UniProtKB - Q86WA9 (S2611_HUMAN)
Protein
Sodium-independent sulfate anion transporter
Gene
SLC26A11
Organism
Homo sapiens (Human)
Status
Functioni
Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC).1 Publication
GO - Molecular functioni
- anion:anion antiporter activity Source: GO_Central
- anion transmembrane transporter activity Source: UniProtKB
- secondary active sulfate transmembrane transporter activity Source: InterPro
- sulfate transmembrane transporter activity Source: GO_Central
GO - Biological processi
- ion transport Source: Reactome
- sulfate transport Source: UniProtKB
Keywordsi
Biological process | Anion exchange, Ion transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q86WA9 |
Reactomei | R-HSA-427601, Multifunctional anion exchangers |
Protein family/group databases
TCDBi | 2.A.53.1.10, the sulfate permease (sulp) family |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium-independent sulfate anion transporterAlternative name(s): Solute carrier family 26 member 11 |
Gene namesi | Name:SLC26A11Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000181045.14 |
HGNCi | HGNC:14471, SLC26A11 |
MIMi | 610117, gene |
neXtProti | NX_Q86WA9 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Lysosome
- Lysosome membrane ; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Lysosome
- lysosomal membrane Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 51 | ExtracellularSequence analysisAdd BLAST | 51 | |
Transmembranei | 52 – 72 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 73 | CytoplasmicSequence analysis | 1 | |
Transmembranei | 74 – 94 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 95 – 100 | ExtracellularSequence analysis | 6 | |
Transmembranei | 101 – 117 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 118 – 119 | CytoplasmicSequence analysis | 2 | |
Transmembranei | 120 – 140 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 141 – 147 | ExtracellularSequence analysis | 7 | |
Transmembranei | 148 – 168 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 169 – 197 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 198 – 218 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 219 – 250 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 251 – 271 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 272 – 307 | CytoplasmicSequence analysisAdd BLAST | 36 | |
Transmembranei | 308 – 328 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 329 – 341 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 342 – 362 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 363 – 374 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 375 – 395 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 396 – 398 | ExtracellularSequence analysis | 3 | |
Transmembranei | 399 – 419 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 420 – 441 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 442 – 462 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 463 – 606 | ExtracellularSequence analysisAdd BLAST | 144 |
Keywords - Cellular componenti
Cell membrane, Lysosome, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 284129 |
OpenTargetsi | ENSG00000181045 |
PharmGKBi | PA37888 |
Miscellaneous databases
Pharosi | Q86WA9, Tdark |
Polymorphism and mutation databases
BioMutai | SLC26A11 |
DMDMi | 182705284 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000320686 | 1 – 606 | Sodium-independent sulfate anion transporterAdd BLAST | 606 |
Proteomic databases
EPDi | Q86WA9 |
jPOSTi | Q86WA9 |
MassIVEi | Q86WA9 |
MaxQBi | Q86WA9 |
PaxDbi | Q86WA9 |
PeptideAtlasi | Q86WA9 |
PRIDEi | Q86WA9 |
ProteomicsDBi | 70139 |
PTM databases
iPTMneti | Q86WA9 |
PhosphoSitePlusi | Q86WA9 |
SwissPalmi | Q86WA9 |
Expressioni
Tissue specificityi
Detected in all tissues tested with highest expression observed in brain, kidney, HEVEC and placenta and lowest in pancreas, skeletal muscle, liver, lung and heart.2 Publications
Gene expression databases
Bgeei | ENSG00000181045, Expressed in left lobe of thyroid gland and 205 other tissues |
