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Protein

Protein NLRC5

Gene

NLRC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.2 Publications

Caution

Supposed to contain a CARD domain at the N-terminus (PubMed:20434986). However, this domain is not detected by Pfam, PROSITE or SMART. Has a weak similarity with a DAPIN domain.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi228 – 235ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity, Innate immunity
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein NLRC5
Alternative name(s):
Caterpiller protein 16.1
Short name:
CLR16.1
Nucleotide-binding oligomerization domain protein 27
Nucleotide-binding oligomerization domain protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NLRC5
Synonyms:NOD27, NOD4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000140853.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29933 NLRC5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
613537 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86WI3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84166

Open Targets

More...
OpenTargetsi
ENSG00000140853

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162397694

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NLRC5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
269849666

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002961891 – 1866Protein NLRC5Add BLAST1866

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q86WI3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86WI3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86WI3

PeptideAtlas

More...
PeptideAtlasi
Q86WI3

PRoteomics IDEntifications database

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PRIDEi
Q86WI3

ProteomicsDB human proteome resource

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ProteomicsDBi
70166
70167 [Q86WI3-2]
70168 [Q86WI3-3]
70169 [Q86WI3-4]
70170 [Q86WI3-5]
70171 [Q86WI3-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86WI3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q86WI3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in spleen, thymus, lung, brain, tonsil, heart and prostate.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By IFNG/IFN-gamma.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000140853 Expressed in 165 organ(s), highest expression level in spleen

CleanEx database of gene expression profiles

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CleanExi
HS_NLRC5

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q86WI3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q86WI3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA059120
HPA060405

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CHUK and IKBKB; prevents CHUK and IKBKB phosphorylation and inhibits their kinase activity. Interacts with DDX58 and IFIH1; blocks the interaction of MAVS to DDX58.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123922, 5 interactors

Protein interaction database and analysis system

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IntActi
Q86WI3, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262510

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q86WI3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q86WI3

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini222 – 539NACHTPROSITE-ProRule annotationAdd BLAST318
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati599 – 622LRR 1Add BLAST24
Repeati713 – 737LRR 2Add BLAST25
Repeati741 – 765LRR 3Add BLAST25
Repeati769 – 792LRR 4Add BLAST24
Repeati869 – 892LRR 5Add BLAST24
Repeati897 – 921LRR 6Add BLAST25
Repeati930 – 953LRR 7Add BLAST24
Repeati976 – 1000LRR 8Add BLAST25
Repeati1004 – 1026LRR 9Add BLAST23
Repeati1031 – 1058LRR 10Add BLAST28
Repeati1138 – 1161LRR 11Add BLAST24
Repeati1162 – 1184LRR 12Add BLAST23
Repeati1242 – 1265LRR 13Add BLAST24
Repeati1272 – 1294LRR 14Add BLAST23
Repeati1462 – 1488LRR 15Add BLAST27
Repeati1493 – 1516LRR 16Add BLAST24
Repeati1521 – 1544LRR 17Add BLAST24
Repeati1554 – 1577LRR 18Add BLAST24
Repeati1578 – 1600LRR 19Add BLAST23
Repeati1605 – 1628LRR 20Add BLAST24
Repeati1633 – 1656LRR 21Add BLAST24
Repeati1661 – 1684LRR 22Add BLAST24
Repeati1687 – 1714LRR 23Add BLAST28
Repeati1715 – 1739LRR 24Add BLAST25
Repeati1741 – 1762LRR 25Add BLAST22
Repeati1795 – 1818LRR 26Add BLAST24

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NLRP family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4308 Eukaryota
ENOG4112B0K LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160652

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108194

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q86WI3

KEGG Orthology (KO)

