UniProtKB - Q86W92 (LIPB1_HUMAN)
Protein
Liprin-beta-1
Gene
PPFIBP1
Organism
Homo sapiens (Human)
Status
Functioni
May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.1 Publication
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
GO - Biological processi
- cell adhesion Source: ProtInc
- neuromuscular junction development Source: GO_Central
- synapse organization Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q86W92 |
Reactomei | R-HSA-388844, Receptor-type tyrosine-protein phosphatases |
Names & Taxonomyi
Protein namesi | Recommended name: Liprin-beta-1Alternative name(s): Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1 Short name: PTPRF-interacting protein-binding protein 1 hSGT2 |
Gene namesi | Name:PPFIBP1 Synonyms:KIAA1230 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9249, PPFIBP1 |
MIMi | 603141, gene |
neXtProti | NX_Q86W92 |
VEuPathDBi | HostDB:ENSG00000110841.13 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Plasma Membrane
- plasma membrane Source: ProtInc
Other locations
- focal adhesion Source: UniProtKB
- presynaptic active zone Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 8496 |
OpenTargetsi | ENSG00000110841 |
PharmGKBi | PA33570 |
Miscellaneous databases
Pharosi | Q86W92, Tbio |
Genetic variation databases
BioMutai | PPFIBP1 |
DMDMi | 90185247 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191034 | 1 – 1011 | Liprin-beta-1Add BLAST | 1011 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 37 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 39 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 40 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 322 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 434 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 466 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 471 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 540 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 579 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 601 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 636 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 794 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 999 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1001 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1003 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1005 | PhosphothreonineCombined sources | 1 | ||
Isoform 2 (identifier: Q86W92-2) | |||||
Modified residuei | 523 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q86W92 |
jPOSTi | Q86W92 |
MassIVEi | Q86W92 |
MaxQBi | Q86W92 |
PaxDbi | Q86W92 |
PeptideAtlasi | Q86W92 |
PRIDEi | Q86W92 |
ProteomicsDBi | 70131 [Q86W92-1] 70132 [Q86W92-2] 70133 [Q86W92-3] 70134 [Q86W92-4] 70135 [Q86W92-5] |
PTM databases
iPTMneti | Q86W92 |
MetOSitei | Q86W92 |
PhosphoSitePlusi | Q86W92 |
Expressioni
Tissue specificityi
Widely expressed. Absent in liver.1 Publication
Gene expression databases
Bgeei | ENSG00000110841, Expressed in epithelium of mammary gland and 243 other tissues |
ExpressionAtlasi | Q86W92, baseline and differential |
Genevisiblei | Q86W92, HS |
Organism-specific databases
HPAi | ENSG00000110841, Low tissue specificity |
Interactioni
Subunit structurei
Forms homodimers and heterodimers.
Interacts with S100A4 in a calcium-dependent mode.
1 PublicationBinary interactionsi
Q86W92
With | #Exp. | IntAct |
---|---|---|
PBX2 [P40425] | 3 | EBI-1045582,EBI-348489 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 114068, 62 interactors |
DIPi | DIP-42195N |
IntActi | Q86W92, 33 interactors |
MINTi | Q86W92 |
STRINGi | 9606.ENSP00000314724 |
Miscellaneous databases
RNActi | Q86W92, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 647 – 711 | SAM 1PROSITE-ProRule annotationAdd BLAST | 65 | |
Domaini | 719 – 782 | SAM 2PROSITE-ProRule annotationAdd BLAST | 64 | |
Domaini | 804 – 876 | SAM 3PROSITE-ProRule annotationAdd BLAST | 73 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 156 – 405 | Sequence analysisAdd BLAST | 250 |
Domaini
The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha and interaction with S100A4.
