UniProtKB - Q86WH2 (RASF3_HUMAN)
Protein
Ras association domain-containing protein 3
Gene
RASSF3
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Was termed (Ref. 1) RASSF5.Curated
GO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- regulation of apoptotic process Source: InterPro
- signal transduction Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q86WH2 |
Names & Taxonomyi
Protein namesi | Recommended name: Ras association domain-containing protein 3 |
Gene namesi | Name:RASSF3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14271, RASSF3 |
MIMi | 607019, gene |
neXtProti | NX_Q86WH2 |
VEuPathDBi | HostDB:ENSG00000153179.11 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: Localized to microtubules in vascular endothelial cells.
Cytoskeleton
- microtubule Source: UniProtKB-KW
Cytosol
- cytosol Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Organism-specific databases
DisGeNETi | 283349 |
OpenTargetsi | ENSG00000153179 |
PharmGKBi | PA34247 |
Miscellaneous databases
Pharosi | Q86WH2, Tbio |
Genetic variation databases
BioMutai | RASSF3 |
DMDMi | 74714093 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000240396 | 2 – 238 | Ras association domain-containing protein 3Add BLAST | 237 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q86WH2 |
jPOSTi | Q86WH2 |
MassIVEi | Q86WH2 |
MaxQBi | Q86WH2 |
PaxDbi | Q86WH2 |
PeptideAtlasi | Q86WH2 |
PRIDEi | Q86WH2 |
ProteomicsDBi | 70160 [Q86WH2-1] 70161 [Q86WH2-2] |
PTM databases
iPTMneti | Q86WH2 |
PhosphoSitePlusi | Q86WH2 |
Expressioni
Tissue specificityi
Widely expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000153179, Expressed in blood and 222 other tissues |
ExpressionAtlasi | Q86WH2, baseline and differential |
Genevisiblei | Q86WH2, HS |
Organism-specific databases
HPAi | ENSG00000153179, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ86WH2
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 129534, 34 interactors |
IntActi | Q86WH2, 38 interactors |
STRINGi | 9606.ENSP00000443021 |
Miscellaneous databases
RNActi | Q86WH2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 79 – 186 | Ras-associatingPROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 187 – 234 | SARAHPROSITE-ProRule annotationAdd BLAST | 48 |
Phylogenomic databases
eggNOGi | KOG4239, Eukaryota |
GeneTreei | ENSGT00940000157502 |
HOGENOMi | CLU_2440221_0_0_1 |
InParanoidi | Q86WH2 |
OrthoDBi | 1120975at2759 |
PhylomeDBi | Q86WH2 |
TreeFami | TF319243 |
Family and domain databases
InterProi | View protein in InterPro IPR033614, C-RASSF IPR000159, RA_dom IPR033619, RASSF3 IPR011524, SARAH_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR22738, PTHR22738, 1 hit PTHR22738:SF8, PTHR22738:SF8, 1 hit |
Pfami | View protein in Pfam PF16517, Nore1-SARAH, 1 hit PF00788, RA, 1 hit |
SMARTi | View protein in SMART SM00314, RA, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50200, RA, 1 hit PS50951, SARAH, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q86WH2-1) [UniParc]FASTAAdd to basket
Also known as: A
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSGYSSLEE DAEDFFFTAR TSFFRRAPQG KPRSGQQDVE KEKETHSYLS
60 70 80 90 100
KEEIKEKVHK YNLAVTDKLK MTLNSNGIYT GFIKVQMELC KPPQTSPNSG
110 120 130 140 150
KLSPSSNGCM NTLHISSTNT VGEVIEALLK KFLVTESPAK FALYKRCHRE
160 170 180 190 200
DQVYACKLSD REHPLYLRLV AGPRTDTLSF VLREHEIGEW EAFSLPELQN
210 220 230
FLRILDKEED EQLQNLKRRY TAYRQKLEEA LREVWKPD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GUG6 | A0A1B0GUG6_HUMAN | Ras association domain-containing p... | RASSF3 | 299 | Annotation score: | ||