ExpressionAtlasi | Q86WA9, baseline and differential |
Genevisiblei | Q86WA9, HS |
Organism-specific databases
HPAi | ENSG00000181045, Low tissue specificity |
Interactioni
Binary interactionsi
Q86WA9
With | #Exp. | IntAct |
---|---|---|
SMIM1 [B2RUZ4] | 3 | EBI-19115335,EBI-12188413 |
Protein-protein interaction databases
BioGRIDi | 129771, 2 interactors |
IntActi | Q86WA9, 2 interactors |
MINTi | Q86WA9 |
STRINGi | 9606.ENSP00000355384 |
Miscellaneous databases
RNActi | Q86WA9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 470 – 584 | STASPROSITE-ProRule annotationAdd BLAST | 115 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0236, Eukaryota |
GeneTreei | ENSGT01010000222385 |
HOGENOMi | CLU_003182_12_2_1 |
InParanoidi | Q86WA9 |
OMAi | CELRVSN |
OrthoDBi | 289441at2759 |
PhylomeDBi | Q86WA9 |
TreeFami | TF323537 |
Family and domain databases
Gene3Di | 3.30.750.24, 1 hit |
InterProi | View protein in InterPro IPR018045, S04_transporter_CS IPR011547, SLC26A/SulP_dom IPR001902, SLC26A/SulP_fam IPR002645, STAS_dom IPR036513, STAS_dom_sf |
PANTHERi | PTHR11814, PTHR11814, 1 hit |
Pfami | View protein in Pfam PF01740, STAS, 1 hit PF00916, Sulfate_transp, 1 hit |
SUPFAMi | SSF52091, SSF52091, 1 hit |
PROSITEi | View protein in PROSITE PS01130, SLC26A, 1 hit PS50801, STAS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q86WA9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPSSVTALGQ ARSSGPGMAP SACCCSPAAL QRRLPILAWL PSYSLQWLKM
60 70 80 90 100
DFVAGLSVGL TAIPQALAYA EVAGLPPQYG LYSAFMGCFV YFFLGTSRDV
110 120 130 140 150
TLGPTAIMSL LVSFYTFHEP AYAVLLAFLS GCIQLAMGVL RLGFLLDFIS
160 170 180 190 200
YPVIKGFTSA AAVTIGFGQI KNLLGLQNIP RPFFLQVYHT FLRIAETRVG
210 220 230 240 250
DAVLGLVCML LLLVLKLMRD HVPPVHPEMP PGVRLSRGLV WAATTARNAL
260 270 280 290 300
VVSFAALVAY SFEVTGYQPF ILTGETAEGL PPVRIPPFSV TTANGTISFT
310 320 330 340 350
EMVQDMGAGL AVVPLMGLLE SIAVAKAFAS QNNYRIDANQ ELLAIGLTNM
360 370 380 390 400
LGSLVSSYPV TGSFGRTAVN AQSGVCTPAG GLVTGVLVLL SLDYLTSLFY
410 420 430 440 450
YIPKSALAAV IIMAVAPLFD TKIFRTLWRV KRLDLLPLCV TFLLCFWEVQ
460 470 480 490 500
YGILAGALVS LLMLLHSAAR PETKVSEGPV LVLQPASGLS FPAMEALREE
510 520 530 540 550
ILSRALEVSP PRCLVLECTH VCSIDYTVVL GLGELLQDFQ KQGVALAFVG
560 570 580 590 600
LQVPVLRVLL SADLKGFQYF STLEEAEKHL RQEPGTQPYN IREDSILDQK
VALLKA
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L124 | I3L124_HUMAN | Sodium-independent sulfate anion tr... | SLC26A11 | 153 | Annotation score: | ||
I3L1H1 | I3L1H1_HUMAN | Sodium-independent sulfate anion tr... | SLC26A11 | 210 | Annotation score: | ||
I3L2J9 | I3L2J9_HUMAN | Sodium-independent sulfate anion tr... | SLC26A11 | 64 | Annotation score: | ||
I3L266 | I3L266_HUMAN | Sodium-independent sulfate anion tr... | SLC26A11 | 133 | Annotation score: | ||
I3L0N9 | I3L0N9_HUMAN | Sodium-independent sulfate anion tr... | SLC26A11 | 197 | Annotation score: | ||
I3L3K8 | I3L3K8_HUMAN | Sodium-independent sulfate anion tr... | SLC26A11 | 77 | Annotation score: | ||
I3L250 | I3L250_HUMAN | Sodium-independent sulfate anion tr... | SLC26A11 | 58 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 14 | S → Y in CAD66450 (PubMed:12626430).Curated | 1 | |
Sequence conflicti | 319 | L → M in CAD66450 (PubMed:12626430).Curated | 1 | |
Sequence conflicti | 324 | V → M in AAM92902 (PubMed:11087667).Curated | 1 | |
Sequence conflicti | 328 | F → S in AAO26673 (Ref. 2) Curated | 1 | |
Sequence conflicti | 332 | N → D in CAD66450 (PubMed:12626430).Curated | 1 | |
Sequence conflicti | 415 | V → A in AAO26673 (Ref. 2) Curated | 1 | |
Sequence conflicti | 569 | Y → H in AAO26673 (Ref. 2) Curated | 1 | |
Sequence conflicti | 579 | H → R in BAC11496 (PubMed:16303743).Curated | 1 | |
Sequence conflicti | 583 | E → K in AAH35900 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068239 | 122 | Y → C1 PublicationCorresponds to variant dbSNP:rs765188926Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ544073 mRNA Translation: CAD66450.1 AF345195 mRNA Translation: AAO26673.1 AK315132 mRNA Translation: BAG37584.1 AK075248 mRNA Translation: BAC11496.1 BC035900 mRNA Translation: AAH35900.2 BC047451 mRNA Translation: AAH47451.1 AF331524 mRNA Translation: AAM92902.1 |