Sequence similaritiesi
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG1899, Eukaryota |
GeneTreei | ENSGT00990000203651 |
HOGENOMi | CLU_011689_2_0_1 |
InParanoidi | Q86W92 |
OMAi | VETQPCD |
PhylomeDBi | Q86W92 |
TreeFami | TF314207 |
Family and domain databases
CDDi | cd09563, SAM_liprin-beta1_2_repeat1, 1 hit cd09566, SAM_liprin-beta1_2_repeat2, 1 hit cd09569, SAM_liprin-beta1_2_repeat3, 1 hit |
Gene3Di | 1.10.150.50, 3 hits 1.20.5.1160, 2 hits |
InterProi | View protein in InterPro IPR042180, IF_rod_dom_coil1B IPR029515, Liprin IPR037617, Liprin-beta_SAM_rpt_1 IPR037618, Liprin-beta_SAM_rpt_2 IPR037619, Liprin-beta_SAM_rpt_3 IPR030437, PPFIBP1 IPR001660, SAM IPR013761, SAM/pointed_sf |
PANTHERi | PTHR12587, PTHR12587, 1 hit PTHR12587:SF16, PTHR12587:SF16, 1 hit |
Pfami | View protein in Pfam PF00536, SAM_1, 2 hits PF07647, SAM_2, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 3 hits |
SUPFAMi | SSF47769, SSF47769, 3 hits |
PROSITEi | View protein in PROSITE PS50105, SAM_DOMAIN, 2 hits |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q86W92-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMSDASDMLA AALEQMDGII AGSKALEYSN GIFDCQSPTS PFMGSLRALH
60 70 80 90 100
LVEDLRGLLE MMETDEKEGL RCQIPDSTAE TLVEWLQSQM TNGHLPGNGD
110 120 130 140 150
VYQERLARLE NDKESLVLQV SVLTDQVEAQ GEKIRDLEFC LEEHREKVNA
160 170 180 190 200
TEEMLQQELL SRTSLETQKL DLMAEISNLK LKLTAVEKDR LDYEDKFRDT
210 220 230 240 250
EGLIQEINDL RLKVSEMDSE RLQYEKKLKS TKSLMAKLSS MKIKVGQMQY
260 270 280 290 300
EKQRMEQKWE SLKDELASLK EQLEEKESEV KRLQEKLVCK MKGEGVEIVD
310 320 330 340 350
RDIEVQKMKK AVESLMAANE EKDRKIEDLR QCLNRYKKMQ DTVVLAQGKD
360 370 380 390 400
GEYEELLNSS SISSLLDAQG FSDLEKSPSP TPVMGSPSCD PFNTSVPEEF
410 420 430 440 450
HTTILQVSIP SLLPATVSME TSEKSKLTPK PETSFEENDG NIILGATVDT
460 470 480 490 500
QLCDKLLTSS LQKSSSLGNL KKETSDGEKE TIQKTSEDRA PAESRPFGTL
510 520 530 540 550
PPRPPGQDTS MDDNPFGTRK VRSSFGRGFF KIKSNKRTAS APNLAETEKE
560 570 580 590 600
TAEHLDLAGA SSRPKDSQRN SPFQIPPPSP DSKKKSRGIM KLFGKLRRSQ
610 620 630 640 650
STTFNPDDMS EPEFKRGGTR ATAGPRLGWS RDLGQSNSDL DMPFAKWTKE
660 670 680 690 700
QVCNWLMEQG LGSYLNSGKH WIASGQTLLQ ASQQDLEKEL GIKHSLHRKK
710 720 730 740 750
LQLALQALGS EEETNHGKLD FNWVTRWLDD IGLPQYKTQF DEGRVDGRML
760 770 780 790 800
HYMTVDDLLS LKVVSVLHHL SIKRAIQVLR INNFEPNCLR RRPSDENTIA
810 820 830 840 850
PSEVQKWTNH RVMEWLRSVD LAEYAPNLRG SGVHGGLMVL EPRFNVETMA
860 870 880 890 900
QLLNIPPNKT LLRRHLATHF NLLIGAEAQH QKRDAMELPD YVLLTATAKV
910 920 930 940 950
KPKKLAFSNF GNLRKKKQED GEEYVCPMEL GQASGSASKK GFKPGLDMRL
960 970 980 990 1000
YEEDDLDRLE QMEDSEGTVR QIGAFSEGIN NLTHMLKEDD MFKDFAARSP
1010
SASITDEDSN V
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5GZP6 | F5GZP6_HUMAN | Liprin-beta-1 | PPFIBP1 | 744 | Annotation score: | ||
H0YGH8 | H0YGH8_HUMAN | Liprin-beta-1 | PPFIBP1 | 205 | Annotation score: | ||
F5H495 | F5H495_HUMAN | Liprin-beta-1 | PPFIBP1 | 152 | Annotation score: | ||
A0A0A0MTP2 | A0A0A0MTP2_HUMAN | Liprin-beta-1 | PPFIBP1 | 281 | Annotation score: | ||
A0A087WVX8 | A0A087WVX8_HUMAN | Liprin-beta-1 | PPFIBP1 | 86 | Annotation score: | ||
H0YFE4 | H0YFE4_HUMAN | Liprin-beta-1 | PPFIBP1 | 242 | Annotation score: | ||
F5H0E0 | F5H0E0_HUMAN | Liprin-beta-1 | PPFIBP1 | 109 | Annotation score: | ||
F5H6Q7 | F5H6Q7_HUMAN | Liprin-beta-1 | PPFIBP1 | 86 | Annotation score: | ||
F5H7K5 | F5H7K5_HUMAN | Liprin-beta-1 | PPFIBP1 | 18 | Annotation score: |
Sequence cautioni
The sequence AAH46159 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA86544 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 308 | M → K in AAH46159 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 453 | C → R in AAC26103 (PubMed:9624153).Curated | 1 | |
Sequence conflicti | 553 | E → A in AAC26103 (PubMed:9624153).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_017758 | 148 | V → L5 PublicationsCorresponds to variant dbSNP:rs2194816Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009394 | 1 – 153 | Missing in isoform 3. 1 PublicationAdd BLAST | 153 | |
Alternative sequenceiVSP_009395 | 158 – 170 | ELLSR…ETQKL → VCAEARTKMGFPC in isoform 5. 2 PublicationsAdd BLAST | 13 | |
Alternative sequenceiVSP_009396 | 171 – 1011 | Missing in isoform 5. 2 PublicationsAdd BLAST | 841 | |
Alternative sequenceiVSP_009397 | 233 – 263 | Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST | 31 | |
Alternative sequenceiVSP_009398 | 302 | D → DENFKKKLKEKN in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_009399 | 349 | K → KKGK in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_009400 | 544 | L → LDRKRSASAPTL in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF034802 mRNA Translation: AAC26103.1 AB033056 mRNA Translation: BAA86544.2 Different initiation. AJ276680 mRNA Translation: CAB77544.1 AB049149 mRNA Translation: BAB39690.1 BC046159 mRNA Translation: AAH46159.1 Different initiation. BC050281 mRNA Translation: AAH50281.1 |
CCDSi | CCDS55812.1 [Q86W92-1] CCDS55813.1 [Q86W92-4] CCDS55814.1 [Q86W92-3] CCDS8713.1 [Q86W92-2] |
RefSeqi | NP_001185844.1, NM_001198915.1 [Q86W92-3] NP_001185845.1, NM_001198916.1 [Q86W92-4] NP_003613.3, NM_003622.3 [Q86W92-2] NP_803193.2, NM_177444.2 [Q86W92-1] |
Genome annotation databases
Ensembli | ENST00000228425; ENSP00000228425; ENSG00000110841 [Q86W92-2] ENST00000318304; ENSP00000314724; ENSG00000110841 [Q86W92-1] ENST00000535047; ENSP00000444046; ENSG00000110841 [Q86W92-5] ENST00000537927; ENSP00000445425; ENSG00000110841 [Q86W92-3] ENST00000542629; ENSP00000443442; ENSG00000110841 [Q86W92-4] |
GeneIDi | 8496 |
KEGGi | hsa:8496 |
UCSCi | uc001rhz.3, human [Q86W92-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF034802 mRNA Translation: AAC26103.1 AB033056 mRNA Translation: BAA86544.2 Different initiation. AJ276680 mRNA Translation: CAB77544.1 AB049149 mRNA Translation: BAB39690.1 BC046159 mRNA Translation: AAH46159.1 Different initiation. BC050281 mRNA Translation: AAH50281.1 |
CCDSi | CCDS55812.1 [Q86W92-1] CCDS55813.1 [Q86W92-4] CCDS55814.1 [Q86W92-3] CCDS8713.1 [Q86W92-2] |
RefSeqi | NP_001185844.1, NM_001198915.1 [Q86W92-3] NP_001185845.1, NM_001198916.1 [Q86W92-4] NP_003613.3, NM_003622.3 [Q86W92-2] NP_803193.2, NM_177444.2 [Q86W92-1] |
3D structure databases
SMRi | Q86W92 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114068, 62 interactors |
DIPi | DIP-42195N |
IntActi | Q86W92, 33 interactors |
MINTi | Q86W92 |
STRINGi | 9606.ENSP00000314724 |
PTM databases
iPTMneti | Q86W92 |
MetOSitei | Q86W92 |
PhosphoSitePlusi | Q86W92 |
Genetic variation databases
BioMutai | PPFIBP1 |
DMDMi | 90185247 |
Proteomic databases
EPDi | Q86W92 |
jPOSTi | Q86W92 |
MassIVEi | Q86W92 |
MaxQBi | Q86W92 |
PaxDbi | Q86W92 |
PeptideAtlasi | Q86W92 |
PRIDEi | Q86W92 |
ProteomicsDBi | 70131 [Q86W92-1] 70132 [Q86W92-2] 70133 [Q86W92-3] 70134 [Q86W92-4] 70135 [Q86W92-5] |
Protocols and materials databases
Antibodypediai | 1098, 160 antibodies |
Genome annotation databases
Ensembli | ENST00000228425; ENSP00000228425; ENSG00000110841 [Q86W92-2] ENST00000318304; ENSP00000314724; ENSG00000110841 [Q86W92-1] ENST00000535047; ENSP00000444046; ENSG00000110841 [Q86W92-5] ENST00000537927; ENSP00000445425; ENSG00000110841 [Q86W92-3] ENST00000542629; ENSP00000443442; ENSG00000110841 [Q86W92-4] |
GeneIDi | 8496 |
KEGGi | hsa:8496 |
UCSCi | uc001rhz.3, human [Q86W92-1] |
Organism-specific databases
CTDi | 8496 |
DisGeNETi | 8496 |
GeneCardsi | PPFIBP1 |
HGNCi | HGNC:9249, PPFIBP1 |
HPAi | ENSG00000110841, Low tissue specificity |
MIMi | 603141, gene |
neXtProti | NX_Q86W92 |
OpenTargetsi | ENSG00000110841 |
PharmGKBi | PA33570 |
VEuPathDBi | HostDB:ENSG00000110841.13 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1899, Eukaryota |
GeneTreei | ENSGT00990000203651 |
HOGENOMi | CLU_011689_2_0_1 |
InParanoidi | Q86W92 |
OMAi | VETQPCD |
PhylomeDBi | Q86W92 |
TreeFami | TF314207 |
Enzyme and pathway databases
PathwayCommonsi | Q86W92 |
Reactomei | R-HSA-388844, Receptor-type tyrosine-protein phosphatases |
Miscellaneous databases
BioGRID-ORCSi | 8496, 6 hits in 987 CRISPR screens |
ChiTaRSi | PPFIBP1, human |
GeneWikii | PPFIBP1 |
GenomeRNAii | 8496 |
Pharosi | Q86W92, Tbio |
PROi | PR:Q86W92 |
RNActi | Q86W92, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000110841, Expressed in epithelium of mammary gland and 243 other tissues |
ExpressionAtlasi | Q86W92, baseline and differential |
Genevisiblei | Q86W92, HS |
Family and domain databases
CDDi | cd09563, SAM_liprin-beta1_2_repeat1, 1 hit cd09566, SAM_liprin-beta1_2_repeat2, 1 hit cd09569, SAM_liprin-beta1_2_repeat3, 1 hit |
Gene3Di | 1.10.150.50, 3 hits 1.20.5.1160, 2 hits |
InterProi | View protein in InterPro IPR042180, IF_rod_dom_coil1B IPR029515, Liprin IPR037617, Liprin-beta_SAM_rpt_1 IPR037618, Liprin-beta_SAM_rpt_2 IPR037619, Liprin-beta_SAM_rpt_3 IPR030437, PPFIBP1 IPR001660, SAM IPR013761, SAM/pointed_sf |
PANTHERi | PTHR12587, PTHR12587, 1 hit PTHR12587:SF16, PTHR12587:SF16, 1 hit |
Pfami | View protein in Pfam PF00536, SAM_1, 2 hits PF07647, SAM_2, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 3 hits |
SUPFAMi | SSF47769, SSF47769, 3 hits |
PROSITEi | View protein in PROSITE PS50105, SAM_DOMAIN, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LIPB1_HUMAN | |
Accessioni | Q86W92Primary (citable) accession number: Q86W92 Secondary accession number(s): O75336 Q9ULJ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 16, 2004 |
Last sequence update: | March 7, 2006 | |
Last modified: | April 7, 2021 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families