A0A1B0GWJ9 | A0A1B0GWJ9_HUMAN | Ras association domain-containing p... | RASSF3 | 64 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026724 | 232 | R → H1 PublicationCorresponds to variant dbSNP:rs74098110Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_019353 | 74 – 90 | NSNGI…QMELC → STPASSQTGNIHSTCVW in isoform 2. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_019354 | 91 – 238 | Missing in isoform 2. 1 PublicationAdd BLAST | 148 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY217662 mRNA Translation: AAO61687.1 AY217663 mRNA Translation: AAO61688.1 BC100951 mRNA Translation: AAI00952.1 BC100949 mRNA Translation: AAI00950.1 |
CCDSi | CCDS8969.1 [Q86WH2-1] |
RefSeqi | NP_835463.1, NM_178169.3 [Q86WH2-1] |
Genome annotation databases
Ensembli | ENST00000283172; ENSP00000283172; ENSG00000153179 [Q86WH2-2] ENST00000336061; ENSP00000336616; ENSG00000153179 [Q86WH2-1] ENST00000542104; ENSP00000443021; ENSG00000153179 [Q86WH2-1] |
GeneIDi | 283349 |
KEGGi | hsa:283349 |
UCSCi | uc001ssd.3, human [Q86WH2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY217662 mRNA Translation: AAO61687.1 AY217663 mRNA Translation: AAO61688.1 BC100951 mRNA Translation: AAI00952.1 BC100949 mRNA Translation: AAI00950.1 |
CCDSi | CCDS8969.1 [Q86WH2-1] |
RefSeqi | NP_835463.1, NM_178169.3 [Q86WH2-1] |
3D structure databases
SMRi | Q86WH2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129534, 34 interactors |
IntActi | Q86WH2, 38 interactors |
STRINGi | 9606.ENSP00000443021 |
PTM databases
iPTMneti | Q86WH2 |
PhosphoSitePlusi | Q86WH2 |
Genetic variation databases
BioMutai | RASSF3 |
DMDMi | 74714093 |
Proteomic databases
EPDi | Q86WH2 |
jPOSTi | Q86WH2 |
MassIVEi | Q86WH2 |
MaxQBi | Q86WH2 |
PaxDbi | Q86WH2 |
PeptideAtlasi | Q86WH2 |
PRIDEi | Q86WH2 |
ProteomicsDBi | 70160 [Q86WH2-1] 70161 [Q86WH2-2] |
Protocols and materials databases
Antibodypediai | 29184, 189 antibodies |
Genome annotation databases
Ensembli | ENST00000283172; ENSP00000283172; ENSG00000153179 [Q86WH2-2] ENST00000336061; ENSP00000336616; ENSG00000153179 [Q86WH2-1] ENST00000542104; ENSP00000443021; ENSG00000153179 [Q86WH2-1] |
GeneIDi | 283349 |
KEGGi | hsa:283349 |
UCSCi | uc001ssd.3, human [Q86WH2-1] |
Organism-specific databases
CTDi | 283349 |
DisGeNETi | 283349 |
GeneCardsi | RASSF3 |
HGNCi | HGNC:14271, RASSF3 |
HPAi | ENSG00000153179, Low tissue specificity |
MIMi | 607019, gene |
neXtProti | NX_Q86WH2 |
OpenTargetsi | ENSG00000153179 |
PharmGKBi | PA34247 |
VEuPathDBi | HostDB:ENSG00000153179.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4239, Eukaryota |
GeneTreei | ENSGT00940000157502 |
HOGENOMi | CLU_2440221_0_0_1 |
InParanoidi | Q86WH2 |
OrthoDBi | 1120975at2759 |
PhylomeDBi | Q86WH2 |
TreeFami | TF319243 |
Enzyme and pathway databases
PathwayCommonsi | Q86WH2 |
Miscellaneous databases
BioGRID-ORCSi | 283349, 10 hits in 995 CRISPR screens |
ChiTaRSi | RASSF3, human |
GenomeRNAii | 283349 |
Pharosi | Q86WH2, Tbio |
PROi | PR:Q86WH2 |
RNActi | Q86WH2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000153179, Expressed in blood and 222 other tissues |
ExpressionAtlasi | Q86WH2, baseline and differential |
Genevisiblei | Q86WH2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033614, C-RASSF IPR000159, RA_dom IPR033619, RASSF3 IPR011524, SARAH_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR22738, PTHR22738, 1 hit PTHR22738:SF8, PTHR22738:SF8, 1 hit |
Pfami | View protein in Pfam PF16517, Nore1-SARAH, 1 hit PF00788, RA, 1 hit |
SMARTi | View protein in SMART SM00314, RA, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50200, RA, 1 hit PS50951, SARAH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RASF3_HUMAN | |
Accessioni | Q86WH2Primary (citable) accession number: Q86WH2 Secondary accession number(s): Q86WH1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | June 1, 2003 | |
Last modified: | April 7, 2021 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot