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Protein

Protein phosphatase 1 regulatory subunit 27

Gene

PPP1R27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.1 Publication

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB
  • protein phosphatase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 27
Alternative name(s):
Dysferlin-interacting protein 1
Toonin
Gene namesi
Name:PPP1R27
Synonyms:DYSFIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000182676.4
HGNCiHGNC:16813 PPP1R27
neXtProtiNX_Q86WC6

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182676
PharmGKBiPA27555

Polymorphism and mutation databases

BioMutaiPPP1R27
DMDMi74750495

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002644691 – 154Protein phosphatase 1 regulatory subunit 27Add BLAST154

Proteomic databases

PaxDbiQ86WC6
PeptideAtlasiQ86WC6
PRIDEiQ86WC6
ProteomicsDBi70146

PTM databases

iPTMnetiQ86WC6
PhosphoSitePlusiQ86WC6

Expressioni

Gene expression databases

BgeeiENSG00000182676 Expressed in 84 organ(s), highest expression level in gastrocnemius
CleanExiHS_DYSFIP1
ExpressionAtlasiQ86WC6 baseline and differential
GenevisibleiQ86WC6 HS

Organism-specific databases

HPAiHPA048632

Interactioni

Subunit structurei

Interacts with DYSF and PPP1CA.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621366EBI-5235602,EBI-357253

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125525, 1 interactor
IntActiQ86WC6, 9 interactors
STRINGi9606.ENSP00000331065

Structurei

3D structure databases

ProteinModelPortaliQ86WC6
SMRiQ86WC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati63 – 92ANK 1Add BLAST30
Repeati96 – 125ANK 2Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 19Poly-Arg6

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0505 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150998
HOGENOMiHOG000231238
HOVERGENiHBG080189
InParanoidiQ86WC6
KOiK17566
OMAiHFPNDVV
OrthoDBiEOG091G0U5T
PhylomeDBiQ86WC6
TreeFamiTF333311

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q86WC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSRTARYAR YSPRQRRRRM LADRSVRFPN DVLFLDHIRQ GDLEQVGRFI
60 70 80 90 100
RTRKVSLATI HPSGLAALHE AVLSGNLECV KLLVKYGADI HQRDEAGWTP
110 120 130 140 150
LHIACSDGYP DIARYLISLG ADRDATNDDG DLPSDLIDPD YKELVELFKG

TTMD
Length:154
Mass (Da):17,438
Last modified:June 1, 2003 - v1
Checksum:iD7D1644A5C906B76
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L267I3L267_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R27
114Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF434846 mRNA Translation: AAO67357.1
BC093707 mRNA Translation: AAH93707.1
BC112094 mRNA Translation: AAI12095.1
CCDSiCCDS32767.1
RefSeqiNP_001007534.1, NM_001007533.3
UniGeneiHs.454720

Genome annotation databases

EnsembliENST00000330261; ENSP00000331065; ENSG00000182676
GeneIDi116729
KEGGihsa:116729
UCSCiuc002kbj.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF434846 mRNA Translation: AAO67357.1
BC093707 mRNA Translation: AAH93707.1
BC112094 mRNA Translation: AAI12095.1
CCDSiCCDS32767.1
RefSeqiNP_001007534.1, NM_001007533.3
UniGeneiHs.454720

3D structure databases

ProteinModelPortaliQ86WC6
SMRiQ86WC6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125525, 1 interactor
IntActiQ86WC6, 9 interactors
STRINGi9606.ENSP00000331065

PTM databases

iPTMnetiQ86WC6
PhosphoSitePlusiQ86WC6

Polymorphism and mutation databases

BioMutaiPPP1R27
DMDMi74750495

Proteomic databases

PaxDbiQ86WC6
PeptideAtlasiQ86WC6
PRIDEiQ86WC6
ProteomicsDBi70146

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330261; ENSP00000331065; ENSG00000182676
GeneIDi116729
KEGGihsa:116729
UCSCiuc002kbj.2 human

Organism-specific databases

CTDi116729
EuPathDBiHostDB:ENSG00000182676.4
GeneCardsiPPP1R27
HGNCiHGNC:16813 PPP1R27
HPAiHPA048632
neXtProtiNX_Q86WC6
OpenTargetsiENSG00000182676
PharmGKBiPA27555
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0505 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150998
HOGENOMiHOG000231238
HOVERGENiHBG080189
InParanoidiQ86WC6
KOiK17566
OMAiHFPNDVV
OrthoDBiEOG091G0U5T
PhylomeDBiQ86WC6
TreeFamiTF333311

Miscellaneous databases

GenomeRNAii116729
PROiPR:Q86WC6

Gene expression databases

BgeeiENSG00000182676 Expressed in 84 organ(s), highest expression level in gastrocnemius
CleanExiHS_DYSFIP1
ExpressionAtlasiQ86WC6 baseline and differential
GenevisibleiQ86WC6 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPPR27_HUMAN
AccessioniPrimary (citable) accession number: Q86WC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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