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Protein

Membrane progestin receptor alpha

Gene

PAQR7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (PubMed:12601167). Involved in neurosteroid inhibition of apoptosis (PubMed:23161870). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).1 Publication2 Publications

Miscellaneous

Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).1 Publication

GO - Molecular functioni

  • signaling receptor activity Source: GO_Central
  • steroid binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processDifferentiation, Oogenesis
LigandLipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane progestin receptor alpha1 Publication
Short name:
mPR alpha1 Publication
Alternative name(s):
Membrane progesterone P4 receptor alpha1 Publication
Membrane progesterone receptor alpha1 Publication
Progesterone and adipoQ receptor family member 7
Progestin and adipoQ receptor family member 71 Publication
Progestin and adipoQ receptor family member VII
Gene namesi
Name:PAQR7Imported
Synonyms:MRPA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000182749.5
HGNCiHGNC:23146 PAQR7
MIMi607779 gene
neXtProtiNX_Q86WK9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 72CytoplasmicSequence analysisAdd BLAST72
Transmembranei73 – 93Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini94 – 103ExtracellularSequence analysis10
Transmembranei104 – 124Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini125 – 137CytoplasmicSequence analysisAdd BLAST13
Transmembranei138 – 158Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini159 – 169ExtracellularSequence analysisAdd BLAST11
Transmembranei170 – 190Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini191 – 237CytoplasmicSequence analysisAdd BLAST47
Transmembranei238 – 258Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini259 – 276ExtracellularSequence analysisAdd BLAST18
Transmembranei277 – 297Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini298 – 316CytoplasmicSequence analysisAdd BLAST19
Transmembranei317 – 337Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini338 – 346ExtracellularSequence analysis9

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi164091
OpenTargetsiENSG00000182749
PharmGKBiPA142671200

Polymorphism and mutation databases

BioMutaiPAQR7
DMDMi51316435

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188351 – 346Membrane progestin receptor alphaAdd BLAST346

Proteomic databases

EPDiQ86WK9
MaxQBiQ86WK9
PaxDbiQ86WK9
PeptideAtlasiQ86WK9
PRIDEiQ86WK9
ProteomicsDBi70180

PTM databases

iPTMnetiQ86WK9
PhosphoSitePlusiQ86WK9

Expressioni

Tissue specificityi

Expressed in a wide range of tissues including ovary, testis, placenta, uterus and bladder.2 Publications

Gene expression databases

BgeeiENSG00000182749 Expressed in 198 organ(s), highest expression level in vagina
CleanExiHS_PAQR7
GenevisibleiQ86WK9 HS

Organism-specific databases

HPAiHPA046936

Interactioni

Protein-protein interaction databases

BioGridi127887, 2 interactors
IntActiQ86WK9, 3 interactors
STRINGi9606.ENSP00000363414

Structurei

3D structure databases

ProteinModelPortaliQ86WK9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00530000062965
HOGENOMiHOG000230872
HOVERGENiHBG052504
InParanoidiQ86WK9
OMAiYCLDISP
OrthoDBiEOG091G0QDA
PhylomeDBiQ86WK9
TreeFamiTF319738

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit

Sequencei

Sequence statusi: Complete.

Q86WK9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMAQKLSHL LPSLRQVIQE PQLSLQPEPV FTVDRAEVPP LFWKPYIYAG
60 70 80 90 100
YRPLHQTWRF YFRTLFQQHN EAVNVWTHLL AALVLLLRLA LFVETVDFWG
110 120 130 140 150
DPHALPLFII VLASFTYLSF SALAHLLQAK SEFWHYSFFF LDYVGVAVYQ
160 170 180 190 200
FGSALAHFYY AIEPAWHAQV QAVFLPMAAF LAWLSCIGSC YNKYIQKPGL
210 220 230 240 250
LGRTCQEVPS VLAYALDISP VVHRIFVSSD PTTDDPALLY HKCQVVFFLL
260 270 280 290 300
AAAFFSTFMP ERWFPGSCHV FGQGHQLFHI FLVLCTLAQL EAVALDYEAR
310 320 330 340
RPIYEPLHTH WPHNFSGLFL LTVGSSILTA FLLSQLVQRK LDQKTK
Length:346
Mass (Da):39,719
Last modified:June 1, 2003 - v1
Checksum:i7D12639DD4756501
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060999227V → M1 PublicationCorresponds to variant dbSNP:rs55948644Ensembl.1
Natural variantiVAR_048204272G → R. Corresponds to variant dbSNP:rs6689014Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313620 mRNA Translation: AAO47233.1
AY424285 mRNA Translation: AAR08373.1
AL033528 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07862.1
BC034015 mRNA Translation: AAH34015.1
BC042298 mRNA No translation available.
CCDSiCCDS267.1
RefSeqiNP_848509.1, NM_178422.5
XP_005245802.1, XM_005245745.3
XP_005245803.1, XM_005245746.3
XP_011539163.1, XM_011540861.1
XP_011539164.1, XM_011540862.2
UniGeneiHs.523652

Genome annotation databases

EnsembliENST00000374296; ENSP00000363414; ENSG00000182749
GeneIDi164091
KEGGihsa:164091
UCSCiuc001bkx.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313620 mRNA Translation: AAO47233.1
AY424285 mRNA Translation: AAR08373.1
AL033528 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07862.1
BC034015 mRNA Translation: AAH34015.1
BC042298 mRNA No translation available.
CCDSiCCDS267.1
RefSeqiNP_848509.1, NM_178422.5
XP_005245802.1, XM_005245745.3
XP_005245803.1, XM_005245746.3
XP_011539163.1, XM_011540861.1
XP_011539164.1, XM_011540862.2
UniGeneiHs.523652

3D structure databases

ProteinModelPortaliQ86WK9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127887, 2 interactors
IntActiQ86WK9, 3 interactors
STRINGi9606.ENSP00000363414

PTM databases

iPTMnetiQ86WK9
PhosphoSitePlusiQ86WK9

Polymorphism and mutation databases

BioMutaiPAQR7
DMDMi51316435

Proteomic databases

EPDiQ86WK9
MaxQBiQ86WK9
PaxDbiQ86WK9
PeptideAtlasiQ86WK9
PRIDEiQ86WK9
ProteomicsDBi70180

Protocols and materials databases

DNASUi164091
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374296; ENSP00000363414; ENSG00000182749
GeneIDi164091
KEGGihsa:164091
UCSCiuc001bkx.4 human

Organism-specific databases

CTDi164091
DisGeNETi164091
EuPathDBiHostDB:ENSG00000182749.5
GeneCardsiPAQR7
HGNCiHGNC:23146 PAQR7
HPAiHPA046936
MIMi607779 gene
neXtProtiNX_Q86WK9
OpenTargetsiENSG00000182749
PharmGKBiPA142671200
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00530000062965
HOGENOMiHOG000230872
HOVERGENiHBG052504
InParanoidiQ86WK9
OMAiYCLDISP
OrthoDBiEOG091G0QDA
PhylomeDBiQ86WK9
TreeFamiTF319738

Miscellaneous databases

ChiTaRSiPAQR7 human
GenomeRNAii164091
PROiPR:Q86WK9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182749 Expressed in 198 organ(s), highest expression level in vagina
CleanExiHS_PAQR7
GenevisibleiQ86WK9 HS

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAQR7_HUMAN
AccessioniPrimary (citable) accession number: Q86WK9
Secondary accession number(s): A2A2D3, Q5XKF9, Q86VE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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