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Entry version 139 (16 Oct 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Stimulator of interferon genes protein

Gene

TMEM173

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:18724357, PubMed:18818105, PubMed:19433799, PubMed:19776740, PubMed:23027953, PubMed:23910378, PubMed:23747010, PubMed:30842659). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (PubMed:26300263). Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol (PubMed:21947006, PubMed:23258412, PubMed:23707065, PubMed:23722158, PubMed:26229117, PubMed:23910378, PubMed:23747010, PubMed:30842659). Upon binding of c-di-GMP or cGAMP, TMEM173/STING oligomerizes, translocates from the endoplasmic reticulum and is phosphorylated by TBK1 on the pLxIS motif, leading to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent anti-viral state (PubMed:22394562, PubMed:25636800, PubMed:30842653). In addition to promote the production of type I interferons, plays a direct role in autophagy (PubMed:30568238, PubMed:30842662). Following cGAMP-binding, TMEM173/STING buds from the endoplasmic reticulum into COPII vesicles, which then form the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) (PubMed:30842662). The ERGIC serves as the membrane source for WIPI2 recruitment and LC3 lipidation, leading to formation of autophagosomes that target cytosolic DNA or DNA viruses for degradation by the lysosome (PubMed:30842662). The autophagy- and interferon-inducing activities can be uncoupled and autophagy induction is independent of TBK1 phosphorylation (PubMed:30568238, PubMed:30842662). Autophagy is also triggered upon infection by bacteria: following c-di-GMP-binding, which is produced by live Gram-positive bacteria, promotes reticulophagy (By similarity). Exhibits 2',3' phosphodiester linkage-specific ligand recognition: can bind both 2'-3' linked cGAMP (2'-3'-cGAMP) and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (PubMed:26300263, PubMed:23910378, PubMed:23747010). The preference for 2'-3'-cGAMP, compared to other linkage isomers is probably due to the ligand itself, whichs adopts an organized free-ligand conformation that resembles the TMEM173/STING-bound conformation and pays low energy costs in changing into the active conformation (PubMed:26150511). May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons (PubMed:18724357). May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) (By similarity).By similarity20 Publications
(Microbial infection) Antiviral activity is antagonized by oncoproteins, such as papillomavirus (HPV) protein E7 and adenovirus early E1A protein (PubMed:26405230). Such oncoproteins prevent the ability to sense cytosolic DNA (PubMed:26405230).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated upon binding to the hydrolysis-resistant 2'3'-cG(s)A(s)MP, an analog of cGAMP, in which phosphodiester linkages are replaced by phosphothioate linkages (PubMed:25344812). In contrast to mouse protein, not activated by anticancer molecule 5,6-dimethylxanthenone 4-acetic acid (DMXAA) (PubMed:26669264, PubMed:23910378, PubMed:25199835). Inhibited by compound 18 ([(3s,4s)-2-(4-Tert-Butyl-3-Chlorophenyl)-3-(2,3- Dihydro-1,4-Benzodioxin-6-Yl)-7-Fluoro-1-Oxo-1,2,3,4- Tetrahydroisoquinolin-4-Yl]acetate), a competite inhibitor with slow dissociation kinetics and good oral bioavailability (PubMed:30655953).5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei263Compound 18 inhibitorCombined sources1 Publication1
Binding sitei263Cyclic dinucleotideCombined sources6 Publications1
Binding sitei267Compound 18 inhibitorCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy, Host-virus interaction, Immunity, Innate immunity
LigandNucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1834941 STING mediated induction of host immune responses
R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA
R-HSA-3249367 STAT6-mediated induction of chemokines
R-HSA-3270619 IRF3-mediated induction of type I IFN
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Stimulator of interferon genes protein1 Publication
Short name:
hSTING3 Publications
Alternative name(s):
Endoplasmic reticulum interferon stimulator1 Publication
Short name:
ERIS1 Publication
Mediator of IRF3 activation2 Publications
Short name:
hMITA2 Publications
Transmembrane protein 173Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM173Imported
Synonyms:ERIS1 Publication, MITA2 Publications, STING2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27962 TMEM173

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612374 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86WV6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 17Cytoplasmic1 PublicationAdd BLAST17
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei18 – 34Helical; Name=11 PublicationAdd BLAST17
Topological domaini35 – 44Lumenal1 Publication10
Transmembranei45 – 69Helical; Name=21 PublicationAdd BLAST25
Topological domaini70 – 91Cytoplasmic1 PublicationAdd BLAST22
Transmembranei92 – 106Helical; Name=31 PublicationAdd BLAST15
Topological domaini107 – 116Lumenal1 Publication10
Transmembranei117 – 134Helical; Name=41 PublicationAdd BLAST18
Topological domaini135 – 379Cytoplasmic1 PublicationAdd BLAST245

