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Protein

HEAT repeat-containing protein 4

Gene

HEATR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
HEAT repeat-containing protein 4
Gene namesi
Name:HEATR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000187105.8
HGNCiHGNC:16761 HEATR4
neXtProtiNX_Q86WZ0

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187105
PharmGKBiPA162390631

Polymorphism and mutation databases

BioMutaiHEATR4
DMDMi347595657

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002541291 – 1026HEAT repeat-containing protein 4Add BLAST1026

Proteomic databases

PaxDbiQ86WZ0
PeptideAtlasiQ86WZ0
PRIDEiQ86WZ0
ProteomicsDBi70215

PTM databases

iPTMnetiQ86WZ0
PhosphoSitePlusiQ86WZ0

Expressioni

Gene expression databases

BgeeiENSG00000187105 Expressed in 102 organ(s), highest expression level in right testis
CleanExiHS_HEATR4
ExpressionAtlasiQ86WZ0 baseline and differential
GenevisibleiQ86WZ0 HS

Interactioni

Protein-protein interaction databases

BioGridi134383, 1 interactor
IntActiQ86WZ0, 1 interactor
STRINGi9606.ENSP00000335447

Structurei

3D structure databases

ProteinModelPortaliQ86WZ0
SMRiQ86WZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati530 – 568HEAT 1Add BLAST39
Repeati724 – 760HEAT 2Add BLAST37
Repeati761 – 794HEAT 3Add BLAST34

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IJT8 Eukaryota
ENOG410YWTX LUCA
GeneTreeiENSGT00390000013207
HOGENOMiHOG000112877
HOVERGENiHBG081595
InParanoidiQ86WZ0
OMAiMLAVELN
OrthoDBiEOG091G0A1F
TreeFamiTF329278

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000357 HEAT
PfamiView protein in Pfam
PF02985 HEAT, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q86WZ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRTQKGKTF LPHCFYQSLP PRLGWGMILN YSKLKGKEEC ASVSSVPMVF
60 70 80 90 100
FSSQYRLHRK SQYLKMAAAN LTFSQEVVWQ RGLPSIPYSQ YSFDHLYNTN
110 120 130 140 150
DIIHTPQIRK ARPQKPVSFK FLGSSSPLTG DTSLAVKTES SANPEKKLKK
160 170 180 190 200
SKPASTVREA PRPLIHHPCM HPDMLGRPPS LDVNLEEREA WLLPPEKEAR
210 220 230 240 250
AWEATVLEKL NERTARWIQS KRPRRPGASP NKWQSFLRQQ YDWSHIRDEL
260 270 280 290 300
TSASDLELLK QLEAEETAEF EDQSVILPPQ EKKKPELLLP VYYRLPSYFQ
310 320 330 340 350
QAETVEIMPG NKSTEDIHEK TSLSQPQTQS YFRQVTPRAG KFAYSTDNTF
360 370 380 390 400
EQEIYFDEVQ IIHQIGAKRD QIVLENLNRY NKQLSKVFPE TPEKWSAQAI
410 420 430 440 450
PEASYRPVQG ALRWTALPTP AKDMLLQVGE KDVPIKTRRL KKQAKSLQED
460 470 480 490 500
VTWELVVLRR MLKEWKTAWA LIIEWHHETV ENLLQSLGDL HDDVRIKAIT
510 520 530 540 550
TCATAALERP RIATSQRDSD KTIQDLPEVL LPALEAALCD KNAHVRMAAA
560 570 580 590 600
ICQYAIQSHN PLARNIMQTA LLKGNSVDSW AAAQCLALEG TATYPVIKRI
610 620 630 640 650
LHQLFTKKNE DTEEQSYILL SYLSEKTTLI HTMLAVELNS CQWKNRIVAC
660 670 680 690 700
QAFSRISGNV CLDMKHKLIQ LMWNDWNKEV RRAAAQALGQ MSLGKEVHDI
710 720 730 740 750
IRVKLGQGNS QERVEALYLI GELKLMTAKL LPSFLHCFSD DFTAVRRAAC
760 770 780 790 800
LAAGALQIRD KMVLECLLNL MQRDPYWKIK AFAIRALGQI GQVSPELTDL
810 820 830 840 850
LLWAIHYEES PGVRLEACRS ILALKLQGDR VRDTFLDVLL LENHDAVLKE
860 870 880 890 900
MYQTMKILNL GNEGNQEMLQ EIKNRIKTLS QKDLLTHKIL KLEMVMGKVR
910 920 930 940 950
EEAKRVYLKP KGEQGPLTLQ TLLQETFQDE MVLPRRPSEV CDTEAVIKPV
960 970 980 990 1000
KPRAPNPWLQ SSVPGLTTRS KVRSSLVKDL RTSPEKRIAV GPFRSDYPAL
1010 1020
YLGKFSERTF FSPIMSSPSG KKGAHL
Length:1,026
Mass (Da):117,175
Last modified:September 21, 2011 - v2
Checksum:i7B44D419F58A7B6A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V5L2G3V5L2_HUMAN
HEAT repeat-containing protein 4
HEATR4
191Annotation score:
G3V3Q5G3V3Q5_HUMAN
HEAT repeat-containing protein 4
HEATR4
39Annotation score:
H3BSP2H3BSP2_HUMAN
HEAT repeat-containing protein 4
HEATR4
36Annotation score:

