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Entry version 138 (02 Dec 2020)
Sequence version 2 (21 Sep 2011)
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Protein

HEAT repeat-containing protein 4

Gene

HEATR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q86WZ0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HEAT repeat-containing protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HEATR4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000187105.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16761, HEATR4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86WZ0

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
399671

Open Targets

More...
OpenTargetsi
ENSG00000187105

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162390631

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86WZ0, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HEATR4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
347595657

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002541291 – 1026HEAT repeat-containing protein 4Add BLAST1026

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86WZ0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86WZ0

PeptideAtlas

More...
PeptideAtlasi
Q86WZ0

PRoteomics IDEntifications database

More...
PRIDEi
Q86WZ0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70215

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86WZ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86WZ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187105, Expressed in right testis and 122 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86WZ0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86WZ0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000187105, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
134383, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q86WZ0, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000450444

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86WZ0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86WZ0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati530 – 568HEAT 1Add BLAST39
Repeati724 – 760HEAT 2Add BLAST37
Repeati761 – 794HEAT 3Add BLAST34

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPUU, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013207

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012662_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86WZ0

Identification of Orthologs from Complete Genome Data

More...
OMAi
FLHQQYD

Database of Orthologous Groups

More...
OrthoDBi
991383at2759

TreeFam database of animal gene trees

More...
TreeFami
TF329278

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000357, HEAT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02985, HEAT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q86WZ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRTQKGKTF LPHCFYQSLP PRLGWGMILN YSKLKGKEEC ASVSSVPMVF
60 70 80 90 100
FSSQYRLHRK SQYLKMAAAN LTFSQEVVWQ RGLPSIPYSQ YSFDHLYNTN
110 120 130 140 150
DIIHTPQIRK ARPQKPVSFK FLGSSSPLTG DTSLAVKTES SANPEKKLKK
160 170 180 190 200
SKPASTVREA PRPLIHHPCM HPDMLGRPPS LDVNLEEREA WLLPPEKEAR
210 220 230 240 250
AWEATVLEKL NERTARWIQS KRPRRPGASP NKWQSFLRQQ YDWSHIRDEL
260 270 280 290 300
TSASDLELLK QLEAEETAEF EDQSVILPPQ EKKKPELLLP VYYRLPSYFQ
310 320 330 340 350
QAETVEIMPG NKSTEDIHEK TSLSQPQTQS YFRQVTPRAG KFAYSTDNTF
360 370 380 390 400
EQEIYFDEVQ IIHQIGAKRD QIVLENLNRY NKQLSKVFPE TPEKWSAQAI
410 420 430 440 450
PEASYRPVQG ALRWTALPTP AKDMLLQVGE KDVPIKTRRL KKQAKSLQED
460 470 480 490 500
VTWELVVLRR MLKEWKTAWA LIIEWHHETV ENLLQSLGDL HDDVRIKAIT
510 520 530 540 550
TCATAALERP RIATSQRDSD KTIQDLPEVL LPALEAALCD KNAHVRMAAA
560 570 580 590 600
ICQYAIQSHN PLARNIMQTA LLKGNSVDSW AAAQCLALEG TATYPVIKRI
610 620 630 640 650
LHQLFTKKNE DTEEQSYILL SYLSEKTTLI HTMLAVELNS CQWKNRIVAC
660 670 680 690 700
QAFSRISGNV CLDMKHKLIQ LMWNDWNKEV RRAAAQALGQ MSLGKEVHDI
710 720 730 740 750
IRVKLGQGNS QERVEALYLI GELKLMTAKL LPSFLHCFSD DFTAVRRAAC
760 770 780 790 800
LAAGALQIRD KMVLECLLNL MQRDPYWKIK AFAIRALGQI GQVSPELTDL
810 820 830 840 850
LLWAIHYEES PGVRLEACRS ILALKLQGDR VRDTFLDVLL LENHDAVLKE
860 870 880 890 900
MYQTMKILNL GNEGNQEMLQ EIKNRIKTLS QKDLLTHKIL KLEMVMGKVR
910 920 930 940 950
EEAKRVYLKP KGEQGPLTLQ TLLQETFQDE MVLPRRPSEV CDTEAVIKPV
960 970 980 990 1000
KPRAPNPWLQ SSVPGLTTRS KVRSSLVKDL RTSPEKRIAV GPFRSDYPAL
1010 1020
YLGKFSERTF FSPIMSSPSG KKGAHL
Length:1,026
Mass (Da):117,175
Last modified:September 21, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B44D419F58A7B6A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V5L2G3V5L2_HUMAN
HEAT repeat-containing protein 4
HEATR4
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3Q5G3V3Q5_HUMAN
HEAT repeat-containing protein 4
HEATR4
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSP2H3BSP2_HUMAN
HEAT repeat-containing protein 4
HEATR4
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH47590 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028817634L → H. Corresponds to variant dbSNP:rs12894435Ensembl.1
Natural variantiVAR_028818643W → G. Corresponds to variant dbSNP:rs12894425Ensembl.1
Natural variantiVAR_028819660V → A. Corresponds to variant dbSNP:rs12894400Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK302564 mRNA Translation: BAH13745.1
AC005225 Genomic DNA No translation available.
AC005280 Genomic DNA No translation available.
BC047590 mRNA Translation: AAH47590.1 Sequence problems.
GU727638 mRNA Translation: ADU87640.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9815.2

