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Entry version 126 (08 May 2019)
Sequence version 2 (01 Mar 2004)
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Protein

Calcium-activated potassium channel subunit beta-4

Gene

KCNMB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.3 Publications

Miscellaneous

Treatment with okadaic acid reduces its effect on KCNMA1.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium-activated potassium channel activity Source: UniProtKB
  • potassium channel regulator activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1296052 Ca2+ activated K+ channels
R-HSA-418457 cGMP effects

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium-activated potassium channel subunit beta-4
Alternative name(s):
BK channel subunit beta-4
Short name:
BKbeta4
Short name:
Hbeta4
Calcium-activated potassium channel, subfamily M subunit beta-4
Charybdotoxin receptor subunit beta-4
K(VCA)beta-4
Maxi K channel subunit beta-4
Slo-beta-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNMB4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6289 KCNMB4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605223 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86W47

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini41 – 167ExtracellularSequence analysisAdd BLAST127
Transmembranei168 – 188Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini189 – 210CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi11T → A: Suppresses the effect of okadaic acid and increases activation time constant; when associated with A-17 and A-210. 1 Publication1
Mutagenesisi11T → D: Suppresses its effect on KCNMA1 channel activation and on deactivation kinetics; when associated with E-17 and E-210. 1 Publication1
Mutagenesisi17S → A: Suppresses the effect of okadaic acid and increases activation time constant; when associated with A-11 and A-210. 1 Publication1
Mutagenesisi17S → E: Suppresses its effect on KCNMA1 channel activation and on deactivation kinetics; when associated with D-11 and E-210. 1 Publication1
Mutagenesisi53N → A: Loss of N-glycosylation and reduced protection against charybdotoxin; when associated with A-90. 1 Publication1
Mutagenesisi90N → A: Loss of N-glycosylation and reduced protection against charybdotoxin; when associated with A-53. 1 Publication1
Mutagenesisi210S → A: Suppresses the effect of okadaic acid and increases activation time constant; when associated with A-11 and A-17. 1 Publication1
Mutagenesisi210S → E: Suppresses its effect on KCNMA1 channel activation and on deactivation kinetics; when associated with D-11 and E-17. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
27345

Open Targets

More...
OpenTargetsi
ENSG00000135643

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30069

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01110 Miconazole
DB00721 Procaine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KCNMB4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
46395791

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001870551 – 210Calcium-activated potassium channel subunit beta-4Add BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi53N-linked (GlcNAc...) asparagine1
Glycosylationi90N-linked (GlcNAc...) asparagine1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics.1 Publication
N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86W47

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86W47

PeptideAtlas

More...
PeptideAtlasi
Q86W47

PRoteomics IDEntifications database

More...
PRIDEi
Q86W47

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70115

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86W47

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86W47

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q86W47

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135643 Expressed in 161 organ(s), highest expression level in Brodmann (1909) area 46

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86W47 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86W47 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA072287

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KCNMA1 tetramer (PubMed:10692449, PubMed:10804197). There are probably 4 molecules of KCMNB4 per KCNMA1 tetramer (PubMed:10692449, PubMed:10804197). Interacts with FMR1 (via N-terminus) (PubMed:25561520).3 Publications

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q86W47, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000258111

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5Y7LNMR-A45-166[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86W47

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Resistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJVB Eukaryota
ENOG410XSTD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183039

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113205

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86W47

KEGG Orthology (KO)

More...
KOi
K04941

Identification of Orthologs from Complete Genome Data

More...
OMAi
HEDERQL

Database of Orthologous Groups

More...
OrthoDBi
1178937at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86W47

TreeFam database of animal gene trees

More...
TreeFami
TF328589

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003930 K_chnl_Ca-activ_BK_bsu

The PANTHER Classification System

More...
PANTHERi
PTHR10258 PTHR10258, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03185 CaKB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q86W47-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKLRVAYEY TEAEDKSIRL GLFLIISGVV SLFIFGFCWL SPALQDLQAT
60 70 80 90 100
EANCTVLSVQ QIGEVFECTF TCGADCRGTS QYPCVQVYVN NSESNSRALL
110 120 130 140 150
HSDEHQLLTN PKCSYIPPCK RENQKNLESV MNWQQYWKDE IGSQPFTCYF
160 170 180 190 200
NQHQRPDDVL LHRTHDEIVL LHCFLWPLVT FVVGVLIVVL TICAKSLAVK
210
AEAMKKRKFS
Length:210
Mass (Da):23,949
Last modified:March 1, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA59D56DD034F027A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YC85H0YC85_HUMAN
Calcium-activated potassium channel...
KCNMB4
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018178199V → I1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF160967 mRNA Translation: AAF69805.1
AF170917 mRNA Translation: AAF89699.1
AF207992 mRNA Translation: AAF28333.1
AF215891 mRNA Translation: AAF75596.1
BC042446 mRNA Translation: AAH42446.2
BC050621 mRNA Translation: AAH50621.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8997.1

NCBI Reference Sequences

More...
RefSeqi
NP_055320.4, NM_014505.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000258111; ENSP00000258111; ENSG00000135643

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
27345

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:27345

UCSC genome browser

More...
UCSCi
uc001svx.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF160967 mRNA Translation: AAF69805.1
AF170917 mRNA Translation: AAF89699.1
AF207992 mRNA Translation: AAF28333.1
AF215891 mRNA Translation: AAF75596.1
BC042446 mRNA Translation: AAH42446.2
BC050621 mRNA Translation: AAH50621.2
CCDSiCCDS8997.1
RefSeqiNP_055320.4, NM_014505.5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5Y7LNMR-A45-166[»]
SMRiQ86W47
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ86W47, 2 interactors
STRINGi9606.ENSP00000258111

Chemistry databases

DrugBankiDB01110 Miconazole
DB00721 Procaine

PTM databases

iPTMnetiQ86W47
PhosphoSitePlusiQ86W47
SwissPalmiQ86W47

Polymorphism and mutation databases

BioMutaiKCNMB4
DMDMi46395791

Proteomic databases

EPDiQ86W47
PaxDbiQ86W47
PeptideAtlasiQ86W47
PRIDEiQ86W47
ProteomicsDBi70115

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258111; ENSP00000258111; ENSG00000135643
GeneIDi27345
KEGGihsa:27345
UCSCiuc001svx.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27345
DisGeNETi27345

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KCNMB4
HGNCiHGNC:6289 KCNMB4
HPAiHPA072287
MIMi605223 gene
neXtProtiNX_Q86W47
OpenTargetsiENSG00000135643
PharmGKBiPA30069

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJVB Eukaryota
ENOG410XSTD LUCA
GeneTreeiENSGT00950000183039
HOGENOMiHOG000113205
InParanoidiQ86W47
KOiK04941
OMAiHEDERQL
OrthoDBi1178937at2759
PhylomeDBiQ86W47
TreeFamiTF328589

Enzyme and pathway databases

ReactomeiR-HSA-1296052 Ca2+ activated K+ channels
R-HSA-418457 cGMP effects

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KCNMB4 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
KCNMB4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
27345

Protein Ontology

More...
PROi
PR:Q86W47

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135643 Expressed in 161 organ(s), highest expression level in Brodmann (1909) area 46
ExpressionAtlasiQ86W47 baseline and differential
GenevisibleiQ86W47 HS

Family and domain databases

InterProiView protein in InterPro
IPR003930 K_chnl_Ca-activ_BK_bsu
PANTHERiPTHR10258 PTHR10258, 1 hit
PfamiView protein in Pfam
PF03185 CaKB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCMB4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86W47
Secondary accession number(s): Q8IVR3, Q9NPA4, Q9P0G5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2004
Last modified: May 8, 2019
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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