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UniProtKB - Q86WD7 (SPA9_HUMAN)

Entry version 147 (25 May 2022)
Sequence version 3 (25 Nov 2008)
Previous versions | rss
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Protein

Serpin A9

Gene

SERPINA9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro).

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86WD7

Protein family/group databases

MEROPS protease database

More...MEROPSi		I04.082

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serpin A9
Alternative name(s):
Centerin
Germinal center B-cell-expressed transcript 1 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SERPINA9
Synonyms:GCET1, SERPINA11
ORF Names:UNQ692/PRO1337
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15995, SERPINA9

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615677, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86WD7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000170054

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		327657

Open Targets

More...OpenTargetsi		ENSG00000170054

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38077

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86WD7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SERPINA9

Domain mapping of disease mutations (DMDM)

More...DMDMi		215274213

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004197124 – 417Serpin A9Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi390N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86WD7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86WD7

PeptideAtlas

More...PeptideAtlasi		Q86WD7

PRoteomics IDEntifications database

More...PRIDEi		Q86WD7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70149 [Q86WD7-3]
70150 [Q86WD7-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q86WD7, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86WD7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86WD7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in normal germinal center (GC) B-cells and GC B-cell-derived malignancies.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000170054, Expressed in tonsil and 62 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86WD7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000170054, Tissue enriched (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		130609, 16 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000337133

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86WD7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q86WD7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q86WD7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2392, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162880

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_023330_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86WD7

Identification of Orthologs from Complete Genome Data

More...OMAi		NCSVLQM

Database of Orthologous Groups

More...OrthoDBi		1124079at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86WD7

TreeFam database of animal gene trees

More...TreeFami		TF343201

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.39.10, 1 hit
3.30.497.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR023795, Serpin_CS
IPR023796, Serpin_dom
IPR000215, Serpin_fam
IPR036186, Serpin_sf
IPR042178, Serpin_sf_1
IPR042185, Serpin_sf_2

The PANTHER Classification System

More...PANTHERi		PTHR11461, PTHR11461, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00079, Serpin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00093, SERPIN, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56574, SSF56574, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00284, SERPIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86WD7-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASYLYGVLF AVGLCAPIYC VSPANAPSAY PRPSSTKSTP ASQVYSLNTD 
        60         70         80         90        100
FAFRLYRRLV LETPSQNIFF SPVSVSTSLA MLSLGAHSVT KTQILQGLGF 
       110        120        130        140        150
NLTHTPESAI HQGFQHLVHS LTVPSKDLTL KMGSALFVKK ELQLQANFLG 
       160        170        180        190        200
NVKRLYEAEV FSTDFSNPSI AQARINSHVK KKTQGKVVDI IQGLDLLTAM 
       210        220        230        240        250
VLVNHIFFKA KWEKPFHPEY TRKNFPFLVG EQVTVHVPMM HQKEQFAFGV 
       260        270        280        290        300
DTELNCFVLQ MDYKGDAVAF FVLPSKGKMR QLEQALSART LRKWSHSLQK 
       310        320        330        340        350
RWIEVFIPRF SISASYNLET ILPKMGIQNV FDKNADFSGI AKRDSLQVSK 
       360        370        380        390        400
ATHKAVLDVS EEGTEATAAT TTKFIVRSKD GPSYFTVSFN RTFLMMITNK 
       410 
ATDGILFLGK VENPTKS
Length:417
Mass (Da):46,557
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7693D34FD2E12AB
GO
Isoform 2 (identifier: Q86WD7-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQGQGRRRGTCKDIFCSKM
     73-172: Missing.

Show »
Length:335
Mass (Da):37,776
Checksum:i5141D59448BC3077
GO
Isoform 3 (identifier: Q86WD7-3) [UniParc]FASTAAdd to basket
Also known as: SERPINA11a

The sequence of this isoform differs from the canonical sequence as follows:
     1-417: MASYLYGVLF...LGKVENPTKS → MRSAGGRGEI...KFLGQCQEAV

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:201
Mass (Da):21,908
Checksum:iF805EC2CB516559E
GO
Isoform 4 (identifier: Q86WD7-4) [UniParc]FASTAAdd to basket
Also known as: SERPINA11b

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: MASYLYGVLF...NTDFAFRLYR → MRSAGGRGEI...RTGQEKRNLQ
     351-352: AT → VS
     353-417: Missing.

Show »
Length:334
Mass (Da):37,665
Checksum:i619119ADE7028784
GO
Isoform 5 (identifier: Q86WD7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.

Show »
Length:286
Mass (Da):32,400
Checksum:i529682149DC6DD49
GO
Isoform 6 (identifier: Q86WD7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.

