UniProtKB - Q86WH2 (RASF3_HUMAN)

BLAST

>sp|Q86WH2|RASF3_HUMAN Ras association domain-containing protein 3 OS=Homo sapiens OX=9606 GN=RASSF3 PE=1 SV=1
MSSGYSSLEEDAEDFFFTARTSFFRRAPQGKPRSGQQDVEKEKETHSYLSKEEIKEKVHK
YNLAVTDKLKMTLNSNGIYTGFIKVQMELCKPPQTSPNSGKLSPSSNGCMNTLHISSTNT
VGEVIEALLKKFLVTESPAKFALYKRCHREDQVYACKLSDREHPLYLRLVAGPRTDTLSF
VLREHEIGEWEAFSLPELQNFLRILDKEEDEQLQNLKRRYTAYRQKLEEALREVWKPD

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History
Entry version 119 (07 Nov 2018)
Sequence version 1 (01 Jun 2003)
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Protein

Ras association domain-containing protein 3

Gene

RASSF3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Caution

Was termed (Ref. 1) RASSF5.Curated

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 20920251

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of apoptotic process Source: InterPro
signal transduction Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras association domain-containing protein 3
Gene namesⁱ	Name:RASSF3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000153179.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14271 RASSF3
MIMⁱ	607019 gene
neXtProtⁱ	NX_Q86WH2

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	283349
Open Targets More...OpenTargetsⁱ	ENSG00000153179
PharmGKBⁱ	PA34247

Polymorphism and mutation databases

BioMutaⁱ	RASSF3
DMDMⁱ	74714093

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000240396	2 – 238	Ras association domain-containing protein 3Add BLAST		237

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylserineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q86WH2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q86WH2
PaxDbⁱ	Q86WH2
PeptideAtlas More...PeptideAtlasⁱ	Q86WH2
PRIDEⁱ	Q86WH2
ProteomicsDBⁱ	70160 70161 [Q86WH2-2]

PTM databases

iPTMnetⁱ	Q86WH2
PhosphoSitePlusⁱ	Q86WH2

Expressionⁱ

Tissue specificityⁱ

Widely expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000153179 Expressed in 208 organ(s), highest expression level in blood
CleanExⁱ	HS_RASSF3
ExpressionAtlasⁱ	Q86WH2 baseline and differential
Genevisibleⁱ	Q86WH2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB022664 CAB034035 HPA038469

HPAⁱ

CAB022664
CAB034035
HPA038469

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		2	EBI-2845202,EBI-2845202
STK3	Q13188	6	EBI-2845202,EBI-992580
STK4	Q13043	6	EBI-2845202,EBI-367376

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 20920251

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	129534, 22 interactors
IntActⁱ	Q86WH2, 28 interactors
STRINGⁱ	9606.ENSP00000336616

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q86WH2
SMRⁱ	Q86WH2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	79 – 186	Ras-associatingPROSITE-ProRule annotationAdd BLAST		108
Domainⁱ	187 – 234	SARAHPROSITE-ProRule annotationAdd BLAST		48

Phylogenomic databases

eggNOGⁱ	KOG4239 Eukaryota ENOG410Y2N1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003367
HOGENOMⁱ	HOG000013025
HOVERGENⁱ	HBG054362
InParanoidⁱ	Q86WH2
KEGG Orthology (KO) More...KOⁱ	K09852
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EPB
PhylomeDBⁱ	Q86WH2
TreeFamⁱ	TF319243

Family and domain databases

InterProⁱ	View protein in InterPro IPR033614 C-RASSF IPR000159 RA_dom IPR033619 RASSF3 IPR011524 SARAH_dom IPR029071 Ubiquitin-like_domsf
PANTHERⁱ	PTHR22738 PTHR22738, 1 hit PTHR22738:SF8 PTHR22738:SF8, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16517 Nore1-SARAH, 1 hit PF00788 RA, 1 hit
SMARTⁱ	View protein in SMART SM00314 RA, 1 hit
SUPFAMⁱ	SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50200 RA, 1 hit PS50951 SARAH, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q86WH2-1) [UniParc]FASTA Add to basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSGYSSLEE DAEDFFFTAR TSFFRRAPQG KPRSGQQDVE KEKETHSYLS 
        60         70         80         90        100
KEEIKEKVHK YNLAVTDKLK MTLNSNGIYT GFIKVQMELC KPPQTSPNSG 
       110        120        130        140        150
KLSPSSNGCM NTLHISSTNT VGEVIEALLK KFLVTESPAK FALYKRCHRE 
       160        170        180        190        200
DQVYACKLSD REHPLYLRLV AGPRTDTLSF VLREHEIGEW EAFSLPELQN 
       210        220        230 
FLRILDKEED EQLQNLKRRY TAYRQKLEEA LREVWKPD

Length:238

Mass (Da):27,562

Last modified:June 1, 2003 - v1

Checksum:ⁱ2C8AD10649259811

Isoform 2 (identifier: Q86WH2-2) [UniParc]FASTA Add to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
74-90: NSNGIYTGFIKVQMELC → STPASSQTGNIHSTCVW
91-238: Missing.

« Hide

        10         20         30         40         50
MSSGYSSLEE DAEDFFFTAR TSFFRRAPQG KPRSGQQDVE KEKETHSYLS 
        60         70         80         90
KEEIKEKVHK YNLAVTDKLK MTLSTPASSQ TGNIHSTCVW

Show »

Length:90

Mass (Da):10,265

Checksum:ⁱEEFFEA9B843855E2

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A1B0GUG6	A0A1B0GUG6_HUMAN	Ras association domain-containing p... Ras association domain-containing protein 3	RASSF3	299	Annotation score:
A0A1B0GWJ9	A0A1B0GWJ9_HUMAN	Ras association domain-containing p... Ras association domain-containing protein 3	RASSF3	64	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_026724	232	R → H1 PublicationCorresponds to variant dbSNP:rs74098110Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_019353	74 – 90	NSNGI…QMELC → STPASSQTGNIHSTCVW in isoform 2. 1 PublicationAdd BLAST		17
Alternative sequenceⁱVSP_019354	91 – 238	Missing in isoform 2. 1 PublicationAdd BLAST		148

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY217662 mRNA Translation: AAO61687.1 AY217663 mRNA Translation: AAO61688.1 BC100951 mRNA Translation: AAI00952.1 BC100949 mRNA Translation: AAI00950.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8969.1 [Q86WH2-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_835463.1, NM_178169.3 [Q86WH2-1]
UniGeneⁱ	Hs.643605

Genome annotation databases

Ensemblⁱ	ENST00000283172; ENSP00000283172; ENSG00000153179 [Q86WH2-2] ENST00000336061; ENSP00000336616; ENSG00000153179 [Q86WH2-1] ENST00000542104; ENSP00000443021; ENSG00000153179 [Q86WH2-1]
GeneIDⁱ	283349
KEGGⁱ	hsa:283349
UCSC genome browser More...UCSCⁱ	uc001ssd.3 human [Q86WH2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q86WH2	RASSF3 isoform 1		PANTR		238	UniRef100_Q86WH2
Q86WH2-2	RASSF3 isoform 2		PANTR		90	UniRef100_A0A2J8K0C3

Protein	Similar proteins		Species	Score	Length	Source
Q86WH2	Ras association domain-containing protein 3		MOUSE		232	UniRef90_Q86WH2
RASSF3 isoform 1		PANTR		238
ras association domain-containing protein 3 isoform X1		Yangtze finless porpoise		257
Ras association domain-containing protein 3 (Fragment)		ESCRO		129
ras association domain-containing protein 3 isoform X1		BALAS		243
+82
Q86WH2-2	RASSF3 isoform 2		PANTR		90	UniRef90_A0A2J8K0C3
RASSF3 isoform 3		PONAB		90

Protein	Similar proteins		Species	Score	Length	Source
Q86WH2	Ras association domain-containing protein 3		MOUSE		232	UniRef50_Q86WH2
RASSF3 isoform 1		PANTR		238
ras association domain-containing protein 3 isoform X1		Yangtze finless porpoise		257
Ras association domain-containing protein 3 (Fragment)		ESCRO		129
ras association domain-containing protein 3 isoform X1		BALAS		243
+361
Q86WH2-2	RASSF3 isoform 2		PANTR		90	UniRef50_A0A2J8K0C3
RASSF3 isoform 3		PONAB		90

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY217662 mRNA Translation: AAO61687.1 AY217663 mRNA Translation: AAO61688.1 BC100951 mRNA Translation: AAI00952.1 BC100949 mRNA Translation: AAI00950.1
CCDSⁱ	CCDS8969.1 [Q86WH2-1]
RefSeqⁱ	NP_835463.1, NM_178169.3 [Q86WH2-1]
UniGeneⁱ	Hs.643605

3D structure databases

ProteinModelPortalⁱ	Q86WH2
SMRⁱ	Q86WH2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129534, 22 interactors
IntActⁱ	Q86WH2, 28 interactors
STRINGⁱ	9606.ENSP00000336616

PTM databases

iPTMnetⁱ	Q86WH2
PhosphoSitePlusⁱ	Q86WH2

Polymorphism and mutation databases

BioMutaⁱ	RASSF3
DMDMⁱ	74714093

Proteomic databases

EPDⁱ	Q86WH2
MaxQBⁱ	Q86WH2
PaxDbⁱ	Q86WH2
PeptideAtlasⁱ	Q86WH2
PRIDEⁱ	Q86WH2
ProteomicsDBⁱ	70160 70161 [Q86WH2-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000283172; ENSP00000283172; ENSG00000153179 [Q86WH2-2] ENST00000336061; ENSP00000336616; ENSG00000153179 [Q86WH2-1] ENST00000542104; ENSP00000443021; ENSG00000153179 [Q86WH2-1]
GeneIDⁱ	283349
KEGGⁱ	hsa:283349
UCSCⁱ	uc001ssd.3 human [Q86WH2-1]

Organism-specific databases

CTDⁱ	283349
DisGeNETⁱ	283349
EuPathDBⁱ	HostDB:ENSG00000153179.11
GeneCardsⁱ	RASSF3
HGNCⁱ	HGNC:14271 RASSF3
HPAⁱ	CAB022664 CAB034035 HPA038469
MIMⁱ	607019 gene
neXtProtⁱ	NX_Q86WH2
OpenTargetsⁱ	ENSG00000153179
PharmGKBⁱ	PA34247
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4239 Eukaryota ENOG410Y2N1 LUCA
GeneTreeⁱ	ENSGT00390000003367
HOGENOMⁱ	HOG000013025
HOVERGENⁱ	HBG054362
InParanoidⁱ	Q86WH2
KOⁱ	K09852
OrthoDBⁱ	EOG091G0EPB
PhylomeDBⁱ	Q86WH2
TreeFamⁱ	TF319243

Miscellaneous databases

ChiTaRSⁱ	RASSF3 human
GenomeRNAiⁱ	283349
Protein Ontology More...PROⁱ	PR:Q86WH2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000153179 Expressed in 208 organ(s), highest expression level in blood
CleanExⁱ	HS_RASSF3
ExpressionAtlasⁱ	Q86WH2 baseline and differential
Genevisibleⁱ	Q86WH2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR033614 C-RASSF IPR000159 RA_dom IPR033619 RASSF3 IPR011524 SARAH_dom IPR029071 Ubiquitin-like_domsf
PANTHERⁱ	PTHR22738 PTHR22738, 1 hit PTHR22738:SF8 PTHR22738:SF8, 1 hit
Pfamⁱ	View protein in Pfam PF16517 Nore1-SARAH, 1 hit PF00788 RA, 1 hit
SMARTⁱ	View protein in SMART SM00314 RA, 1 hit
SUPFAMⁱ	SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50200 RA, 1 hit PS50951 SARAH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RASF3_HUMAN
Accessionⁱ	Q86WH2Primary (citable) accession number: Q86WH2 Secondary accession number(s): Q86WH1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
	Last sequence update:	June 1, 2003
	Last modified:	November 7, 2018
	This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - Q86WH2 (RASF3_HUMAN)

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Ras association domain-containing protein 3

RASSF3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Plasma Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