NCBI Reference Sequences

More...
RefSeqi
NP_001207413.1, NM_001220484.1
NP_976054.2, NM_203309.2
XP_006720206.1, XM_006720143.2
XP_011535062.1, XM_011536760.2
XP_016876778.1, XM_017021289.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334988; ENSP00000335447; ENSG00000187105
ENST00000553558; ENSP00000450444; ENSG00000187105

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
399671

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:399671

UCSC genome browser

More...
UCSCi
uc021rwe.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302564 mRNA Translation: BAH13745.1
AC005225 Genomic DNA No translation available.
AC005280 Genomic DNA No translation available.
BC047590 mRNA Translation: AAH47590.1 Sequence problems.
GU727638 mRNA Translation: ADU87640.1
CCDSiCCDS9815.2
RefSeqiNP_001207413.1, NM_001220484.1
NP_976054.2, NM_203309.2
XP_006720206.1, XM_006720143.2
XP_011535062.1, XM_011536760.2
XP_016876778.1, XM_017021289.1

3D structure databases

SMRiQ86WZ0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi134383, 1 interactor
IntActiQ86WZ0, 2 interactors
STRINGi9606.ENSP00000450444

PTM databases

iPTMnetiQ86WZ0
PhosphoSitePlusiQ86WZ0

Polymorphism and mutation databases

BioMutaiHEATR4
DMDMi347595657

Proteomic databases

MassIVEiQ86WZ0
PaxDbiQ86WZ0
PeptideAtlasiQ86WZ0
PRIDEiQ86WZ0
ProteomicsDBi70215

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
171, 71 antibodies

Genome annotation databases

EnsembliENST00000334988; ENSP00000335447; ENSG00000187105
ENST00000553558; ENSP00000450444; ENSG00000187105
GeneIDi399671
KEGGihsa:399671
UCSCiuc021rwe.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
399671
DisGeNETi399671
EuPathDBiHostDB:ENSG00000187105.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HEATR4
HGNCiHGNC:16761, HEATR4
HPAiENSG00000187105, Tissue enhanced (testis)
neXtProtiNX_Q86WZ0
OpenTargetsiENSG00000187105
PharmGKBiPA162390631

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QPUU, Eukaryota
GeneTreeiENSGT00390000013207
HOGENOMiCLU_012662_0_0_1
InParanoidiQ86WZ0
OMAiFLHQQYD
OrthoDBi991383at2759
TreeFamiTF329278

Enzyme and pathway databases

PathwayCommonsiQ86WZ0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
399671, 4 hits in 837 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HEATR4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
399671
PharosiQ86WZ0, Tdark

Protein Ontology

More...
PROi
PR:Q86WZ0
RNActiQ86WZ0, protein

Gene expression databases

BgeeiENSG00000187105, Expressed in right testis and 122 other tissues
ExpressionAtlasiQ86WZ0, baseline and differential
GenevisibleiQ86WZ0, HS

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000357, HEAT
PfamiView protein in Pfam
PF02985, HEAT, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHEAT4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86WZ0
Secondary accession number(s): B7Z7V9, E9KL41
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 21, 2011
Last modified: December 2, 2020
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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