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

STING-associated vasculopathy, infantile-onset (SAVI)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autoinflammatory disease characterized by early-onset systemic inflammation and cutaneous vasculopathy, resulting in severe skin lesions. Violaceous, scaling lesions of fingers, toes, nose, cheeks and ears progress to acral necrosis in most of the patients. Some patients have severe interstitial lung disease.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_071878147V → L in SAVI. 1 PublicationCorresponds to variant dbSNP:rs587777611EnsemblClinVar.1
Natural variantiVAR_071879154N → S in SAVI. 1 PublicationCorresponds to variant dbSNP:rs587777609EnsemblClinVar.1
Natural variantiVAR_071880155V → M in SAVI; constitutively active mutant that promotes the production of type I interferon in absence of cGAMP ligand. 3 PublicationsCorresponds to variant dbSNP:rs587777610EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi10I → Q: Abolished ability to induce the production of type I interferon. 1 Publication1
Mutagenesisi14R → A: Abolished ability to induce the production of type I interferon. 1 Publication1
Mutagenesisi20K → R: Does not affect amount of ubiquitination. 1 Publication1
Mutagenesisi68E → A: Abolished ability to induce the production of type I interferon. 1 Publication1
Mutagenesisi69E → A: Abolished ability to induce the production of type I interferon. 1 Publication1
Mutagenesisi76 – 78RYR → AYA: Abolishes the endoplasmic reticulum location. 1 Publication3
Mutagenesisi137K → R: Does not affect amount of ubiquitination. 1 Publication1
Mutagenesisi150K → R: Abolishes ubiquitination, homodimerization and subsequent production of IFN-beta. 3 Publications1
Mutagenesisi153F → A: Partially constitutively active mutant that promotes the production of type I interferon in absence of cGAMP ligand. 1 Publication1
Mutagenesisi158G → A: Constitutively active mutant that promotes the production of type I interferon in absence of cGAMP ligand. 1 Publication1
Mutagenesisi158G → S or V: Partially constitutively active mutant that promotes the production of type I interferon in absence of cGAMP ligand. 1 Publication1
Mutagenesisi162S → A: Slight decrease in c-di-GMP-binding. Renders the enzyme senstive to 5,6-dimethylxanthenone 4-acetic acid (DMXAA) drug, leading to activation of the TMEM173/STING pathway. Renders the enzyme senstive to 5,6-dimethylxanthenone 4-acetic acid (DMXAA) drug; when associated with I-266. 4 Publications1
Mutagenesisi166G → S: Slight decrease in c-di-GMP-binding. 1 Publication1
Mutagenesisi178 – 180RIR → AIA: Abolishes the endoplasmic reticulum location. 1 Publication3
Mutagenesisi230G → I: Renders the enzyme senstive to 5,6-dimethylxanthenone 4-acetic acid (DMXAA) drug, leading to activation of the TMEM173/STING pathway. 1 Publication1
Mutagenesisi238 – 240RVY → AVA: Strong decrease in cGAMP-binding without affecting interaction with TBK1. Abolished ability to induce autophagy. 2 Publications3
Mutagenesisi238R → A: Abolished cGAMP-binding. Abolished ability to induce autophagy. 2 Publications1
Mutagenesisi240Y → A: Abolished cGAMP-binding. 1 Publication1
Mutagenesisi240Y → S: Strong decrease in c-di-GMP-binding. 1 Publication1
Mutagenesisi242N → A: Strong decrease in c-di-GMP and cGAMP-binding. 2 Publications1
Mutagenesisi260E → A: Strong decrease in c-di-GMP and cGAMP-binding. 2 Publications1
Mutagenesisi263T → A: Strong decrease in c-di-GMP-binding. 1 Publication1
Mutagenesisi264P → A: Strong decrease in c-di-GMP-binding. 1 Publication1
Mutagenesisi266Q → I: Renders the enzyme senstive to 5,6-dimethylxanthenone 4-acetic acid (DMXAA) drug, leading to activation of the TMEM173/STING pathway; when associated with A-162. 1 Publication1
Mutagenesisi267T → A: Strong decrease in c-di-GMP-binding. 1 Publication1
Mutagenesisi273Q → A: Abolished translocation from the endoplasmic reticulum in response to cGAMP-binding. Reduced phosphorylation by TBK1. 2 Publications1
Mutagenesisi277A → Q: Abolished translocation from the endoplasmic reticulum in response to cGAMP-binding. Reduced phosphorylation by TBK1. 2 Publications1
Mutagenesisi324 – 326SLS → ALA: Induces a decrease in phosphorylation by TBK1. 1 Publication3
Mutagenesisi333 – 334LR → AA: Abolished ability to induce autophagy. Abolished interaction with SEC24C. 1 Publication2
Mutagenesisi341V → A: Does not affect ability to activate IRF3. 1 Publication1
Mutagenesisi342T → A: Does not affect ability to activate IRF3. 1 Publication1
Mutagenesisi358S → A: Induces a decrease in phosphorylation by TBK1. Does not affect ability to activate IRF3. 4 Publications1
Mutagenesisi360E → A: Does not affect ability to activate IRF3. 1 Publication1
Mutagenesisi362E → A: Slightly affects ability to induce the production of type I interferon. 1 Publication1
Mutagenesisi363L → A: Abolished ability to induce the production of type I interferon. 1 Publication1
Mutagenesisi364L → A: Slightly affects ability to induce the production of type I interferon. 1 Publication1
Mutagenesisi365I → A: Abolished ability to induce the production of type I interferon. 1 Publication1
Mutagenesisi366S → A, N or C: Induces a decrease in phosphorylation by TBK1. Abolished ability to activate IRF3. 3 Publications1
Mutagenesisi366S → D: Phosphomimetic mutant; retains some ability to activate IRF3. It probably incompletely mimics phosphorylation. 1 Publication1
Mutagenesisi367G → A: Does not affect ability to activate IRF3. 1 Publication1
Mutagenesisi371P → Q: Abolished ability to induce the production of type I interferon. 1 Publication1
Mutagenesisi374L → A: Abolished ability to activate IRF3 and induce the production of type I interferon. 2 Publications1
Mutagenesisi375R → A: Does not affect ability to activate IRF3. Abolished ability to induce the production of type I interferon. 2 Publications1
Mutagenesisi376T → A: Does not affect ability to activate IRF3. 1 Publication1
Mutagenesisi377D → A: Does not affect ability to activate IRF3. 1 Publication1
Mutagenesisi379S → A: Does not affect ability to activate IRF3. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

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DisGeNETi
340061

MalaCards human disease database

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MalaCardsi
TMEM173
MIMi615934 phenotype

Open Targets

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OpenTargetsi
ENSG00000184584

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
481662 Familial Chilblain lupus
425120 STING-associated vasculopathy with onset in infancy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162405934

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q86WV6

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2902

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TMEM173

Domain mapping of disease mutations (DMDM)

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DMDMi
74727720

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002711161 – 379Stimulator of interferon genes proteinAdd BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki150Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei358Phosphoserine; by TBK11 Publication1
Modified residuei366Phosphoserine; by TBK12 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by TBK1 leads to activation and production of IFN-beta (PubMed:18818105, PubMed:19433799, PubMed:25636800, PubMed:30842659, PubMed:30842653, PubMed:27302953). Following cyclic nucleotide (c-di-GMP or cGAMP)-binding, activation and translocation from the endoplasmic reticulum, TMEM173/STING is phosphorylated by TBK1 at Ser-366 in the pLxIS motif (PubMed:25636800). The phosphorylated pLxIS motif constitutes an IRF3-binding motif, leading to recruitment of the transcription factor IRF3 to induce type-I interferons and other cytokines (PubMed:25636800). Phosphorylated on tyrosine residues upon MHC-II aggregation (By similarity).By similarity6 Publications
Ubiquitinated (PubMed:19285439, PubMed:19433799, PubMed:21074459, PubMed:25254379). Ubiquitinated via 'Lys-63'-linked ubiquitin chains in response to double-stranded DNA treatment, leading to relocalization to autophagosomes and subsequent degradation; this process is dependent on SQSTM1 (By similarity). 'Lys-63'-linked ubiquitination mediated by TRIM56 at Lys-150 promotes homodimerization and recruitment of the antiviral kinase TBK1 and subsequent production of IFN-beta (PubMed:21074459). 'Lys-48'-linked polyubiquitination at Lys-150 occurring after viral infection is mediated by RNF5 and leads to proteasomal degradation (PubMed:19285439). 'Lys-11'-linked polyubiquitination at Lys-150 by RNF26 leads to stabilize TMEM173/STING: it protects TMEM173/STING from RNF5-mediated 'Lys-48'-linked polyubiquitination (PubMed:25254379).By similarity4 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q86WV6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q86WV6

