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Entry version 143 (26 Feb 2020)
Sequence version 2 (11 Jan 2011)
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Protein

Archaemetzincin-2

Gene

AMZ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Zinc metalloprotease. Exhibits activity against angiotensin-3 in vitro. Does not hydrolyze either neurogranin or angiotensin-2.1 Publication

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit. One is catalytic, whereas the other seems to have a structural role.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by the general metalloprotease inhibitors o-phenanthroline and batimastat. Also significantly inhibited by amastatin, which is an inhibitor of aminopeptidases. Not inhibited by 4-(2-aminoethyl)-benzenesulfonyl fluoride, E-64, and TIMPS (tissue inhibitors of metalloproteinases), which are inhibitors of serine, cysteine, and matrix metalloproteases, respectively.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 7.0.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi254Zinc 1; via pros nitrogen; catalyticBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei255Proton acceptorPROSITE-ProRule annotation1
Metal bindingi258Zinc 1; via pros nitrogen; catalyticBy similarity1
Metal bindingi264Zinc 1; via pros nitrogen; catalyticBy similarity1
Metal bindingi265Zinc 2By similarity1
Metal bindingi270Zinc 2By similarity1
Metal bindingi289Zinc 2By similarity1
Metal bindingi292Zinc 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M54.002

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Archaemetzincin-2 (EC:3.4.-.-)
Alternative name(s):
Archeobacterial metalloproteinase-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AMZ2
ORF Names:BM-014
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28041 AMZ2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
615169 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86W34

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000196704

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162376414

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86W34 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AMZ2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373321

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001596171 – 360Archaemetzincin-2Add BLAST360

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86W34

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86W34

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86W34

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86W34

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86W34

PeptideAtlas

More...
PeptideAtlasi
Q86W34

PRoteomics IDEntifications database

More...
PRIDEi
Q86W34

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
1468
70111 [Q86W34-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86W34

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86W34

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in heart and testis. Also expressed at lower levels in kidney, liver, pancreas, lung, brain and placenta. Expressed in fetal tissues such as kidney, liver, lung and brain. Down-regulated in testis from patients with maturation arrest (MA) or Sertoli cell-only syndrome (SCOS).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196704 Expressed in right testis and 225 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86W34 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86W34 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023299
HPA052406

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119472, 21 interactors

Protein interaction database and analysis system

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IntActi
Q86W34, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000352976

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86W34 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M54 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IVMN Eukaryota
COG1913 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063996

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_029710_2_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q86W34

KEGG Orthology (KO)

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KOi
K06974

Identification of Orthologs from Complete Genome Data

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OMAi
QCVMQGS

Database of Orthologous Groups

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OrthoDBi
1092305at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86W34

TreeFam database of animal gene trees

More...
TreeFami
TF328603

Family and domain databases

Conserved Domains Database

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CDDi
cd11375 Peptidase_M54, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR024079 MetalloPept_cat_dom_sf
IPR012962 Pept_M54_archaemetzincn

The PANTHER Classification System

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PANTHERi
PTHR32205:SF5 PTHR32205:SF5, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF07998 Peptidase_M54, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86W34-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQIIRHSEQT LKTALISKNP VLVSQYEKLN AGEQRLMNEA FQPASDLFGP
60 70 80 90 100
ITLHSPSDWI TSHPEAPQDF EQFFSDPYRK TPSPNKRSIY IQSIGSLGNT
110 120 130 140 150
RIISEEYIKW LTGYCKAYFY GLRVKLLEPV PVSVTRCSFR VNENTHNLQI
160 170 180 190 200
HAGDILKFLK KKKPEDAFCV VGITMIDLYP RDSWNFVFGQ ASLTDGVGIF
210 220 230 240 250
SFARYGSDFY SMHYKGKVKK LKKTSSSDYS IFDNYYIPEI TSVLLLRSCK
260 270 280 290 300
TLTHEIGHIF GLRHCQWLAC LMQGSNHLEE ADRRPLNLCP ICLHKLQCAV
310 320 330 340 350
GFSIVERYKA LVRWIDDESS DTPGATPEHS HEDNGNLPKP VEAFKEWKEW
360
IIKCLAVLQK
Length:360
Mass (Da):41,263
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD74E7F7CE7873CBF
GO
Isoform 2 (identifier: Q86W34-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-153: Missing.

Show »
Length:302
Mass (Da):34,595
Checksum:i2AE9FB8B77CC8293
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KSH1J3KSH1_HUMAN
Archaemetzincin-2
AMZ2
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTM1J3KTM1_HUMAN
Archaemetzincin-2
AMZ2
221Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRD0J3KRD0_HUMAN
Archaemetzincin-2
AMZ2
248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRS2J3KRS2_HUMAN
Archaemetzincin-2
AMZ2
201Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLK6J3QLK6_HUMAN
Archaemetzincin-2
AMZ2
206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS38J3KS38_HUMAN
Archaemetzincin-2
AMZ2
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QL25J3QL25_HUMAN
Archaemetzincin-2
AMZ2
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQR3J3QQR3_HUMAN
Archaemetzincin-2
AMZ2
23Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF64270 differs from that shown. Reason: Frameshift.Curated
The sequence AAF64270 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4I → V in AAF64270 (PubMed:11042152).Curated1
Sequence conflicti6H → Y in AAF64270 (PubMed:11042152).Curated1
Sequence conflicti13T → I in AAF64270 (PubMed:11042152).Curated1
Sequence conflicti15L → V in AAF64270 (PubMed:11042152).Curated1
Sequence conflicti29L → V in AAF64270 (PubMed:11042152).Curated1
Sequence conflicti51 – 52IT → CI in AAF64270 (PubMed:11042152).Curated2
Sequence conflicti76D → H in AAF64270 (PubMed:11042152).Curated1
Sequence conflicti81T → I in AAF64270 (PubMed:11042152).Curated1
Sequence conflicti85N → D in AAF64270 (PubMed:11042152).Curated1
Sequence conflicti92Q → R in AAF64270 (PubMed:11042152).Curated1
Sequence conflicti99N → S in AAF64270 (PubMed:11042152).Curated1
Sequence conflicti121G → R in AAF64270 (PubMed:11042152).Curated1
Sequence conflicti207S → G in AAF64270 (PubMed:11042152).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02485030N → D5 PublicationsCorresponds to variant dbSNP:rs3213690Ensembl.1
Natural variantiVAR_047343146H → Q. Corresponds to variant dbSNP:rs3207194Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04726396 – 153Missing in isoform 2. CuratedAdd BLAST58

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ635358 mRNA Translation: CAG25750.1
AF208856 mRNA Translation: AAF64270.1 Sequence problems.
AK126146 mRNA Translation: BAC86462.1
AK090981 mRNA Translation: BAG52256.1
AC005332 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89050.1
BC050709 mRNA Translation: AAH50709.1
BC056271 mRNA Translation: AAH56271.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11674.1 [Q86W34-4]
CCDS32714.1 [Q86W34-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001028741.1, NM_001033569.1 [Q86W34-4]
NP_001028742.1, NM_001033570.1 [Q86W34-4]
NP_001028743.1, NM_001033571.1 [Q86W34-4]
NP_001028744.1, NM_001033572.1 [Q86W34-4]
NP_001028746.1, NM_001033574.1 [Q86W34-5]
NP_001275983.1, NM_001289054.1 [Q86W34-4]
NP_001275985.1, NM_001289056.1 [Q86W34-4]
NP_001333400.1, NM_001346471.1 [Q86W34-4]
NP_001333401.1, NM_001346472.1 [Q86W34-4]
NP_001333402.1, NM_001346473.1 [Q86W34-4]
NP_001333403.1, NM_001346474.1 [Q86W34-4]
NP_001333404.1, NM_001346475.1 [Q86W34-4]
NP_001333405.1, NM_001346476.1 [Q86W34-4]
NP_001333406.1, NM_001346477.1 [Q86W34-4]
NP_001333407.1, NM_001346478.1 [Q86W34-4]
NP_001333408.1, NM_001346479.1 [Q86W34-4]
NP_001333409.1, NM_001346480.1 [Q86W34-5]
NP_057711.3, NM_016627.4 [Q86W34-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000359783; ENSP00000352831; ENSG00000196704 [Q86W34-5]
ENST00000359904; ENSP00000352976; ENSG00000196704 [Q86W34-4]
ENST00000392720; ENSP00000376481; ENSG00000196704 [Q86W34-4]
ENST00000577866; ENSP00000464133; ENSG00000196704 [Q86W34-4]
ENST00000577985; ENSP00000464635; ENSG00000196704 [Q86W34-4]
ENST00000580753; ENSP00000463012; ENSG00000196704 [Q86W34-4]
ENST00000612294; ENSP00000483162; ENSG00000196704 [Q86W34-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51321

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51321

UCSC genome browser

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UCSCi
uc002jgs.2 human [Q86W34-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ635358 mRNA Translation: CAG25750.1
AF208856 mRNA Translation: AAF64270.1 Sequence problems.
AK126146 mRNA Translation: BAC86462.1
AK090981 mRNA Translation: BAG52256.1
AC005332 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89050.1
BC050709 mRNA Translation: AAH50709.1
BC056271 mRNA Translation: AAH56271.1
CCDSiCCDS11674.1 [Q86W34-4]
CCDS32714.1 [Q86W34-5]
RefSeqiNP_001028741.1, NM_001033569.1 [Q86W34-4]
NP_001028742.1, NM_001033570.1 [Q86W34-4]
NP_001028743.1, NM_001033571.1 [Q86W34-4]
NP_001028744.1, NM_001033572.1 [Q86W34-4]
NP_001028746.1, NM_001033574.1 [Q86W34-5]
NP_001275983.1, NM_001289054.1 [Q86W34-4]
NP_001275985.1, NM_001289056.1 [Q86W34-4]
NP_001333400.1, NM_001346471.1 [Q86W34-4]
NP_001333401.1, NM_001346472.1 [Q86W34-4]
NP_001333402.1, NM_001346473.1 [Q86W34-4]
NP_001333403.1, NM_001346474.1 [Q86W34-4]
NP_001333404.1, NM_001346475.1 [Q86W34-4]
NP_001333405.1, NM_001346476.1 [Q86W34-4]
NP_001333406.1, NM_001346477.1 [Q86W34-4]
NP_001333407.1, NM_001346478.1 [Q86W34-4]
NP_001333408.1, NM_001346479.1 [Q86W34-4]
NP_001333409.1, NM_001346480.1 [Q86W34-5]
NP_057711.3, NM_016627.4 [Q86W34-4]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi119472, 21 interactors
IntActiQ86W34, 12 interactors
STRINGi9606.ENSP00000352976

Protein family/group databases

MEROPSiM54.002

PTM databases

iPTMnetiQ86W34
PhosphoSitePlusiQ86W34

Polymorphism and mutation databases

BioMutaiAMZ2
DMDMi317373321

Proteomic databases

EPDiQ86W34
jPOSTiQ86W34
MassIVEiQ86W34
MaxQBiQ86W34
PaxDbiQ86W34
PeptideAtlasiQ86W34
PRIDEiQ86W34
ProteomicsDBi1468
70111 [Q86W34-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
51321

Genome annotation databases

EnsembliENST00000359783; ENSP00000352831; ENSG00000196704 [Q86W34-5]
ENST00000359904; ENSP00000352976; ENSG00000196704 [Q86W34-4]
ENST00000392720; ENSP00000376481; ENSG00000196704 [Q86W34-4]
ENST00000577866; ENSP00000464133; ENSG00000196704 [Q86W34-4]
ENST00000577985; ENSP00000464635; ENSG00000196704 [Q86W34-4]
ENST00000580753; ENSP00000463012; ENSG00000196704 [Q86W34-4]
ENST00000612294; ENSP00000483162; ENSG00000196704 [Q86W34-4]
GeneIDi51321
KEGGihsa:51321
UCSCiuc002jgs.2 human [Q86W34-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51321

GeneCards: human genes, protein and diseases

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GeneCardsi
AMZ2
HGNCiHGNC:28041 AMZ2
HPAiHPA023299
HPA052406
MIMi615169 gene
neXtProtiNX_Q86W34
OpenTargetsiENSG00000196704
PharmGKBiPA162376414

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVMN Eukaryota
COG1913 LUCA
GeneTreeiENSGT00530000063996
HOGENOMiCLU_029710_2_1_1
InParanoidiQ86W34
KOiK06974
OMAiQCVMQGS
OrthoDBi1092305at2759
PhylomeDBiQ86W34
TreeFamiTF328603

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AMZ2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51321
PharosiQ86W34 Tdark

Protein Ontology

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PROi
PR:Q86W34
RNActiQ86W34 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196704 Expressed in right testis and 225 other tissues
ExpressionAtlasiQ86W34 baseline and differential
GenevisibleiQ86W34 HS

Family and domain databases

CDDicd11375 Peptidase_M54, 1 hit
Gene3Di3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR024079 MetalloPept_cat_dom_sf
IPR012962 Pept_M54_archaemetzincn
PANTHERiPTHR32205:SF5 PTHR32205:SF5, 1 hit
PfamiView protein in Pfam
PF07998 Peptidase_M54, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMZ2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86W34
Secondary accession number(s): A6NLD9
, B3KR44, Q5XKF1, Q9NZE2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 11, 2011
Last modified: February 26, 2020
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Peptidase families
    Classification of peptidase families and list of entries
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