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Entry version 136 (12 Aug 2020)
Sequence version 2 (12 Aug 2020)
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Protein

Ankyrin repeat domain-containing protein 46

Gene

ANKRD46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q86W74

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 46
Alternative name(s):
Ankyrin repeat small protein
Short name:
ANK-S
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKRD46
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000186106.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27229, ANKRD46

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86W74

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei190 – 210HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
157567

Open Targets

More...
OpenTargetsi
ENSG00000186106

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672613

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86W74, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANKRD46

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74750488

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002445771 – 228Ankyrin repeat domain-containing protein 46Add BLAST228

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86W74

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86W74

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86W74

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86W74

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86W74

PeptideAtlas

More...
PeptideAtlasi
Q86W74

PRoteomics IDEntifications database

More...
PRIDEi
Q86W74

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70129 [Q86W74-1]
70130 [Q86W74-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86W74

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86W74

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186106, Expressed in endothelial cell and 249 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86W74, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86W74, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000186106, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Isoform 1 [Q86W74-2]
With#Exp.IntAct
AMIGO1 [Q86WK6]3EBI-12109402,EBI-19125216
APH1A [Q96BI3]3EBI-12109402,EBI-2606935
AQP6 [Q13520]3EBI-12109402,EBI-13059134
ARL13B [Q3SXY8]3EBI-12109402,EBI-11343438
BIK [Q13323]3EBI-12109402,EBI-700794
BSCL2 [J3KQ12]3EBI-12109402,EBI-11532900
C16orf54 [Q6UWD8]3EBI-12109402,EBI-18041102
CCDC155 [Q8N6L0]3EBI-12109402,EBI-749265
CD22 - isoform 5 [P20273-5]3EBI-12109402,EBI-13320645
CD46 - isoform D [P15529-3]3EBI-12109402,EBI-13046140
CLDN20 [P56880]3EBI-12109402,EBI-23801559
CLDN7 [O95471]3EBI-12109402,EBI-740744
CLEC4D [Q8WXI8]3EBI-12109402,EBI-12703404
CRB3 - isoform 2 [Q9BUF7-2]3EBI-12109402,EBI-17233035
CREB3L1 [Q96BA8]3EBI-12109402,EBI-6942903
CXADR [P78310]3EBI-12109402,EBI-747931
CYB561 [P49447]3EBI-12109402,EBI-8646596
EBP [Q15125]3EBI-12109402,EBI-3915253
EFNB1 [P98172]3EBI-12109402,EBI-538287
EFNB2 [P52799]3EBI-12109402,EBI-7532268
ELOVL4 [Q9GZR5]3EBI-12109402,EBI-18535450
FAM174A [Q8TBP5]3EBI-12109402,EBI-18636064
FAM209A [Q5JX71]3EBI-12109402,EBI-18304435
GOLM1 [Q8NBJ4]3EBI-12109402,EBI-712073
GPR152 [Q8TDT2]3EBI-12109402,EBI-13345167
GPR42 [O15529]3EBI-12109402,EBI-18076404
HSD17B11 [Q8NBQ5]3EBI-12109402,EBI-1052304
HSD17B13 [Q7Z5P4]3EBI-12109402,EBI-18053395
IFNLR1 [Q8IU57]3EBI-12109402,EBI-373215
KIR2DL3 [P43628]3EBI-12109402,EBI-8632435
LDLRAD1 [Q5T700]3EBI-12109402,EBI-10173166
LRRC25 [Q8N386]3EBI-12109402,EBI-11304917
MFF - isoform 5 [Q9GZY8-5]3EBI-12109402,EBI-11956541
MMGT1 [Q8N4V1]3EBI-12109402,EBI-6163737
MUC1 - isoform Y-LSP [P15941-11]3EBI-12109402,EBI-17263240
NCAPH2 - isoform 4 [Q6IBW4-4]3EBI-12109402,EBI-10247000
NSG2 [Q9Y328]3EBI-12109402,EBI-7101695
PLPP4 [Q5VZY2]3EBI-12109402,EBI-10485931
PVR [P15151]3EBI-12109402,EBI-3919694
RELL2 [Q8NC24]3EBI-12109402,EBI-10269209
RETREG3 [Q86VR2]3EBI-12109402,EBI-10192441
SCN3B [Q9NY72]3EBI-12109402,EBI-17247926
SECTM1 [Q8WVN6]3EBI-12109402,EBI-2855289
SHISA3 [A0PJX4]3EBI-12109402,EBI-10171518
SLC10A6 [Q3KNW5]3EBI-12109402,EBI-18159983
SLC18A1 - isoform 3 [P54219-3]3EBI-12109402,EBI-17595455
SLC39A9 [Q9NUM3]3EBI-12109402,EBI-2823239
ST6GALNAC6 [Q969X2]3EBI-12109402,EBI-949146
STX1A [Q16623]3EBI-12109402,EBI-712466
STX2 - isoform 1 [P32856-2]3EBI-12109402,EBI-11956649
STX4 [Q12846]3EBI-12109402,EBI-744942
SUSD3 [Q96L08]3EBI-12109402,EBI-18194029
THAP4 [Q8WY91]3EBI-12109402,EBI-726691
TIMMDC1 [Q9NPL8]3EBI-12109402,EBI-6268651
TMEM248 [Q9NWD8]3EBI-12109402,EBI-10314986
TMEM45B [Q96B21]3EBI-12109402,EBI-3923061
TMEM79 [Q9BSE2]3EBI-12109402,EBI-8649725
TMPRSS2 - isoform 2 [O15393-2]3EBI-12109402,EBI-12345267