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q86WV6

MaxQB - The MaxQuant DataBase

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MaxQBi
Q86WV6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q86WV6

PeptideAtlas

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PeptideAtlasi
Q86WV6

PRoteomics IDEntifications database

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PRIDEi
Q86WV6

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
70211

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q86WV6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q86WV6

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q86WV6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophages.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000184584 Expressed in 188 organ(s), highest expression level in right uterine tube

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q86WV6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q86WV6 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA038116
HPA038534

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; forms a homodimer in absence of cyclic nucleotide (c-di-GMP or cGAMP); 'Lys-63'-linked ubiquitination at Lys-150 is required for homodimerization (PubMed:22579474, PubMed:22705373, PubMed:22728658, PubMed:22728660, PubMed:22728659, PubMed:19285439, PubMed:30842659). Homotetramer; in presence of cyclic nucleotide (c-di-GMP or cGAMP), forms tetramers and higher-order oligomers through side-by-side packing (Probable).

Interacts (when phosphorylated) with IRF3; following activation and phosphorylation on the pLxIS motif by TBK1, recruits IRF3 (PubMed:22394562, PubMed:25636800, PubMed:27302953).

Interacts with DDX58/RIG-I, MAVS and SSR2 (PubMed:18818105, PubMed:18724357).

Interacts with RNF5 and TRIM56 (PubMed:19285439, PubMed:21074459).

Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta (PubMed:19416887).

Interacts with IFIT1 and IFIT2 (PubMed:19416887).

Interacts with TRIM29; this interaction induces TMEM173/STING ubiquitination and subsequent degradation (PubMed:29038422). Associates with the MHC-II complex (By similarity).

Interacts with SEC24C; promoting translocation to the COPII vesicles (PubMed:30842662).

Interacts (when ubiquitinated) with SQSTM1; leading to relocalization to autophagosomes (By similarity).

Interacts with SURF4 (PubMed:29251827).

Interacts with HNRNPA2B1 (PubMed:31320558).

By similarity1 Publication18 Publications

(Microbial infection) Interacts with human papillomavirus (HPV) protein E7.

1 Publication

(Microbial infection) Interacts with adenovirus early E1A protein.

1 Publication

(Microbial infection) Interacts with herpes simplex virus 1 protein ICP34.5; this interaction inhibits the intracellular DNA sensing pathway.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
130988, 50 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2127 Sting complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q86WV6

Database of interacting proteins

More...
DIPi
DIP-48847N

Protein interaction database and analysis system

More...
IntActi
Q86WV6, 71 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000331288

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1379
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86WV6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni153 – 340Cyclic dinucleotide-binding domain (CBD)1 PublicationAdd BLAST188
Regioni162 – 167Cyclic dinucleotide bindingCombined sources7 Publications6
Regioni238 – 241Cyclic dinucleotide bindingCombined sources8 Publications4
Regioni340 – 379C-terminal tail (CTT)1 PublicationAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi363 – 366pLxIS motif1 Publication4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

In absence of cGAMP, the transmembrane and cytoplasmic regions interact to form an integrated, domain-swapped dimeric assembly (By similarity). In absence of cyclic nucleotide (c-di-GMP or cGAMP), the protein is autoinhibited by an intramolecular interaction between the cyclic dinucleotide-binding domain (CBD) and the C-terminal tail (CTT) (PubMed:22579474, PubMed:22705373, PubMed:22728658, PubMed:22728660, PubMed:22728659). Following cGAMP-binding, the cyclic dinucleotide-binding domain (CBD) is closed, leading to a 180 degrees rotation of the CBD domain relative to the transmembrane domain. This rotation is coupled to a conformational change in a loop on the side of the CBD dimer, which leads to the formation of the TMEM173/STING tetramer and higher-order oligomers through side-by-side packing (By similarity). The N-terminal part of the CBD region was initially though to contain a fifth transmembrane region (TM5) but is part of the folded, soluble CBD (PubMed:22579474, PubMed:22705373, PubMed:22728658, PubMed:22728660, PubMed:22728659).By similarity5 Publications
The pLxIS motif constitutes an IRF3-binding motif: following phosphorylation by TBK1, the phosphorylated pLxIS motif of TMEM173/STING recruits IRF3 (PubMed:25636800). IRF3 is then phosphorylated and activated by TBK1 to induce type-I interferons and other cytokines (PubMed:25636800).1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM173 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH2R Eukaryota
ENOG4111M85 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008582

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000076316

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86WV6

KEGG Orthology (KO)

More...
KOi
K12654

Identification of Orthologs from Complete Genome Data

More...
OMAi
FAMSQYG

Database of Orthologous Groups

More...
OrthoDBi
865174at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86WV6

TreeFam database of animal gene trees

More...
TreeFami
TF324444

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12146 STING_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.12100, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029158 STING
IPR033952 STING_C
IPR038623 STING_C_sf

The PANTHER Classification System

More...
PANTHERi
PTHR34339 PTHR34339, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15009 TMEM173, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q86WV6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPHSSLHPSI PCPRGHGAQK AALVLLSACL VTLWGLGEPP EHTLRYLVLH
60 70 80 90 100
LASLQLGLLL NGVCSLAEEL RHIHSRYRGS YWRTVRACLG CPLRRGALLL
110 120 130 140 150
LSIYFYYSLP NAVGPPFTWM LALLGLSQAL NILLGLKGLA PAEISAVCEK
160 170 180 190 200
GNFNVAHGLA WSYYIGYLRL ILPELQARIR TYNQHYNNLL RGAVSQRLYI
210 220 230 240 250
LLPLDCGVPD NLSMADPNIR FLDKLPQQTG DHAGIKDRVY SNSIYELLEN
260 270 280 290 300
GQRAGTCVLE YATPLQTLFA MSQYSQAGFS REDRLEQAKL FCRTLEDILA
310 320 330 340 350
DAPESQNNCR LIAYQEPADD SSFSLSQEVL RHLRQEEKEE VTVGSLKTSA
360 370
VPSTSTMSQE PELLISGMEK PLPLRTDFS
Length:379
Mass (Da):42,193
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB54D6A4D4D8E7C0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494C0W5A0A494C0W5_HUMAN
Stimulator of interferon genes prot...
TMEM173
260Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0T1A0A494C0T1_HUMAN
Stimulator of interferon genes prot...
TMEM173
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1N5A0A494C1N5_HUMAN
Stimulator of interferon genes prot...
TMEM173
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QTB1J3QTB1_HUMAN
Stimulator of interferon genes prot...
TMEM173
283Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti262A → T in BAF83350 (PubMed:14702039).Curated1
Sequence conflicti363L → F in BAF83350 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02986371R → H. Corresponds to variant dbSNP:rs11554776Ensembl.1
Natural variantiVAR_071878147V → L in SAVI. 1 PublicationCorresponds to variant dbSNP:rs587777611EnsemblClinVar.1
Natural variantiVAR_071879154N → S in SAVI. 1 PublicationCorresponds to variant dbSNP:rs587777609EnsemblClinVar.1
Natural variantiVAR_071880155V → M in SAVI; constitutively active mutant that promotes the production of type I interferon in absence of cGAMP ligand. 3 PublicationsCorresponds to variant dbSNP:rs587777610EnsemblClinVar.1
Natural variantiVAR_029864232H → R Activated by both 2'-3' linked cGAMP and 3'-3' linked cGAMP. 2 PublicationsCorresponds to variant dbSNP:rs1131769EnsemblClinVar.1
Natural variantiVAR_081660284R → S Probable disease-associated mutation found in a 9-month-old patient who died following a fever and severe neck abscess without indication of any severe bacterial infection; may affect splicing; constitutively active mutant that promotes the production of type I interferon in absence of cyclic dinucleotide ligand; localizes to the perinuclear region in absence of cyclic dinucleotide ligand. 1 Publication1
Natural variantiVAR_029865293R → Q. Corresponds to variant dbSNP:rs7380824Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FJ222241 mRNA Translation: ACI46648.1
AK290661 mRNA Translation: BAF83350.1
AC138517 Genomic DNA No translation available.
BC047779 mRNA Translation: AAH47779.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4215.1

NCBI Reference Sequences

More...
RefSeqi
NP_938023.1, NM_198282.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000330794; ENSP00000331288; ENSG00000184584
ENST00000651699; ENSP00000499166; ENSG00000184584
ENST00000652271; ENSP00000498596; ENSG00000184584

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
340061

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:340061

UCSC genome browser

More...
UCSCi
uc003lep.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ222241 mRNA Translation: ACI46648.1
AK290661 mRNA Translation: BAF83350.1
AC138517 Genomic DNA No translation available.
BC047779 mRNA Translation: AAH47779.1
CCDSiCCDS4215.1
RefSeqiNP_938023.1, NM_198282.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4EF4X-ray2.15A/B139-379[»]
4EF5X-ray2.45A139-379[»]
4EMTX-ray1.50A/B155-341[»]
4EMUX-ray1.90A/B155-341[»]
4F5DX-ray3.00A/B141-379[»]
4F5EX-ray2.60A141-379[»]
4F5WX-ray2.20A149-379[»]
4F5YX-ray2.40A/B149-379[»]
4F9EX-ray2.75A139-379[»]
4F9GX-ray2.95A/C139-379[»]
4KSYX-ray1.88A138-379[»]
4LOHX-ray2.25A/B155-341[»]
4LOIX-ray1.89A/B155-341[»]
4QXOX-ray1.88A155-341[»]
4QXPX-ray2.51A/B155-341[»]
4QXQX-ray2.42A/B155-341[»]
4QXRX-ray2.37A/B155-341[»]
5BQXX-ray2.00A138-379[»]
5JEJX-ray2.00C/D/E342-377[»]
6CFFX-ray2.40A139-379[»]
6CY7X-ray2.20A139-379[»]
6DNKX-ray1.95A154-337[»]
6DXGX-ray1.91A153-343[»]
6DXLX-ray2.45A/B153-343[»]
6MX0X-ray1.73A/B155-341[»]
6MX3X-ray1.36A/B155-341[»]
6MXEX-ray2.47A/B155-341[»]
6NT5electron microscopy4.1A/B1-379[»]
6O8BX-ray3.40D/E155-379[»]
6O8CX-ray3.17D/E342-379[»]
SMRiQ86WV6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi130988, 50 interactors
ComplexPortaliCPX-2127 Sting complex
CORUMiQ86WV6
DIPiDIP-48847N
IntActiQ86WV6, 71 interactors
STRINGi9606.ENSP00000331288

Chemistry databases

GuidetoPHARMACOLOGYi2902

PTM databases

iPTMnetiQ86WV6
PhosphoSitePlusiQ86WV6
SwissPalmiQ86WV6

Polymorphism and mutation databases

BioMutaiTMEM173
DMDMi74727720

Proteomic databases

EPDiQ86WV6
jPOSTiQ86WV6
MassIVEiQ86WV6
MaxQBiQ86WV6
PaxDbiQ86WV6
PeptideAtlasiQ86WV6
PRIDEiQ86WV6
ProteomicsDBi70211

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
340061

Genome annotation databases

EnsembliENST00000330794; ENSP00000331288; ENSG00000184584
ENST00000651699; ENSP00000499166; ENSG00000184584
ENST00000652271; ENSP00000498596; ENSG00000184584
GeneIDi340061
KEGGihsa:340061
UCSCiuc003lep.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
340061
DisGeNETi340061

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM173
HGNCiHGNC:27962 TMEM173
HPAiHPA038116
HPA038534
MalaCardsiTMEM173
MIMi612374 gene
615934 phenotype
neXtProtiNX_Q86WV6
OpenTargetsiENSG00000184584
Orphaneti481662 Familial Chilblain lupus
425120 STING-associated vasculopathy with onset in infancy
PharmGKBiPA162405934

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IH2R Eukaryota
ENOG4111M85 LUCA
GeneTreeiENSGT00390000008582
HOGENOMiHOG000076316
InParanoidiQ86WV6
KOiK12654
OMAiFAMSQYG
OrthoDBi865174at2759
PhylomeDBiQ86WV6
TreeFamiTF324444

Enzyme and pathway databases

ReactomeiR-HSA-1834941 STING mediated induction of host immune responses
R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA
R-HSA-3249367 STAT6-mediated induction of chemokines
R-HSA-3270619 IRF3-mediated induction of type I IFN
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TMEM173 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
340061
PharosiQ86WV6

Protein Ontology

More...
PROi
PR:Q86WV6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184584 Expressed in 188 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ86WV6 baseline and differential
GenevisibleiQ86WV6 HS

Family and domain databases

CDDicd12146 STING_C, 1 hit
Gene3Di3.40.50.12100, 1 hit
InterProiView protein in InterPro
IPR029158 STING
IPR033952 STING_C
IPR038623 STING_C_sf
PANTHERiPTHR34339 PTHR34339, 1 hit
PfamiView protein in Pfam
PF15009 TMEM173, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTING_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86WV6
Secondary accession number(s): A8K3P6
, B6EB35, D6RBX0, D6RE01, D6RID9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2003
Last modified: October 16, 2019
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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