UniProtKB - Q86WZ0 (HEAT4_HUMAN)

BLAST

>sp|Q86WZ0|HEAT4_HUMAN HEAT repeat-containing protein 4 OS=Homo sapiens OX=9606 GN=HEATR4 PE=2 SV=2
MTRTQKGKTFLPHCFYQSLPPRLGWGMILNYSKLKGKEECASVSSVPMVFFSSQYRLHRK
SQYLKMAAANLTFSQEVVWQRGLPSIPYSQYSFDHLYNTNDIIHTPQIRKARPQKPVSFK
FLGSSSPLTGDTSLAVKTESSANPEKKLKKSKPASTVREAPRPLIHHPCMHPDMLGRPPS
LDVNLEEREAWLLPPEKEARAWEATVLEKLNERTARWIQSKRPRRPGASPNKWQSFLRQQ
YDWSHIRDELTSASDLELLKQLEAEETAEFEDQSVILPPQEKKKPELLLPVYYRLPSYFQ
QAETVEIMPGNKSTEDIHEKTSLSQPQTQSYFRQVTPRAGKFAYSTDNTFEQEIYFDEVQ
IIHQIGAKRDQIVLENLNRYNKQLSKVFPETPEKWSAQAIPEASYRPVQGALRWTALPTP
AKDMLLQVGEKDVPIKTRRLKKQAKSLQEDVTWELVVLRRMLKEWKTAWALIIEWHHETV
ENLLQSLGDLHDDVRIKAITTCATAALERPRIATSQRDSDKTIQDLPEVLLPALEAALCD
KNAHVRMAAAICQYAIQSHNPLARNIMQTALLKGNSVDSWAAAQCLALEGTATYPVIKRI
LHQLFTKKNEDTEEQSYILLSYLSEKTTLIHTMLAVELNSCQWKNRIVACQAFSRISGNV
CLDMKHKLIQLMWNDWNKEVRRAAAQALGQMSLGKEVHDIIRVKLGQGNSQERVEALYLI
GELKLMTAKLLPSFLHCFSDDFTAVRRAACLAAGALQIRDKMVLECLLNLMQRDPYWKIK
AFAIRALGQIGQVSPELTDLLLWAIHYEESPGVRLEACRSILALKLQGDRVRDTFLDVLL
LENHDAVLKEMYQTMKILNLGNEGNQEMLQEIKNRIKTLSQKDLLTHKILKLEMVMGKVR
EEAKRVYLKPKGEQGPLTLQTLLQETFQDEMVLPRRPSEVCDTEAVIKPVKPRAPNPWLQ
SSVPGLTTRSKVRSSLVKDLRTSPEKRIAVGPFRSDYPALYLGKFSERTFFSPIMSSPSG
KKGAHL

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History
Entry version 123 (12 Sep 2018)
Sequence version 2 (21 Sep 2011)
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Protein

HEAT repeat-containing protein 4

Gene

HEATR4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: HEAT repeat-containing protein 4
Gene namesⁱ	Name:HEATR4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000187105.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16761 HEATR4
neXtProtⁱ	NX_Q86WZ0

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000187105
PharmGKBⁱ	PA162390631

Polymorphism and mutation databases

BioMutaⁱ	HEATR4
DMDMⁱ	347595657

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000254129	1 – 1026	HEAT repeat-containing protein 4Add BLAST		1026

Proteomic databases

PaxDbⁱ	Q86WZ0
PeptideAtlas More...PeptideAtlasⁱ	Q86WZ0
PRIDEⁱ	Q86WZ0
ProteomicsDBⁱ	70215

PTM databases

iPTMnetⁱ	Q86WZ0
PhosphoSitePlusⁱ	Q86WZ0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000187105 Expressed in 102 organ(s), highest expression level in right testis
CleanExⁱ	HS_HEATR4
ExpressionAtlasⁱ	Q86WZ0 baseline and differential
Genevisibleⁱ	Q86WZ0 HS

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	134383, 1 interactor
IntActⁱ	Q86WZ0, 1 interactor
STRINGⁱ	9606.ENSP00000335447

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q86WZ0
SMRⁱ	Q86WZ0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	530 – 568	HEAT 1Add BLAST	39
Repeatⁱ	724 – 760	HEAT 2Add BLAST	37
Repeatⁱ	761 – 794	HEAT 3Add BLAST	34

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IJT8 Eukaryota ENOG410YWTX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013207
HOGENOMⁱ	HOG000112877
HOVERGENⁱ	HBG081595
InParanoidⁱ	Q86WZ0
OMAⁱ	MLAVELN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A1F
TreeFamⁱ	TF329278

