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UniProtKB - Q86WB0 (NIPA_HUMAN)

Entry version 155 (02 Jun 2021)
Sequence version 1 (01 Jun 2003)
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Protein

Nuclear-interacting partner of ALK

Gene

ZC3HC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.

1 Publication

Caution

Reported to contain a F-box domain (PubMed:16009132). Such domain is however not predicted by any detection method.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri102 – 156C3HC-typeAdd BLAST55

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86WB0

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q86WB0

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear-interacting partner of ALK
Alternative name(s):
Nuclear-interacting partner of anaplastic lymphoma kinase
Short name:
hNIPA
Zinc finger C3HC-type protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZC3HC1
Synonyms:NIPA
ORF Names:HSPC216
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29913, ZC3HC1

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86WB0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000091732.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi105Y → F: Does not strongly affect phosphorylation status; when associated with F-137. 1 Publication1
Mutagenesisi137Y → F: Does not strongly affect phosphorylation status; when associated with F-105. 1 Publication1
Mutagenesisi170 – 171LP → FM: Abolishes interaction with SKP1. 1 Publication2
Mutagenesisi354S → A: Strongly reduces phosphorylation and induces the formation of a constitutive SCF(NIPA) E3 complex that degrades CCNB1 at G2/M phase and delays mitotic entry. 2 Publications1
Mutagenesisi398 – 401RKAK → AAAA: Induces a complete cytoplasmic redistribution. 1 Publication4
Mutagenesisi399K → P: Induces a partial cytoplasmic redistribution. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		51530

Open Targets

More...OpenTargetsi		ENSG00000091732

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134931869

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86WB0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZC3HC1

Domain mapping of disease mutations (DMDM)

More...DMDMi		73921220

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000968492 – 502Nuclear-interacting partner of ALKAdd BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei28PhosphothreonineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei62PhosphoserineCombined sources1
Modified residuei84PhosphothreonineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei329PhosphoserineCombined sources1
Modified residuei333PhosphothreonineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Modified residuei344PhosphoserineCombined sources1
Modified residuei354PhosphoserineCombined sources1 Publication1
Modified residuei359PhosphoserineCombined sources1
Modified residuei370PhosphoserineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Modified residuei384PhosphothreonineCombined sources1
Modified residuei387PhosphothreonineCombined sources1
Modified residuei395PhosphoserineCombined sources1
Modified residuei407PhosphoserineCombined sources1
Modified residuei483PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylated on Ser residues at G2/M phase, but not during S and G0 phases. May also be weakly phosphorylated on Tyr residues. Ser-354 phosphorylation, a major site during the course of cell-cycle-dependent phosphorylation, results in its dissociation from the SCF(NIPA) complex, thereby preventing CCNB1 degradation leading to mitotic entry.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q86WB0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q86WB0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86WB0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86WB0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86WB0

PeptideAtlas

More...PeptideAtlasi		Q86WB0

PRoteomics IDEntifications database

More...PRIDEi		Q86WB0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70140 [Q86WB0-1]
70141 [Q86WB0-2]
70142 [Q86WB0-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86WB0

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q86WB0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86WB0

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q86WB0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Weakly expressed in G0/G1 phases, abundant during S and G2/M phases, and strongly decreases thereafter.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000091732, Expressed in quadriceps femoris and 205 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86WB0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86WB0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000091732, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the NPM-ALK fusion protein in a tyrosine phosphorylation-dependent manner.

Interacts with SKP1.

Component of a SCF(NIPA) E3 complex with SKP1, RBX1 and CUL1 when not phosphorylated on Ser-354.

Interacts with CCNB1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119592, 42 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q86WB0

Protein interaction database and analysis system

More...IntActi		Q86WB0, 21 interactors

Molecular INTeraction database

More...MINTi		Q86WB0

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000351052

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86WB0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni36 – 73DisorderedSequence analysisAdd BLAST38
Regioni170 – 210F-box-likeAdd BLAST41
Regioni302 – 423DisorderedSequence analysisAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi396 – 402Nuclear localization signal1 Publication7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi50 – 73Polar residuesSequence analysisAdd BLAST24
Compositional biasi326 – 359Polar residuesSequence analysisAdd BLAST34
Compositional biasi404 – 422Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The F-box-like region is required for the interaction with SKP1.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri102 – 156C3HC-typeAdd BLAST55

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4765, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006086

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86WB0

Identification of Orthologs from Complete Genome Data

More...OMAi		SLPILTC

Database of Orthologous Groups

More...OrthoDBi		1626741at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86WB0

TreeFam database of animal gene trees

More...TreeFami		TF314674

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013909, NIPA/Rsm1
IPR012935, Znf_C3HC-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08600, Rsm1, 1 hit
PF07967, zf-C3HC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86WB0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPCEGQAF AVGVEKNWGA VVRSPEGTPQ KIRQLIDEGI APEEGGVDAK 
        60         70         80         90        100
DTSATSQSVN GSPQAEQPSL ESTSKEAFFS RVETFSSLKW AGKPFELSPL 
       110        120        130        140        150
VCAKYGWVTV ECDMLKCSSC QAFLCASLQP AFDFDRYKQR CAELKKALCT 
       160        170        180        190        200
AHEKFCFWPD SPSPDRFGML PLDEPAILVS EFLDRFQSLC HLDLQLPSLR 
       210        220        230        240        250
PEDLKTMCLT EDKISLLLHL LEDELDHRTD ERKTTIKLGS DIQVHVTACI 
       260        270        280        290        300
LSVCGWACSS SLESMQLSLI TCSQCMRKVG LWGFQQIESS MTDLDASFGL 
       310        320        330        340        350
TSSPIPGLEG RPERLPLVPE SPRRMMTRSQ DATFSPGSEQ AEKSPGPIVS 
       360        370        380        390        400
RTRSWDSSSP VDRPEPEAAS PTTRTRPVTR SMGTGDTPGL EVPSSPLRKA 
       410        420        430        440        450
KRARLCSSSS SDTSSRSFFD PTSQHRDWCP WVNITLGKES RENGGTEPDA 
       460        470        480        490        500
SAPAEPGWKA VLTILLAHKQ SSQPAETDSM SLSEKSRKVF RIFRQWESLC 

SC
Length:502
Mass (Da):55,262
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD5DEDF9E30070586
GO
Isoform 2 (identifier: Q86WB0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: MAAPCEGQAF...IAPEEGGVDA → MRGLPRKREAWTQPHPLEALYESLRVLE

Show »
Length:481
Mass (Da):53,559
Checksum:iB0EF4F07386A8554
GO
Isoform 3 (identifier: Q86WB0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     341-411: Missing.

Show »
Length:431
Mass (Da):47,771
Checksum:iEC1DCB8077C127C7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J0I9C9J0I9_HUMAN
Nuclear-interacting partner of ALK
ZC3HC1
459Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAU5F8WAU5_HUMAN
Nuclear-interacting partner of ALK
ZC3HC1
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBD7F8WBD7_HUMAN
Nuclear-interacting partner of ALK
ZC3HC1
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDK5F8WDK5_HUMAN
Nuclear-interacting partner of ALK
ZC3HC1
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF13F8WF13_HUMAN
Nuclear-interacting partner of ALK
ZC3HC1
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF36136 differs from that shown. Reason: Frameshift.Curated
The sequence AAH28917 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAS07546 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAS07547 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti179V → I in BAB14024 (PubMed:14702039).Curated1
Sequence conflicti278K → R in AAF36136 (PubMed:11042152).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_023312271T → A1 PublicationCorresponds to variant dbSNP:rs1464890Ensembl.1
Natural variantiVAR_023313363R → H1 PublicationCorresponds to variant dbSNP:rs11556924Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0152171 – 49MAAPC…GGVDA → MRGLPRKREAWTQPHPLEAL YESLRVLE in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_015218341 – 411Missing in isoform 3. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ537494 mRNA Translation: CAD61161.1
AF151050 mRNA Translation: AAF36136.1 Frameshift.
AK001317 mRNA Translation: BAA91619.1
AK022373 mRNA Translation: BAB14024.1
AC073320 Genomic DNA Translation: AAS07546.1 Sequence problems.
AC073320 Genomic DNA Translation: AAS07547.1 Sequence problems.
AC087071 Genomic DNA No translation available.
BC011551 mRNA Translation: AAH11551.1
BC028917 mRNA Translation: AAH28917.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34753.1 [Q86WB0-1]
CCDS64767.1 [Q86WB0-2]
CCDS75659.1 [Q86WB0-3]

NCBI Reference Sequences

More...RefSeqi		NP_001269119.1, NM_001282190.1 [Q86WB0-2]
NP_001269120.1, NM_001282191.1 [Q86WB0-3]
NP_057562.3, NM_016478.4 [Q86WB0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000311873; ENSP00000309301; ENSG00000091732 [Q86WB0-2]
ENST00000358303; ENSP00000351052; ENSG00000091732 [Q86WB0-1]
ENST00000360708; ENSP00000353933; ENSG00000091732 [Q86WB0-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51530

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51530

UCSC genome browser

More...UCSCi		uc003vpi.4, human [Q86WB0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ537494 mRNA Translation: CAD61161.1
AF151050 mRNA Translation: AAF36136.1 Frameshift.
AK001317 mRNA Translation: BAA91619.1
AK022373 mRNA Translation: BAB14024.1
AC073320 Genomic DNA Translation: AAS07546.1 Sequence problems.
AC073320 Genomic DNA Translation: AAS07547.1 Sequence problems.
AC087071 Genomic DNA No translation available.
BC011551 mRNA Translation: AAH11551.1
BC028917 mRNA Translation: AAH28917.1 Different initiation.
CCDSiCCDS34753.1 [Q86WB0-1]
CCDS64767.1 [Q86WB0-2]
CCDS75659.1 [Q86WB0-3]
RefSeqiNP_001269119.1, NM_001282190.1 [Q86WB0-2]
NP_001269120.1, NM_001282191.1 [Q86WB0-3]
NP_057562.3, NM_016478.4 [Q86WB0-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi119592, 42 interactors
CORUMiQ86WB0
IntActiQ86WB0, 21 interactors
MINTiQ86WB0
STRINGi9606.ENSP00000351052

PTM databases

iPTMnetiQ86WB0
MetOSiteiQ86WB0
PhosphoSitePlusiQ86WB0
SwissPalmiQ86WB0

Genetic variation databases

BioMutaiZC3HC1
DMDMi73921220

Proteomic databases

EPDiQ86WB0
jPOSTiQ86WB0
MassIVEiQ86WB0
MaxQBiQ86WB0
PaxDbiQ86WB0
PeptideAtlasiQ86WB0
PRIDEiQ86WB0
ProteomicsDBi70140 [Q86WB0-1]
70141 [Q86WB0-2]
70142 [Q86WB0-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17928, 253 antibodies

The DNASU plasmid repository

More...DNASUi		51530

Genome annotation databases

EnsembliENST00000311873; ENSP00000309301; ENSG00000091732 [Q86WB0-2]
ENST00000358303; ENSP00000351052; ENSG00000091732 [Q86WB0-1]
ENST00000360708; ENSP00000353933; ENSG00000091732 [Q86WB0-3]
GeneIDi51530
KEGGihsa:51530
UCSCiuc003vpi.4, human [Q86WB0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51530
DisGeNETi51530

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZC3HC1
HGNCiHGNC:29913, ZC3HC1
HPAiENSG00000091732, Low tissue specificity
neXtProtiNX_Q86WB0
OpenTargetsiENSG00000091732
PharmGKBiPA134931869
VEuPathDBiHostDB:ENSG00000091732.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4765, Eukaryota
GeneTreeiENSGT00390000006086
InParanoidiQ86WB0
OMAiSLPILTC
OrthoDBi1626741at2759
PhylomeDBiQ86WB0
TreeFamiTF314674

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ86WB0
SIGNORiQ86WB0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51530, 49 hits in 1002 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZC3HC1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ZC3HC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51530
PharosiQ86WB0, Tbio

Protein Ontology

More...PROi		PR:Q86WB0
RNActiQ86WB0, protein

Gene expression databases

BgeeiENSG00000091732, Expressed in quadriceps femoris and 205 other tissues
ExpressionAtlasiQ86WB0, baseline and differential
GenevisibleiQ86WB0, HS

Family and domain databases

InterProiView protein in InterPro
IPR013909, NIPA/Rsm1
IPR012935, Znf_C3HC-like
PfamiView protein in Pfam
PF08600, Rsm1, 1 hit
PF07967, zf-C3HC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNIPA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86WB0
Secondary accession number(s): A6NH66
, Q75MF3, Q75MF4, Q8N330, Q96F75, Q9HA34, Q9NVX4, Q9P0R0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2003
Last modified: June 2, 2021
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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