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Protein

Active regulator of SIRT1

Gene

RPS19BP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.1 Publication

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • RNA binding Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Active regulator of SIRT1
Alternative name(s):
40S ribosomal protein S19-binding protein 1
Short name:
RPS19-binding protein 1
Short name:
S19BP
Gene namesi
Name:RPS19BP1
Synonyms:AROS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000187051.8
HGNCiHGNC:28749 RPS19BP1
MIMi610225 gene
neXtProtiNX_Q86WX3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi91582
OpenTargetsiENSG00000187051
PharmGKBiPA143485599

Polymorphism and mutation databases

BioMutaiRPS19BP1
DMDMi74727734

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002523931 – 136Active regulator of SIRT1Add BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7CitrullineBy similarity1
Modified residuei84PhosphoserineCombined sources1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Phosphoprotein

Proteomic databases

EPDiQ86WX3
MaxQBiQ86WX3
PaxDbiQ86WX3
PeptideAtlasiQ86WX3
PRIDEiQ86WX3
ProteomicsDBi70214

PTM databases

iPTMnetiQ86WX3
PhosphoSitePlusiQ86WX3

Expressioni

Tissue specificityi

Widely expressed (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000187051 Expressed in 200 organ(s), highest expression level in substantia nigra
CleanExiHS_RPS19BP1
ExpressionAtlasiQ86WX3 baseline and differential
GenevisibleiQ86WX3 HS

Organism-specific databases

HPAiHPA042874

Interactioni

Subunit structurei

Interacts with RPS19 (By similarity). Interacts with SIRT1.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124848, 28 interactors
IntActiQ86WX3, 15 interactors
MINTiQ86WX3
STRINGi9606.ENSP00000333948

Structurei

3D structure databases

ProteinModelPortaliQ86WX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AROS family.Curated

Phylogenomic databases

eggNOGiENOG410J1DB Eukaryota
ENOG41126PZ LUCA
GeneTreeiENSGT00390000016774
HOGENOMiHOG000034068
HOVERGENiHBG097440
InParanoidiQ86WX3
OMAiQGRKACD
OrthoDBiEOG091G0YGT
PhylomeDBiQ86WX3
TreeFamiTF333429

Family and domain databases

InterProiView protein in InterPro
IPR023262 AROS
PANTHERiPTHR31454 PTHR31454, 1 hit
PfamiView protein in Pfam
PF15684 AROS, 1 hit
PRINTSiPR02029 ACTREGSIRT1

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q86WX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAALLRRGL ELLAASEAPR DPPGQAKPRG APVKRPRKTK AIQAQKLRNS
60 70 80 90 100
AKGKVPKSAL DEYRKRECRD HLRVNLKFLT RTRSTVAESV SQQILRQNRG
110 120 130
RKACDRPVAK TKKKKAEGTV FTEEDFQKFQ QEYFGS
Length:136
Mass (Da):15,434
Last modified:June 1, 2003 - v1
Checksum:iF7CE798D68CC0941
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WFE7F8WFE7_HUMAN
Active regulator of SIRT1
RPS19BP1
69Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051330124E → A. Corresponds to variant dbSNP:rs17001278Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456443 mRNA Translation: CAG30329.1
AL022312 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60343.1
BC047711 mRNA Translation: AAH47711.1
BC037573 mRNA Translation: AAH37573.1
CCDSiCCDS13997.1
RefSeqiNP_919307.1, NM_194326.3
UniGeneiHs.526933

Genome annotation databases

EnsembliENST00000334678; ENSP00000333948; ENSG00000187051
GeneIDi91582
KEGGihsa:91582
UCSCiuc003ayb.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456443 mRNA Translation: CAG30329.1
AL022312 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60343.1
BC047711 mRNA Translation: AAH47711.1
BC037573 mRNA Translation: AAH37573.1
CCDSiCCDS13997.1
RefSeqiNP_919307.1, NM_194326.3
UniGeneiHs.526933

3D structure databases

ProteinModelPortaliQ86WX3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124848, 28 interactors
IntActiQ86WX3, 15 interactors
MINTiQ86WX3
STRINGi9606.ENSP00000333948

PTM databases

iPTMnetiQ86WX3
PhosphoSitePlusiQ86WX3

Polymorphism and mutation databases

BioMutaiRPS19BP1
DMDMi74727734

Proteomic databases

EPDiQ86WX3
MaxQBiQ86WX3
PaxDbiQ86WX3
PeptideAtlasiQ86WX3
PRIDEiQ86WX3
ProteomicsDBi70214

Protocols and materials databases

DNASUi91582
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334678; ENSP00000333948; ENSG00000187051
GeneIDi91582
KEGGihsa:91582
UCSCiuc003ayb.3 human

Organism-specific databases

CTDi91582
DisGeNETi91582
EuPathDBiHostDB:ENSG00000187051.8
GeneCardsiRPS19BP1
HGNCiHGNC:28749 RPS19BP1
HPAiHPA042874
MIMi610225 gene
neXtProtiNX_Q86WX3
OpenTargetsiENSG00000187051
PharmGKBiPA143485599
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1DB Eukaryota
ENOG41126PZ LUCA
GeneTreeiENSGT00390000016774
HOGENOMiHOG000034068
HOVERGENiHBG097440
InParanoidiQ86WX3
OMAiQGRKACD
OrthoDBiEOG091G0YGT
PhylomeDBiQ86WX3
TreeFamiTF333429

Enzyme and pathway databases

ReactomeiR-HSA-3371453 Regulation of HSF1-mediated heat shock response

Miscellaneous databases

ChiTaRSiRPS19BP1 human
GenomeRNAii91582
PROiPR:Q86WX3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187051 Expressed in 200 organ(s), highest expression level in substantia nigra
CleanExiHS_RPS19BP1
ExpressionAtlasiQ86WX3 baseline and differential
GenevisibleiQ86WX3 HS

Family and domain databases

InterProiView protein in InterPro
IPR023262 AROS
PANTHERiPTHR31454 PTHR31454, 1 hit
PfamiView protein in Pfam
PF15684 AROS, 1 hit
PRINTSiPR02029 ACTREGSIRT1
ProtoNetiSearch...

Entry informationi

Entry nameiAROS_HUMAN
AccessioniPrimary (citable) accession number: Q86WX3
Secondary accession number(s): B0QY96, Q5JZA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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