Sequence cautioni

The sequence AAH47590 differs from that shown. Reason: Erroneous termination at position 39. Translated as Glu.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028817634L → H. Corresponds to variant dbSNP:rs12894435Ensembl.1
Natural variantiVAR_028818643W → G. Corresponds to variant dbSNP:rs12894425Ensembl.1
Natural variantiVAR_028819660V → A. Corresponds to variant dbSNP:rs12894400Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302564 mRNA Translation: BAH13745.1
AC005225 Genomic DNA No translation available.
AC005280 Genomic DNA No translation available.
BC047590 mRNA Translation: AAH47590.1 Sequence problems.
GU727638 mRNA Translation: ADU87640.1
CCDSiCCDS9815.2
RefSeqiNP_001207413.1, NM_001220484.1
NP_976054.2, NM_203309.2
XP_006720206.1, XM_006720143.2
XP_011535062.1, XM_011536760.2
XP_016876778.1, XM_017021289.1
UniGeneiHs.660774

Genome annotation databases

EnsembliENST00000334988; ENSP00000335447; ENSG00000187105
ENST00000553558; ENSP00000450444; ENSG00000187105
GeneIDi399671
KEGGihsa:399671
UCSCiuc021rwe.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302564 mRNA Translation: BAH13745.1
AC005225 Genomic DNA No translation available.
AC005280 Genomic DNA No translation available.
BC047590 mRNA Translation: AAH47590.1 Sequence problems.
GU727638 mRNA Translation: ADU87640.1
CCDSiCCDS9815.2
RefSeqiNP_001207413.1, NM_001220484.1
NP_976054.2, NM_203309.2
XP_006720206.1, XM_006720143.2
XP_011535062.1, XM_011536760.2
XP_016876778.1, XM_017021289.1
UniGeneiHs.660774

3D structure databases

ProteinModelPortaliQ86WZ0
SMRiQ86WZ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134383, 1 interactor
IntActiQ86WZ0, 1 interactor
STRINGi9606.ENSP00000335447

PTM databases

iPTMnetiQ86WZ0
PhosphoSitePlusiQ86WZ0

Polymorphism and mutation databases

BioMutaiHEATR4
DMDMi347595657

Proteomic databases

PaxDbiQ86WZ0
PeptideAtlasiQ86WZ0
PRIDEiQ86WZ0
ProteomicsDBi70215

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334988; ENSP00000335447; ENSG00000187105
ENST00000553558; ENSP00000450444; ENSG00000187105
GeneIDi399671
KEGGihsa:399671
UCSCiuc021rwe.2 human

Organism-specific databases

CTDi399671
EuPathDBiHostDB:ENSG00000187105.8
GeneCardsiHEATR4
H-InvDBiHIX0011793
HIX0018563
HIX0037875
HGNCiHGNC:16761 HEATR4
neXtProtiNX_Q86WZ0
OpenTargetsiENSG00000187105
PharmGKBiPA162390631
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJT8 Eukaryota
ENOG410YWTX LUCA
GeneTreeiENSGT00390000013207
HOGENOMiHOG000112877
HOVERGENiHBG081595
InParanoidiQ86WZ0
OMAiMLAVELN
OrthoDBiEOG091G0A1F
TreeFamiTF329278

Miscellaneous databases

ChiTaRSiHEATR4 human
GenomeRNAii399671
PROiPR:Q86WZ0

Gene expression databases

BgeeiENSG00000187105 Expressed in 102 organ(s), highest expression level in right testis
CleanExiHS_HEATR4
ExpressionAtlasiQ86WZ0 baseline and differential
GenevisibleiQ86WZ0 HS

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000357 HEAT
PfamiView protein in Pfam
PF02985 HEAT, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHEAT4_HUMAN
AccessioniPrimary (citable) accession number: Q86WZ0
Secondary accession number(s): B7Z7V9, E9KL41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 21, 2011
Last modified: September 12, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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