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Protein

Stimulator of interferon genes protein

Gene

TMEM173

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection. Exhibits 2',3' phosphodiester linkage-specific ligand recognition. Can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (PubMed:26300263).13 Publications
(Microbial infection) Antiviral activity is antagonized by oncoproteins, such as papillomavirus (HPV) protein E7 and adenovirus early E1A protein (PubMed:26405230). Such oncoproteins prevent the ability to sense cytosolic DNA (PubMed:26405230).1 Publication

Miscellaneous

Contrary to human and rat TMEM173/STING, mouse TMEM173/STING mediates not only responses to cyclic nucleotide signaling molecules, but is also strongly activated by antiviral and anticancer molecules, such as 5,6-dimethylxanthenone 4-acetic acid (DMXAA) and 10-carboxymethyl-9-acridanone (CMA).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei263c-di-GMP1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Host-virus interaction, Immunity, Innate immunity
LigandNucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1834941 STING mediated induction of host immune responses
R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA
R-HSA-3249367 STAT6-mediated induction of chemokines
R-HSA-3270619 IRF3-mediated induction of type I IFN
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Stimulator of interferon genes protein1 Publication
Short name:
hSTING2 Publications
Alternative name(s):
Endoplasmic reticulum interferon stimulator
Short name:
ERIS
Mediator of IRF3 activation2 Publications
Short name:
hMITA2 Publications
Transmembrane protein 173
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM173
Synonyms:ERIS, MITA2 Publications, STING2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000184584.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27962 TMEM173

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612374 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86WV6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini42 – 46ExtracellularSequence analysis5
Transmembranei47 – 67Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini68 – 86CytoplasmicSequence analysisAdd BLAST19
Transmembranei87 – 106Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini107 – 115ExtracellularSequence analysis9
Transmembranei116 – 136Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini137 – 379CytoplasmicSequence analysisAdd BLAST243

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

STING-associated vasculopathy, infantile-onset (SAVI)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autoinflammatory disease characterized by early-onset systemic inflammation and cutaneous vasculopathy, resulting in severe skin lesions. Violaceous, scaling lesions of fingers, toes, nose, cheeks and ears progress to acral necrosis in most of the patients. Some patients have severe interstitial lung disease.
See also OMIM:615934
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_071878147V → L in SAVI. 1 PublicationCorresponds to variant dbSNP:rs587777611EnsemblClinVar.1
Natural variantiVAR_071879154N → S in SAVI. 1 PublicationCorresponds to variant dbSNP:rs587777609EnsemblClinVar.1
Natural variantiVAR_071880155V → M in SAVI. 1 PublicationCorresponds to variant dbSNP:rs587777610EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi20K → R: Does not affect amount of ubiquitination. 1 Publication1
Mutagenesisi76 – 78RYR → AYA: Abolishes the endoplasmic reticulum location. 1 Publication3
Mutagenesisi137K → R: Does not affect amount of ubiquitination. 1 Publication1
Mutagenesisi150K → R: Abolishes ubiquitination, homodimerization and subsequent production of IFN-beta. 3 Publications1
Mutagenesisi162S → A: Slight decrease in c-di-GMP-binding. Strongly increases response to the synthetic compound 5,6-dimethylxanthenone 4-acetic acid (DMXAA). 2 Publications1
Mutagenesisi166G → S: Slight decrease in c-di-GMP-binding. 1 Publication1
Mutagenesisi178 – 180RIR → AIA: Abolishes the endoplasmic reticulum location. 1 Publication3
Mutagenesisi240Y → S: Strong decrease in c-di-GMP-binding. 1 Publication1
Mutagenesisi242N → A: Strong decrease in c-di-GMP-binding. 1 Publication1
Mutagenesisi260E → A: Strong decrease in c-di-GMP-binding. 1 Publication1
Mutagenesisi263T → A: Strong decrease in c-di-GMP-binding. 1 Publication1
Mutagenesisi264P → A: Strong decrease in c-di-GMP-binding. 1 Publication1
Mutagenesisi267T → A: Strong decrease in c-di-GMP-binding. 1 Publication1
Mutagenesisi324 – 326SLS → ALA: Induces a decrease in phosphorylation by TBK1. 1 Publication3
Mutagenesisi358S → A: Induces a decrease in phosphorylation by TBK1 and ability to activate IRF-E. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
340061

MalaCards human disease database

More...
MalaCardsi
TMEM173
MIMi615934 phenotype

Open Targets

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OpenTargetsi
ENSG00000184584

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
481662 Familial Chilblain lupus
425120 STING-associated vasculopathy with onset in infancy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162405934

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2902

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM173

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74727720

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002711161 – 379Stimulator of interferon genes proteinAdd BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki150Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei358Phosphoserine; by TBK11 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues upon MHC-II aggregation (By similarity). Phosphorylated on Ser-358 by TBK1, leading to activation and production of IFN-beta.By similarity2 Publications
Ubiquitinated (PubMed:19285439, PubMed:19433799, PubMed:21074459, PubMed:25254379). 'Lys-63'-linked ubiquitination mediated by TRIM56 at Lys-150 promotes homodimerization and recruitment of the antiviral kinase TBK1 and subsequent production of IFN-beta (PubMed:21074459). 'Lys-48'-linked polyubiquitination at Lys-150 occurring after viral infection is mediated by RNF5 and leads to proteasomal degradation (PubMed:19285439). 'Lys-11'-linked polyubiquitination at Lys-150 by RNF26 leads to stabilize TMEM173/STING: it protects TMEM173/STING from RNF5-mediated 'Lys-48'-linked polyubiquitination (PubMed:25254379).4 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q86WV6

MaxQB - The MaxQuant DataBase

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MaxQBi
Q86WV6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q86WV6

PeptideAtlas

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PeptideAtlasi
Q86WV6

PRoteomics IDEntifications database

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PRIDEi
Q86WV6

ProteomicsDB human proteome resource

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ProteomicsDBi
70211

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q86WV6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q86WV6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q86WV6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophages.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184584 Expressed in 188 organ(s), highest expression level in right uterine tube

CleanEx database of gene expression profiles

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CleanExi
HS_TMEM173

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q86WV6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86WV6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038116
HPA038534

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with the MHC-II complex (By similarity). Homodimer; 'Lys-63'-linked ubiquitination at Lys-150 is required for homodimerization. Interacts with DDX58/RIG-I, MAVS and SSR2. Interacts with RNF5 and TRIM56. Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Interacts with IFIT1 and IFIT2. Interacts with TRIM29; this interaction induces TMEM173/STING ubiquitination and subsequent degradation (PubMed:29038422).By similarity10 Publications
(Microbial infection) Interacts with human papillomavirus (HPV) protein E7.1 Publication
(Microbial infection) Interacts with adenovirus early E1A protein.1 Publication
(Microbial infection) Interacts with herpes simplex virus 1 protein ICP34.5; this interaction inhibits the intracellular DNA sensing pathway.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
130988, 47 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-2127 Sting complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q86WV6

Database of interacting proteins

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DIPi
DIP-48847N

Protein interaction database and analysis system

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IntActi
Q86WV6, 70 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000331288

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1379
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q86WV6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q86WV6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni153 – 340c-di-GMP-binding domain (CBD)Add BLAST188
Regioni162 – 167c-di-GMP binding6
Regioni238 – 241c-di-GMP binding4
Regioni340 – 379C-terminal tail (CTT)Add BLAST40

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The c-di-GMP-binding domain (CBD) forms a homodimer via hydrophobic interactions and binds both the cyclic diguanylate monophosphate (c-di-GMP) and the cyclic GMP-AMP (cGAMP) messengers. In absence of c-di-GMP or cGAMP, the protein is autoinhibited by an intramolecular interaction between the CBD and the C-terminal tail (CTT). Binding of c-di-GMP or cGAMP to the CBD releases the autoinhibition by displacing the CTT, leading to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon. The N-terminal part of the CBD region was initially though to contain a fifth transmembrane region (TM5) but is part of the folded, soluble CBD (PubMed:22579474, PubMed:22705373, PubMed:22728658, PubMed:22728660 and PubMed:22728659).

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM173 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH2R Eukaryota
ENOG4111M85 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000008582

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000076316

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG094065

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q86WV6

KEGG Orthology (KO)

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KOi
K12654

Identification of Orthologs from Complete Genome Data

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OMAi
YSNSVYE

Database of Orthologous Groups

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OrthoDBi
EOG091G08B2

Database for complete collections of gene phylogenies

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PhylomeDBi
Q86WV6

TreeFam database of animal gene trees

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TreeFami
TF324444

Family and domain databases

Conserved Domains Database

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CDDi
cd12146 STING_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.12100, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029158 STING
IPR033952 STING_C
IPR038623 STING_C_sf

The PANTHER Classification System

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PANTHERi
PTHR34339 PTHR34339, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15009 TMEM173, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q86WV6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPHSSLHPSI PCPRGHGAQK AALVLLSACL VTLWGLGEPP EHTLRYLVLH
60 70 80 90 100
LASLQLGLLL NGVCSLAEEL RHIHSRYRGS YWRTVRACLG CPLRRGALLL
110 120 130 140 150
LSIYFYYSLP NAVGPPFTWM LALLGLSQAL NILLGLKGLA PAEISAVCEK
160 170 180 190 200
GNFNVAHGLA WSYYIGYLRL ILPELQARIR TYNQHYNNLL RGAVSQRLYI
210 220 230 240 250
LLPLDCGVPD NLSMADPNIR FLDKLPQQTG DHAGIKDRVY SNSIYELLEN
260 270 280 290 300
GQRAGTCVLE YATPLQTLFA MSQYSQAGFS REDRLEQAKL FCRTLEDILA
310 320 330 340 350
DAPESQNNCR LIAYQEPADD SSFSLSQEVL RHLRQEEKEE VTVGSLKTSA
360 370
VPSTSTMSQE PELLISGMEK PLPLRTDFS
Length:379
Mass (Da):42,193
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB54D6A4D4D8E7C0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QTB1J3QTB1_HUMAN
Stimulator of interferon genes prot...
TMEM173
253Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti262A → T in BAF83350 (PubMed:14702039).Curated1
Sequence conflicti363L → F in BAF83350 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02986371R → H. Corresponds to variant dbSNP:rs11554776Ensembl.1
Natural variantiVAR_071878147V → L in SAVI. 1 PublicationCorresponds to variant dbSNP:rs587777611EnsemblClinVar.1
Natural variantiVAR_071879154N → S in SAVI. 1 PublicationCorresponds to variant dbSNP:rs587777609EnsemblClinVar.1
Natural variantiVAR_071880155V → M in SAVI. 1 PublicationCorresponds to variant dbSNP:rs587777610EnsemblClinVar.1
Natural variantiVAR_029864232H → R Activated by both 2'-3' linked cGAMP and 3'-3' linked cGAMP. 2 PublicationsCorresponds to variant dbSNP:rs1131769EnsemblClinVar.1
Natural variantiVAR_029865293R → Q. Corresponds to variant dbSNP:rs7380824Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FJ222241 mRNA Translation: ACI46648.1
AK290661 mRNA Translation: BAF83350.1
AC138517 Genomic DNA No translation available.
BC047779 mRNA Translation: AAH47779.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4215.1

NCBI Reference Sequences

More...
RefSeqi
NP_938023.1, NM_198282.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.379754

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000330794; ENSP00000331288; ENSG00000184584

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
340061

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:340061

UCSC genome browser

More...
UCSCi
uc003lep.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ222241 mRNA Translation: ACI46648.1
AK290661 mRNA Translation: BAF83350.1
AC138517 Genomic DNA No translation available.
BC047779 mRNA Translation: AAH47779.1
CCDSiCCDS4215.1
RefSeqiNP_938023.1, NM_198282.3
UniGeneiHs.379754

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4EF4X-ray2.15A/B139-379[»]
4EF5X-ray2.45A139-379[»]
4EMTX-ray1.50A/B155-341[»]
4EMUX-ray1.90A/B155-341[»]
4F5DX-ray3.00A/B141-379[»]
4F5EX-ray2.60A141-379[»]
4F5WX-ray2.20A149-379[»]
4F5YX-ray2.40A/B149-379[»]
4F9EX-ray2.75A139-379[»]
4F9GX-ray2.95A/C139-379[»]
4KSYX-ray1.88A138-379[»]
4LOHX-ray2.25A/B155-341[»]
4LOIX-ray1.89A/B155-341[»]
4QXOX-ray1.88A155-341[»]
4QXPX-ray2.51A/B155-341[»]
4QXQX-ray2.42A/B155-341[»]
4QXRX-ray2.37A/B155-341[»]
5BQXX-ray2.00A138-379[»]
5JEJX-ray2.00C/D/E342-377[»]
ProteinModelPortaliQ86WV6
SMRiQ86WV6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130988, 47 interactors
ComplexPortaliCPX-2127 Sting complex
CORUMiQ86WV6
DIPiDIP-48847N
IntActiQ86WV6, 70 interactors
STRINGi9606.ENSP00000331288

Chemistry databases

GuidetoPHARMACOLOGYi2902

PTM databases

iPTMnetiQ86WV6
PhosphoSitePlusiQ86WV6
SwissPalmiQ86WV6

Polymorphism and mutation databases

BioMutaiTMEM173
DMDMi74727720

Proteomic databases

EPDiQ86WV6
MaxQBiQ86WV6
PaxDbiQ86WV6
PeptideAtlasiQ86WV6
PRIDEiQ86WV6
ProteomicsDBi70211

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
340061
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330794; ENSP00000331288; ENSG00000184584
GeneIDi340061
KEGGihsa:340061
UCSCiuc003lep.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
340061
DisGeNETi340061
EuPathDBiHostDB:ENSG00000184584.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM173
HGNCiHGNC:27962 TMEM173
HPAiHPA038116
HPA038534
MalaCardsiTMEM173
MIMi612374 gene
615934 phenotype
neXtProtiNX_Q86WV6
OpenTargetsiENSG00000184584
Orphaneti481662 Familial Chilblain lupus
425120 STING-associated vasculopathy with onset in infancy
PharmGKBiPA162405934

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IH2R Eukaryota
ENOG4111M85 LUCA
GeneTreeiENSGT00390000008582
HOGENOMiHOG000076316
HOVERGENiHBG094065
InParanoidiQ86WV6
KOiK12654
OMAiYSNSVYE
OrthoDBiEOG091G08B2
PhylomeDBiQ86WV6
TreeFamiTF324444

Enzyme and pathway databases

ReactomeiR-HSA-1834941 STING mediated induction of host immune responses
R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA
R-HSA-3249367 STAT6-mediated induction of chemokines
R-HSA-3270619 IRF3-mediated induction of type I IFN
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TMEM173 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
340061

Protein Ontology

More...
PROi
PR:Q86WV6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184584 Expressed in 188 organ(s), highest expression level in right uterine tube
CleanExiHS_TMEM173
ExpressionAtlasiQ86WV6 baseline and differential
GenevisibleiQ86WV6 HS

Family and domain databases

CDDicd12146 STING_C, 1 hit
Gene3Di3.40.50.12100, 1 hit
InterProiView protein in InterPro
IPR029158 STING
IPR033952 STING_C
IPR038623 STING_C_sf
PANTHERiPTHR34339 PTHR34339, 1 hit
PfamiView protein in Pfam
PF15009 TMEM173, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTING_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86WV6
Secondary accession number(s): A8K3P6
, B6EB35, D6RBX0, D6RE01, D6RID9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2003
Last modified: December 5, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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