UniProtKB - Q86WK6 (AMGO1_HUMAN)
Amphoterin-induced protein 1
AMIGO1
Functioni
Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.
By similarityGO - Molecular functioni
- potassium channel regulator activity Source: UniProtKB
GO - Biological processi
- axonal fasciculation Source: UniProtKB
- axonogenesis Source: Ensembl
- brain development Source: GO_Central
- cellular response to L-glutamate Source: Ensembl
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
- homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
- myelination Source: UniProtKB
- positive regulation of axonogenesis Source: UniProtKB
- positive regulation of neuron projection development Source: Ensembl
- positive regulation of potassium ion transmembrane transport Source: UniProtKB
- positive regulation of synapse assembly Source: Ensembl
- positive regulation of voltage-gated potassium channel activity Source: Ensembl
Keywordsi
Molecular function | Developmental protein |
Biological process | Cell adhesion, Differentiation, Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q86WK6 |
SignaLinki | Q86WK6 |
Protein family/group databases
TCDBi | 8.A.43.1.10, the neat-domain containing methaemoglobin heme sequestration (n-mhs) family |
Names & Taxonomyi
Protein namesi | Recommended name: Amphoterin-induced protein 1Alternative name(s): AMIGO-1 Alivin-2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20824, AMIGO1 |
MIMi | 615689, gene |
neXtProti | NX_Q86WK6 |
VEuPathDBi | HostDB:ENSG00000181754 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Other locations
- Perikaryon By similarity
- dendrite By similarity
- axon By similarity
Note: Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal and cortical neurons. Associated with axons of neuronal cells.By similarity
Plasma Membrane
- neuronal cell body membrane Source: UniProtKB
- voltage-gated potassium channel complex Source: Ensembl
Other locations
- dendrite Source: UniProtKB
- integral component of membrane Source: GO_Central
- pericellular basket Source: Ensembl
- perikaryon Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 28 – 372 | ExtracellularSequence analysisAdd BLAST | 345 | |
Transmembranei | 373 – 393 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 394 – 493 | CytoplasmicSequence analysisAdd BLAST | 100 |
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 57463 |
OpenTargetsi | ENSG00000181754 |
PharmGKBi | PA142672625 |
Miscellaneous databases
Pharosi | Q86WK6, Tbio |
Genetic variation databases
BioMutai | AMIGO1 |
DMDMi | 68052342 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_0000014506 | 28 – 493 | Amphoterin-induced protein 1Sequence analysisAdd BLAST | 466 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 34 ↔ 40 | PROSITE-ProRule annotation | ||
Disulfide bondi | 38 ↔ 47 | PROSITE-ProRule annotation | ||
Glycosylationi | 72 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 225 ↔ 253 | PROSITE-ProRule annotation | ||
Disulfide bondi | 227 ↔ 270 | PROSITE-ProRule annotation | ||
Glycosylationi | 264 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 290 ↔ 341 | PROSITE-ProRule annotation | ||
Glycosylationi | 315 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 349 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 360 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 477 | PhosphoserineCombined sources | 1 | |
Modified residuei | 481 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q86WK6 |
MassIVEi | Q86WK6 |
MaxQBi | Q86WK6 |
PaxDbi | Q86WK6 |
PeptideAtlasi | Q86WK6 |
PRIDEi | Q86WK6 |
ProteomicsDBi | 70178 |
PTM databases
GlyGeni | Q86WK6, 5 sites |
iPTMneti | Q86WK6 |
PhosphoSitePlusi | Q86WK6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000181754, Expressed in substantia nigra and 193 other tissues |
Genevisiblei | Q86WK6, HS |
Organism-specific databases
HPAi | ENSG00000181754, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer, and heterodimer with AMIGO2 and AMIGO3.
Interacts with KCNB1.
By similarityBinary interactionsi
Q86WK6
Protein-protein interaction databases
BioGRIDi | 121533, 89 interactors |
IntActi | Q86WK6, 61 interactors |
STRINGi | 9606.ENSP00000358880 |
Miscellaneous databases
RNActi | Q86WK6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 61 | LRRNTAdd BLAST | 34 | |
Repeati | 62 – 83 | LRR 1Add BLAST | 22 | |
Repeati | 87 – 108 | LRR 2Add BLAST | 22 | |
Repeati | 111 – 132 | LRR 3Add BLAST | 22 | |
Repeati | 135 – 156 | LRR 4Add BLAST | 22 | |
Repeati | 159 – 179 | LRR 5Add BLAST | 21 | |
Repeati | 186 – 206 | LRR 6Add BLAST | 21 | |
Domaini | 221 – 272 | LRRCTAdd BLAST | 52 | |
Domaini | 269 – 353 | Ig-like C2-typeSequence analysisAdd BLAST | 85 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 405 – 493 | DisorderedSequence analysisAdd BLAST | 89 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 408 – 424 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 476 – 493 | Polar residuesSequence analysisAdd BLAST | 18 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QVUQ, Eukaryota |
GeneTreei | ENSGT00950000183146 |
HOGENOMi | CLU_030478_0_0_1 |
InParanoidi | Q86WK6 |
OMAi | VFSDTPM |
OrthoDBi | 671228at2759 |
PhylomeDBi | Q86WK6 |
TreeFami | TF326838 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR031283, AMIGO IPR031284, AMIGO1 IPR000483, Cys-rich_flank_reg_C IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
PANTHERi | PTHR24368, PTHR24368, 1 hit PTHR24368:SF1, PTHR24368:SF1, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit PF13855, LRR_8, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00369, LRR_TYP, 5 hits SM00082, LRRCT, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS51450, LRR, 6 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MHPHRDPRGL WLLLPSLSLL LFEVARAGRA VVSCPAACLC ASNILSCSKQ
60 70 80 90 100
QLPNVPHSLP SYTALLDLSH NNLSRLRAEW TPTRLTQLHS LLLSHNHLNF
110 120 130 140 150
ISSEAFSPVP NLRYLDLSSN QLRTLDEFLF SDLQVLEVLL LYNNHIMAVD
160 170 180 190 200
RCAFDDMAQL QKLYLSQNQI SRFPLELVKE GAKLPKLTLL DLSSNKLKNL
210 220 230 240 250
PLPDLQKLPA WIKNGLYLHN NPLNCDCELY QLFSHWQYRQ LSSVMDFQED
260 270 280 290 300
LYCMNSKKLH NVFNLSFLNC GEYKERAWEA HLGDTLIIKC DTKQQGMTKV
310 320 330 340 350
WVTPSNERVL DEVTNGTVSV SKDGSLLFQQ VQVEDGGVYT CYAMGETFNE
360 370 380 390 400
TLSVELKVHN FTLHGHHDTL NTAYTTLVGC ILSVVLVLIY LYLTPCRCWC
410 420 430 440 450
RGVEKPSSHQ GDSLSSSMLS TTPNHDPMAG GDKDDGFDRR VAFLEPAGPG
460 470 480 490
QGQNGKLKPG NTLPVPEATG KGQRRMSDPE SVSSVFSDTP IVV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 454 | N → S in AAH40879 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY237007 mRNA Translation: AAO48948.1 AK295678 mRNA Translation: BAG58535.1 AL355145 Genomic DNA No translation available. BC040879 mRNA Translation: AAH40879.1 AB032989 mRNA Translation: BAA86477.1 |
CCDSi | CCDS30795.1 |
RefSeqi | NP_065754.2, NM_020703.2 XP_011540114.1, XM_011541812.2 |
Genome annotation databases
Ensembli | ENST00000369862; ENSP00000358878; ENSG00000181754 ENST00000369864; ENSP00000358880; ENSG00000181754 |
GeneIDi | 57463 |
KEGGi | hsa:57463 |
MANE-Selecti | ENST00000369864.5; ENSP00000358880.4; NM_020703.4; NP_065754.2 |
UCSCi | uc001dxx.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY237007 mRNA Translation: AAO48948.1 AK295678 mRNA Translation: BAG58535.1 AL355145 Genomic DNA No translation available. BC040879 mRNA Translation: AAH40879.1 AB032989 mRNA Translation: BAA86477.1 |
CCDSi | CCDS30795.1 |
RefSeqi | NP_065754.2, NM_020703.2 XP_011540114.1, XM_011541812.2 |
3D structure databases
SMRi | Q86WK6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121533, 89 interactors |
IntActi | Q86WK6, 61 interactors |
STRINGi | 9606.ENSP00000358880 |
Protein family/group databases
TCDBi | 8.A.43.1.10, the neat-domain containing methaemoglobin heme sequestration (n-mhs) family |
PTM databases
GlyGeni | Q86WK6, 5 sites |
iPTMneti | Q86WK6 |
PhosphoSitePlusi | Q86WK6 |
Genetic variation databases
BioMutai | AMIGO1 |
DMDMi | 68052342 |
Proteomic databases
EPDi | Q86WK6 |
MassIVEi | Q86WK6 |
MaxQBi | Q86WK6 |
PaxDbi | Q86WK6 |
PeptideAtlasi | Q86WK6 |
PRIDEi | Q86WK6 |
ProteomicsDBi | 70178 |
Protocols and materials databases
ABCDi | Q86WK6, 4 sequenced antibodies |
Antibodypediai | 53745, 336 antibodies from 33 providers |
DNASUi | 57463 |
Genome annotation databases
Ensembli | ENST00000369862; ENSP00000358878; ENSG00000181754 ENST00000369864; ENSP00000358880; ENSG00000181754 |
GeneIDi | 57463 |
KEGGi | hsa:57463 |
MANE-Selecti | ENST00000369864.5; ENSP00000358880.4; NM_020703.4; NP_065754.2 |
UCSCi | uc001dxx.5, human |
Organism-specific databases
CTDi | 57463 |
DisGeNETi | 57463 |
GeneCardsi | AMIGO1 |
HGNCi | HGNC:20824, AMIGO1 |
HPAi | ENSG00000181754, Low tissue specificity |
MIMi | 615689, gene |
neXtProti | NX_Q86WK6 |
OpenTargetsi | ENSG00000181754 |
PharmGKBi | PA142672625 |
VEuPathDBi | HostDB:ENSG00000181754 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVUQ, Eukaryota |
GeneTreei | ENSGT00950000183146 |
HOGENOMi | CLU_030478_0_0_1 |
InParanoidi | Q86WK6 |
OMAi | VFSDTPM |
OrthoDBi | 671228at2759 |
PhylomeDBi | Q86WK6 |
TreeFami | TF326838 |
Enzyme and pathway databases
PathwayCommonsi | Q86WK6 |
SignaLinki | Q86WK6 |
Miscellaneous databases
BioGRID-ORCSi | 57463, 20 hits in 1034 CRISPR screens |
ChiTaRSi | AMIGO1, human |
GenomeRNAii | 57463 |
Pharosi | Q86WK6, Tbio |
PROi | PR:Q86WK6 |
RNActi | Q86WK6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000181754, Expressed in substantia nigra and 193 other tissues |
Genevisiblei | Q86WK6, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR031283, AMIGO IPR031284, AMIGO1 IPR000483, Cys-rich_flank_reg_C IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
PANTHERi | PTHR24368, PTHR24368, 1 hit PTHR24368:SF1, PTHR24368:SF1, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit PF13855, LRR_8, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00369, LRR_TYP, 5 hits SM00082, LRRCT, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS51450, LRR, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | AMGO1_HUMAN | |
Accessioni | Q86WK6Primary (citable) accession number: Q86WK6 Secondary accession number(s): B4DIM3, Q8IW71, Q9ULQ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2005 |
Last sequence update: | June 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families