UniProtKB - Q86WZ0 (HEAT4_HUMAN)
Protein
HEAT repeat-containing protein 4
Gene
HEATR4
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- deoxyhypusine monooxygenase activity Source: GO_Central
- oxidoreductase activity Source: GO_Central
GO - Biological processi
- peptidyl-lysine modification to peptidyl-hypusine Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q86WZ0 |
Names & Taxonomyi
Protein namesi | Recommended name: HEAT repeat-containing protein 4 |
Gene namesi | Name:HEATR4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16761, HEATR4 |
neXtProti | NX_Q86WZ0 |
VEuPathDBi | HostDB:ENSG00000187105.8 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 399671 |
OpenTargetsi | ENSG00000187105 |
PharmGKBi | PA162390631 |
Miscellaneous databases
Pharosi | Q86WZ0, Tdark |
Genetic variation databases
BioMutai | HEATR4 |
DMDMi | 347595657 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000254129 | 1 – 1026 | HEAT repeat-containing protein 4Add BLAST | 1026 |
Proteomic databases
MassIVEi | Q86WZ0 |
PaxDbi | Q86WZ0 |
PeptideAtlasi | Q86WZ0 |
PRIDEi | Q86WZ0 |
ProteomicsDBi | 70215 |
PTM databases
iPTMneti | Q86WZ0 |
PhosphoSitePlusi | Q86WZ0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000187105, Expressed in right testis and 122 other tissues |
ExpressionAtlasi | Q86WZ0, baseline and differential |
Genevisiblei | Q86WZ0, HS |
Organism-specific databases
HPAi | ENSG00000187105, Tissue enhanced (testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 134383, 2 interactors |
IntActi | Q86WZ0, 2 interactors |
STRINGi | 9606.ENSP00000450444 |
Miscellaneous databases
RNActi | Q86WZ0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 530 – 568 | HEAT 1Add BLAST | 39 | |
Repeati | 724 – 760 | HEAT 2Add BLAST | 37 | |
Repeati | 761 – 794 | HEAT 3Add BLAST | 34 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QPUU, Eukaryota |
GeneTreei | ENSGT00390000013207 |
HOGENOMi | CLU_012662_0_0_1 |
InParanoidi | Q86WZ0 |
OMAi | FLHQQYD |
OrthoDBi | 991383at2759 |
TreeFami | TF329278 |
Family and domain databases
Gene3Di | 1.25.10.10, 2 hits |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000357, HEAT |
Pfami | View protein in Pfam PF02985, HEAT, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q86WZ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTRTQKGKTF LPHCFYQSLP PRLGWGMILN YSKLKGKEEC ASVSSVPMVF
60 70 80 90 100
FSSQYRLHRK SQYLKMAAAN LTFSQEVVWQ RGLPSIPYSQ YSFDHLYNTN
110 120 130 140 150
DIIHTPQIRK ARPQKPVSFK FLGSSSPLTG DTSLAVKTES SANPEKKLKK
160 170 180 190 200
SKPASTVREA PRPLIHHPCM HPDMLGRPPS LDVNLEEREA WLLPPEKEAR
210 220 230 240 250
AWEATVLEKL NERTARWIQS KRPRRPGASP NKWQSFLRQQ YDWSHIRDEL
260 270 280 290 300
TSASDLELLK QLEAEETAEF EDQSVILPPQ EKKKPELLLP VYYRLPSYFQ
310 320 330 340 350
QAETVEIMPG NKSTEDIHEK TSLSQPQTQS YFRQVTPRAG KFAYSTDNTF
360 370 380 390 400
EQEIYFDEVQ IIHQIGAKRD QIVLENLNRY NKQLSKVFPE TPEKWSAQAI
410 420 430 440 450
PEASYRPVQG ALRWTALPTP AKDMLLQVGE KDVPIKTRRL KKQAKSLQED
460 470 480 490 500
VTWELVVLRR MLKEWKTAWA LIIEWHHETV ENLLQSLGDL HDDVRIKAIT
510 520 530 540 550
TCATAALERP RIATSQRDSD KTIQDLPEVL LPALEAALCD KNAHVRMAAA
560 570 580 590 600
ICQYAIQSHN PLARNIMQTA LLKGNSVDSW AAAQCLALEG TATYPVIKRI
610 620 630 640 650
LHQLFTKKNE DTEEQSYILL SYLSEKTTLI HTMLAVELNS CQWKNRIVAC
660 670 680 690 700
QAFSRISGNV CLDMKHKLIQ LMWNDWNKEV RRAAAQALGQ MSLGKEVHDI
710 720 730 740 750
IRVKLGQGNS QERVEALYLI GELKLMTAKL LPSFLHCFSD DFTAVRRAAC
760 770 780 790 800
LAAGALQIRD KMVLECLLNL MQRDPYWKIK AFAIRALGQI GQVSPELTDL
810 820 830 840 850
LLWAIHYEES PGVRLEACRS ILALKLQGDR VRDTFLDVLL LENHDAVLKE
860 870 880 890 900
MYQTMKILNL GNEGNQEMLQ EIKNRIKTLS QKDLLTHKIL KLEMVMGKVR
910 920 930 940 950
EEAKRVYLKP KGEQGPLTLQ TLLQETFQDE MVLPRRPSEV CDTEAVIKPV
960 970 980 990 1000
KPRAPNPWLQ SSVPGLTTRS KVRSSLVKDL RTSPEKRIAV GPFRSDYPAL
1010 1020
YLGKFSERTF FSPIMSSPSG KKGAHL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V5L2 | G3V5L2_HUMAN | HEAT repeat-containing protein 4 | HEATR4 | 191 | Annotation score: | ||
G3V3Q5 | G3V3Q5_HUMAN | HEAT repeat-containing protein 4 | HEATR4 | 39 | Annotation score: | ||
H3BSP2 | H3BSP2_HUMAN | HEAT repeat-containing protein 4 | HEATR4 | 36 | Annotation score: |
Sequence cautioni
The sequence AAH47590 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028817 | 634 | L → H. Corresponds to variant dbSNP:rs12894435Ensembl. | 1 | |
Natural variantiVAR_028818 | 643 | W → G. Corresponds to variant dbSNP:rs12894425Ensembl. | 1 | |
Natural variantiVAR_028819 | 660 | V → A. Corresponds to variant dbSNP:rs12894400Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK302564 mRNA Translation: BAH13745.1 AC005225 Genomic DNA No translation available. AC005280 Genomic DNA No translation available. BC047590 mRNA Translation: AAH47590.1 Sequence problems. GU727638 mRNA Translation: ADU87640.1 |
CCDSi | CCDS9815.2 |
RefSeqi | NP_001207413.1, NM_001220484.1 NP_976054.2, NM_203309.2 XP_006720206.1, XM_006720143.2 XP_011535062.1, XM_011536760.2 XP_016876778.1, XM_017021289.1 |
Genome annotation databases
Ensembli | ENST00000334988; ENSP00000335447; ENSG00000187105 ENST00000553558; ENSP00000450444; ENSG00000187105 |
GeneIDi | 399671 |
KEGGi | hsa:399671 |
UCSCi | uc021rwe.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK302564 mRNA Translation: BAH13745.1 AC005225 Genomic DNA No translation available. AC005280 Genomic DNA No translation available. BC047590 mRNA Translation: AAH47590.1 Sequence problems. GU727638 mRNA Translation: ADU87640.1 |
CCDSi | CCDS9815.2 |
RefSeqi | NP_001207413.1, NM_001220484.1 NP_976054.2, NM_203309.2 XP_006720206.1, XM_006720143.2 XP_011535062.1, XM_011536760.2 XP_016876778.1, XM_017021289.1 |
3D structure databases
SMRi | Q86WZ0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 134383, 2 interactors |
IntActi | Q86WZ0, 2 interactors |
STRINGi | 9606.ENSP00000450444 |
PTM databases
iPTMneti | Q86WZ0 |
PhosphoSitePlusi | Q86WZ0 |
Genetic variation databases
BioMutai | HEATR4 |
DMDMi | 347595657 |
Proteomic databases
MassIVEi | Q86WZ0 |
PaxDbi | Q86WZ0 |
PeptideAtlasi | Q86WZ0 |
PRIDEi | Q86WZ0 |
ProteomicsDBi | 70215 |
Protocols and materials databases
Antibodypediai | 171, 71 antibodies |
Genome annotation databases
Ensembli | ENST00000334988; ENSP00000335447; ENSG00000187105 ENST00000553558; ENSP00000450444; ENSG00000187105 |
GeneIDi | 399671 |
KEGGi | hsa:399671 |
UCSCi | uc021rwe.2, human |
Organism-specific databases
CTDi | 399671 |
DisGeNETi | 399671 |
GeneCardsi | HEATR4 |
HGNCi | HGNC:16761, HEATR4 |
HPAi | ENSG00000187105, Tissue enhanced (testis) |
neXtProti | NX_Q86WZ0 |
OpenTargetsi | ENSG00000187105 |
PharmGKBi | PA162390631 |
VEuPathDBi | HostDB:ENSG00000187105.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPUU, Eukaryota |
GeneTreei | ENSGT00390000013207 |
HOGENOMi | CLU_012662_0_0_1 |
InParanoidi | Q86WZ0 |
OMAi | FLHQQYD |
OrthoDBi | 991383at2759 |
TreeFami | TF329278 |
Enzyme and pathway databases
PathwayCommonsi | Q86WZ0 |
Miscellaneous databases
BioGRID-ORCSi | 399671, 5 hits in 865 CRISPR screens |
ChiTaRSi | HEATR4, human |
GenomeRNAii | 399671 |
Pharosi | Q86WZ0, Tdark |
PROi | PR:Q86WZ0 |
RNActi | Q86WZ0, protein |
Gene expression databases
Bgeei | ENSG00000187105, Expressed in right testis and 122 other tissues |
ExpressionAtlasi | Q86WZ0, baseline and differential |
Genevisiblei | Q86WZ0, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 2 hits |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000357, HEAT |
Pfami | View protein in Pfam PF02985, HEAT, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HEAT4_HUMAN | |
Accessioni | Q86WZ0Primary (citable) accession number: Q86WZ0 Secondary accession number(s): B7Z7V9, E9KL41 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | September 21, 2011 | |
Last modified: | February 10, 2021 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports