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Protein

Oocyte-secreted protein 2

Gene

OOSP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Oocyte-secreted protein 2
Alternative name(s):
Placenta-specific 1-like protein
Protein TMEM122
Gene namesi
Name:OOSP2
Synonyms:PLAC1L, TMEM122
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149507.6
HGNCiHGNC:26699 OOSP2
neXtProtiNX_Q86WS3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000149507
PharmGKBiPA162399666

Polymorphism and mutation databases

BioMutaiPLAC1L

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000025115018 – 158Oocyte-secreted protein 2Add BLAST141

Proteomic databases

PaxDbiQ86WS3
PeptideAtlasiQ86WS3
PRIDEiQ86WS3
ProteomicsDBi70195
TopDownProteomicsiQ86WS3

PTM databases

iPTMnetiQ86WS3
PhosphoSitePlusiQ86WS3

Expressioni

Gene expression databases

BgeeiENSG00000149507 Expressed in 25 organ(s), highest expression level in secondary oocyte
CleanExiHS_PLAC1L
ExpressionAtlasiQ86WS3 baseline and differential
GenevisibleiQ86WS3 HS

Organism-specific databases

HPAiHPA050914

Interactioni

Protein-protein interaction databases

BioGridi128614, 1 interactor
STRINGi9606.ENSP00000278855

Structurei

3D structure databases

ProteinModelPortaliQ86WS3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PLAC1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JAPA Eukaryota
ENOG41117A8 LUCA
GeneTreeiENSGT00530000064049
HOGENOMiHOG000115573
HOVERGENiHBG082150
InParanoidiQ86WS3
OMAiECSASRK
OrthoDBiEOG091G0WSR
PhylomeDBiQ86WS3
TreeFamiTF338479

Family and domain databases

InterProiView protein in InterPro
IPR033219 Oosp2
IPR033222 PLAC1_fam
PANTHERiPTHR14380 PTHR14380, 1 hit
PTHR14380:SF7 PTHR14380:SF7, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q86WS3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALEVLMLLA VLIWTGAENL HVKISCSLDW LMVSVIPVAE SRNLYIFADE
60 70 80 90 100
LHLGMGCPAN RIHTYVYEFI YLVRDCGIRT RVVSEETLLF QTELYFTPRN
110 120 130 140 150
IDHDPQEIHL ECSTSRKSVW LTPVSTENEI KLDPSPFIAD FQTTAEELGL

LSSSPNLL
Length:158
Mass (Da):17,971
Last modified:June 1, 2003 - v1
Checksum:iEEB43D6FB8AB81FF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MTE3A0A0A0MTE3_HUMAN
Oocyte-secreted protein 2
OOSP2
86Annotation score:

Sequence cautioni

The sequence AP000790 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33V → A in BAC04191 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093517 mRNA Translation: BAC04191.1
AP000790 Genomic DNA No translation available.
BC036256 mRNA Translation: AAH36256.1
BC048121 mRNA Translation: AAH48121.1
CCDSiCCDS7979.1
RefSeqiNP_776162.2, NM_173801.4
UniGeneiHs.132310

Genome annotation databases

EnsembliENST00000278855; ENSP00000278855; ENSG00000149507
ENST00000647205; ENSP00000494787; ENSG00000285422
GeneIDi219990
KEGGihsa:219990
UCSCiuc001nol.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093517 mRNA Translation: BAC04191.1
AP000790 Genomic DNA No translation available.
BC036256 mRNA Translation: AAH36256.1
BC048121 mRNA Translation: AAH48121.1
CCDSiCCDS7979.1
RefSeqiNP_776162.2, NM_173801.4
UniGeneiHs.132310

3D structure databases

ProteinModelPortaliQ86WS3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128614, 1 interactor
STRINGi9606.ENSP00000278855

PTM databases

iPTMnetiQ86WS3
PhosphoSitePlusiQ86WS3

Polymorphism and mutation databases

BioMutaiPLAC1L

Proteomic databases

PaxDbiQ86WS3
PeptideAtlasiQ86WS3
PRIDEiQ86WS3
ProteomicsDBi70195
TopDownProteomicsiQ86WS3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278855; ENSP00000278855; ENSG00000149507
ENST00000647205; ENSP00000494787; ENSG00000285422
GeneIDi219990
KEGGihsa:219990
UCSCiuc001nol.4 human

Organism-specific databases

CTDi219990
EuPathDBiHostDB:ENSG00000149507.6
GeneCardsiOOSP2
HGNCiHGNC:26699 OOSP2
HPAiHPA050914
neXtProtiNX_Q86WS3
OpenTargetsiENSG00000149507
PharmGKBiPA162399666
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAPA Eukaryota
ENOG41117A8 LUCA
GeneTreeiENSGT00530000064049
HOGENOMiHOG000115573
HOVERGENiHBG082150
InParanoidiQ86WS3
OMAiECSASRK
OrthoDBiEOG091G0WSR
PhylomeDBiQ86WS3
TreeFamiTF338479

Miscellaneous databases

GenomeRNAii219990
PROiPR:Q86WS3

Gene expression databases

BgeeiENSG00000149507 Expressed in 25 organ(s), highest expression level in secondary oocyte
CleanExiHS_PLAC1L
ExpressionAtlasiQ86WS3 baseline and differential
GenevisibleiQ86WS3 HS

Family and domain databases

InterProiView protein in InterPro
IPR033219 Oosp2
IPR033222 PLAC1_fam
PANTHERiPTHR14380 PTHR14380, 1 hit
PTHR14380:SF7 PTHR14380:SF7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOOSP2_HUMAN
AccessioniPrimary (citable) accession number: Q86WS3
Secondary accession number(s): E9PJA4, Q8N9U6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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