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127604, 30 interactors

Protein interaction database and analysis system

More...
IntActi
Q86W74, 79 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000429015

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86W74, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86W74

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati11 – 40ANK 1Add BLAST30
Repeati44 – 73ANK 2Add BLAST30
Repeati77 – 103ANK 3Add BLAST27
Repeati107 – 138ANK 4Add BLAST32

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0508, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157094

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86W74

Identification of Orthologs from Complete Genome Data

More...
OMAi
CRFLHKF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86W74

TreeFam database of animal gene trees

More...
TreeFami
TF330790

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86W74-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYVFVNDSS QTNVPLLQAC IDGDFNYSKR LLESGFDPNI RDSRGRTGLH
60 70 80 90 100
LAAARGNVDI CQLLHKFGAD LLATDYQGNT ALHLCGHVDT IQFLVSNGLK
110 120 130 140 150
IDICNHQGAT PLVLAKRRGV NKDVIRLLES LEEQEVKGFN RGTHSKLETM
160 170 180 190 200
QTAESESAME SHSLLNPNLQ QGEGVLSSFR TTWQEFVEDL GFWRVLLLIF
210 220
VIALLSLGIA YYVSGVLPFV ENQPELVH
Length:228
Mass (Da):25,330
Last modified:August 12, 2020 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF49A43CE49A28A0C
GO
Isoform 2 (identifier: Q86W74-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-228: VSGVLPFVENQPELVH → RRTLRLGSFARQDRSRIQAI

Show »
Length:232
Mass (Da):25,967
Checksum:i63A3088747ED7E9A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RI04E5RI04_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD46
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFM7E5RFM7_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD46
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHV2E5RHV2_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD46
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KP26J3KP26_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD46
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI20E5RI20_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD46
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_060673213 – 228VSGVL…PELVH → RRTLRLGSFARQDRSRIQAI in isoform 2. CuratedAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB077205 mRNA Translation: BAD23947.1
AL832842 mRNA Translation: CAI46169.1
BC050396 mRNA Translation: AAH50396.1
BC060843 mRNA Translation: AAH60843.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS59109.1 [Q86W74-1]
CCDS6287.1 [Q86W74-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001257306.1, NM_001270377.1 [Q86W74-2]
NP_001257307.1, NM_001270378.1 [Q86W74-2]
NP_001257308.1, NM_001270379.1 [Q86W74-1]
NP_940683.1, NM_198401.3 [Q86W74-2]
XP_006716572.1, XM_006716509.1
XP_016868595.1, XM_017013106.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000335659; ENSP00000335287; ENSG00000186106 [Q86W74-2]
ENST00000519597; ENSP00000430056; ENSG00000186106 [Q86W74-2]
ENST00000520311; ENSP00000428388; ENSG00000186106 [Q86W74-2]
ENST00000520552; ENSP00000429015; ENSG00000186106 [Q86W74-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
157567

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:157567

UCSC genome browser

More...
UCSCi
uc003yjm.5, human [Q86W74-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077205 mRNA Translation: BAD23947.1
AL832842 mRNA Translation: CAI46169.1
BC050396 mRNA Translation: AAH50396.1
BC060843 mRNA Translation: AAH60843.1
CCDSiCCDS59109.1 [Q86W74-1]
CCDS6287.1 [Q86W74-2]
RefSeqiNP_001257306.1, NM_001270377.1 [Q86W74-2]
NP_001257307.1, NM_001270378.1 [Q86W74-2]
NP_001257308.1, NM_001270379.1 [Q86W74-1]
NP_940683.1, NM_198401.3 [Q86W74-2]
XP_006716572.1, XM_006716509.1
XP_016868595.1, XM_017013106.1

3D structure databases

SMRiQ86W74
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127604, 30 interactors
IntActiQ86W74, 79 interactors
STRINGi9606.ENSP00000429015

PTM databases

iPTMnetiQ86W74
PhosphoSitePlusiQ86W74

Polymorphism and mutation databases

BioMutaiANKRD46
DMDMi74750488

Proteomic databases

EPDiQ86W74
jPOSTiQ86W74
MassIVEiQ86W74
MaxQBiQ86W74
PaxDbiQ86W74
PeptideAtlasiQ86W74
PRIDEiQ86W74
ProteomicsDBi70129 [Q86W74-1]
70130 [Q86W74-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
51983, 68 antibodies

Genome annotation databases

EnsembliENST00000335659; ENSP00000335287; ENSG00000186106 [Q86W74-2]
ENST00000519597; ENSP00000430056; ENSG00000186106 [Q86W74-2]
ENST00000520311; ENSP00000428388; ENSG00000186106 [Q86W74-2]
ENST00000520552; ENSP00000429015; ENSG00000186106 [Q86W74-1]
GeneIDi157567
KEGGihsa:157567
UCSCiuc003yjm.5, human [Q86W74-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
157567
DisGeNETi157567
EuPathDBiHostDB:ENSG00000186106.11

GeneCards: human genes, protein and diseases

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GeneCardsi
ANKRD46
HGNCiHGNC:27229, ANKRD46
HPAiENSG00000186106, Low tissue specificity
neXtProtiNX_Q86W74
OpenTargetsiENSG00000186106
PharmGKBiPA142672613

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0508, Eukaryota
GeneTreeiENSGT00940000157094
InParanoidiQ86W74
OMAiCRFLHKF
PhylomeDBiQ86W74
TreeFamiTF330790

Enzyme and pathway databases

PathwayCommonsiQ86W74

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
157567, 4 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ANKRD46, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
157567
PharosiQ86W74, Tbio

Protein Ontology

More...
PROi
PR:Q86W74
RNActiQ86W74, protein

Gene expression databases

BgeeiENSG00000186106, Expressed in endothelial cell and 249 other tissues
ExpressionAtlasiQ86W74, baseline and differential
GenevisibleiQ86W74, HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 3 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANR46_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86W74
Secondary accession number(s): Q6P9B7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: August 12, 2020
Last modified: August 12, 2020
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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