Family and domain databases

Gene3Dⁱ	1.25.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR000357 HEAT
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02985 HEAT, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q86WZ0-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MTRTQKGKTF LPHCFYQSLP PRLGWGMILN YSKLKGKEEC ASVSSVPMVF 
        60         70         80         90        100
FSSQYRLHRK SQYLKMAAAN LTFSQEVVWQ RGLPSIPYSQ YSFDHLYNTN 
       110        120        130        140        150
DIIHTPQIRK ARPQKPVSFK FLGSSSPLTG DTSLAVKTES SANPEKKLKK 
       160        170        180        190        200
SKPASTVREA PRPLIHHPCM HPDMLGRPPS LDVNLEEREA WLLPPEKEAR 
       210        220        230        240        250
AWEATVLEKL NERTARWIQS KRPRRPGASP NKWQSFLRQQ YDWSHIRDEL 
       260        270        280        290        300
TSASDLELLK QLEAEETAEF EDQSVILPPQ EKKKPELLLP VYYRLPSYFQ 
       310        320        330        340        350
QAETVEIMPG NKSTEDIHEK TSLSQPQTQS YFRQVTPRAG KFAYSTDNTF 
       360        370        380        390        400
EQEIYFDEVQ IIHQIGAKRD QIVLENLNRY NKQLSKVFPE TPEKWSAQAI 
       410        420        430        440        450
PEASYRPVQG ALRWTALPTP AKDMLLQVGE KDVPIKTRRL KKQAKSLQED 
       460        470        480        490        500
VTWELVVLRR MLKEWKTAWA LIIEWHHETV ENLLQSLGDL HDDVRIKAIT 
       510        520        530        540        550
TCATAALERP RIATSQRDSD KTIQDLPEVL LPALEAALCD KNAHVRMAAA 
       560        570        580        590        600
ICQYAIQSHN PLARNIMQTA LLKGNSVDSW AAAQCLALEG TATYPVIKRI 
       610        620        630        640        650
LHQLFTKKNE DTEEQSYILL SYLSEKTTLI HTMLAVELNS CQWKNRIVAC 
       660        670        680        690        700
QAFSRISGNV CLDMKHKLIQ LMWNDWNKEV RRAAAQALGQ MSLGKEVHDI 
       710        720        730        740        750
IRVKLGQGNS QERVEALYLI GELKLMTAKL LPSFLHCFSD DFTAVRRAAC 
       760        770        780        790        800
LAAGALQIRD KMVLECLLNL MQRDPYWKIK AFAIRALGQI GQVSPELTDL 
       810        820        830        840        850
LLWAIHYEES PGVRLEACRS ILALKLQGDR VRDTFLDVLL LENHDAVLKE 
       860        870        880        890        900
MYQTMKILNL GNEGNQEMLQ EIKNRIKTLS QKDLLTHKIL KLEMVMGKVR 
       910        920        930        940        950
EEAKRVYLKP KGEQGPLTLQ TLLQETFQDE MVLPRRPSEV CDTEAVIKPV 
       960        970        980        990       1000
KPRAPNPWLQ SSVPGLTTRS KVRSSLVKDL RTSPEKRIAV GPFRSDYPAL 
      1010       1020 
YLGKFSERTF FSPIMSSPSG KKGAHL

Length:1,026

Mass (Da):117,175

Last modified:September 21, 2011 - v2

Checksum:ⁱ7B44D419F58A7B6A

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G3V5L2	G3V5L2_HUMAN	HEAT repeat-containing protein 4 HEAT repeat-containing protein 4	HEATR4	191	Annotation score:
G3V3Q5	G3V3Q5_HUMAN	HEAT repeat-containing protein 4 HEAT repeat-containing protein 4	HEATR4	39	Annotation score:
H3BSP2	H3BSP2_HUMAN	HEAT repeat-containing protein 4 HEAT repeat-containing protein 4	HEATR4	36	Annotation score:

Sequence cautionⁱ

The sequence AAH47590 differs from that shown. Reason: Erroneous termination at position 39. Translated as Glu.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_028817	634	L → H. Corresponds to variant dbSNP:rs12894435Ensembl.	1
Natural variantⁱVAR_028818	643	W → G. Corresponds to variant dbSNP:rs12894425Ensembl.	1
Natural variantⁱVAR_028819	660	V → A. Corresponds to variant dbSNP:rs12894400Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK302564 mRNA Translation: BAH13745.1 AC005225 Genomic DNA No translation available. AC005280 Genomic DNA No translation available. BC047590 mRNA Translation: AAH47590.1 Sequence problems. GU727638 mRNA Translation: ADU87640.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9815.2
NCBI Reference Sequences More...RefSeqⁱ	NP_001207413.1, NM_001220484.1 NP_976054.2, NM_203309.2 XP_006720206.1, XM_006720143.2 XP_011535062.1, XM_011536760.2 XP_016876778.1, XM_017021289.1
UniGeneⁱ	Hs.660774

