation: EAW89224.1 BC047534 mRNA Translation: AAH47534.1 Different initiation. |
CCDSi | CCDS11710.2 |
RefSeqi | NP_055418.2, NM_014603.2 |
Genome annotation databases
Ensembli | ENST00000337231; ENSP00000336587; ENSG00000109089 |
GeneIDi | 30850 |
KEGGi | hsa:30850 |
UCSCi | uc002jml.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L02867 mRNA Translation: AAA91850.1 Frameshift. AK294006 mRNA Translation: BAG57368.1 CH471099 Genomic DNA Translation: EAW89224.1 BC047534 mRNA Translation: AAH47534.1 Different initiation. |
CCDSi | CCDS11710.2 |
RefSeqi | NP_055418.2, NM_014603.2 |
3D structure databases
SMRi | Q86X02 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119060, 67 interactors |
IntActi | Q86X02, 64 interactors |
STRINGi | 9606.ENSP00000336587 |
PTM databases
iPTMneti | Q86X02 |
PhosphoSitePlusi | Q86X02 |
Genetic variation databases
BioMutai | CDR2L |
DMDMi | 160017566 |
Proteomic databases
EPDi | Q86X02 |
jPOSTi | Q86X02 |
MassIVEi | Q86X02 |
MaxQBi | Q86X02 |
PaxDbi | Q86X02 |
PeptideAtlasi | Q86X02 |
PRIDEi | Q86X02 |
ProteomicsDBi | 70217 |
Protocols and materials databases
Antibodypediai | 19492, 88 antibodies |
DNASUi | 30850 |
Genome annotation databases
Ensembli | ENST00000337231; ENSP00000336587; ENSG00000109089 |
GeneIDi | 30850 |
KEGGi | hsa:30850 |
UCSCi | uc002jml.5, human |
Organism-specific databases
CTDi | 30850 |
DisGeNETi | 30850 |
GeneCardsi | CDR2L |
HGNCi | HGNC:29999, CDR2L |
HPAi | ENSG00000109089, Tissue enhanced (brain) |
neXtProti | NX_Q86X02 |
OpenTargetsi | ENSG00000109089 |
PharmGKBi | PA142672137 |
VEuPathDBi | HostDB:ENSG00000109089.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRN3, Eukaryota |
GeneTreei | ENSGT00390000018570 |
HOGENOMi | CLU_048751_0_0_1 |
InParanoidi | Q86X02 |
OMAi | RDFRGEG |
OrthoDBi | 1101523at2759 |
PhylomeDBi | Q86X02 |
TreeFami | TF326183 |
Enzyme and pathway databases
PathwayCommonsi | Q86X02 |
Miscellaneous databases
BioGRID-ORCSi | 30850, 6 hits in 872 CRISPR screens |
ChiTaRSi | CDR2L, human |
GenomeRNAii | 30850 |
Pharosi | Q86X02, Tbio |
PROi | PR:Q86X02 |
RNActi | Q86X02, protein |
Gene expression databases
Bgeei | ENSG00000109089, Expressed in cerebellar hemisphere and 217 other tissues |
ExpressionAtlasi | Q86X02, baseline and differential |
Genevisiblei | Q86X02, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026079, CDR2 |
PANTHERi | PTHR19232, PTHR19232, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDR2L_HUMAN | |
Accessioni | Q86X02Primary (citable) accession number: Q86X02 Secondary accession number(s): B4DFA7, Q15175 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | October 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 117 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families