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Protein

Protein unc-93 homolog A

Gene

UNC93A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Although UNC93A gene is located in a region of the genome frequently associated with ovarian cancer, no evidence have been found for a tumor suppressor function.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein unc-93 homolog A
Short name:
HmUnc-93A
Short name:
Unc-93A
Gene namesi
Name:UNC93A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112494.9
HGNCiHGNC:12570 UNC93A
MIMi607995 gene
neXtProtiNX_Q86WB7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54346
OpenTargetsiENSG00000112494
PharmGKBiPA37207

Polymorphism and mutation databases

BioMutaiUNC93A
DMDMi67462066

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900361 – 457Protein unc-93 homolog AAdd BLAST457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86WB7
PeptideAtlasiQ86WB7
PRIDEiQ86WB7
ProteomicsDBi70143
70144 [Q86WB7-2]

Expressioni

Tissue specificityi

Expressed in testis, small intestine, spleen, prostate and ovary.1 Publication

Gene expression databases

BgeeiENSG00000112494 Expressed in 37 organ(s), highest expression level in skin of leg
CleanExiHS_UNC93A
ExpressionAtlasiQ86WB7 baseline and differential
GenevisibleiQ86WB7 HS

Organism-specific databases

HPAiHPA035729

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TMEM237Q96Q45-24EBI-13356252,EBI-10982110

Protein-protein interaction databases

IntActiQ86WB7, 16 interactors
STRINGi9606.ENSP00000230256

Structurei

3D structure databases

ProteinModelPortaliQ86WB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the unc-93 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3097 Eukaryota
ENOG410XTFP LUCA
GeneTreeiENSGT00530000063359
HOGENOMiHOG000007567
HOVERGENiHBG080785
InParanoidiQ86WB7
OMAiKRFGCKW
OrthoDBiEOG091G07EN
PhylomeDBiQ86WB7
TreeFamiTF314905

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR010291 Ion_channel_UNC-93
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF05978 UNC-93, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86WB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRSLRNVLV VSFGFLLLFT AYGGLQSLQS SLYSEEGLGV TALSTLYGGM
60 70 80 90 100
LLSSMFLPPL LIERLGCKGT IILSMCGYVA FSVGNFFASW YTLIPTSILL
110 120 130 140 150
GLGAAPLWSA QCTYLTITGN THAEKAGKRG KDMVNQYFGI FFLIFQSSGV
160 170 180 190 200
WGNLISSLVF GQTPSQETLP EEQLTSCGAS DCLMATTTTN STQRPSQQLV
210 220 230 240 250
YTLLGIYTGS GVLAVLMIAA FLQPIRDVQR ESEGEKKSVP FWSTLLSTFK
260 270 280 290 300
LYRDKRLCLL ILLPLYSGLQ QGFLSSEYTR SYVTCTLGIQ FVGYVMICFS
310 320 330 340 350
ATDALCSVLY GKVSQYTGRA VLYVLGAVTH VSCMIALLLW RPRADHLAVF
360 370 380 390 400
FVFSGLWGVA DAVWQTQNNA LYGVLFEKSK EAAFANYRLW EALGFVIAFG
410 420 430 440 450
YSMFLCVHVK LYILLGVLSL TMVAYGLVEC VESKNPIRPH APGQVNQAED

EEIQTKM
Length:457
Mass (Da):50,270
Last modified:June 1, 2003 - v1
Checksum:iB73491988637AA26
GO
Isoform 2 (identifier: Q86WB7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     167-208: Missing.

Note: No experimental confirmation available.
Show »
Length:415
Mass (Da):45,721
Checksum:i318D73E77F926E26
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RFH7D6RFH7_HUMAN
Protein unc-93 homolog A
UNC93A
144Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0524736R → K. Corresponds to variant dbSNP:rs36110805Ensembl.1
Natural variantiVAR_052474128K → Q. Corresponds to variant dbSNP:rs35313366Ensembl.1
Natural variantiVAR_022650292V → I1 PublicationCorresponds to variant dbSNP:rs2072767Ensembl.1
Natural variantiVAR_052475295V → M. Corresponds to variant dbSNP:rs4708771Ensembl.1
Natural variantiVAR_061874308V → M. Corresponds to variant dbSNP:rs35854179Ensembl.1
Natural variantiVAR_022651387Y → H1 PublicationCorresponds to variant dbSNP:rs663227Ensembl.1
Natural variantiVAR_059849403M → I. Corresponds to variant dbSNP:rs9459921Ensembl.1
Natural variantiVAR_022652403M → T1 PublicationCorresponds to variant dbSNP:rs663606Ensembl.1
Natural variantiVAR_022653409V → I1 PublicationCorresponds to variant dbSNP:rs7739897Ensembl.1
Natural variantiVAR_022654445V → A1 PublicationCorresponds to variant dbSNP:rs752323292Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042772167 – 208Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ508812 mRNA Translation: CAD48541.1
AJ422141 mRNA Translation: CAD19521.1
AK091987 mRNA Translation: BAG52457.1
AL021331 Genomic DNA No translation available.
BC098248 mRNA Translation: AAH98248.1
BC099718 mRNA Translation: AAH99718.1
BC105635 mRNA Translation: AAI05636.1
CCDSiCCDS47515.1 [Q86WB7-2]
CCDS5300.1 [Q86WB7-1]
RefSeqiNP_001137419.1, NM_001143947.1 [Q86WB7-2]
NP_061847.2, NM_018974.3 [Q86WB7-1]
XP_011534207.1, XM_011535905.2 [Q86WB7-1]
XP_011534208.1, XM_011535906.2 [Q86WB7-1]
XP_011534209.1, XM_011535907.2 [Q86WB7-1]
XP_016866447.1, XM_017010958.1 [Q86WB7-1]
UniGeneiHs.567508

Genome annotation databases

EnsembliENST00000230256; ENSP00000230256; ENSG00000112494 [Q86WB7-1]
ENST00000366829; ENSP00000355794; ENSG00000112494 [Q86WB7-2]
GeneIDi54346
KEGGihsa:54346
UCSCiuc003qvq.4 human [Q86WB7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ508812 mRNA Translation: CAD48541.1
AJ422141 mRNA Translation: CAD19521.1
AK091987 mRNA Translation: BAG52457.1
AL021331 Genomic DNA No translation available.
BC098248 mRNA Translation: AAH98248.1
BC099718 mRNA Translation: AAH99718.1
BC105635 mRNA Translation: AAI05636.1
CCDSiCCDS47515.1 [Q86WB7-2]
CCDS5300.1 [Q86WB7-1]
RefSeqiNP_001137419.1, NM_001143947.1 [Q86WB7-2]
NP_061847.2, NM_018974.3 [Q86WB7-1]
XP_011534207.1, XM_011535905.2 [Q86WB7-1]
XP_011534208.1, XM_011535906.2 [Q86WB7-1]
XP_011534209.1, XM_011535907.2 [Q86WB7-1]
XP_016866447.1, XM_017010958.1 [Q86WB7-1]
UniGeneiHs.567508

3D structure databases

ProteinModelPortaliQ86WB7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ86WB7, 16 interactors
STRINGi9606.ENSP00000230256

Polymorphism and mutation databases

BioMutaiUNC93A
DMDMi67462066

Proteomic databases

PaxDbiQ86WB7
PeptideAtlasiQ86WB7
PRIDEiQ86WB7
ProteomicsDBi70143
70144 [Q86WB7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230256; ENSP00000230256; ENSG00000112494 [Q86WB7-1]
ENST00000366829; ENSP00000355794; ENSG00000112494 [Q86WB7-2]
GeneIDi54346
KEGGihsa:54346
UCSCiuc003qvq.4 human [Q86WB7-1]

Organism-specific databases

CTDi54346
DisGeNETi54346
EuPathDBiHostDB:ENSG00000112494.9
GeneCardsiUNC93A
HGNCiHGNC:12570 UNC93A
HPAiHPA035729
MIMi607995 gene
neXtProtiNX_Q86WB7
OpenTargetsiENSG00000112494
PharmGKBiPA37207
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3097 Eukaryota
ENOG410XTFP LUCA
GeneTreeiENSGT00530000063359
HOGENOMiHOG000007567
HOVERGENiHBG080785
InParanoidiQ86WB7
OMAiKRFGCKW
OrthoDBiEOG091G07EN
PhylomeDBiQ86WB7
TreeFamiTF314905

Miscellaneous databases

GenomeRNAii54346
PROiPR:Q86WB7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112494 Expressed in 37 organ(s), highest expression level in skin of leg
CleanExiHS_UNC93A
ExpressionAtlasiQ86WB7 baseline and differential
GenevisibleiQ86WB7 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR010291 Ion_channel_UNC-93
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF05978 UNC-93, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUN93A_HUMAN
AccessioniPrimary (citable) accession number: Q86WB7
Secondary accession number(s): B3KRP5, Q4QQJ4, Q5JZD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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