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Protein

Amphoterin-induced protein 1

Gene

AMIGO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.By similarity

GO - Molecular functioni

GO - Biological processi

  • axonal fasciculation Source: UniProtKB
  • axonogenesis Source: Ensembl
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
  • myelination Source: UniProtKB
  • positive regulation of axonogenesis Source: UniProtKB
  • positive regulation of potassium ion transmembrane transport Source: UniProtKB
  • positive regulation of synapse assembly Source: Ensembl

Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion, Differentiation, Neurogenesis

Protein family/group databases

TCDBi8.A.43.1.10 the neat-domain containing methaemoglobin heme sequestration (n-mhs) family

Names & Taxonomyi

Protein namesi
Recommended name:
Amphoterin-induced protein 1
Alternative name(s):
AMIGO-1
Alivin-2
Gene namesi
Name:AMIGO1Imported
Synonyms:ALI2By similarity, AMIGO1 Publication, KIAA1163Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000181754.6
HGNCiHGNC:20824 AMIGO1
MIMi615689 gene
neXtProtiNX_Q86WK6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 372ExtracellularSequence analysisAdd BLAST345
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 493CytoplasmicSequence analysisAdd BLAST100

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57463
OpenTargetsiENSG00000181754
PharmGKBiPA142672625

Polymorphism and mutation databases

BioMutaiAMIGO1
DMDMi68052342

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000001450628 – 493Amphoterin-induced protein 1Sequence analysisAdd BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 40PROSITE-ProRule annotation
Disulfide bondi38 ↔ 47PROSITE-ProRule annotation
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi225 ↔ 253PROSITE-ProRule annotation
Disulfide bondi227 ↔ 270PROSITE-ProRule annotation
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi290 ↔ 341PROSITE-ProRule annotation
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi349N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi360N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei477PhosphoserineCombined sources1
Modified residuei481PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ86WK6
MaxQBiQ86WK6
PaxDbiQ86WK6
PeptideAtlasiQ86WK6
PRIDEiQ86WK6
ProteomicsDBi70178

PTM databases

iPTMnetiQ86WK6
PhosphoSitePlusiQ86WK6

Expressioni

Gene expression databases

BgeeiENSG00000181754
CleanExiHS_AMIGO1
GenevisibleiQ86WK6 HS

Organism-specific databases

HPAiHPA046152

Interactioni

Subunit structurei

Homodimer, and heterodimer with AMIGO2 and AMIGO3. Interacts with KCNB1.By similarity

Protein-protein interaction databases

BioGridi121533, 50 interactors
IntActiQ86WK6, 31 interactors
STRINGi9606.ENSP00000358878

Structurei

3D structure databases

ProteinModelPortaliQ86WK6
SMRiQ86WK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 61LRRNTAdd BLAST34
Repeati62 – 83LRR 1Add BLAST22
Repeati87 – 108LRR 2Add BLAST22
Repeati111 – 132LRR 3Add BLAST22
Repeati135 – 156LRR 4Add BLAST22
Repeati159 – 179LRR 5Add BLAST21
Repeati186 – 206LRR 6Add BLAST21
Domaini221 – 272LRRCTAdd BLAST52
Domaini269 – 353Ig-like C2-typeSequence analysisAdd BLAST85

Domaini

The LRR repeat region mediates homodimerization.By similarity

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGN4 Eukaryota
ENOG410ZZH4 LUCA
GeneTreeiENSGT00530000063545
HOGENOMiHOG000231327
HOVERGENiHBG080231
InParanoidiQ86WK6
KOiK22529
OMAiCSEYKER
OrthoDBiEOG091G06PG
PhylomeDBiQ86WK6
TreeFamiTF326838

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR031283 AMIGO
IPR031284 AMIGO1
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PANTHERiPTHR24368 PTHR24368, 1 hit
PTHR24368:SF1 PTHR24368:SF1, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00369 LRR_TYP, 5 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86WK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPHRDPRGL WLLLPSLSLL LFEVARAGRA VVSCPAACLC ASNILSCSKQ
60 70 80 90 100
QLPNVPHSLP SYTALLDLSH NNLSRLRAEW TPTRLTQLHS LLLSHNHLNF
110 120 130 140 150
ISSEAFSPVP NLRYLDLSSN QLRTLDEFLF SDLQVLEVLL LYNNHIMAVD
160 170 180 190 200
RCAFDDMAQL QKLYLSQNQI SRFPLELVKE GAKLPKLTLL DLSSNKLKNL
210 220 230 240 250
PLPDLQKLPA WIKNGLYLHN NPLNCDCELY QLFSHWQYRQ LSSVMDFQED
260 270 280 290 300
LYCMNSKKLH NVFNLSFLNC GEYKERAWEA HLGDTLIIKC DTKQQGMTKV
310 320 330 340 350
WVTPSNERVL DEVTNGTVSV SKDGSLLFQQ VQVEDGGVYT CYAMGETFNE
360 370 380 390 400
TLSVELKVHN FTLHGHHDTL NTAYTTLVGC ILSVVLVLIY LYLTPCRCWC
410 420 430 440 450
RGVEKPSSHQ GDSLSSSMLS TTPNHDPMAG GDKDDGFDRR VAFLEPAGPG
460 470 480 490
QGQNGKLKPG NTLPVPEATG KGQRRMSDPE SVSSVFSDTP IVV
Length:493
Mass (Da):55,239
Last modified:June 1, 2003 - v1
Checksum:i8685B358570D9455
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti454N → S in AAH40879 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237007 mRNA Translation: AAO48948.1
AK295678 mRNA Translation: BAG58535.1
AL355145 Genomic DNA No translation available.
BC040879 mRNA Translation: AAH40879.1
AB032989 mRNA Translation: BAA86477.1
CCDSiCCDS30795.1
RefSeqiNP_065754.2, NM_020703.2
XP_011540114.1, XM_011541812.2
UniGeneiHs.12264
Hs.726479

Genome annotation databases

EnsembliENST00000369862; ENSP00000358878; ENSG00000181754
ENST00000369864; ENSP00000358880; ENSG00000181754
GeneIDi57463
KEGGihsa:57463
UCSCiuc001dxx.5 human

Similar proteinsi

Entry informationi

Entry nameiAMGO1_HUMAN
AccessioniPrimary (citable) accession number: Q86WK6
Secondary accession number(s): B4DIM3, Q8IW71, Q9ULQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 1, 2003
Last modified: July 18, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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