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Protein

Vasculin

Gene

GPBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a GC-rich promoter-specific transactivating transcription factor.By similarity

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA-binding transcription factor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Vasculin
Alternative name(s):
GC-rich promoter-binding protein 1
Vascular wall-linked protein
Gene namesi
Name:GPBP1
Synonyms:GPBP, SSH6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000062194.15
HGNCiHGNC:29520 GPBP1
MIMi608412 gene
neXtProtiNX_Q86WP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000062194
PharmGKBiPA142671714

Polymorphism and mutation databases

BioMutaiGPBP1
DMDMi74714120

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003241101 – 473VasculinAdd BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineCombined sources1
Modified residuei87Omega-N-methylarginineCombined sources1
Modified residuei274PhosphoserineBy similarity1
Modified residuei276PhosphoserineBy similarity1
Modified residuei322PhosphoserineCombined sources1
Modified residuei381PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ86WP2
PaxDbiQ86WP2
PeptideAtlasiQ86WP2
PRIDEiQ86WP2
ProteomicsDBi70185
70186 [Q86WP2-2]
70187 [Q86WP2-3]
70188 [Q86WP2-4]

PTM databases

iPTMnetiQ86WP2
PhosphoSitePlusiQ86WP2

Expressioni

Tissue specificityi

Widely expressed. Some isoforms may be specifically expressed in veins and arteries (at protein level). Isoform 4 is widely expressed. Isoform 1, isoform 2 and isoform 3 may be specifically expressed in vascular smooth muscle cells.2 Publications

Gene expression databases

BgeeiENSG00000062194 Expressed in 203 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_GPBP1
ExpressionAtlasiQ86WP2 baseline and differential
GenevisibleiQ86WP2 HS

Organism-specific databases

HPAiHPA037773

Interactioni

Subunit structurei

Interacts with GTF2B, GTF2F2, RNA polymerase II and TBP.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi122378, 32 interactors
IntActiQ86WP2, 22 interactors
STRINGi9606.ENSP00000264779

Structurei

3D structure databases

ProteinModelPortaliQ86WP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasculin family.Curated

Phylogenomic databases

eggNOGiENOG410IJH3 Eukaryota
ENOG410Y09K LUCA
GeneTreeiENSGT00420000029753
HOGENOMiHOG000049182
HOVERGENiHBG056980
InParanoidiQ86WP2
PhylomeDBiQ86WP2
TreeFamiTF332220

Family and domain databases

InterProiView protein in InterPro
IPR028128 Vasculin_fam
PfamiView protein in Pfam
PF15337 Vasculin, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86WP2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQHDFAPAW LNFPTPPSST KSSLNFEKHS ENFAWTENRY DVNRRRHNSS
60 70 80 90 100
DGFDSAIGRP NGGNFGRKEK NGWRTHGRNG TENINHRGGY HGGSSRSRSS
110 120 130 140 150
IFHAGKSQGL HENNIPDNET GRKEDKRERK QFEAEDFPSL NPEYEREPNH
160 170 180 190 200
NKSLAAGVWE YPPNPKSRAP RMLVIKKGNT KDLQLSGFPV VGNLPSQPVK
210 220 230 240 250
NGTGPSVYKG LVPKPAAPPT KPTQWKSQTK ENKVGTSFPH ESTFGVGNFN
260 270 280 290 300
AFKSTAKNFS PSTNSVKECN RSNSSSPVDK LNQQPRLTKL TRMRTDKKSE
310 320 330 340 350
FLKALKRDRV EEEHEDESRA GSEKDDDSFN LHNSNSTHQE RDINRNFDEN
360 370 380 390 400
EIPQENGNAS VISQQIIRSS TFPQTDVLSS SLEAEHRLLK EMGWQEDSEN
410 420 430 440 450
DETCAPLTED EMREFQVISE QLQKNGLRKN GILKNGLICD FKFGPWKNST
460 470
FKPTTENDDT ETSSSDTSDD DDV
Length:473
Mass (Da):53,339
Last modified:June 1, 2003 - v1
Checksum:i932A7681860622C4
GO
Isoform 2 (identifier: Q86WP2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: T → TKVLTSSL

Show »
Length:480
Mass (Da):54,068
Checksum:i5CDD94AF77BA000F
GO
Isoform 3 (identifier: Q86WP2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: T → TKVLTSSL
     269-283: Missing.

Note: No experimental confirmation available.
Show »
Length:465
Mass (Da):52,437
Checksum:iDCB1357E3D0DC49A
GO
Isoform 4 (identifier: Q86WP2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.

Show »
Length:302
Mass (Da):33,830
Checksum:i7C4DB60FB19008EC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D4PHA4D4PHA4_HUMAN
GC-rich promoter binding protein 1,...
GPBP1 hCG_40617
493Annotation score:

