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Protein

Liprin-beta-1

Gene

PPFIBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-388844 Receptor-type tyrosine-protein phosphatases

Names & Taxonomyi

Protein namesi
Recommended name:
Liprin-beta-1
Alternative name(s):
Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1
Short name:
PTPRF-interacting protein-binding protein 1
hSGT2
Gene namesi
Name:PPFIBP1
Synonyms:KIAA1230
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000110841.13
HGNCiHGNC:9249 PPFIBP1
MIMi603141 gene
neXtProtiNX_Q86W92

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi8496
OpenTargetsiENSG00000110841
PharmGKBiPA33570

Polymorphism and mutation databases

BioMutaiPPFIBP1
DMDMi90185247

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910341 – 1011Liprin-beta-1Add BLAST1011

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphoserineCombined sources1
Modified residuei39PhosphothreonineCombined sources1
Modified residuei40PhosphoserineCombined sources1
Modified residuei322N6-acetyllysineCombined sources1
Modified residuei434PhosphoserineBy similarity1
Modified residuei466PhosphoserineCombined sources1
Cross-linki471Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei540PhosphoserineCombined sources1
Modified residuei579PhosphoserineCombined sources1
Modified residuei601PhosphoserineCombined sources1
Modified residuei636PhosphoserineBy similarity1
Modified residuei794PhosphoserineCombined sources1
Modified residuei999PhosphoserineCombined sources1
Modified residuei1001PhosphoserineCombined sources1
Modified residuei1003PhosphoserineCombined sources1
Modified residuei1005PhosphothreonineCombined sources1
Isoform 2 (identifier: Q86W92-2)
Modified residuei523PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ86W92
MaxQBiQ86W92
PaxDbiQ86W92
PeptideAtlasiQ86W92
PRIDEiQ86W92
ProteomicsDBi70131
70132 [Q86W92-2]
70133 [Q86W92-3]
70134 [Q86W92-4]
70135 [Q86W92-5]

PTM databases

iPTMnetiQ86W92
PhosphoSitePlusiQ86W92

Expressioni

Tissue specificityi

Widely expressed. Absent in liver.1 Publication

Gene expression databases

BgeeiENSG00000110841 Expressed in 234 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_PPFIBP1
ExpressionAtlasiQ86W92 baseline and differential
GenevisibleiQ86W92 HS

Organism-specific databases

HPAiHPA001924

Interactioni

Subunit structurei

Forms homodimers and heterodimers. Interacts with S100A4 in a calcium-dependent mode.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114068, 38 interactors
DIPiDIP-42195N
IntActiQ86W92, 18 interactors
MINTiQ86W92
STRINGi9606.ENSP00000314724

Structurei

3D structure databases

ProteinModelPortaliQ86W92
SMRiQ86W92
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini647 – 711SAM 1PROSITE-ProRule annotationAdd BLAST65
Domaini719 – 782SAM 2PROSITE-ProRule annotationAdd BLAST64
Domaini804 – 876SAM 3PROSITE-ProRule annotationAdd BLAST73

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili156 – 405Sequence analysisAdd BLAST250

Domaini

The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha and interaction with S100A4.

Sequence similaritiesi

Belongs to the liprin family. Liprin-beta subfamily.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1899 Eukaryota
ENOG410XSFF LUCA
GeneTreeiENSGT00760000119138
HOGENOMiHOG000082535
HOVERGENiHBG052331
InParanoidiQ86W92
OMAiQVCNWLQ
OrthoDBiEOG091G01OJ
PhylomeDBiQ86W92
TreeFamiTF314207

Family and domain databases

CDDicd09563 SAM_liprin-beta1_2_repeat1, 1 hit
cd09566 SAM_liprin-beta1_2_repeat2, 1 hit
cd09569 SAM_liprin-beta1_2_repeat3, 1 hit
InterProiView protein in InterPro
IPR029515 Liprin
IPR037617 Liprin-beta_SAM_rpt_1
IPR037618 Liprin-beta_SAM_rpt_2
IPR037619 Liprin-beta_SAM_rpt_3
IPR030437 PPFIBP1
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR12587 PTHR12587, 1 hit
PTHR12587:SF16 PTHR12587:SF16, 1 hit
PfamiView protein in Pfam
PF00536 SAM_1, 2 hits
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 3 hits
SUPFAMiSSF47769 SSF47769, 3 hits
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 2 hits

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86W92-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMSDASDMLA AALEQMDGII AGSKALEYSN GIFDCQSPTS PFMGSLRALH
60 70 80 90 100
LVEDLRGLLE MMETDEKEGL RCQIPDSTAE TLVEWLQSQM TNGHLPGNGD
110 120 130 140 150
VYQERLARLE NDKESLVLQV SVLTDQVEAQ GEKIRDLEFC LEEHREKVNA
160 170 180 190 200
TEEMLQQELL SRTSLETQKL DLMAEISNLK LKLTAVEKDR LDYEDKFRDT
210 220 230 240 250
EGLIQEINDL RLKVSEMDSE RLQYEKKLKS TKSLMAKLSS MKIKVGQMQY
260 270 280 290 300
EKQRMEQKWE SLKDELASLK EQLEEKESEV KRLQEKLVCK MKGEGVEIVD
310 320 330 340 350
RDIEVQKMKK AVESLMAANE EKDRKIEDLR QCLNRYKKMQ DTVVLAQGKD
360 370 380 390 400
GEYEELLNSS SISSLLDAQG FSDLEKSPSP TPVMGSPSCD PFNTSVPEEF
410 420 430 440 450
HTTILQVSIP SLLPATVSME TSEKSKLTPK PETSFEENDG NIILGATVDT
460 470 480 490 500
QLCDKLLTSS LQKSSSLGNL KKETSDGEKE TIQKTSEDRA PAESRPFGTL
510 520 530 540 550
PPRPPGQDTS MDDNPFGTRK VRSSFGRGFF KIKSNKRTAS APNLAETEKE
560 570 580 590 600
TAEHLDLAGA SSRPKDSQRN SPFQIPPPSP DSKKKSRGIM KLFGKLRRSQ
610 620 630 640 650
STTFNPDDMS EPEFKRGGTR ATAGPRLGWS RDLGQSNSDL DMPFAKWTKE
660 670 680 690 700
QVCNWLMEQG LGSYLNSGKH WIASGQTLLQ ASQQDLEKEL GIKHSLHRKK
710 720 730 740 750
LQLALQALGS EEETNHGKLD FNWVTRWLDD IGLPQYKTQF DEGRVDGRML
760 770 780 790 800
HYMTVDDLLS LKVVSVLHHL SIKRAIQVLR INNFEPNCLR RRPSDENTIA
810 820 830 840 850
PSEVQKWTNH RVMEWLRSVD LAEYAPNLRG SGVHGGLMVL EPRFNVETMA
860 870 880 890 900
QLLNIPPNKT LLRRHLATHF NLLIGAEAQH QKRDAMELPD YVLLTATAKV
910 920 930 940 950
KPKKLAFSNF GNLRKKKQED GEEYVCPMEL GQASGSASKK GFKPGLDMRL
960 970 980 990 1000
YEEDDLDRLE QMEDSEGTVR QIGAFSEGIN NLTHMLKEDD MFKDFAARSP
1010
SASITDEDSN V
Note: No experimental confirmation available.
Length:1,011
Mass (Da):114,024
Last modified:March 7, 2006 - v2
Checksum:i20E30DD99ACD5A92
GO
Isoform 2 (identifier: Q86W92-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-263: Missing.
     302-302: D → DENFKKKLKEKN
     349-349: K → KKGK
     544-544: L → LDRKRSASAPTL

Note: No experimental confirmation available.Combined sources
Show »
Length:1,005
Mass (Da):113,181
Checksum:iE399A3BB86F46BAE
GO
Isoform 3 (identifier: Q86W92-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.

Note: No experimental confirmation available.
Show »
Length:858
Mass (Da):96,965
Checksum:iD5BE6B7D1D47C76A
GO
Isoform 4 (identifier: Q86W92-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-263: Missing.

Note: No experimental confirmation available.
Show »
Length:980
Mass (Da):110,297
Checksum:iA521EFCC0589E24B
GO
Isoform 5 (identifier: Q86W92-5) [UniParc]FASTAAdd to basket
Also known as: L2

The sequence of this isoform differs from the canonical sequence as follows:
     158-170: ELLSRTSLETQKL → VCAEARTKMGFPC
     171-1011: Missing.

Note: Due to intron retention.
Show »
Length:170
Mass (Da):18,972
Checksum:iC281D0F4E7896A7B
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GZP6F5GZP6_HUMAN
Liprin-beta-1
PPFIBP1
744Annotation score:
F5H495F5H495_HUMAN
Liprin-beta-1
PPFIBP1
152Annotation score:
H0YGH8H0YGH8_HUMAN
Liprin-beta-1
PPFIBP1
205Annotation score:
A0A0A0MTP2A0A0A0MTP2_HUMAN
Liprin-beta-1
PPFIBP1
281Annotation score:
H0YFE4H0YFE4_HUMAN
Liprin-beta-1
PPFIBP1
242Annotation score:
F5H6Q7F5H6Q7_HUMAN
Liprin-beta-1
PPFIBP1
86Annotation score:
F5H0E0F5H0E0_HUMAN
Liprin-beta-1
PPFIBP1
109Annotation score:
F5H7K5F5H7K5_HUMAN
Liprin-beta-1
PPFIBP1
18Annotation score:
A0A087WVX8A0A087WVX8_HUMAN
Liprin-beta-1
PPFIBP1
86Annotation score:

Sequence cautioni

The sequence AAH46159 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA86544 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti308M → K in AAH46159 (PubMed:15489334).Curated1
Sequence conflicti453C → R in AAC26103 (PubMed:9624153).Curated1
Sequence conflicti553E → A in AAC26103 (PubMed:9624153).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017758148V → L5 PublicationsCorresponds to variant dbSNP:rs2194816Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0093941 – 153Missing in isoform 3. 1 PublicationAdd BLAST153
Alternative sequenceiVSP_009395158 – 170ELLSR…ETQKL → VCAEARTKMGFPC in isoform 5. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_009396171 – 1011Missing in isoform 5. 2 PublicationsAdd BLAST841
Alternative sequenceiVSP_009397233 – 263Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST31
Alternative sequenceiVSP_009398302D → DENFKKKLKEKN in isoform 2. 1 Publication1
Alternative sequenceiVSP_009399349K → KKGK in isoform 2. 1 Publication1
Alternative sequenceiVSP_009400544L → LDRKRSASAPTL in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034802 mRNA Translation: AAC26103.1
AB033056 mRNA Translation: BAA86544.2 Different initiation.
AJ276680 mRNA Translation: CAB77544.1
AB049149 mRNA Translation: BAB39690.1
BC046159 mRNA Translation: AAH46159.1 Different initiation.
BC050281 mRNA Translation: AAH50281.1
CCDSiCCDS55812.1 [Q86W92-1]
CCDS55813.1 [Q86W92-4]
CCDS55814.1 [Q86W92-3]
CCDS8713.1 [Q86W92-2]
RefSeqiNP_001185844.1, NM_001198915.1 [Q86W92-3]
NP_001185845.1, NM_001198916.1
NP_003613.3, NM_003622.3
NP_803193.2, NM_177444.2
UniGeneiHs.172445

Genome annotation databases

EnsembliENST00000228425; ENSP00000228425; ENSG00000110841 [Q86W92-2]
ENST00000318304; ENSP00000314724; ENSG00000110841 [Q86W92-1]
ENST00000535047; ENSP00000444046; ENSG00000110841 [Q86W92-5]
ENST00000537927; ENSP00000445425; ENSG00000110841 [Q86W92-3]
ENST00000542629; ENSP00000443442; ENSG00000110841 [Q86W92-4]
GeneIDi8496
KEGGihsa:8496
UCSCiuc001rhz.3 human [Q86W92-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034802 mRNA Translation: AAC26103.1
AB033056 mRNA Translation: BAA86544.2 Different initiation.
AJ276680 mRNA Translation: CAB77544.1
AB049149 mRNA Translation: BAB39690.1
BC046159 mRNA Translation: AAH46159.1 Different initiation.
BC050281 mRNA Translation: AAH50281.1
CCDSiCCDS55812.1 [Q86W92-1]
CCDS55813.1 [Q86W92-4]
CCDS55814.1 [Q86W92-3]
CCDS8713.1 [Q86W92-2]
RefSeqiNP_001185844.1, NM_001198915.1 [Q86W92-3]
NP_001185845.1, NM_001198916.1
NP_003613.3, NM_003622.3
NP_803193.2, NM_177444.2
UniGeneiHs.172445

3D structure databases

ProteinModelPortaliQ86W92
SMRiQ86W92
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114068, 38 interactors
DIPiDIP-42195N
IntActiQ86W92, 18 interactors
MINTiQ86W92
STRINGi9606.ENSP00000314724

PTM databases

iPTMnetiQ86W92
PhosphoSitePlusiQ86W92

Polymorphism and mutation databases

BioMutaiPPFIBP1
DMDMi90185247

Proteomic databases

EPDiQ86W92
MaxQBiQ86W92
PaxDbiQ86W92
PeptideAtlasiQ86W92
PRIDEiQ86W92
ProteomicsDBi70131
70132 [Q86W92-2]
70133 [Q86W92-3]
70134 [Q86W92-4]
70135 [Q86W92-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228425; ENSP00000228425; ENSG00000110841 [Q86W92-2]
ENST00000318304; ENSP00000314724; ENSG00000110841 [Q86W92-1]
ENST00000535047; ENSP00000444046; ENSG00000110841 [Q86W92-5]
ENST00000537927; ENSP00000445425; ENSG00000110841 [Q86W92-3]
ENST00000542629; ENSP00000443442; ENSG00000110841 [Q86W92-4]
GeneIDi8496
KEGGihsa:8496
UCSCiuc001rhz.3 human [Q86W92-1]

Organism-specific databases

CTDi8496
DisGeNETi8496
EuPathDBiHostDB:ENSG00000110841.13
GeneCardsiPPFIBP1
HGNCiHGNC:9249 PPFIBP1
HPAiHPA001924
MIMi603141 gene
neXtProtiNX_Q86W92
OpenTargetsiENSG00000110841
PharmGKBiPA33570
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1899 Eukaryota
ENOG410XSFF LUCA
GeneTreeiENSGT00760000119138
HOGENOMiHOG000082535
HOVERGENiHBG052331
InParanoidiQ86W92
OMAiQVCNWLQ
OrthoDBiEOG091G01OJ
PhylomeDBiQ86W92
TreeFamiTF314207

Enzyme and pathway databases

ReactomeiR-HSA-388844 Receptor-type tyrosine-protein phosphatases

Miscellaneous databases

ChiTaRSiPPFIBP1 human
GeneWikiiPPFIBP1
GenomeRNAii8496
PROiPR:Q86W92
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110841 Expressed in 234 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_PPFIBP1
ExpressionAtlasiQ86W92 baseline and differential
GenevisibleiQ86W92 HS

Family and domain databases

CDDicd09563 SAM_liprin-beta1_2_repeat1, 1 hit
cd09566 SAM_liprin-beta1_2_repeat2, 1 hit
cd09569 SAM_liprin-beta1_2_repeat3, 1 hit
InterProiView protein in InterPro
IPR029515 Liprin
IPR037617 Liprin-beta_SAM_rpt_1
IPR037618 Liprin-beta_SAM_rpt_2
IPR037619 Liprin-beta_SAM_rpt_3
IPR030437 PPFIBP1
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR12587 PTHR12587, 1 hit
PTHR12587:SF16 PTHR12587:SF16, 1 hit
PfamiView protein in Pfam
PF00536 SAM_1, 2 hits
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 3 hits
SUPFAMiSSF47769 SSF47769, 3 hits
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLIPB1_HUMAN
AccessioniPrimary (citable) accession number: Q86W92
Secondary accession number(s): O75336
, Q86X70, Q9NY03, Q9ULJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 7, 2006
Last modified: November 7, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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