CCDSi | CCDS11771.2 |
RefSeqi | NP_001159819.1, NM_001166347.1 NP_001159820.1, NM_001166348.1 NP_001159821.1, NM_001166349.1 NP_775897.3, NM_173626.3 |
Genome annotation databases
Ensembli | ENST00000361193; ENSP00000355384; ENSG00000181045 ENST00000411502; ENSP00000403998; ENSG00000181045 ENST00000546047; ENSP00000440724; ENSG00000181045 ENST00000572725; ENSP00000459470; ENSG00000181045 |
GeneIDi | 284129 |
KEGGi | hsa:284129 |
UCSCi | uc002jyb.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ544073 mRNA Translation: CAD66450.1 AF345195 mRNA Translation: AAO26673.1 AK315132 mRNA Translation: BAG37584.1 AK075248 mRNA Translation: BAC11496.1 BC035900 mRNA Translation: AAH35900.2 BC047451 mRNA Translation: AAH47451.1 AF331524 mRNA Translation: AAM92902.1 |
CCDSi | CCDS11771.2 |
RefSeqi | NP_001159819.1, NM_001166347.1 NP_001159820.1, NM_001166348.1 NP_001159821.1, NM_001166349.1 NP_775897.3, NM_173626.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 129771, 2 interactors |
IntActi | Q86WA9, 2 interactors |
MINTi | Q86WA9 |
STRINGi | 9606.ENSP00000355384 |
Protein family/group databases
TCDBi | 2.A.53.1.10, the sulfate permease (sulp) family |
PTM databases
iPTMneti | Q86WA9 |
PhosphoSitePlusi | Q86WA9 |
SwissPalmi | Q86WA9 |
Polymorphism and mutation databases
BioMutai | SLC26A11 |
DMDMi | 182705284 |
Proteomic databases
EPDi | Q86WA9 |
jPOSTi | Q86WA9 |
MassIVEi | Q86WA9 |
MaxQBi | Q86WA9 |
PaxDbi | Q86WA9 |
PeptideAtlasi | Q86WA9 |
PRIDEi | Q86WA9 |
ProteomicsDBi | 70139 |
Protocols and materials databases
Antibodypediai | 32732, 12 antibodies |
Genome annotation databases
Ensembli | ENST00000361193; ENSP00000355384; ENSG00000181045 ENST00000411502; ENSP00000403998; ENSG00000181045 ENST00000546047; ENSP00000440724; ENSG00000181045 ENST00000572725; ENSP00000459470; ENSG00000181045 |
GeneIDi | 284129 |
KEGGi | hsa:284129 |
UCSCi | uc002jyb.3, human |
Organism-specific databases
CTDi | 284129 |
DisGeNETi | 284129 |
EuPathDBi | HostDB:ENSG00000181045.14 |
GeneCardsi | SLC26A11 |
HGNCi | HGNC:14471, SLC26A11 |
HPAi | ENSG00000181045, Low tissue specificity |
MIMi | 610117, gene |
neXtProti | NX_Q86WA9 |
OpenTargetsi | ENSG00000181045 |
PharmGKBi | PA37888 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0236, Eukaryota |
GeneTreei | ENSGT01010000222385 |
HOGENOMi | CLU_003182_12_2_1 |
InParanoidi | Q86WA9 |
OMAi | CELRVSN |
OrthoDBi | 289441at2759 |
PhylomeDBi | Q86WA9 |
TreeFami | TF323537 |
Enzyme and pathway databases
PathwayCommonsi | Q86WA9 |
Reactomei | R-HSA-427601, Multifunctional anion exchangers |
Miscellaneous databases
BioGRID-ORCSi | 284129, 5 hits in 842 CRISPR screens |
ChiTaRSi | SLC26A11, human |
GenomeRNAii | 284129 |
Pharosi | Q86WA9, Tdark |
PROi | PR:Q86WA9 |
RNActi | Q86WA9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000181045, Expressed in left lobe of thyroid gland and 205 other tissues |
ExpressionAtlasi | Q86WA9, baseline and differential |
Genevisiblei | Q86WA9, HS |
Family and domain databases
Gene3Di | 3.30.750.24, 1 hit |
InterProi | View protein in InterPro IPR018045, S04_transporter_CS IPR011547, SLC26A/SulP_dom IPR001902, SLC26A/SulP_fam IPR002645, STAS_dom IPR036513, STAS_dom_sf |
PANTHERi | PTHR11814, PTHR11814, 1 hit |
Pfami | View protein in Pfam PF01740, STAS, 1 hit PF00916, Sulfate_transp, 1 hit |
SUPFAMi | SSF52091, SSF52091, 1 hit |
PROSITEi | View protein in PROSITE PS01130, SLC26A, 1 hit PS50801, STAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S2611_HUMAN | |
Accessioni | Q86WA9Primary (citable) accession number: Q86WA9 Secondary accession number(s): B2RCI7 Q8NG03 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | February 26, 2008 | |
Last modified: | December 2, 2020 | |
This is version 135 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations