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Protein

Interferon epsilon

Gene

IFNE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon epsilon
Short name:
IFN-epsilon
Alternative name(s):
Interferon epsilon-1
Gene namesi
Name:IFNE
Synonyms:IFNE1
ORF Names:UNQ360/PRO655
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000184995.7
HGNCiHGNC:18163 IFNE
MIMi615223 gene
neXtProtiNX_Q86WN2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi338376
OpenTargetsiENSG00000184995
PharmGKBiPA164720874

Polymorphism and mutation databases

BioMutaiIFNE
DMDMi74727686

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000031763122 – 208Interferon epsilonAdd BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 163By similarity
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ86WN2
PeptideAtlasiQ86WN2
PRIDEiQ86WN2
ProteomicsDBi70184

PTM databases

iPTMnetiQ86WN2
PhosphoSitePlusiQ86WN2

Expressioni

Tissue specificityi

Endometrium-specific.1 Publication

Developmental stagei

Highly expressed in endometrial epithelial cells in proliferative phase of the menstrual cycle. Levels decrease approximately 10-fold in the secretory phase. Virtually undetectable in samples from postmenopausal women.1 Publication

Inductioni

By estrogens.1 Publication

Gene expression databases

BgeeiENSG00000184995
GenevisibleiQ86WN2 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi130722, 11 interactors
STRINGi9606.ENSP00000418018

Structurei

3D structure databases

ProteinModelPortaliQ86WN2
SMRiQ86WN2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JB9C Eukaryota
ENOG4111BCG LUCA
GeneTreeiENSGT00920000149151
HOGENOMiHOG000230501
InParanoidiQ86WN2
KOiK05442
OMAiKMYFRRI
OrthoDBiEOG091G0R2T
PhylomeDBiQ86WN2
TreeFamiTF336177

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86WN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIKHFFGTV LVLLASTTIF SLDLKLIIFQ QRQVNQESLK LLNKLQTLSI
60 70 80 90 100
QQCLPHRKNF LLPQKSLSPQ QYQKGHTLAI LHEMLQQIFS LFRANISLDG
110 120 130 140 150
WEENHTEKFL IQLHQQLEYL EALMGLEAEK LSGTLGSDNL RLQVKMYFRR
160 170 180 190 200
IHDYLENQDY STCAWAIVQV EISRCLFFVF SLTEKLSKQG RPLNDMKQEL

TTEFRSPR
Length:208
Mass (Da):24,414
Last modified:June 1, 2003 - v1
Checksum:i65FB861407F14E5F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04963946Q → H. Corresponds to variant dbSNP:rs1125488Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY190045 mRNA Translation: AAO38686.1
AY358570 mRNA Translation: AAQ88933.1
BC100871 mRNA Translation: AAI00872.1
BC100872 mRNA Translation: AAI00873.1
BC100873 mRNA Translation: AAI00874.1
CCDSiCCDS34997.1
RefSeqiNP_795372.1, NM_176891.4
UniGeneiHs.682604

Genome annotation databases

EnsembliENST00000448696; ENSP00000418018; ENSG00000184995
GeneIDi338376
KEGGihsa:338376
UCSCiuc003zpg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIFNE_HUMAN
AccessioniPrimary (citable) accession number: Q86WN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: June 20, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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