Show »
Length:337
Mass (Da):37,915
Checksum:iC948BF44A88BC48F
GO
Isoform 7 (identifier: Q86WD7-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQGQGRRRGTCKDIFCSKM

Show »
Length:435
Mass (Da):48,610
Checksum:i66C6CB6397A442D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A6Q8JH89A0A6Q8JH89_HUMAN
Serpin A9
SERPINA9
317Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8LYX2A0A6Q8LYX2_HUMAN
Serpin A9
SERPINA9
272Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAO32345 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti23P → L in AAO65242 (PubMed:12819018).Curated1
Sequence conflicti23P → L in AAO65243 (PubMed:12819018).Curated1
Sequence conflicti23P → L in AAQ89063 (PubMed:12975309).Curated1
Sequence conflicti93Q → E in BAG62686 (PubMed:14702039).Curated1
Sequence conflicti174R → G in AAO65245 (PubMed:12819018).Curated1
Sequence conflicti207F → S in BAG62686 (PubMed:14702039).Curated1
Sequence conflicti224N → D in AAO65242 (PubMed:12819018).Curated1
Sequence conflicti228L → P in AAO65244 (PubMed:12819018).Curated1
Sequence conflicti371T → A in AAO65242 (PubMed:12819018).Curated1
Sequence conflicti411V → A in AAO65243 (PubMed:12819018).Curated1
Sequence conflicti411V → A in BAG62686 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04734424A → V. Corresponds to variant dbSNP:rs4905204Ensembl.1
Natural variantiVAR_047345218P → L1 PublicationCorresponds to variant dbSNP:rs17090921Ensembl.1
Natural variantiVAR_047346236H → Q1 PublicationCorresponds to variant dbSNP:rs28583900Ensembl.1
Natural variantiVAR_047347292R → I1 PublicationCorresponds to variant dbSNP:rs28618118Ensembl.1
Natural variantiVAR_047348330V → A2 PublicationsCorresponds to variant dbSNP:rs11628722Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0414921 – 417MASYL…NPTKS → MRSAGGRGEIKVRRELQPSK QVSGLTNHARTGQEKRNLQR HILFQNGILPLWSTLCCWPL CSNLLCVPGQCPQCIPPPFL HKEHPCLTGVFPQHRLCLPP IPQAGFGDPESEHLLLPCEC LHFPGHALPWGPLSHQDPDS PGPGLQPHTHTRVCHPPGLP APGSLTDCSQQRPDLEDGKC PLRQEGAAAAGKFLGQCQEA V in isoform 3. 1 PublicationAdd BLAST417
Alternative sequenceiVSP_0414881 – 131Missing in isoform 5. 1 PublicationAdd BLAST131
Alternative sequenceiVSP_0414891 – 80Missing in isoform 6. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_0414901 – 57MASYL…FRLYR → MRSAGGRGEIKVRRELQPSK QVSGLTNHARTGQEKRNLQ in isoform 4. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_0414911M → MQGQGRRRGTCKDIFCSKM in isoform 2 and isoform 7. 3 Publications1
Alternative sequenceiVSP_04149373 – 172Missing in isoform 2. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_041494351 – 352AT → VS in isoform 4. 1 Publication2
Alternative sequenceiVSP_041495353 – 417Missing in isoform 4. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY220118 mRNA Translation: AAO65242.1
AY220119 mRNA Translation: AAO65243.1
AY220120 mRNA Translation: AAO65244.1
AY220121 mRNA Translation: AAO65245.1
AY185496 mRNA Translation: AAO32345.1 Sequence problems.
AY185497 mRNA Translation: AAO32346.1
AY358700 mRNA Translation: AAQ89063.1
AK301082 mRNA Translation: BAG62686.1
AL132708 Genomic DNA No translation available.
BC111498 mRNA Translation: AAI11499.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41982.1 [Q86WD7-1]
CCDS61542.1 [Q86WD7-5]

NCBI Reference Sequences

More...RefSeqi		NP_001035983.1, NM_001042518.1
NP_001271204.1, NM_001284275.1 [Q86WD7-6]
NP_001271205.1, NM_001284276.1 [Q86WD7-5]
NP_783866.2, NM_175739.3 [Q86WD7-1]
XP_011535016.1, XM_011536714.2 [Q86WD7-1]
XP_011535017.1, XM_011536715.2 [Q86WD7-1]
XP_011535018.1, XM_011536716.2 [Q86WD7-6]
XP_011535019.1, XM_011536717.1 [Q86WD7-6]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000337425.10; ENSP00000337133.5; ENSG00000170054.16 [Q86WD7-7]
ENST00000380365.7; ENSP00000369723.3; ENSG00000170054.16
ENST00000424550.6; ENSP00000409012.2; ENSG00000170054.16 [Q86WD7-5]
ENST00000448305.6; ENSP00000414092.2; ENSG00000170054.16 [Q86WD7-6]
ENST00000538527.5; ENSP00000441511.1; ENSG00000170054.16 [Q86WD7-3]
ENST00000674164.1; ENSP00000501328.1; ENSG00000170054.16 [Q86WD7-2]
ENST00000674397.2; ENSP00000501517.1; ENSG00000170054.16

Database of genes from NCBI RefSeq genomes

More...GeneIDi		327657

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:327657

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000674397.2; ENSP00000501517.1; NM_175739.4; NP_783866.3

