UniProtKB - Q86WB0 (NIPA_HUMAN)
Nuclear-interacting partner of ALK
ZC3HC1
Functioni
Caution
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 102 – 156 | C3HC-typeAdd BLAST | 55 |
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
- protein ubiquitination Source: UniProtKB-UniPathway
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q86WB0 |
SIGNORi | Q86WB0 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear-interacting partner of ALKAlternative name(s): Nuclear-interacting partner of anaplastic lymphoma kinase Short name: hNIPA Zinc finger C3HC-type protein 1 |
Gene namesi | Name:ZC3HC1 Synonyms:NIPA ORF Names:HSPC216 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29913, ZC3HC1 |
neXtProti | NX_Q86WB0 |
VEuPathDBi | HostDB:ENSG00000091732.15 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nuclear membrane Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: LIFEdb
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 105 | Y → F: Does not strongly affect phosphorylation status; when associated with F-137. 1 Publication | 1 | |
Mutagenesisi | 137 | Y → F: Does not strongly affect phosphorylation status; when associated with F-105. 1 Publication | 1 | |
Mutagenesisi | 170 – 171 | LP → FM: Abolishes interaction with SKP1. 1 Publication | 2 | |
Mutagenesisi | 354 | S → A: Strongly reduces phosphorylation and induces the formation of a constitutive SCF(NIPA) E3 complex that degrades CCNB1 at G2/M phase and delays mitotic entry. 2 Publications | 1 | |
Mutagenesisi | 398 – 401 | RKAK → AAAA: Induces a complete cytoplasmic redistribution. 1 Publication | 4 | |
Mutagenesisi | 399 | K → P: Induces a partial cytoplasmic redistribution. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 51530 |
OpenTargetsi | ENSG00000091732 |
PharmGKBi | PA134931869 |
Miscellaneous databases
Pharosi | Q86WB0, Tbio |
Genetic variation databases
BioMutai | ZC3HC1 |
DMDMi | 73921220 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000096849 | 2 – 502 | Nuclear-interacting partner of ALKAdd BLAST | 501 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 24 | PhosphoserineCombined sources | 1 | |
Modified residuei | 28 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 58 | PhosphoserineCombined sources | 1 | |
Modified residuei | 62 | PhosphoserineCombined sources | 1 | |
Modified residuei | 84 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 321 | PhosphoserineCombined sources | 1 | |
Modified residuei | 329 | PhosphoserineCombined sources | 1 | |
Modified residuei | 333 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 335 | PhosphoserineCombined sources | 1 | |
Modified residuei | 338 | PhosphoserineCombined sources | 1 | |
Modified residuei | 344 | PhosphoserineCombined sources | 1 | |
Modified residuei | 354 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 359 | PhosphoserineCombined sources | 1 | |
Modified residuei | 370 | PhosphoserineCombined sources | 1 | |
Modified residuei | 381 | PhosphoserineCombined sources | 1 | |
Modified residuei | 384 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 387 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 395 | PhosphoserineCombined sources | 1 | |
Modified residuei | 407 | PhosphoserineCombined sources | 1 | |
Modified residuei | 483 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q86WB0 |
jPOSTi | Q86WB0 |
MassIVEi | Q86WB0 |
MaxQBi | Q86WB0 |
PaxDbi | Q86WB0 |
PeptideAtlasi | Q86WB0 |
PRIDEi | Q86WB0 |
ProteomicsDBi | 70140 [Q86WB0-1] 70141 [Q86WB0-2] 70142 [Q86WB0-3] |
PTM databases
iPTMneti | Q86WB0 |
MetOSitei | Q86WB0 |
PhosphoSitePlusi | Q86WB0 |
SwissPalmi | Q86WB0 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000091732, Expressed in quadriceps femoris and 205 other tissues |
ExpressionAtlasi | Q86WB0, baseline and differential |
Genevisiblei | Q86WB0, HS |
Organism-specific databases
HPAi | ENSG00000091732, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with the NPM-ALK fusion protein in a tyrosine phosphorylation-dependent manner.
Interacts with SKP1.
Component of a SCF(NIPA) E3 complex with SKP1, RBX1 and CUL1 when not phosphorylated on Ser-354.
Interacts with CCNB1.
2 PublicationsBinary interactionsi
Hide detailsIsoform 2 [Q86WB0-2]
With | #Exp. | IntAct |
---|---|---|
ATXN1 [P54253] | 6 | EBI-25894765,EBI-930964 |
SPRED1 [Q7Z699] | 3 | EBI-25894765,EBI-5235340 |
UCHL1 [P09936] | 3 | EBI-25894765,EBI-714860 |
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 119592, 39 interactors |
CORUMi | Q86WB0 |
IntActi | Q86WB0, 20 interactors |
MINTi | Q86WB0 |
STRINGi | 9606.ENSP00000351052 |
Miscellaneous databases
RNActi | Q86WB0, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 170 – 210 | F-box-likeAdd BLAST | 41 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 396 – 402 | Nuclear localization signal1 Publication | 7 |
Domaini
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 102 – 156 | C3HC-typeAdd BLAST | 55 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG4765, Eukaryota |
GeneTreei | ENSGT00390000006086 |
InParanoidi | Q86WB0 |
OMAi | SLPILTC |
OrthoDBi | 1626741at2759 |
PhylomeDBi | Q86WB0 |
TreeFami | TF314674 |
Family and domain databases
InterProi | View protein in InterPro IPR013909, NIPA/Rsm1 IPR012935, Znf_C3HC-like |
Pfami | View protein in Pfam PF08600, Rsm1, 1 hit PF07967, zf-C3HC, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAPCEGQAF AVGVEKNWGA VVRSPEGTPQ KIRQLIDEGI APEEGGVDAK
60 70 80 90 100
DTSATSQSVN GSPQAEQPSL ESTSKEAFFS RVETFSSLKW AGKPFELSPL
110 120 130 140 150
VCAKYGWVTV ECDMLKCSSC QAFLCASLQP AFDFDRYKQR CAELKKALCT
160 170 180 190 200
AHEKFCFWPD SPSPDRFGML PLDEPAILVS EFLDRFQSLC HLDLQLPSLR
210 220 230 240 250
PEDLKTMCLT EDKISLLLHL LEDELDHRTD ERKTTIKLGS DIQVHVTACI
260 270 280 290 300
LSVCGWACSS SLESMQLSLI TCSQCMRKVG LWGFQQIESS MTDLDASFGL
310 320 330 340 350
TSSPIPGLEG RPERLPLVPE SPRRMMTRSQ DATFSPGSEQ AEKSPGPIVS
360 370 380 390 400
RTRSWDSSSP VDRPEPEAAS PTTRTRPVTR SMGTGDTPGL EVPSSPLRKA
410 420 430 440 450
KRARLCSSSS SDTSSRSFFD PTSQHRDWCP WVNITLGKES RENGGTEPDA
460 470 480 490 500
SAPAEPGWKA VLTILLAHKQ SSQPAETDSM SLSEKSRKVF RIFRQWESLC
SC
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J0I9 | C9J0I9_HUMAN | Nuclear-interacting partner of ALK | ZC3HC1 | 459 | Annotation score: | ||
F8WAU5 | F8WAU5_HUMAN | Nuclear-interacting partner of ALK | ZC3HC1 | 95 | Annotation score: | ||
F8WBD7 | F8WBD7_HUMAN | Nuclear-interacting partner of ALK | ZC3HC1 | 49 | Annotation score: | ||
F8WDK5 | F8WDK5_HUMAN | Nuclear-interacting partner of ALK | ZC3HC1 | 50 | Annotation score: | ||
F8WF13 | F8WF13_HUMAN | Nuclear-interacting partner of ALK | ZC3HC1 | 53 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 179 | V → I in BAB14024 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 278 | K → R in AAF36136 (PubMed:11042152).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023312 | 271 | T → A1 PublicationCorresponds to variant dbSNP:rs1464890Ensembl. | 1 | |
Natural variantiVAR_023313 | 363 | R → H1 PublicationCorresponds to variant dbSNP:rs11556924Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015217 | 1 – 49 | MAAPC…GGVDA → MRGLPRKREAWTQPHPLEAL YESLRVLE in isoform 2. 1 PublicationAdd BLAST | 49 | |
Alternative sequenceiVSP_015218 | 341 – 411 | Missing in isoform 3. 1 PublicationAdd BLAST | 71 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ537494 mRNA Translation: CAD61161.1 AF151050 mRNA Translation: AAF36136.1 Frameshift. AK001317 mRNA Translation: BAA91619.1 AK022373 mRNA Translation: BAB14024.1 AC073320 Genomic DNA Translation: AAS07546.1 Sequence problems. AC073320 Genomic DNA Translation: AAS07547.1 Sequence problems. AC087071 Genomic DNA No translation available. BC011551 mRNA Translation: AAH11551.1 BC028917 mRNA Translation: AAH28917.1 Different initiation. |
CCDSi | CCDS34753.1 [Q86WB0-1] CCDS64767.1 [Q86WB0-2] CCDS75659.1 [Q86WB0-3] |
RefSeqi | NP_001269119.1, NM_001282190.1 [Q86WB0-2] NP_001269120.1, NM_001282191.1 [Q86WB0-3] NP_057562.3, NM_016478.4 [Q86WB0-1] |
Genome annotation databases
Ensembli | ENST00000311873; ENSP00000309301; ENSG00000091732 [Q86WB0-2] ENST00000358303; ENSP00000351052; ENSG00000091732 [Q86WB0-1] ENST00000360708; ENSP00000353933; ENSG00000091732 [Q86WB0-3] |
GeneIDi | 51530 |
KEGGi | hsa:51530 |
UCSCi | uc003vpi.4, human [Q86WB0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ537494 mRNA Translation: CAD61161.1 AF151050 mRNA Translation: AAF36136.1 Frameshift. AK001317 mRNA Translation: BAA91619.1 AK022373 mRNA Translation: BAB14024.1 AC073320 Genomic DNA Translation: AAS07546.1 Sequence problems. AC073320 Genomic DNA Translation: AAS07547.1 Sequence problems. AC087071 Genomic DNA No translation available. BC011551 mRNA Translation: AAH11551.1 BC028917 mRNA Translation: AAH28917.1 Different initiation. |
CCDSi | CCDS34753.1 [Q86WB0-1] CCDS64767.1 [Q86WB0-2] CCDS75659.1 [Q86WB0-3] |
RefSeqi | NP_001269119.1, NM_001282190.1 [Q86WB0-2] NP_001269120.1, NM_001282191.1 [Q86WB0-3] NP_057562.3, NM_016478.4 [Q86WB0-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119592, 39 interactors |
CORUMi | Q86WB0 |
IntActi | Q86WB0, 20 interactors |
MINTi | Q86WB0 |
STRINGi | 9606.ENSP00000351052 |
PTM databases
iPTMneti | Q86WB0 |
MetOSitei | Q86WB0 |
PhosphoSitePlusi | Q86WB0 |
SwissPalmi | Q86WB0 |
Genetic variation databases
BioMutai | ZC3HC1 |
DMDMi | 73921220 |
Proteomic databases
EPDi | Q86WB0 |
jPOSTi | Q86WB0 |
MassIVEi | Q86WB0 |
MaxQBi | Q86WB0 |
PaxDbi | Q86WB0 |
PeptideAtlasi | Q86WB0 |
PRIDEi | Q86WB0 |
ProteomicsDBi | 70140 [Q86WB0-1] 70141 [Q86WB0-2] 70142 [Q86WB0-3] |
Protocols and materials databases
Antibodypediai | 17928, 246 antibodies |
DNASUi | 51530 |
Genome annotation databases
Ensembli | ENST00000311873; ENSP00000309301; ENSG00000091732 [Q86WB0-2] ENST00000358303; ENSP00000351052; ENSG00000091732 [Q86WB0-1] ENST00000360708; ENSP00000353933; ENSG00000091732 [Q86WB0-3] |
GeneIDi | 51530 |
KEGGi | hsa:51530 |
UCSCi | uc003vpi.4, human [Q86WB0-1] |
Organism-specific databases
CTDi | 51530 |
DisGeNETi | 51530 |
GeneCardsi | ZC3HC1 |
HGNCi | HGNC:29913, ZC3HC1 |
HPAi | ENSG00000091732, Low tissue specificity |
neXtProti | NX_Q86WB0 |
OpenTargetsi | ENSG00000091732 |
PharmGKBi | PA134931869 |
VEuPathDBi | HostDB:ENSG00000091732.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4765, Eukaryota |
GeneTreei | ENSGT00390000006086 |
InParanoidi | Q86WB0 |
OMAi | SLPILTC |
OrthoDBi | 1626741at2759 |
PhylomeDBi | Q86WB0 |
TreeFami | TF314674 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q86WB0 |
SIGNORi | Q86WB0 |
Miscellaneous databases
BioGRID-ORCSi | 51530, 38 hits in 881 CRISPR screens |
ChiTaRSi | ZC3HC1, human |
GeneWikii | ZC3HC1 |
GenomeRNAii | 51530 |
Pharosi | Q86WB0, Tbio |
PROi | PR:Q86WB0 |
RNActi | Q86WB0, protein |
Gene expression databases
Bgeei | ENSG00000091732, Expressed in quadriceps femoris and 205 other tissues |
ExpressionAtlasi | Q86WB0, baseline and differential |
Genevisiblei | Q86WB0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013909, NIPA/Rsm1 IPR012935, Znf_C3HC-like |
Pfami | View protein in Pfam PF08600, Rsm1, 1 hit PF07967, zf-C3HC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NIPA_HUMAN | |
Accessioni | Q86WB0Primary (citable) accession number: Q86WB0 Secondary accession number(s): A6NH66 Q9P0R0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | June 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - PATHWAY comments
Index of metabolic and biosynthesis pathways