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UniProtKB - Q86WB7 (UN93A_HUMAN)

Entry version 121 (02 Dec 2020)
Sequence version 1 (01 Jun 2003)
Previous versions | rss
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Protein

Protein unc-93 homolog A

Gene

UNC93A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Although UNC93A gene is located in a region of the genome frequently associated with ovarian cancer, no evidence have been found for a tumor suppressor function.

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86WB7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein unc-93 homolog A
Short name:
HmUnc-93A
Short name:
Unc-93A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UNC93A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000112494.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:12570, UNC93A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607995, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86WB7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		54346

Open Targets

More...OpenTargetsi		ENSG00000112494

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37207

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86WB7, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UNC93A

Domain mapping of disease mutations (DMDM)

More...DMDMi		67462066

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001900361 – 457Protein unc-93 homolog AAdd BLAST457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86WB7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86WB7

PeptideAtlas

More...PeptideAtlasi		Q86WB7

PRoteomics IDEntifications database

More...PRIDEi		Q86WB7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70143 [Q86WB7-1]
70144 [Q86WB7-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q86WB7, 1 site

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis, small intestine, spleen, prostate and ovary.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000112494, Expressed in skin of leg and 57 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86WB7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86WB7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000112494, Tissue enhanced (intestine, liver, skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119937, 23 interactors

Protein interaction database and analysis system

More...IntActi		Q86WB7, 19 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000230256

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86WB7, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the unc-93 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3097, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063359

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_025356_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86WB7

Identification of Orthologs from Complete Genome Data

More...OMAi		FLCLEYK

Database of Orthologous Groups

More...OrthoDBi		1145833at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86WB7

TreeFam database of animal gene trees

More...TreeFami		TF314905

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010291, Ion_channel_UNC-93
IPR036259, MFS_trans_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05978, UNC-93, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86WB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRSLRNVLV VSFGFLLLFT AYGGLQSLQS SLYSEEGLGV TALSTLYGGM 
        60         70         80         90        100
LLSSMFLPPL LIERLGCKGT IILSMCGYVA FSVGNFFASW YTLIPTSILL 
       110        120        130        140        150
GLGAAPLWSA QCTYLTITGN THAEKAGKRG KDMVNQYFGI FFLIFQSSGV 
       160        170        180        190        200
WGNLISSLVF GQTPSQETLP EEQLTSCGAS DCLMATTTTN STQRPSQQLV 
       210        220        230        240        250
YTLLGIYTGS GVLAVLMIAA FLQPIRDVQR ESEGEKKSVP FWSTLLSTFK 
       260        270        280        290        300
LYRDKRLCLL ILLPLYSGLQ QGFLSSEYTR SYVTCTLGIQ FVGYVMICFS 
       310        320        330        340        350
ATDALCSVLY GKVSQYTGRA VLYVLGAVTH VSCMIALLLW RPRADHLAVF 
       360        370        380        390        400
FVFSGLWGVA DAVWQTQNNA LYGVLFEKSK EAAFANYRLW EALGFVIAFG 
       410        420        430        440        450
YSMFLCVHVK LYILLGVLSL TMVAYGLVEC VESKNPIRPH APGQVNQAED 

EEIQTKM
Length:457
Mass (Da):50,270
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB73491988637AA26
GO
Isoform 2 (identifier: Q86WB7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     167-208: Missing.

Show »
Length:415
Mass (Da):45,721
Checksum:i318D73E77F926E26
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RFH7D6RFH7_HUMAN
Protein unc-93 homolog A
UNC93A
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0524736R → K. Corresponds to variant dbSNP:rs36110805Ensembl.1
Natural variantiVAR_052474128K → Q. Corresponds to variant dbSNP:rs35313366Ensembl.1
Natural variantiVAR_022650292V → I1 PublicationCorresponds to variant dbSNP:rs2072767Ensembl.1
Natural variantiVAR_052475295V → M. Corresponds to variant dbSNP:rs4708771Ensembl.1
Natural variantiVAR_061874308V → M. Corresponds to variant dbSNP:rs35854179EnsemblClinVar.1
Natural variantiVAR_022651387Y → H1 PublicationCorresponds to variant dbSNP:rs663227Ensembl.1
Natural variantiVAR_059849403M → I. Corresponds to variant dbSNP:rs9459921EnsemblClinVar.1
Natural variantiVAR_022652403M → T1 PublicationCorresponds to variant dbSNP:rs663606EnsemblClinVar.1
Natural variantiVAR_022653409V → I1 PublicationCorresponds to variant dbSNP:rs7739897Ensembl.1
Natural variantiVAR_022654445V → A1 PublicationCorresponds to variant dbSNP:rs752323292Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042772167 – 208Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ508812 mRNA Translation: CAD48541.1
AJ422141 mRNA Translation: CAD19521.1
AK091987 mRNA Translation: BAG52457.1
AL021331 Genomic DNA No translation available.
BC098248 mRNA Translation: AAH98248.1
BC099718 mRNA Translation: AAH99718.1
BC105635 mRNA Translation: AAI05636.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47515.1 [Q86WB7-2]
CCDS5300.1 [Q86WB7-1]

NCBI Reference Sequences

More...RefSeqi		NP_001137419.1, NM_001143947.1 [Q86WB7-2]
NP_061847.2, NM_018974.3 [Q86WB7-1]
XP_011534207.1, XM_011535905.2 [Q86WB7-1]
XP_011534208.1, XM_011535906.2 [Q86WB7-1]
XP_011534209.1, XM_011535907.2 [Q86WB7-1]
XP_016866447.1, XM_017010958.1 [Q86WB7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000230256; ENSP00000230256; ENSG00000112494 [Q86WB7-1]
ENST00000366829; ENSP00000355794; ENSG00000112494 [Q86WB7-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54346

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54346

UCSC genome browser

More...UCSCi		uc003qvq.4, human [Q86WB7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ508812 mRNA Translation: CAD48541.1
AJ422141 mRNA Translation: CAD19521.1
AK091987 mRNA Translation: BAG52457.1
AL021331 Genomic DNA No translation available.
BC098248 mRNA Translation: AAH98248.1
BC099718 mRNA Translation: AAH99718.1
BC105635 mRNA Translation: AAI05636.1
CCDSiCCDS47515.1 [Q86WB7-2]
CCDS5300.1 [Q86WB7-1]
RefSeqiNP_001137419.1, NM_001143947.1 [Q86WB7-2]
NP_061847.2, NM_018974.3 [Q86WB7-1]
XP_011534207.1, XM_011535905.2 [Q86WB7-1]
XP_011534208.1, XM_011535906.2 [Q86WB7-1]
XP_011534209.1, XM_011535907.2 [Q86WB7-1]
XP_016866447.1, XM_017010958.1 [Q86WB7-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi119937, 23 interactors
IntActiQ86WB7, 19 interactors
STRINGi9606.ENSP00000230256

PTM databases

GlyGeniQ86WB7, 1 site

Polymorphism and mutation databases

BioMutaiUNC93A
DMDMi67462066

Proteomic databases

MassIVEiQ86WB7
PaxDbiQ86WB7
PeptideAtlasiQ86WB7
PRIDEiQ86WB7
ProteomicsDBi70143 [Q86WB7-1]
70144 [Q86WB7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33537, 97 antibodies

Genome annotation databases

EnsembliENST00000230256; ENSP00000230256; ENSG00000112494 [Q86WB7-1]
ENST00000366829; ENSP00000355794; ENSG00000112494 [Q86WB7-2]
GeneIDi54346
KEGGihsa:54346
UCSCiuc003qvq.4, human [Q86WB7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54346
DisGeNETi54346
EuPathDBiHostDB:ENSG00000112494.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		UNC93A
HGNCiHGNC:12570, UNC93A
HPAiENSG00000112494, Tissue enhanced (intestine, liver, skin)
MIMi607995, gene
neXtProtiNX_Q86WB7
OpenTargetsiENSG00000112494
PharmGKBiPA37207

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3097, Eukaryota
GeneTreeiENSGT00530000063359
HOGENOMiCLU_025356_1_1_1
InParanoidiQ86WB7
OMAiFLCLEYK
OrthoDBi1145833at2759
PhylomeDBiQ86WB7
TreeFamiTF314905

Enzyme and pathway databases

PathwayCommonsiQ86WB7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54346, 2 hits in 839 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54346
PharosiQ86WB7, Tdark

Protein Ontology

More...PROi		PR:Q86WB7
RNActiQ86WB7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000112494, Expressed in skin of leg and 57 other tissues
ExpressionAtlasiQ86WB7, baseline and differential
GenevisibleiQ86WB7, HS

Family and domain databases

InterProiView protein in InterPro
IPR010291, Ion_channel_UNC-93
IPR036259, MFS_trans_sf
PfamiView protein in Pfam
PF05978, UNC-93, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUN93A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86WB7
Secondary accession number(s): B3KRP5, Q4QQJ4, Q5JZD6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2003
Last modified: December 2, 2020
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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