Genome annotation databases

Ensemblⁱ	ENST00000334988; ENSP00000335447; ENSG00000187105 ENST00000553558; ENSP00000450444; ENSG00000187105
GeneIDⁱ	399671
KEGGⁱ	hsa:399671
UCSC genome browser More...UCSCⁱ	uc021rwe.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q86WZ0	HEAT repeat-containing protein 4 (Fragment)		HUMAN		39	UniRef100_Q86WZ0
HEAT repeat-containing protein 4 (Fragment)		HUMAN		191
HEAT repeat-containing protein 4 (Fragment)		HUMAN		36

Protein	Similar proteins		Species	Score	Length	Source
Q86WZ0	HEAT repeat-containing protein 4 (Fragment)		HUMAN		39	UniRef90_Q86WZ0
HEAT repeat containing 4		PANTR		1026
HEATR4 isoform 1		PONAB		1026
Uncharacterized protein		PANPA		1026
Uncharacterized protein		NOMLE		1026
+29

Protein	Similar proteins		Species	Score	Length	Source
Q86WZ0	HEAT repeat-containing protein 4 (Fragment)		HUMAN		39	UniRef50_Q86WZ0
Uncharacterized protein		PANPA		1026
Uncharacterized protein		NOMLE		1026
HEAT repeat containing 4		PANTR		1026
HEATR4 isoform 1		PONAB		1026
+148

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK302564 mRNA Translation: BAH13745.1 AC005225 Genomic DNA No translation available. AC005280 Genomic DNA No translation available. BC047590 mRNA Translation: AAH47590.1 Sequence problems. GU727638 mRNA Translation: ADU87640.1
CCDSⁱ	CCDS9815.2
RefSeqⁱ	NP_001207413.1, NM_001220484.1 NP_976054.2, NM_203309.2 XP_006720206.1, XM_006720143.2 XP_011535062.1, XM_011536760.2 XP_016876778.1, XM_017021289.1
UniGeneⁱ	Hs.660774

3D structure databases

ProteinModelPortalⁱ	Q86WZ0
SMRⁱ	Q86WZ0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	134383, 1 interactor
IntActⁱ	Q86WZ0, 1 interactor
STRINGⁱ	9606.ENSP00000335447

PTM databases

iPTMnetⁱ	Q86WZ0
PhosphoSitePlusⁱ	Q86WZ0

Polymorphism and mutation databases

BioMutaⁱ	HEATR4
DMDMⁱ	347595657

Proteomic databases

PaxDbⁱ	Q86WZ0
PeptideAtlasⁱ	Q86WZ0
PRIDEⁱ	Q86WZ0
ProteomicsDBⁱ	70215

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000334988; ENSP00000335447; ENSG00000187105 ENST00000553558; ENSP00000450444; ENSG00000187105
GeneIDⁱ	399671
KEGGⁱ	hsa:399671
UCSCⁱ	uc021rwe.2 human

Organism-specific databases

CTDⁱ	399671
EuPathDBⁱ	HostDB:ENSG00000187105.8
GeneCardsⁱ	HEATR4
H-InvDBⁱ	HIX0011793 HIX0018563 HIX0037875
HGNCⁱ	HGNC:16761 HEATR4
neXtProtⁱ	NX_Q86WZ0
OpenTargetsⁱ	ENSG00000187105
PharmGKBⁱ	PA162390631
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJT8 Eukaryota ENOG410YWTX LUCA
GeneTreeⁱ	ENSGT00390000013207
HOGENOMⁱ	HOG000112877
HOVERGENⁱ	HBG081595
InParanoidⁱ	Q86WZ0
OMAⁱ	MLAVELN
OrthoDBⁱ	EOG091G0A1F
TreeFamⁱ	TF329278

Miscellaneous databases

ChiTaRSⁱ	HEATR4 human
GenomeRNAiⁱ	399671
Protein Ontology More...PROⁱ	PR:Q86WZ0

Gene expression databases

Bgeeⁱ	ENSG00000187105 Expressed in 102 organ(s), highest expression level in right testis
CleanExⁱ	HS_HEATR4
ExpressionAtlasⁱ	Q86WZ0 baseline and differential
Genevisibleⁱ	Q86WZ0 HS

Family and domain databases

Gene3Dⁱ	1.25.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR000357 HEAT
Pfamⁱ	View protein in Pfam PF02985 HEAT, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HEAT4_HUMAN
Accessionⁱ	Q86WZ0Primary (citable) accession number: Q86WZ0 Secondary accession number(s): B7Z7V9, E9KL41
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
	Last sequence update:	September 21, 2011
	Last modified:	September 12, 2018
	This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniRef

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Supporting data

UniProtKB - Q86WZ0 (HEAT4_HUMAN)

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HEAT repeat-containing protein 4

HEATR4

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