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UniProtKB - Q86WA9 (S2611_HUMAN)

Entry version 135 (02 Dec 2020)
Sequence version 2 (26 Feb 2008)
Previous versions | rss
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Protein

Sodium-independent sulfate anion transporter

Gene

SLC26A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAnion exchange, Ion transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86WA9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-427601, Multifunctional anion exchangers

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.53.1.10, the sulfate permease (sulp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium-independent sulfate anion transporter
Alternative name(s):
Solute carrier family 26 member 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC26A11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000181045.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:14471, SLC26A11

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610117, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86WA9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 51ExtracellularSequence analysisAdd BLAST51
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Topological domaini73CytoplasmicSequence analysis1
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95 – 100ExtracellularSequence analysis6
Transmembranei101 – 117HelicalSequence analysisAdd BLAST17
Topological domaini118 – 119CytoplasmicSequence analysis2
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 147ExtracellularSequence analysis7
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Topological domaini169 – 197CytoplasmicSequence analysisAdd BLAST29
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 250ExtracellularSequence analysisAdd BLAST32
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 307CytoplasmicSequence analysisAdd BLAST36
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 341ExtracellularSequence analysisAdd BLAST13
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 374CytoplasmicSequence analysisAdd BLAST12
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 398ExtracellularSequence analysis3
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 441CytoplasmicSequence analysisAdd BLAST22
Transmembranei442 – 462HelicalSequence analysisAdd BLAST21
Topological domaini463 – 606ExtracellularSequence analysisAdd BLAST144

Keywords - Cellular componenti

Cell membrane, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		284129

Open Targets

More...OpenTargetsi		ENSG00000181045

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37888

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86WA9, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC26A11

Domain mapping of disease mutations (DMDM)

More...DMDMi		182705284

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003206861 – 606Sodium-independent sulfate anion transporterAdd BLAST606

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q86WA9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q86WA9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86WA9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86WA9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86WA9

PeptideAtlas

More...PeptideAtlasi		Q86WA9

PRoteomics IDEntifications database

More...PRIDEi		Q86WA9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70139

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86WA9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86WA9

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q86WA9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in all tissues tested with highest expression observed in brain, kidney, HEVEC and placenta and lowest in pancreas, skeletal muscle, liver, lung and heart.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000181045, Expressed in left lobe of thyroid gland and 205 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86WA9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86WA9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000181045, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		129771, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q86WA9, 2 interactors

Molecular INTeraction database

More...MINTi		Q86WA9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000355384

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86WA9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini470 – 584STASPROSITE-ProRule annotationAdd BLAST115

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. [View classification]Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0236, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01010000222385

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003182_12_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86WA9

Identification of Orthologs from Complete Genome Data

More...OMAi		CELRVSN

Database of Orthologous Groups

More...OrthoDBi		289441at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86WA9

TreeFam database of animal gene trees

More...TreeFami		TF323537

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.750.24, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018045, S04_transporter_CS
IPR011547, SLC26A/SulP_dom
IPR001902, SLC26A/SulP_fam
IPR002645, STAS_dom
IPR036513, STAS_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR11814, PTHR11814, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01740, STAS, 1 hit
PF00916, Sulfate_transp, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52091, SSF52091, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01130, SLC26A, 1 hit
PS50801, STAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q86WA9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSSVTALGQ ARSSGPGMAP SACCCSPAAL QRRLPILAWL PSYSLQWLKM 
        60         70         80         90        100
DFVAGLSVGL TAIPQALAYA EVAGLPPQYG LYSAFMGCFV YFFLGTSRDV 
       110        120        130        140        150
TLGPTAIMSL LVSFYTFHEP AYAVLLAFLS GCIQLAMGVL RLGFLLDFIS 
       160        170        180        190        200
YPVIKGFTSA AAVTIGFGQI KNLLGLQNIP RPFFLQVYHT FLRIAETRVG 
       210        220        230        240        250
DAVLGLVCML LLLVLKLMRD HVPPVHPEMP PGVRLSRGLV WAATTARNAL 
       260        270        280        290        300
VVSFAALVAY SFEVTGYQPF ILTGETAEGL PPVRIPPFSV TTANGTISFT 
       310        320        330        340        350
EMVQDMGAGL AVVPLMGLLE SIAVAKAFAS QNNYRIDANQ ELLAIGLTNM 
       360        370        380        390        400
LGSLVSSYPV TGSFGRTAVN AQSGVCTPAG GLVTGVLVLL SLDYLTSLFY 
       410        420        430        440        450
YIPKSALAAV IIMAVAPLFD TKIFRTLWRV KRLDLLPLCV TFLLCFWEVQ 
       460        470        480        490        500
YGILAGALVS LLMLLHSAAR PETKVSEGPV LVLQPASGLS FPAMEALREE 
       510        520        530        540        550
ILSRALEVSP PRCLVLECTH VCSIDYTVVL GLGELLQDFQ KQGVALAFVG 
       560        570        580        590        600
LQVPVLRVLL SADLKGFQYF STLEEAEKHL RQEPGTQPYN IREDSILDQK 

VALLKA
Length:606
Mass (Da):65,299
Last modified:February 26, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA0D974B49F16450D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L124I3L124_HUMAN
Sodium-independent sulfate anion tr...
SLC26A11
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1H1I3L1H1_HUMAN
Sodium-independent sulfate anion tr...
SLC26A11
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2J9I3L2J9_HUMAN
Sodium-independent sulfate anion tr...
SLC26A11
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L266I3L266_HUMAN
Sodium-independent sulfate anion tr...
SLC26A11
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L0N9I3L0N9_HUMAN
Sodium-independent sulfate anion tr...
SLC26A11
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3K8I3L3K8_HUMAN
Sodium-independent sulfate anion tr...
SLC26A11
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L250I3L250_HUMAN
Sodium-independent sulfate anion tr...
SLC26A11
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14S → Y in CAD66450 (PubMed:12626430).Curated1
Sequence conflicti319L → M in CAD66450 (PubMed:12626430).Curated1
Sequence conflicti324V → M in AAM92902 (PubMed:11087667).Curated1
Sequence conflicti328F → S in AAO26673 (Ref. 2) Curated1
Sequence conflicti332N → D in CAD66450 (PubMed:12626430).Curated1
Sequence conflicti415V → A in AAO26673 (Ref. 2) Curated1
Sequence conflicti569Y → H in AAO26673 (Ref. 2) Curated1
Sequence conflicti579H → R in BAC11496 (PubMed:16303743).Curated1
Sequence conflicti583E → K in AAH35900 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_068239122Y → C1 PublicationCorresponds to variant dbSNP:rs765188926Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ544073 mRNA Translation: CAD66450.1
AF345195 mRNA Translation: AAO26673.1
AK315132 mRNA Translation: BAG37584.1
AK075248 mRNA Translation: BAC11496.1
BC035900 mRNA Translation: AAH35900.2
BC047451 mRNA Translation: AAH47451.1
AF331524 mRNA Translation: AAM92902.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11771.2

NCBI Reference Sequences

More...RefSeqi		NP_001159819.1, NM_001166347.1
NP_001159820.1, NM_001166348.1
NP_001159821.1, NM_001166349.1
NP_775897.3, NM_173626.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000361193; ENSP00000355384; ENSG00000181045
ENST00000411502; ENSP00000403998; ENSG00000181045
ENST00000546047; ENSP00000440724; ENSG00000181045
ENST00000572725; ENSP00000459470; ENSG00000181045

Database of genes from NCBI RefSeq genomes

More...GeneIDi		284129

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:284129

UCSC genome browser

More...UCSCi		uc002jyb.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ544073 mRNA Translation: CAD66450.1
AF345195 mRNA Translation: AAO26673.1
AK315132 mRNA Translation: BAG37584.1
AK075248 mRNA Translation: BAC11496.1
BC035900 mRNA Translation: AAH35900.2
BC047451 mRNA Translation: AAH47451.1
AF331524 mRNA Translation: AAM92902.1
CCDSiCCDS11771.2
RefSeqiNP_001159819.1, NM_001166347.1
NP_001159820.1, NM_001166348.1
NP_001159821.1, NM_001166349.1
NP_775897.3, NM_173626.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi129771, 2 interactors
IntActiQ86WA9, 2 interactors
MINTiQ86WA9
STRINGi9606.ENSP00000355384

Protein family/group databases

TCDBi2.A.53.1.10, the sulfate permease (sulp) family

PTM databases

iPTMnetiQ86WA9
PhosphoSitePlusiQ86WA9
SwissPalmiQ86WA9

Polymorphism and mutation databases

BioMutaiSLC26A11
DMDMi182705284

Proteomic databases

EPDiQ86WA9
jPOSTiQ86WA9
MassIVEiQ86WA9
MaxQBiQ86WA9
PaxDbiQ86WA9
PeptideAtlasiQ86WA9
PRIDEiQ86WA9
ProteomicsDBi70139

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32732, 12 antibodies

Genome annotation databases

EnsembliENST00000361193; ENSP00000355384; ENSG00000181045
ENST00000411502; ENSP00000403998; ENSG00000181045
ENST00000546047; ENSP00000440724; ENSG00000181045
ENST00000572725; ENSP00000459470; ENSG00000181045
GeneIDi284129
KEGGihsa:284129
UCSCiuc002jyb.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		284129
DisGeNETi284129
EuPathDBiHostDB:ENSG00000181045.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC26A11
HGNCiHGNC:14471, SLC26A11
HPAiENSG00000181045, Low tissue specificity
MIMi610117, gene
neXtProtiNX_Q86WA9
OpenTargetsiENSG00000181045
PharmGKBiPA37888

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0236, Eukaryota
GeneTreeiENSGT01010000222385
HOGENOMiCLU_003182_12_2_1
InParanoidiQ86WA9
OMAiCELRVSN
OrthoDBi289441at2759
PhylomeDBiQ86WA9
TreeFamiTF323537

Enzyme and pathway databases

PathwayCommonsiQ86WA9
ReactomeiR-HSA-427601, Multifunctional anion exchangers

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		284129, 5 hits in 842 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC26A11, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		284129
PharosiQ86WA9, Tdark

Protein Ontology

More...PROi		PR:Q86WA9
RNActiQ86WA9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000181045, Expressed in left lobe of thyroid gland and 205 other tissues
ExpressionAtlasiQ86WA9, baseline and differential
GenevisibleiQ86WA9, HS

Family and domain databases

Gene3Di3.30.750.24, 1 hit
InterProiView protein in InterPro
IPR018045, S04_transporter_CS
IPR011547, SLC26A/SulP_dom
IPR001902, SLC26A/SulP_fam
IPR002645, STAS_dom
IPR036513, STAS_dom_sf
PANTHERiPTHR11814, PTHR11814, 1 hit
PfamiView protein in Pfam
PF01740, STAS, 1 hit
PF00916, Sulfate_transp, 1 hit
SUPFAMiSSF52091, SSF52091, 1 hit
PROSITEiView protein in PROSITE
PS01130, SLC26A, 1 hit
PS50801, STAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS2611_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86WA9
Secondary accession number(s): B2RCI7
, Q86VX1, Q86YX7, Q8IV11, Q8N2I1, Q8NG03
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: December 2, 2020
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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