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KOi
K22615

Identification of Orthologs from Complete Genome Data

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OMAi
CHCVGET

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01CG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86WI3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 8 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13516 LRR_6, 6 hits
PF05729 NACHT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00367 LRR_CC, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 13 hits
PS50837 NACHT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86WI3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPVGLQLGN KNLWSCLVRL LTKDPEWLNA KMKFFLPNTD LDSRNETLDP
60 70 80 90 100
EQRVILQLNK LHVQGSDTWQ SFIHCVCMQL EVPLDLEVLL LSTFGYDDGF
110 120 130 140 150
TSQLGAEGKS QPESQLHHGL KRPHQSCGSS PRRKQCKKQQ LELAKKYLQL
160 170 180 190 200
LRTSAQQRYR SQIPGSGQPH AFHQVYVPPI LRRATASLDT PEGAIMGDVK
210 220 230 240 250
VEDGADVSIS DLFNTRVNKG PRVTVLLGKA GMGKTTLAHR LCQKWAEGHL
260 270 280 290 300
NCFQALFLFE FRQLNLITRF LTPSELLFDL YLSPESDHDT VFQYLEKNAD
310 320 330 340 350
QVLLIFDGLD EALQPMGPDG PGPVLTLFSH LCNGTLLPGC RVMATSRPGK
360 370 380 390 400
LPACLPAEAA MVHMLGFDGP RVEEYVNHFF SAQPSREGAL VELQTNGRLR
410 420 430 440 450
SLCAVPALCQ VACLCLHHLL PDHAPGQSVA LLPNMTQLYM QMVLALSPPG
460 470 480 490 500
HLPTSSLLDL GEVALRGLET GKVIFYAKDI APPLIAFGAT HSLLTSFCVC
510 520 530 540 550
TGPGHQQTGY AFTHLSLQEF LAALHLMASP KVNKDTLTQY VTLHSRWVQR
560 570 580 590 600
TKARLGLSDH LPTFLAGLAS CTCRPFLSHL AQGNEDCVGA KQAAVVQVLK
610 620 630 640 650
KLATRKLTGP KVVELCHCVD ETQEPELASL TAQSLPYQLP FHNFPLTCTD
660 670 680 690 700
LATLTNILEH REAPIHLDFD GCPLEPHCPE ALVGCGQIEN LSFKSRKCGD
710 720 730 740 750
AFAEALSRSL PTMGRLQMLG LAGSKITARG ISHLVKALPL CPQLKEVSFR
760 770 780 790 800
DNQLSDQVVL NIVEVLPHLP RLRKLDLSSN SICVSTLLCL ARVAVTCPTV
810 820 830 840 850
RMLQAREADL IFLLSPPTET TAELQRAPDL QESDGQRKGA QSRSLTLRLQ
860 870 880 890 900
KCQLQVHDAE ALIALLQEGP HLEEVDLSGN QLEDEGCRLM AEAASQLHIA
910 920 930 940 950
RKLDLSNNGL SVAGVHCVLR AVSACWTLAE LHISLQHKTV IFMFAQEPEE
960 970 980 990 1000
QKGPQERAAF LDSLMLQMPS ELPLSSRRMR LTHCGLQEKH LEQLCKALGG
1010 1020 1030 1040 1050
SCHLGHLHLD FSGNALGDEG AARLAQLLPG LGALQSLNLS ENGLSLDAVL
1060 1070 1080 1090 1100
GLVRCFSTLQ WLFRLDISFE SQHILLRGDK TSRDMWATGS LPDFPAAAKF
1110 1120 1130 1140 1150
LGFRQRCIPR SLCLSECPLE PPSLTRLCAT LKDCPGPLEL QLSCEFLSDQ
1160 1170 1180 1190 1200
SLETLLDCLP QLPQLSLLQL SQTGLSPKSP FLLANTLSLC PRVKKVDLRS
1210 1220 1230 1240 1250
LHHATLHFRS NEEEEGVCCG RFTGCSLSQE HVESLCWLLS KCKDLSQVDL
1260 1270 1280 1290 1300
SANLLGDSGL RCLLECLPQV PISGLLDLSH NSISQESALY LLETLPSCPR
1310 1320 1330 1340 1350
VREASVNLGS EQSFRIHFSR EDQAGKTLRL SECSFRPEHV SRLATGLSKS
1360 1370 1380 1390 1400
LQLTELTLTQ CCLGQKQLAI LLSLVGRPAG LFSLRVQEPW ADRARVLSLL
1410 1420 1430 1440 1450
EVCAQASGSV TEISISETQQ QLCVQLEFPR QEENPEAVAL RLAHCDLGAH
1460 1470 1480 1490 1500
HSLLVGQLME TCARLQQLSL SQVNLCEDDD ASSLLLQSLL LSLSELKTFR
1510 1520 1530 1540 1550
LTSSCVSTEG LAHLASGLGH CHHLEELDLS NNQFDEEGTK ALMRALEGKW
1560 1570 1580 1590 1600
MLKRLDLSHL LLNSSTLALL THRLSQMTCL QSLRLNRNSI GDVGCCHLSE
1610 1620 1630 1640 1650
ALRAATSLEE LDLSHNQIGD AGVQHLATIL PGLPELRKID LSGNSISSAG
1660 1670 1680 1690 1700
GVQLAESLVL CRRLEELMLG CNALGDPTAL GLAQELPQHL RVLHLPFSHL
1710 1720 1730 1740 1750
GPGGALSLAQ ALDGSPHLEE ISLAENNLAG GVLRFCMELP LLRQIDLVSC
1760 1770 1780 1790 1800
KIDNQTAKLL TSSFTSCPAL EVILLSWNLL GDEAAAELAQ VLPQMGRLKR
1810 1820 1830 1840 1850
VDLEKNQITA LGAWLLAEGL AQGSSIQVIR LWNNPIPCDM AQHLKSQEPR
1860
LDFAFFDNQP QAPWGT
Length:1,866
Mass (Da):204,595
Last modified:November 24, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E3BDED8E1624967
GO
Isoform 2 (identifier: Q86WI3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1307-1328: NLGSEQSFRIHFSREDQAGKTL → KCLGSWHVWAPCFPRPFSLQPGL
     1329-1866: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:1,329
Mass (Da):146,203
Checksum:i88549300F78231D0
GO
Isoform 3 (identifier: Q86WI3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     721-1866: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:720
Mass (Da):79,324
Checksum:i88BA764FA11781C7
GO
Isoform 4 (identifier: Q86WI3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1221-1249: Missing.

Note: No experimental confirmation available.
Show »
Length:1,837
Mass (Da):201,300
Checksum:i3DEED7B4B9E094E2
GO
Isoform 5 (identifier: Q86WI3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1221-1249: Missing.
     1385-1385: R → S
     1386-1866: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:1,356
Mass (Da):148,956
Checksum:iF6BE709CA4115698
GO
Isoform 6 (identifier: Q86WI3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1501-1551: LTSSCVSTEG...LMRALEGKWM → IQSSQDPGRL...LPPLGGAGLV
     1552-1866: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:1,551
Mass (Da):170,417
Checksum:i4F701C542D352429
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YGE2H0YGE2_HUMAN
Protein NLRC5
NLRC5
1,180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGM1H0YGM1_HUMAN
Protein NLRC5
NLRC5
1,057Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGT6H0YGT6_HUMAN
Protein NLRC5
NLRC5
702Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGV6H0YGV6_HUMAN
Protein NLRC5
NLRC5
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YF88H0YF88_HUMAN
Protein NLRC5
NLRC5
325Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFG4H0YFG4_HUMAN
Protein NLRC5
NLRC5
387Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YG32H0YG32_HUMAN
Protein NLRC5
NLRC5
885Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFT1H0YFT1_HUMAN
Protein NLRC5
NLRC5
631Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFT3H0YFT3_HUMAN
Protein NLRC5
NLRC5
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H274F5H274_HUMAN
Protein NLRC5
NLRC5
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB55096 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55098 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB85008 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti808 – 810ADL → RTI in AAO59377 (PubMed:12615073).Curated3
Sequence conflicti808 – 810ADL → RTI in ABO40479 (Ref. 2) Curated3
Sequence conflicti1411T → A in BAB55096 (PubMed:14702039).Curated1
Sequence conflicti1411T → A in BAB55098 (PubMed:14702039).Curated1
Sequence conflicti1715S → F in BAB55096 (PubMed:14702039).Curated1
Sequence conflicti1715S → F in BAB55098 (PubMed:14702039).Curated1
Sequence conflicti1794Q → K in AAO59377 (PubMed:12615073).Curated1
Sequence conflicti1794Q → K in ABO40479 (Ref. 2) Curated1
Sequence conflicti1794Q → K in AAH63566 (PubMed:15489334).Curated1
Sequence conflicti1803L → P in BAB55096 (PubMed:14702039).Curated1
Sequence conflicti1803L → P in BAB55098 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034607210S → L. Corresponds to variant dbSNP:rs16965150Ensembl.1
Natural variantiVAR_036388361M → I in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_034608453P → L1 PublicationCorresponds to variant dbSNP:rs9938543Ensembl.1
Natural variantiVAR_034609500C → R1 PublicationCorresponds to variant dbSNP:rs28438857Ensembl.1
Natural variantiVAR_034610833S → N. Corresponds to variant dbSNP:rs35534915Ensembl.1
Natural variantiVAR_060589907N → D3 PublicationsCorresponds to variant dbSNP:rs1672867Ensembl.1
Natural variantiVAR_0346111105Q → K2 PublicationsCorresponds to variant dbSNP:rs289723Ensembl.1
Natural variantiVAR_0346121455V → A. Corresponds to variant dbSNP:rs7190199Ensembl.1
Natural variantiVAR_0346131466Q → R. Corresponds to variant dbSNP:rs7185320Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027150721 – 1866Missing in isoform 3. 1 PublicationAdd BLAST1146
Alternative sequenceiVSP_0271511221 – 1249Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_0271521307 – 1328NLGSE…AGKTL → KCLGSWHVWAPCFPRPFSLQ PGL in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_0271531329 – 1866Missing in isoform 2. 1 PublicationAdd BLAST538
Alternative sequenceiVSP_0271541385R → S in isoform 5. 1 Publication1
Alternative sequenceiVSP_0271551386 – 1866Missing in isoform 5. 1 PublicationAdd BLAST481
Alternative sequenceiVSP_0271561501 – 1551LTSSC…EGKWM → IQSSQDPGRLLPDLLPFDPH QADLQLCEHRGPRPPGIWSG PLPPLGGAGLV in isoform 6. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_0271571552 – 1866Missing in isoform 6. 1 PublicationAdd BLAST315

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF389420 mRNA Translation: AAO59377.1
EF452236 mRNA Translation: ABO40479.1
AK074133 mRNA Translation: BAB84959.1
AK074182 mRNA Translation: BAB85008.1 Different initiation.
AC009090 Genomic DNA No translation available.
AC023825 Genomic DNA No translation available.
AK090439 mRNA Translation: BAC03420.1
BC050527 mRNA Translation: AAH50527.1
BC063566 mRNA Translation: AAH63566.1
AK027414 mRNA Translation: BAB55096.1 Different initiation.
AK027416 mRNA Translation: BAB55098.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10773.1 [Q86WI3-1]
CCDS81985.1 [Q86WI3-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001317481.1, NM_001330552.1 [Q86WI3-4]
NP_115582.4, NM_032206.4 [Q86WI3-1]
XP_005256250.1, XM_005256193.2 [Q86WI3-1]
XP_005256251.1, XM_005256194.3 [Q86WI3-1]
XP_005256254.1, XM_005256197.2 [Q86WI3-4]
XP_006721360.1, XM_006721297.2 [Q86WI3-1]
XP_011521675.1, XM_011523373.2 [Q86WI3-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.528836

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262510; ENSP00000262510; ENSG00000140853 [Q86WI3-1]
ENST00000436936; ENSP00000389739; ENSG00000140853 [Q86WI3-1]
ENST00000539144; ENSP00000441727; ENSG00000140853 [Q86WI3-4]
ENST00000539881; ENSP00000441679; ENSG00000140853 [Q86WI3-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84166

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84166

UCSC genome browser

More...
UCSCi
uc010ccq.2 human [Q86WI3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF389420 mRNA Translation: AAO59377.1
EF452236 mRNA Translation: ABO40479.1
AK074133 mRNA Translation: BAB84959.1
AK074182 mRNA Translation: BAB85008.1 Different initiation.
AC009090 Genomic DNA No translation available.
AC023825 Genomic DNA No translation available.
AK090439 mRNA Translation: BAC03420.1
BC050527 mRNA Translation: AAH50527.1
BC063566 mRNA Translation: AAH63566.1
AK027414 mRNA Translation: BAB55096.1 Different initiation.
AK027416 mRNA Translation: BAB55098.1 Different initiation.
CCDSiCCDS10773.1 [Q86WI3-1]
CCDS81985.1 [Q86WI3-4]
RefSeqiNP_001317481.1, NM_001330552.1 [Q86WI3-4]
NP_115582.4, NM_032206.4 [Q86WI3-1]
XP_005256250.1, XM_005256193.2 [Q86WI3-1]
XP_005256251.1, XM_005256194.3 [Q86WI3-1]
XP_005256254.1, XM_005256197.2 [Q86WI3-4]
XP_006721360.1, XM_006721297.2 [Q86WI3-1]
XP_011521675.1, XM_011523373.2 [Q86WI3-1]
UniGeneiHs.528836

3D structure databases

ProteinModelPortaliQ86WI3
SMRiQ86WI3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123922, 5 interactors
IntActiQ86WI3, 2 interactors
STRINGi9606.ENSP00000262510

PTM databases

iPTMnetiQ86WI3
PhosphoSitePlusiQ86WI3

Polymorphism and mutation databases

BioMutaiNLRC5
DMDMi269849666

Proteomic databases

EPDiQ86WI3
MaxQBiQ86WI3
PaxDbiQ86WI3
PeptideAtlasiQ86WI3
PRIDEiQ86WI3
ProteomicsDBi70166
70167 [Q86WI3-2]
70168 [Q86WI3-3]
70169 [Q86WI3-4]
70170 [Q86WI3-5]
70171 [Q86WI3-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
84166
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262510; ENSP00000262510; ENSG00000140853 [Q86WI3-1]
ENST00000436936; ENSP00000389739; ENSG00000140853 [Q86WI3-1]
ENST00000539144; ENSP00000441727; ENSG00000140853 [Q86WI3-4]
ENST00000539881; ENSP00000441679; ENSG00000140853 [Q86WI3-3]
GeneIDi84166
KEGGihsa:84166
UCSCiuc010ccq.2 human [Q86WI3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84166
DisGeNETi84166
EuPathDBiHostDB:ENSG00000140853.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NLRC5
HGNCiHGNC:29933 NLRC5
HPAiHPA059120
HPA060405
MIMi613537 gene
neXtProtiNX_Q86WI3
OpenTargetsiENSG00000140853
PharmGKBiPA162397694

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4308 Eukaryota
ENOG4112B0K LUCA
GeneTreeiENSGT00940000160652
HOVERGENiHBG108194
InParanoidiQ86WI3
KOiK22615
OMAiCHCVGET
OrthoDBiEOG091G01CG
PhylomeDBiQ86WI3

Enzyme and pathway databases

ReactomeiR-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NLRC5 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NLRC5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84166

Protein Ontology

More...
PROi
PR:Q86WI3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140853 Expressed in 165 organ(s), highest expression level in spleen
CleanExiHS_NLRC5
ExpressionAtlasiQ86WI3 baseline and differential
GenevisibleiQ86WI3 HS

Family and domain databases

Gene3Di3.80.10.10, 8 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF13516 LRR_6, 6 hits
PF05729 NACHT, 1 hit
SMARTiView protein in SMART
SM00367 LRR_CC, 9 hits
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 13 hits
PS50837 NACHT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNLRC5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86WI3
Secondary accession number(s): B5MEF1
, C9JMD8, Q6P4A6, Q86VM7, Q8NF42, Q8TEE2, Q8TEJ1, Q969L7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: November 24, 2009
Last modified: December 5, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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