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Protein

Ras association domain-containing protein 3

Gene

RASSF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Was termed (Ref. 1) RASSF5.Curated

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ras association domain-containing protein 3
Gene namesi
Name:RASSF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000153179.11
HGNCiHGNC:14271 RASSF3
MIMi607019 gene
neXtProtiNX_Q86WH2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi283349
OpenTargetsiENSG00000153179
PharmGKBiPA34247

Polymorphism and mutation databases

BioMutaiRASSF3
DMDMi74714093

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002403962 – 238Ras association domain-containing protein 3Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ86WH2
MaxQBiQ86WH2
PaxDbiQ86WH2
PeptideAtlasiQ86WH2
PRIDEiQ86WH2
ProteomicsDBi70160
70161 [Q86WH2-2]

PTM databases

iPTMnetiQ86WH2
PhosphoSitePlusiQ86WH2

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000153179 Expressed in 208 organ(s), highest expression level in blood
CleanExiHS_RASSF3
ExpressionAtlasiQ86WH2 baseline and differential
GenevisibleiQ86WH2 HS

Organism-specific databases

HPAiCAB022664
CAB034035
HPA038469

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi129534, 22 interactors
IntActiQ86WH2, 28 interactors
STRINGi9606.ENSP00000336616

Structurei

3D structure databases

ProteinModelPortaliQ86WH2
SMRiQ86WH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 186Ras-associatingPROSITE-ProRule annotationAdd BLAST108
Domaini187 – 234SARAHPROSITE-ProRule annotationAdd BLAST48

Phylogenomic databases

eggNOGiKOG4239 Eukaryota
ENOG410Y2N1 LUCA
GeneTreeiENSGT00390000003367
HOGENOMiHOG000013025
HOVERGENiHBG054362
InParanoidiQ86WH2
KOiK09852
OrthoDBiEOG091G0EPB
PhylomeDBiQ86WH2
TreeFamiTF319243

Family and domain databases

InterProiView protein in InterPro
IPR033614 C-RASSF
IPR000159 RA_dom
IPR033619 RASSF3
IPR011524 SARAH_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR22738 PTHR22738, 1 hit
PTHR22738:SF8 PTHR22738:SF8, 1 hit
PfamiView protein in Pfam
PF16517 Nore1-SARAH, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM00314 RA, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS50951 SARAH, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86WH2-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSGYSSLEE DAEDFFFTAR TSFFRRAPQG KPRSGQQDVE KEKETHSYLS
60 70 80 90 100
KEEIKEKVHK YNLAVTDKLK MTLNSNGIYT GFIKVQMELC KPPQTSPNSG
110 120 130 140 150
KLSPSSNGCM NTLHISSTNT VGEVIEALLK KFLVTESPAK FALYKRCHRE
160 170 180 190 200
DQVYACKLSD REHPLYLRLV AGPRTDTLSF VLREHEIGEW EAFSLPELQN
210 220 230
FLRILDKEED EQLQNLKRRY TAYRQKLEEA LREVWKPD
Length:238
Mass (Da):27,562
Last modified:June 1, 2003 - v1
Checksum:i2C8AD10649259811
GO
Isoform 2 (identifier: Q86WH2-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     74-90: NSNGIYTGFIKVQMELC → STPASSQTGNIHSTCVW
     91-238: Missing.

Show »
Length:90
Mass (Da):10,265
Checksum:iEEFFEA9B843855E2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GUG6A0A1B0GUG6_HUMAN
Ras association domain-containing p...
RASSF3
299Annotation score:
A0A1B0GWJ9A0A1B0GWJ9_HUMAN
Ras association domain-containing p...
RASSF3
64Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026724232R → H1 PublicationCorresponds to variant dbSNP:rs74098110Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01935374 – 90NSNGI…QMELC → STPASSQTGNIHSTCVW in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_01935491 – 238Missing in isoform 2. 1 PublicationAdd BLAST148

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY217662 mRNA Translation: AAO61687.1
AY217663 mRNA Translation: AAO61688.1
BC100951 mRNA Translation: AAI00952.1
BC100949 mRNA Translation: AAI00950.1
CCDSiCCDS8969.1 [Q86WH2-1]
RefSeqiNP_835463.1, NM_178169.3 [Q86WH2-1]
UniGeneiHs.643605

Genome annotation databases

EnsembliENST00000283172; ENSP00000283172; ENSG00000153179 [Q86WH2-2]
ENST00000336061; ENSP00000336616; ENSG00000153179 [Q86WH2-1]
ENST00000542104; ENSP00000443021; ENSG00000153179 [Q86WH2-1]
GeneIDi283349
KEGGihsa:283349
UCSCiuc001ssd.3 human [Q86WH2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY217662 mRNA Translation: AAO61687.1
AY217663 mRNA Translation: AAO61688.1
BC100951 mRNA Translation: AAI00952.1
BC100949 mRNA Translation: AAI00950.1
CCDSiCCDS8969.1 [Q86WH2-1]
RefSeqiNP_835463.1, NM_178169.3 [Q86WH2-1]
UniGeneiHs.643605

3D structure databases

ProteinModelPortaliQ86WH2
SMRiQ86WH2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129534, 22 interactors
IntActiQ86WH2, 28 interactors
STRINGi9606.ENSP00000336616

PTM databases

iPTMnetiQ86WH2
PhosphoSitePlusiQ86WH2

Polymorphism and mutation databases

BioMutaiRASSF3
DMDMi74714093

Proteomic databases

EPDiQ86WH2
MaxQBiQ86WH2
PaxDbiQ86WH2
PeptideAtlasiQ86WH2
PRIDEiQ86WH2
ProteomicsDBi70160
70161 [Q86WH2-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283172; ENSP00000283172; ENSG00000153179 [Q86WH2-2]
ENST00000336061; ENSP00000336616; ENSG00000153179 [Q86WH2-1]
ENST00000542104; ENSP00000443021; ENSG00000153179 [Q86WH2-1]
GeneIDi283349
KEGGihsa:283349
UCSCiuc001ssd.3 human [Q86WH2-1]

Organism-specific databases

CTDi283349
DisGeNETi283349
EuPathDBiHostDB:ENSG00000153179.11
GeneCardsiRASSF3
HGNCiHGNC:14271 RASSF3
HPAiCAB022664
CAB034035
HPA038469
MIMi607019 gene
neXtProtiNX_Q86WH2
OpenTargetsiENSG00000153179
PharmGKBiPA34247
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4239 Eukaryota
ENOG410Y2N1 LUCA
GeneTreeiENSGT00390000003367
HOGENOMiHOG000013025
HOVERGENiHBG054362
InParanoidiQ86WH2
KOiK09852
OrthoDBiEOG091G0EPB
PhylomeDBiQ86WH2
TreeFamiTF319243

Miscellaneous databases

ChiTaRSiRASSF3 human
GenomeRNAii283349
PROiPR:Q86WH2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153179 Expressed in 208 organ(s), highest expression level in blood
CleanExiHS_RASSF3
ExpressionAtlasiQ86WH2 baseline and differential
GenevisibleiQ86WH2 HS

Family and domain databases

InterProiView protein in InterPro
IPR033614 C-RASSF
IPR000159 RA_dom
IPR033619 RASSF3
IPR011524 SARAH_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR22738 PTHR22738, 1 hit
PTHR22738:SF8 PTHR22738:SF8, 1 hit
PfamiView protein in Pfam
PF16517 Nore1-SARAH, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM00314 RA, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS50951 SARAH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRASF3_HUMAN
AccessioniPrimary (citable) accession number: Q86WH2
Secondary accession number(s): Q86WH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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