UniProtKB - Q86WB7 (UN93A_HUMAN)
Protein
Protein unc-93 homolog A
Gene
UNC93A
Organism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
Although UNC93A gene is located in a region of the genome frequently associated with ovarian cancer, no evidence have been found for a tumor suppressor function.
Enzyme and pathway databases
PathwayCommonsi | Q86WB7 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein unc-93 homolog AShort name: HmUnc-93A Short name: Unc-93A |
Gene namesi | Name:UNC93A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000112494.9 |
HGNCi | HGNC:12570, UNC93A |
MIMi | 607995, gene |
neXtProti | NX_Q86WB7 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 8 – 28 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 42 – 62 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 65 – 85 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 86 – 106 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 140 – 160 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 202 – 222 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 257 – 277 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 291 – 311 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 320 – 340 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 344 – 364 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 395 – 415 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 54346 |
OpenTargetsi | ENSG00000112494 |
PharmGKBi | PA37207 |
Miscellaneous databases
Pharosi | Q86WB7, Tdark |
Polymorphism and mutation databases
BioMutai | UNC93A |
DMDMi | 67462066 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190036 | 1 – 457 | Protein unc-93 homolog AAdd BLAST | 457 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 190 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | Q86WB7 |
PaxDbi | Q86WB7 |
PeptideAtlasi | Q86WB7 |
PRIDEi | Q86WB7 |
ProteomicsDBi | 70143 [Q86WB7-1] 70144 [Q86WB7-2] |
PTM databases
GlyGeni | Q86WB7, 1 site |
Expressioni
Tissue specificityi
Expressed in testis, small intestine, spleen, prostate and ovary.1 Publication
Gene expression databases
Bgeei | ENSG00000112494, Expressed in skin of leg and 57 other tissues |
ExpressionAtlasi | Q86WB7, baseline and differential |
Genevisiblei | Q86WB7, HS |
Organism-specific databases
HPAi | ENSG00000112494, Tissue enhanced (intestine, liver, skin) |
Interactioni
Binary interactionsi
Hide detailsIsoform 2 [Q86WB7-2]
Protein-protein interaction databases
BioGRIDi | 119937, 23 interactors |
IntActi | Q86WB7, 19 interactors |
STRINGi | 9606.ENSP00000230256 |
Miscellaneous databases
RNActi | Q86WB7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the unc-93 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3097, Eukaryota |
GeneTreei | ENSGT00530000063359 |
HOGENOMi | CLU_025356_1_1_1 |
InParanoidi | Q86WB7 |
OMAi | FLCLEYK |
OrthoDBi | 1145833at2759 |
PhylomeDBi | Q86WB7 |
TreeFami | TF314905 |
Family and domain databases
InterProi | View protein in InterPro IPR010291, Ion_channel_UNC-93 IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF05978, UNC-93, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q86WB7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDRSLRNVLV VSFGFLLLFT AYGGLQSLQS SLYSEEGLGV TALSTLYGGM
60 70 80 90 100
LLSSMFLPPL LIERLGCKGT IILSMCGYVA FSVGNFFASW YTLIPTSILL
110 120 130 140 150
GLGAAPLWSA QCTYLTITGN THAEKAGKRG KDMVNQYFGI FFLIFQSSGV
160 170 180 190 200
WGNLISSLVF GQTPSQETLP EEQLTSCGAS DCLMATTTTN STQRPSQQLV
210 220 230 240 250
YTLLGIYTGS GVLAVLMIAA FLQPIRDVQR ESEGEKKSVP FWSTLLSTFK
260 270 280 290 300
LYRDKRLCLL ILLPLYSGLQ QGFLSSEYTR SYVTCTLGIQ FVGYVMICFS
310 320 330 340 350
ATDALCSVLY GKVSQYTGRA VLYVLGAVTH VSCMIALLLW RPRADHLAVF
360 370 380 390 400
FVFSGLWGVA DAVWQTQNNA LYGVLFEKSK EAAFANYRLW EALGFVIAFG
410 420 430 440 450
YSMFLCVHVK LYILLGVLSL TMVAYGLVEC VESKNPIRPH APGQVNQAED
EEIQTKM
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6RFH7 | D6RFH7_HUMAN | Protein unc-93 homolog A | UNC93A | 144 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052473 | 6 | R → K. Corresponds to variant dbSNP:rs36110805Ensembl. | 1 | |
Natural variantiVAR_052474 | 128 | K → Q. Corresponds to variant dbSNP:rs35313366Ensembl. | 1 | |
Natural variantiVAR_022650 | 292 | V → I1 PublicationCorresponds to variant dbSNP:rs2072767Ensembl. | 1 | |
Natural variantiVAR_052475 | 295 | V → M. Corresponds to variant dbSNP:rs4708771Ensembl. | 1 | |
Natural variantiVAR_061874 | 308 | V → M. Corresponds to variant dbSNP:rs35854179EnsemblClinVar. | 1 | |
Natural variantiVAR_022651 | 387 | Y → H1 PublicationCorresponds to variant dbSNP:rs663227Ensembl. | 1 | |
Natural variantiVAR_059849 | 403 | M → I. Corresponds to variant dbSNP:rs9459921EnsemblClinVar. | 1 | |
Natural variantiVAR_022652 | 403 | M → T1 PublicationCorresponds to variant dbSNP:rs663606EnsemblClinVar. | 1 | |
Natural variantiVAR_022653 | 409 | V → I1 PublicationCorresponds to variant dbSNP:rs7739897Ensembl. | 1 | |
Natural variantiVAR_022654 | 445 | V → A1 PublicationCorresponds to variant dbSNP:rs752323292Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042772 | 167 – 208 | Missing in isoform 2. 1 PublicationAdd BLAST | 42 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ508812 mRNA Translation: CAD48541.1 AJ422141 mRNA Translation: CAD19521.1 AK091987 mRNA Translation: BAG52457.1 AL021331 Genomic DNA No translation available. BC098248 mRNA Translation: AAH98248.1 BC099718 mRNA Translation: AAH99718.1 BC105635 mRNA Translation: AAI05636.1 |
CCDSi | CCDS47515.1 [Q86WB7-2] CCDS5300.1 [Q86WB7-1] |
RefSeqi | NP_001137419.1, NM_001143947.1 [Q86WB7-2] NP_061847.2, NM_018974.3 [Q86WB7-1] XP_011534207.1, XM_011535905.2 [Q86WB7-1] XP_011534208.1, XM_011535906.2 [Q86WB7-1] XP_011534209.1, XM_011535907.2 [Q86WB7-1] XP_016866447.1, XM_017010958.1 [Q86WB7-1] |
Genome annotation databases
Ensembli | ENST00000230256; ENSP00000230256; ENSG00000112494 [Q86WB7-1] ENST00000366829; ENSP00000355794; ENSG00000112494 [Q86WB7-2] |
GeneIDi | 54346 |
KEGGi | hsa:54346 |
UCSCi | uc003qvq.4, human [Q86WB7-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ508812 mRNA Translation: CAD48541.1 AJ422141 mRNA Translation: CAD19521.1 AK091987 mRNA Translation: BAG52457.1 AL021331 Genomic DNA No translation available. BC098248 mRNA Translation: AAH98248.1 BC099718 mRNA Translation: AAH99718.1 BC105635 mRNA Translation: AAI05636.1 |
CCDSi | CCDS47515.1 [Q86WB7-2] CCDS5300.1 [Q86WB7-1] |
RefSeqi | NP_001137419.1, NM_001143947.1 [Q86WB7-2] NP_061847.2, NM_018974.3 [Q86WB7-1] XP_011534207.1, XM_011535905.2 [Q86WB7-1] XP_011534208.1, XM_011535906.2 [Q86WB7-1] XP_011534209.1, XM_011535907.2 [Q86WB7-1] XP_016866447.1, XM_017010958.1 [Q86WB7-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119937, 23 interactors |
IntActi | Q86WB7, 19 interactors |
STRINGi | 9606.ENSP00000230256 |
PTM databases
GlyGeni | Q86WB7, 1 site |
Polymorphism and mutation databases
BioMutai | UNC93A |
DMDMi | 67462066 |
Proteomic databases
MassIVEi | Q86WB7 |
PaxDbi | Q86WB7 |
PeptideAtlasi | Q86WB7 |
PRIDEi | Q86WB7 |
ProteomicsDBi | 70143 [Q86WB7-1] 70144 [Q86WB7-2] |
Protocols and materials databases
Antibodypediai | 33537, 97 antibodies |
Genome annotation databases
Ensembli | ENST00000230256; ENSP00000230256; ENSG00000112494 [Q86WB7-1] ENST00000366829; ENSP00000355794; ENSG00000112494 [Q86WB7-2] |
GeneIDi | 54346 |
KEGGi | hsa:54346 |
UCSCi | uc003qvq.4, human [Q86WB7-1] |
Organism-specific databases
CTDi | 54346 |
DisGeNETi | 54346 |
EuPathDBi | HostDB:ENSG00000112494.9 |
GeneCardsi | UNC93A |
HGNCi | HGNC:12570, UNC93A |
HPAi | ENSG00000112494, Tissue enhanced (intestine, liver, skin) |
MIMi | 607995, gene |
neXtProti | NX_Q86WB7 |
OpenTargetsi | ENSG00000112494 |
PharmGKBi | PA37207 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3097, Eukaryota |
GeneTreei | ENSGT00530000063359 |
HOGENOMi | CLU_025356_1_1_1 |
InParanoidi | Q86WB7 |
OMAi | FLCLEYK |
OrthoDBi | 1145833at2759 |
PhylomeDBi | Q86WB7 |
TreeFami | TF314905 |
Enzyme and pathway databases
PathwayCommonsi | Q86WB7 |
Miscellaneous databases
BioGRID-ORCSi | 54346, 2 hits in 839 CRISPR screens |
GenomeRNAii | 54346 |
Pharosi | Q86WB7, Tdark |
PROi | PR:Q86WB7 |
RNActi | Q86WB7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112494, Expressed in skin of leg and 57 other tissues |
ExpressionAtlasi | Q86WB7, baseline and differential |
Genevisiblei | Q86WB7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR010291, Ion_channel_UNC-93 IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF05978, UNC-93, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UN93A_HUMAN | |
Accessioni | Q86WB7Primary (citable) accession number: Q86WB7 Secondary accession number(s): B3KRP5, Q4QQJ4, Q5JZD6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | June 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations