UniProtKB - Q86WD7 (SPA9_HUMAN)
Protein
Serpin A9
Gene
SERPINA9
Organism
Homo sapiens (Human)
Status
Functioni
Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro).1 Publication
GO - Molecular functioni
- serine-type endopeptidase inhibitor activity Source: UniProtKB
GO - Biological processi
- negative regulation of endopeptidase activity Source: GO_Central
Keywordsi
Molecular function | Protease inhibitor, Serine protease inhibitor |
Enzyme and pathway databases
PathwayCommonsi | Q86WD7 |
Protein family/group databases
MEROPSi | I04.082 |
Names & Taxonomyi
Protein namesi | Recommended name: Serpin A9Alternative name(s): Centerin Germinal center B-cell-expressed transcript 1 protein |
Gene namesi | Name:SERPINA9 Synonyms:GCET1, SERPINA11 ORF Names:UNQ692/PRO1337 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15995, SERPINA9 |
MIMi | 615677, gene |
neXtProti | NX_Q86WD7 |
VEuPathDBi | HostDB:ENSG00000170054.14 |
Subcellular locationi
Extracellular region or secreted
Other locations
- Cytoplasm Curated
Other locations
- Cytoplasm Curated
Other locations
- Cytoplasm Curated
Other locations
- Cytoplasm Curated
Other locations
- Cytoplasm Curated
Other locations
- Membrane Curated; Single-pass type II membrane protein Curated
Extracellular region or secreted
- extracellular space Source: GO_Central
Other locations
Keywords - Cellular componenti
Cytoplasm, Membrane, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 327657 |
OpenTargetsi | ENSG00000170054 |
PharmGKBi | PA38077 |
Miscellaneous databases
Pharosi | Q86WD7, Tbio |
Genetic variation databases
BioMutai | SERPINA9 |
DMDMi | 215274213 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000041971 | 24 – 417 | Serpin A9Add BLAST | 394 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 101 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 390 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | Q86WD7 |
PaxDbi | Q86WD7 |
PeptideAtlasi | Q86WD7 |
PRIDEi | Q86WD7 |
ProteomicsDBi | 70147 [Q86WD7-1] 70148 [Q86WD7-2] 70149 [Q86WD7-3] 70150 [Q86WD7-4] 70151 [Q86WD7-5] 70152 [Q86WD7-6] 70153 [Q86WD7-7] |
PTM databases
GlyGeni | Q86WD7, 2 sites |
iPTMneti | Q86WD7 |
PhosphoSitePlusi | Q86WD7 |
Expressioni
Tissue specificityi
Highly expressed in normal germinal center (GC) B-cells and GC B-cell-derived malignancies.4 Publications
Gene expression databases
Bgeei | ENSG00000170054, Expressed in tonsil and 62 other tissues |
Genevisiblei | Q86WD7, HS |
Organism-specific databases
HPAi | ENSG00000170054, Tissue enriched (lymphoid) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 130609, 2 interactors |
STRINGi | 9606.ENSP00000337133 |
Miscellaneous databases
RNActi | Q86WD7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the serpin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000162880 |
HOGENOMi | CLU_023330_2_1_1 |
InParanoidi | Q86WD7 |
OMAi | NCSVLQM |
OrthoDBi | 1124079at2759 |
PhylomeDBi | Q86WD7 |
TreeFami | TF343201 |
Family and domain databases
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q86WD7-1) [UniParc]FASTAAdd to basket
Also known as: A
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASYLYGVLF AVGLCAPIYC VSPANAPSAY PRPSSTKSTP ASQVYSLNTD
60 70 80 90 100
FAFRLYRRLV LETPSQNIFF SPVSVSTSLA MLSLGAHSVT KTQILQGLGF
110 120 130 140 150
NLTHTPESAI HQGFQHLVHS LTVPSKDLTL KMGSALFVKK ELQLQANFLG
160 170 180 190 200
NVKRLYEAEV FSTDFSNPSI AQARINSHVK KKTQGKVVDI IQGLDLLTAM
210 220 230 240 250
VLVNHIFFKA KWEKPFHPEY TRKNFPFLVG EQVTVHVPMM HQKEQFAFGV
260 270 280 290 300
DTELNCFVLQ MDYKGDAVAF FVLPSKGKMR QLEQALSART LRKWSHSLQK
310 320 330 340 350
RWIEVFIPRF SISASYNLET ILPKMGIQNV FDKNADFSGI AKRDSLQVSK
360 370 380 390 400
ATHKAVLDVS EEGTEATAAT TTKFIVRSKD GPSYFTVSFN RTFLMMITNK
410
ATDGILFLGK VENPTKS
Isoform 3 (identifier: Q86WD7-3) [UniParc]FASTAAdd to basket
Also known as: SERPINA11a
The sequence of this isoform differs from the canonical sequence as follows:
1-417: MASYLYGVLF...LGKVENPTKS → MRSAGGRGEI...KFLGQCQEAV
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A6Q8JH89 | A0A6Q8JH89_HUMAN | Serpin A9 | SERPINA9 | 317 | Annotation score: | ||
A0A6Q8LYX2 | A0A6Q8LYX2_HUMAN | Serpin A9 | SERPINA9 | 272 | Annotation score: |
Sequence cautioni
The sequence AAO32345 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 23 | P → L in AAO65242 (PubMed:12819018).Curated | 1 | |
Sequence conflicti | 23 | P → L in AAO65243 (PubMed:12819018).Curated | 1 | |
Sequence conflicti | 23 | P → L in AAQ89063 (PubMed:12975309).Curated | 1 | |
Sequence conflicti | 93 | Q → E in BAG62686 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 174 | R → G in AAO65245 (PubMed:12819018).Curated | 1 | |
Sequence conflicti | 207 | F → S in BAG62686 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 224 | N → D in AAO65242 (PubMed:12819018).Curated | 1 | |
Sequence conflicti | 228 | L → P in AAO65244 (PubMed:12819018).Curated | 1 | |
Sequence conflicti | 371 | T → A in AAO65242 (PubMed:12819018).Curated | 1 | |
Sequence conflicti | 411 | V → A in AAO65243 (PubMed:12819018).Curated | 1 | |
Sequence conflicti | 411 | V → A in BAG62686 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047344 | 24 | A → V. Corresponds to variant dbSNP:rs4905204Ensembl. | 1 | |
Natural variantiVAR_047345 | 218 | P → L1 PublicationCorresponds to variant dbSNP:rs17090921Ensembl. | 1 | |
Natural variantiVAR_047346 | 236 | H → Q1 PublicationCorresponds to variant dbSNP:rs28583900Ensembl. | 1 | |
Natural variantiVAR_047347 | 292 | R → I1 PublicationCorresponds to variant dbSNP:rs28618118Ensembl. | 1 | |
Natural variantiVAR_047348 | 330 | V → A2 PublicationsCorresponds to variant dbSNP:rs11628722Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041492 | 1 – 417 | MASYL…NPTKS → MRSAGGRGEIKVRRELQPSK QVSGLTNHARTGQEKRNLQR HILFQNGILPLWSTLCCWPL CSNLLCVPGQCPQCIPPPFL HKEHPCLTGVFPQHRLCLPP IPQAGFGDPESEHLLLPCEC LHFPGHALPWGPLSHQDPDS PGPGLQPHTHTRVCHPPGLP APGSLTDCSQQRPDLEDGKC PLRQEGAAAAGKFLGQCQEA V in isoform 3. 1 PublicationAdd BLAST | 417 | |
Alternative sequenceiVSP_041488 | 1 – 131 | Missing in isoform 5. 1 PublicationAdd BLAST | 131 | |
Alternative sequenceiVSP_041489 | 1 – 80 | Missing in isoform 6. 1 PublicationAdd BLAST | 80 | |
Alternative sequenceiVSP_041490 | 1 – 57 | MASYL…FRLYR → MRSAGGRGEIKVRRELQPSK QVSGLTNHARTGQEKRNLQ in isoform 4. 1 PublicationAdd BLAST | 57 | |
Alternative sequenceiVSP_041491 | 1 | M → MQGQGRRRGTCKDIFCSKM in isoform 2 and isoform 7. 3 Publications | 1 | |
Alternative sequenceiVSP_041493 | 73 – 172 | Missing in isoform 2. 1 PublicationAdd BLAST | 100 | |
Alternative sequenceiVSP_041494 | 351 – 352 | AT → VS in isoform 4. 1 Publication | 2 | |
Alternative sequenceiVSP_041495 | 353 – 417 | Missing in isoform 4. 1 PublicationAdd BLAST | 65 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY220118 mRNA Translation: AAO65242.1 AY220119 mRNA Translation: AAO65243.1 AY220120 mRNA Translation: AAO65244.1 AY220121 mRNA Translation: AAO65245.1 AY185496 mRNA Translation: AAO32345.1 Sequence problems. AY185497 mRNA Translation: AAO32346.1 AY358700 mRNA Translation: AAQ89063.1 AK301082 mRNA Translation: BAG62686.1 AL132708 Genomic DNA No translation available. BC111498 mRNA Translation: AAI11499.1 |
CCDSi | CCDS41982.1 [Q86WD7-1] CCDS61542.1 [Q86WD7-5] |
