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Protein

Serpin A9

Gene

SERPINA9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro).1 Publication

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: UniProtKB

GO - Biological processi

  • negative regulation of endopeptidase activity Source: GO_Central

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.082

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin A9
Alternative name(s):
Centerin
Germinal center B-cell-expressed transcript 1 protein
Gene namesi
Name:SERPINA9
Synonyms:GCET1, SERPINA11
ORF Names:UNQ692/PRO1337
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000170054.14
HGNCiHGNC:15995 SERPINA9
MIMi615677 gene
neXtProtiNX_Q86WD7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi327657
OpenTargetsiENSG00000170054
PharmGKBiPA38077

Polymorphism and mutation databases

BioMutaiSERPINA9
DMDMi215274213

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000004197124 – 417Serpin A9Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi390N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86WD7
PeptideAtlasiQ86WD7
PRIDEiQ86WD7
ProteomicsDBi70147
70148 [Q86WD7-2]
70149 [Q86WD7-3]
70150 [Q86WD7-4]
70151 [Q86WD7-5]
70152 [Q86WD7-6]
70153 [Q86WD7-7]

PTM databases

iPTMnetiQ86WD7
PhosphoSitePlusiQ86WD7

Expressioni

Tissue specificityi

Highly expressed in normal germinal center (GC) B-cells and GC B-cell-derived malignancies.4 Publications

Gene expression databases

BgeeiENSG00000170054 Expressed in 49 organ(s), highest expression level in epithelium of nasopharynx
CleanExiHS_SERPINA11
HS_SERPINA9
GenevisibleiQ86WD7 HS

Interactioni

Protein-protein interaction databases

BioGridi130609, 1 interactor
STRINGi9606.ENSP00000337133

Structurei

3D structure databases

ProteinModelPortaliQ86WD7
SMRiQ86WD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOVERGENiHBG005957
InParanoidiQ86WD7
KOiK04525
OMAiPKMGIRD
OrthoDBiEOG091G0ION
PhylomeDBiQ86WD7
TreeFamiTF343201

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q86WD7-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASYLYGVLF AVGLCAPIYC VSPANAPSAY PRPSSTKSTP ASQVYSLNTD
60 70 80 90 100
FAFRLYRRLV LETPSQNIFF SPVSVSTSLA MLSLGAHSVT KTQILQGLGF
110 120 130 140 150
NLTHTPESAI HQGFQHLVHS LTVPSKDLTL KMGSALFVKK ELQLQANFLG
160 170 180 190 200
NVKRLYEAEV FSTDFSNPSI AQARINSHVK KKTQGKVVDI IQGLDLLTAM
210 220 230 240 250
VLVNHIFFKA KWEKPFHPEY TRKNFPFLVG EQVTVHVPMM HQKEQFAFGV
260 270 280 290 300
DTELNCFVLQ MDYKGDAVAF FVLPSKGKMR QLEQALSART LRKWSHSLQK
310 320 330 340 350
RWIEVFIPRF SISASYNLET ILPKMGIQNV FDKNADFSGI AKRDSLQVSK
360 370 380 390 400
ATHKAVLDVS EEGTEATAAT TTKFIVRSKD GPSYFTVSFN RTFLMMITNK
410
ATDGILFLGK VENPTKS
Length:417
Mass (Da):46,557
Last modified:November 25, 2008 - v3
Checksum:iC7693D34FD2E12AB
GO
Isoform 2 (identifier: Q86WD7-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQGQGRRRGTCKDIFCSKM
     73-172: Missing.

Show »
Length:335
Mass (Da):37,776
Checksum:i5141D59448BC3077
GO
Isoform 3 (identifier: Q86WD7-3) [UniParc]FASTAAdd to basket
Also known as: SERPINA11a

The sequence of this isoform differs from the canonical sequence as follows:
     1-417: MASYLYGVLF...LGKVENPTKS → MRSAGGRGEI...KFLGQCQEAV

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:201
Mass (Da):21,908
Checksum:iF805EC2CB516559E
GO
Isoform 4 (identifier: Q86WD7-4) [UniParc]FASTAAdd to basket
Also known as: SERPINA11b

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: MASYLYGVLF...NTDFAFRLYR → MRSAGGRGEI...RTGQEKRNLQ
     351-352: AT → VS
     353-417: Missing.

Show »
Length:334
Mass (Da):37,665
Checksum:i619119ADE7028784
GO
Isoform 5 (identifier: Q86WD7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.

Show »
Length:286
Mass (Da):32,400
Checksum:i529682149DC6DD49
GO
Isoform 6 (identifier: Q86WD7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.

Show »
Length:337
Mass (Da):37,915
Checksum:iC948BF44A88BC48F
GO
Isoform 7 (identifier: Q86WD7-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQGQGRRRGTCKDIFCSKM

Show »
Length:435
Mass (Da):48,610
Checksum:i66C6CB6397A442D6
GO

Sequence cautioni

The sequence AAO32345 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23P → L in AAO65242 (PubMed:12819018).Curated1
Sequence conflicti23P → L in AAO65243 (PubMed:12819018).Curated1
Sequence conflicti23P → L in AAQ89063 (PubMed:12975309).Curated1
Sequence conflicti93Q → E in BAG62686 (PubMed:14702039).Curated1
Sequence conflicti174R → G in AAO65245 (PubMed:12819018).Curated1
Sequence conflicti207F → S in BAG62686 (PubMed:14702039).Curated1
Sequence conflicti224N → D in AAO65242 (PubMed:12819018).Curated1
Sequence conflicti228L → P in AAO65244 (PubMed:12819018).Curated1
Sequence conflicti371T → A in AAO65242 (PubMed:12819018).Curated1
Sequence conflicti411V → A in AAO65243 (PubMed:12819018).Curated1
Sequence conflicti411V → A in BAG62686 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04734424A → V. Corresponds to variant dbSNP:rs4905204Ensembl.1
Natural variantiVAR_047345218P → L1 PublicationCorresponds to variant dbSNP:rs17090921Ensembl.1
Natural variantiVAR_047346236H → Q1 PublicationCorresponds to variant dbSNP:rs28583900Ensembl.1
Natural variantiVAR_047347292R → I1 PublicationCorresponds to variant dbSNP:rs28618118Ensembl.1
Natural variantiVAR_047348330V → A2 PublicationsCorresponds to variant dbSNP:rs11628722Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0414921 – 417MASYL…NPTKS → MRSAGGRGEIKVRRELQPSK QVSGLTNHARTGQEKRNLQR HILFQNGILPLWSTLCCWPL CSNLLCVPGQCPQCIPPPFL HKEHPCLTGVFPQHRLCLPP IPQAGFGDPESEHLLLPCEC LHFPGHALPWGPLSHQDPDS PGPGLQPHTHTRVCHPPGLP APGSLTDCSQQRPDLEDGKC PLRQEGAAAAGKFLGQCQEA V in isoform 3. 1 PublicationAdd BLAST417
Alternative sequenceiVSP_0414881 – 131Missing in isoform 5. 1 PublicationAdd BLAST131
Alternative sequenceiVSP_0414891 – 80Missing in isoform 6. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_0414901 – 57MASYL…FRLYR → MRSAGGRGEIKVRRELQPSK QVSGLTNHARTGQEKRNLQ in isoform 4. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_0414911M → MQGQGRRRGTCKDIFCSKM in isoform 2 and isoform 7. 3 Publications1
Alternative sequenceiVSP_04149373 – 172Missing in isoform 2. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_041494351 – 352AT → VS in isoform 4. 1 Publication2
Alternative sequenceiVSP_041495353 – 417Missing in isoform 4. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY220118 mRNA Translation: AAO65242.1
AY220119 mRNA Translation: AAO65243.1
AY220120 mRNA Translation: AAO65244.1
AY220121 mRNA Translation: AAO65245.1
AY185496 mRNA Translation: AAO32345.1 Sequence problems.
AY185497 mRNA Translation: AAO32346.1
AY358700 mRNA Translation: AAQ89063.1
AK301082 mRNA Translation: BAG62686.1
AL132708 Genomic DNA No translation available.
BC111498 mRNA Translation: AAI11499.1
CCDSiCCDS41982.1 [Q86WD7-7]
CCDS41983.1 [Q86WD7-2]
CCDS61542.1 [Q86WD7-5]
RefSeqiNP_001035983.1, NM_001042518.1 [Q86WD7-2]
NP_001271204.1, NM_001284275.1
NP_001271205.1, NM_001284276.1 [Q86WD7-5]
NP_783866.2, NM_175739.3 [Q86WD7-7]
XP_011535016.1, XM_011536714.2 [Q86WD7-1]
XP_011535017.1, XM_011536715.2 [Q86WD7-1]
XP_011535018.1, XM_011536716.2 [Q86WD7-6]
XP_011535019.1, XM_011536717.1 [Q86WD7-6]
UniGeneiHs.317970

Genome annotation databases

EnsembliENST00000298845; ENSP00000298845; ENSG00000170054 [Q86WD7-2]
ENST00000337425; ENSP00000337133; ENSG00000170054 [Q86WD7-7]
ENST00000380365; ENSP00000369723; ENSG00000170054 [Q86WD7-1]
ENST00000424550; ENSP00000409012; ENSG00000170054 [Q86WD7-5]
ENST00000448305; ENSP00000414092; ENSG00000170054 [Q86WD7-6]
ENST00000538527; ENSP00000441511; ENSG00000170054 [Q86WD7-3]
ENST00000546329; ENSP00000445476; ENSG00000170054 [Q86WD7-4]
GeneIDi327657
KEGGihsa:327657
UCSCiuc001yde.4 human [Q86WD7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY220118 mRNA Translation: AAO65242.1
AY220119 mRNA Translation: AAO65243.1
AY220120 mRNA Translation: AAO65244.1
AY220121 mRNA Translation: AAO65245.1
AY185496 mRNA Translation: AAO32345.1 Sequence problems.
AY185497 mRNA Translation: AAO32346.1
AY358700 mRNA Translation: AAQ89063.1
AK301082 mRNA Translation: BAG62686.1
AL132708 Genomic DNA No translation available.
BC111498 mRNA Translation: AAI11499.1
CCDSiCCDS41982.1 [Q86WD7-7]
CCDS41983.1 [Q86WD7-2]
CCDS61542.1 [Q86WD7-5]
RefSeqiNP_001035983.1, NM_001042518.1 [Q86WD7-2]
NP_001271204.1, NM_001284275.1
NP_001271205.1, NM_001284276.1 [Q86WD7-5]
NP_783866.2, NM_175739.3 [Q86WD7-7]
XP_011535016.1, XM_011536714.2 [Q86WD7-1]
XP_011535017.1, XM_011536715.2 [Q86WD7-1]
XP_011535018.1, XM_011536716.2 [Q86WD7-6]
XP_011535019.1, XM_011536717.1 [Q86WD7-6]
UniGeneiHs.317970

3D structure databases

ProteinModelPortaliQ86WD7
SMRiQ86WD7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130609, 1 interactor
STRINGi9606.ENSP00000337133

Protein family/group databases

MEROPSiI04.082

PTM databases

iPTMnetiQ86WD7
PhosphoSitePlusiQ86WD7

Polymorphism and mutation databases

BioMutaiSERPINA9
DMDMi215274213

Proteomic databases

PaxDbiQ86WD7
PeptideAtlasiQ86WD7
PRIDEiQ86WD7
ProteomicsDBi70147
70148 [Q86WD7-2]
70149 [Q86WD7-3]
70150 [Q86WD7-4]
70151 [Q86WD7-5]
70152 [Q86WD7-6]
70153 [Q86WD7-7]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298845; ENSP00000298845; ENSG00000170054 [Q86WD7-2]
ENST00000337425; ENSP00000337133; ENSG00000170054 [Q86WD7-7]
ENST00000380365; ENSP00000369723; ENSG00000170054 [Q86WD7-1]
ENST00000424550; ENSP00000409012; ENSG00000170054 [Q86WD7-5]
ENST00000448305; ENSP00000414092; ENSG00000170054 [Q86WD7-6]
ENST00000538527; ENSP00000441511; ENSG00000170054 [Q86WD7-3]
ENST00000546329; ENSP00000445476; ENSG00000170054 [Q86WD7-4]
GeneIDi327657
KEGGihsa:327657
UCSCiuc001yde.4 human [Q86WD7-1]

Organism-specific databases

CTDi327657
DisGeNETi327657
EuPathDBiHostDB:ENSG00000170054.14
GeneCardsiSERPINA9
H-InvDBiHIX0037697
HGNCiHGNC:15995 SERPINA9
MIMi615677 gene
neXtProtiNX_Q86WD7
OpenTargetsiENSG00000170054
PharmGKBiPA38077
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOVERGENiHBG005957
InParanoidiQ86WD7
KOiK04525
OMAiPKMGIRD
OrthoDBiEOG091G0ION
PhylomeDBiQ86WD7
TreeFamiTF343201

Miscellaneous databases

ChiTaRSiSERPINA9 human
GeneWikiiSERPINA9
GenomeRNAii327657
PROiPR:Q86WD7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170054 Expressed in 49 organ(s), highest expression level in epithelium of nasopharynx
CleanExiHS_SERPINA11
HS_SERPINA9
GenevisibleiQ86WD7 HS

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPA9_HUMAN
AccessioniPrimary (citable) accession number: Q86WD7
Secondary accession number(s): B4DVH4
, B9ZVX3, Q2T9J2, Q6UWP9, Q86WD4, Q86WD5, Q86WD6, Q86YP6, Q86YP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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