UCSC genome browser

More...UCSCi		uc001yde.4, human [Q86WD7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY220118 mRNA Translation: AAO65242.1
AY220119 mRNA Translation: AAO65243.1
AY220120 mRNA Translation: AAO65244.1
AY220121 mRNA Translation: AAO65245.1
AY185496 mRNA Translation: AAO32345.1 Sequence problems.
AY185497 mRNA Translation: AAO32346.1
AY358700 mRNA Translation: AAQ89063.1
AK301082 mRNA Translation: BAG62686.1
AL132708 Genomic DNA No translation available.
BC111498 mRNA Translation: AAI11499.1
CCDSiCCDS41982.1 [Q86WD7-1]
CCDS61542.1 [Q86WD7-5]
RefSeqiNP_001035983.1, NM_001042518.1
NP_001271204.1, NM_001284275.1 [Q86WD7-6]
NP_001271205.1, NM_001284276.1 [Q86WD7-5]
NP_783866.2, NM_175739.3 [Q86WD7-1]
XP_011535016.1, XM_011536714.2 [Q86WD7-1]
XP_011535017.1, XM_011536715.2 [Q86WD7-1]
XP_011535018.1, XM_011536716.2 [Q86WD7-6]
XP_011535019.1, XM_011536717.1 [Q86WD7-6]

3D structure databases

AlphaFoldDBiQ86WD7
SMRiQ86WD7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi130609, 16 interactors
STRINGi9606.ENSP00000337133

Protein family/group databases

MEROPSiI04.082

PTM databases

GlyGeniQ86WD7, 2 sites
iPTMnetiQ86WD7
PhosphoSitePlusiQ86WD7

Genetic variation databases

BioMutaiSERPINA9
DMDMi215274213

Proteomic databases

MassIVEiQ86WD7
PaxDbiQ86WD7
PeptideAtlasiQ86WD7
PRIDEiQ86WD7
ProteomicsDBi70149 [Q86WD7-3]
70150 [Q86WD7-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		56037, 167 antibodies from 24 providers

The DNASU plasmid repository

More...DNASUi		327657

Genome annotation databases

EnsembliENST00000337425.10; ENSP00000337133.5; ENSG00000170054.16 [Q86WD7-7]
ENST00000380365.7; ENSP00000369723.3; ENSG00000170054.16
ENST00000424550.6; ENSP00000409012.2; ENSG00000170054.16 [Q86WD7-5]
ENST00000448305.6; ENSP00000414092.2; ENSG00000170054.16 [Q86WD7-6]
ENST00000538527.5; ENSP00000441511.1; ENSG00000170054.16 [Q86WD7-3]
ENST00000674164.1; ENSP00000501328.1; ENSG00000170054.16 [Q86WD7-2]
ENST00000674397.2; ENSP00000501517.1; ENSG00000170054.16
GeneIDi327657
KEGGihsa:327657
MANE-SelectiENST00000674397.2; ENSP00000501517.1; NM_175739.4; NP_783866.3
UCSCiuc001yde.4, human [Q86WD7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		327657
DisGeNETi327657

GeneCards: human genes, protein and diseases

More...GeneCardsi		SERPINA9
HGNCiHGNC:15995, SERPINA9
HPAiENSG00000170054, Tissue enriched (lymphoid)
MIMi615677, gene
neXtProtiNX_Q86WD7
OpenTargetsiENSG00000170054
PharmGKBiPA38077
VEuPathDBiHostDB:ENSG00000170054

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2392, Eukaryota
GeneTreeiENSGT00940000162880
HOGENOMiCLU_023330_2_1_1
InParanoidiQ86WD7
OMAiNCSVLQM
OrthoDBi1124079at2759
PhylomeDBiQ86WD7
TreeFamiTF343201

Enzyme and pathway databases

PathwayCommonsiQ86WD7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		327657, 8 hits in 1060 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SERPINA9, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SERPINA9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		327657
PharosiQ86WD7, Tbio

Protein Ontology

More...PROi		PR:Q86WD7
RNActiQ86WD7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000170054, Expressed in tonsil and 62 other tissues
GenevisibleiQ86WD7, HS

Family and domain databases

Gene3Di2.30.39.10, 1 hit
3.30.497.10, 1 hit
InterProiView protein in InterPro
IPR023795, Serpin_CS
IPR023796, Serpin_dom
IPR000215, Serpin_fam
IPR036186, Serpin_sf
IPR042178, Serpin_sf_1
IPR042185, Serpin_sf_2
PANTHERiPTHR11461, PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079, Serpin, 1 hit
SMARTiView protein in SMART
SM00093, SERPIN, 1 hit
SUPFAMiSSF56574, SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284, SERPIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPA9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86WD7
Secondary accession number(s): B4DVH4
, B9ZVX3, Q2T9J2, Q6UWP9, Q86WD4, Q86WD5, Q86WD6, Q86YP6, Q86YP7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: November 25, 2008
Last modified: May 25, 2022
This is version 147 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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