RefSeqi | NP_001035983.1, NM_001042518.1 NP_001271204.1, NM_001284275.1 [Q86WD7-6] NP_001271205.1, NM_001284276.1 [Q86WD7-5] NP_783866.2, NM_175739.3 [Q86WD7-1] XP_011535016.1, XM_011536714.2 [Q86WD7-1] XP_011535017.1, XM_011536715.2 [Q86WD7-1] XP_011535018.1, XM_011536716.2 [Q86WD7-6] XP_011535019.1, XM_011536717.1 [Q86WD7-6] |
Genome annotation databases
Ensembli | ENST00000337425; ENSP00000337133; ENSG00000170054 [Q86WD7-7] ENST00000380365; ENSP00000369723; ENSG00000170054 [Q86WD7-1] ENST00000424550; ENSP00000409012; ENSG00000170054 [Q86WD7-5] ENST00000448305; ENSP00000414092; ENSG00000170054 [Q86WD7-6] ENST00000538527; ENSP00000441511; ENSG00000170054 [Q86WD7-3] ENST00000674164; ENSP00000501328; ENSG00000170054 [Q86WD7-2] ENST00000674397; ENSP00000501517; ENSG00000170054 [Q86WD7-1] |
GeneIDi | 327657 |
KEGGi | hsa:327657 |
UCSCi | uc001yde.4, human [Q86WD7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY220118 mRNA Translation: AAO65242.1 AY220119 mRNA Translation: AAO65243.1 AY220120 mRNA Translation: AAO65244.1 AY220121 mRNA Translation: AAO65245.1 AY185496 mRNA Translation: AAO32345.1 Sequence problems. AY185497 mRNA Translation: AAO32346.1 AY358700 mRNA Translation: AAQ89063.1 AK301082 mRNA Translation: BAG62686.1 AL132708 Genomic DNA No translation available. BC111498 mRNA Translation: AAI11499.1 |
CCDSi | CCDS41982.1 [Q86WD7-1] CCDS61542.1 [Q86WD7-5] |
RefSeqi | NP_001035983.1, NM_001042518.1 NP_001271204.1, NM_001284275.1 [Q86WD7-6] NP_001271205.1, NM_001284276.1 [Q86WD7-5] NP_783866.2, NM_175739.3 [Q86WD7-1] XP_011535016.1, XM_011536714.2 [Q86WD7-1] XP_011535017.1, XM_011536715.2 [Q86WD7-1] XP_011535018.1, XM_011536716.2 [Q86WD7-6] XP_011535019.1, XM_011536717.1 [Q86WD7-6] |
3D structure databases
SMRi | Q86WD7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 130609, 2 interactors |
STRINGi | 9606.ENSP00000337133 |
Protein family/group databases
MEROPSi | I04.082 |
PTM databases
GlyGeni | Q86WD7, 2 sites |
iPTMneti | Q86WD7 |
PhosphoSitePlusi | Q86WD7 |
Genetic variation databases
BioMutai | SERPINA9 |
DMDMi | 215274213 |
Proteomic databases
MassIVEi | Q86WD7 |
PaxDbi | Q86WD7 |
PeptideAtlasi | Q86WD7 |
PRIDEi | Q86WD7 |
ProteomicsDBi | 70147 [Q86WD7-1] 70148 [Q86WD7-2] 70149 [Q86WD7-3] 70150 [Q86WD7-4] 70151 [Q86WD7-5] 70152 [Q86WD7-6] 70153 [Q86WD7-7] |
Protocols and materials databases
Antibodypediai | 56037, 157 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 327657 |
DisGeNETi | 327657 |
GeneCardsi | SERPINA9 |
HGNCi | HGNC:15995, SERPINA9 |
HPAi | ENSG00000170054, Tissue enriched (lymphoid) |
MIMi | 615677, gene |
neXtProti | NX_Q86WD7 |
OpenTargetsi | ENSG00000170054 |
PharmGKBi | PA38077 |
VEuPathDBi | HostDB:ENSG00000170054.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000162880 |
HOGENOMi | CLU_023330_2_1_1 |
InParanoidi | Q86WD7 |
OMAi | NCSVLQM |
OrthoDBi | 1124079at2759 |
PhylomeDBi | Q86WD7 |
TreeFami | TF343201 |
Enzyme and pathway databases
PathwayCommonsi | Q86WD7 |
Miscellaneous databases
BioGRID-ORCSi | 327657, 3 hits in 866 CRISPR screens |
ChiTaRSi | SERPINA9, human |
GeneWikii | SERPINA9 |
GenomeRNAii | 327657 |
Pharosi | Q86WD7, Tbio |
PROi | PR:Q86WD7 |
RNActi | Q86WD7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170054, Expressed in tonsil and 62 other tissues |
Genevisiblei | Q86WD7, HS |
Family and domain databases
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SPA9_HUMAN | |
Accessioni | Q86WD7Primary (citable) accession number: Q86WD7 Secondary accession number(s): B4DVH4 Q86YP7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2005 |
Last sequence update: | November 25, 2008 | |
Last modified: | February 10, 2021 | |
This is version 142 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families