Sequence cautioni

The sequence AAH00267 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH70132 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence BAB15013 differs from that shown. Reason: Frameshift at position 291.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127R → G in AAH70132 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039654122R → G. Corresponds to variant dbSNP:rs1862171Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0321351 – 171Missing in isoform 4. 1 PublicationAdd BLAST171
Alternative sequenceiVSP_03213620T → TKVLTSSL in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_032137269 – 283Missing in isoform 3. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY226828 mRNA Translation: AAO34124.1
AL136844 mRNA Translation: CAB66778.1
AL161991 mRNA Translation: CAB82324.2
AC034244 Genomic DNA No translation available.
CH471123 Genomic DNA Translation: EAW54965.1
CH471123 Genomic DNA Translation: EAW54966.1
BC000267 mRNA Translation: AAH00267.1 Different initiation.
BC070132 mRNA Translation: AAH70132.1 Sequence problems.
BC113004 mRNA Translation: AAI13005.1
AK024807 mRNA Translation: BAB15013.1 Frameshift.
CCDSiCCDS34162.1 [Q86WP2-1]
CCDS47211.1 [Q86WP2-2]
CCDS47212.2 [Q86WP2-3]
CCDS56368.1 [Q86WP2-4]
PIRiT47146
RefSeqiNP_001120707.2, NM_001127235.2 [Q86WP2-3]
NP_001120708.1, NM_001127236.2 [Q86WP2-2]
NP_001190175.1, NM_001203246.1 [Q86WP2-4]
NP_075064.1, NM_022913.3 [Q86WP2-1]
XP_016865245.1, XM_017009756.1
XP_016865246.1, XM_017009757.1 [Q86WP2-2]
XP_016865247.1, XM_017009758.1 [Q86WP2-1]
XP_016865248.1, XM_017009759.1 [Q86WP2-1]
UniGeneiHs.444279

Genome annotation databases

EnsembliENST00000264779; ENSP00000264779; ENSG00000062194 [Q86WP2-2]
ENST00000506184; ENSP00000421202; ENSG00000062194 [Q86WP2-1]
ENST00000511209; ENSP00000422337; ENSG00000062194 [Q86WP2-3]
ENST00000514387; ENSP00000421709; ENSG00000062194 [Q86WP2-4]
GeneIDi65056
KEGGihsa:65056
UCSCiuc003jrh.5 human [Q86WP2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY226828 mRNA Translation: AAO34124.1
AL136844 mRNA Translation: CAB66778.1
AL161991 mRNA Translation: CAB82324.2
AC034244 Genomic DNA No translation available.
CH471123 Genomic DNA Translation: EAW54965.1
CH471123 Genomic DNA Translation: EAW54966.1
BC000267 mRNA Translation: AAH00267.1 Different initiation.
BC070132 mRNA Translation: AAH70132.1 Sequence problems.
BC113004 mRNA Translation: AAI13005.1
AK024807 mRNA Translation: BAB15013.1 Frameshift.
CCDSiCCDS34162.1 [Q86WP2-1]
CCDS47211.1 [Q86WP2-2]
CCDS47212.2 [Q86WP2-3]
CCDS56368.1 [Q86WP2-4]
PIRiT47146
RefSeqiNP_001120707.2, NM_001127235.2 [Q86WP2-3]
NP_001120708.1, NM_001127236.2 [Q86WP2-2]
NP_001190175.1, NM_001203246.1 [Q86WP2-4]
NP_075064.1, NM_022913.3 [Q86WP2-1]
XP_016865245.1, XM_017009756.1
XP_016865246.1, XM_017009757.1 [Q86WP2-2]
XP_016865247.1, XM_017009758.1 [Q86WP2-1]
XP_016865248.1, XM_017009759.1 [Q86WP2-1]
UniGeneiHs.444279

3D structure databases

ProteinModelPortaliQ86WP2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122378, 32 interactors
IntActiQ86WP2, 22 interactors
STRINGi9606.ENSP00000264779

PTM databases

iPTMnetiQ86WP2
PhosphoSitePlusiQ86WP2

Polymorphism and mutation databases

BioMutaiGPBP1
DMDMi74714120

Proteomic databases

MaxQBiQ86WP2
PaxDbiQ86WP2
PeptideAtlasiQ86WP2
PRIDEiQ86WP2
ProteomicsDBi70185
70186 [Q86WP2-2]
70187 [Q86WP2-3]
70188 [Q86WP2-4]

Protocols and materials databases

DNASUi65056
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264779; ENSP00000264779; ENSG00000062194 [Q86WP2-2]
ENST00000506184; ENSP00000421202; ENSG00000062194 [Q86WP2-1]
ENST00000511209; ENSP00000422337; ENSG00000062194 [Q86WP2-3]
ENST00000514387; ENSP00000421709; ENSG00000062194 [Q86WP2-4]
GeneIDi65056
KEGGihsa:65056
UCSCiuc003jrh.5 human [Q86WP2-1]

Organism-specific databases

CTDi65056
EuPathDBiHostDB:ENSG00000062194.15
GeneCardsiGPBP1
HGNCiHGNC:29520 GPBP1
HPAiHPA037773
MIMi608412 gene
neXtProtiNX_Q86WP2
OpenTargetsiENSG00000062194
PharmGKBiPA142671714
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJH3 Eukaryota
ENOG410Y09K LUCA
GeneTreeiENSGT00420000029753
HOGENOMiHOG000049182
HOVERGENiHBG056980
InParanoidiQ86WP2
PhylomeDBiQ86WP2
TreeFamiTF332220

Miscellaneous databases

ChiTaRSiGPBP1 human
GeneWikiiGPBP1
GenomeRNAii65056
PROiPR:Q86WP2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000062194 Expressed in 203 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_GPBP1
ExpressionAtlasiQ86WP2 baseline and differential
GenevisibleiQ86WP2 HS

Family and domain databases

InterProiView protein in InterPro
IPR028128 Vasculin_fam
PfamiView protein in Pfam
PF15337 Vasculin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPBP1_HUMAN
AccessioniPrimary (citable) accession number: Q86WP2
Secondary accession number(s): A6NKW3
, Q6NSH6, Q9H0D4, Q9H785, Q9NSN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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