Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 142 (26 Feb 2020)
Sequence version 2 (03 Apr 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

NACHT, LRR and PYD domains-containing protein 8

Gene

NLRP8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in inflammation.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi210 – 217ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NACHT, LRR and PYD domains-containing protein 8
Alternative name(s):
Nucleotide-binding oligomerization domain protein 16
PYRIN and NACHT-containing protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NLRP8
Synonyms:NALP8, NOD16, PAN4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22940 NLRP8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609659 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86W28

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
126205

Open Targets

More...
OpenTargetsi
ENSG00000179709

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162398028

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86W28 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NLRP8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143355070

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002829901 – 1048NACHT, LRR and PYD domains-containing protein 8Add BLAST1048

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86W28

PeptideAtlas

More...
PeptideAtlasi
Q86W28

PRoteomics IDEntifications database

More...
PRIDEi
Q86W28

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70106 [Q86W28-1]
70107 [Q86W28-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86W28

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86W28

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000179709 Expressed in secondary oocyte and 3 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86W28 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA056989

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000291971

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86W28 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 131PyrinPROSITE-ProRule annotationAdd BLAST99
Domaini204 – 527NACHTPROSITE-ProRule annotationAdd BLAST324
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati815 – 838LRR 2Add BLAST24
Repeati839 – 861LRR 3Add BLAST23
Repeati866 – 890LRR 4Add BLAST25
Repeati923 – 950LRR 5Add BLAST28
Repeati980 – 1007LRR 6Add BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NLRP family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJVQ Eukaryota
ENOG410Y5EC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163909

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002274_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86W28

KEGG Orthology (KO)

More...
KOi
K22662

Identification of Orthologs from Complete Genome Data

More...
OMAi
DIFAKMN

Database of Orthologous Groups

More...
OrthoDBi
114368at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86W28

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR041267 NLRC_HD2
IPR041075 NOD2_WH
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13516 LRR_6, 3 hits
PF05729 NACHT, 1 hit
PF17776 NLRC4_HD2, 1 hit
PF17779 NOD2_WH, 1 hit
PF02758 PYRIN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01289 PYRIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986 SSF47986, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50824 DAPIN, 1 hit
PS50837 NACHT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q86W28-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDVNPPSDT PIPFSSSSTH SSHIPPWTFS CYPGSPCENG VMLYMRNVSH
60 70 80 90 100
EELQRFKQLL LTELSTGTMP ITWDQVETAS WAEVVHLLIE RFPGRRAWDV
110 120 130 140 150
TSNIFAIMNC DKMCVVVRRE INAILPTLEP EDLNVGETQV NLEEGESGKI
160 170 180 190 200
RRYKSNVMEK FFPIWDITTW PGNQRDFFYQ GVHRHEEYLP CLLLPKRPQG
210 220 230 240 250
RQPKTVAIQG APGIGKTILA KKVMFEWARN KFYAHKRWCA FYFHCQEVNQ
260 270 280 290 300
TTDQSFSELI EQKWPGSQDL VSKIMSKPDQ LLLLLDGFEE LTSTLIDRLE
310 320 330 340 350
DLSEDWRQKL PGSVLLSSLL SKTMLPEATL LIMIRFTSWQ TCKPLLKCPS
360 370 380 390 400
LVTLPGFNTM EKIKYFQMYF GHTEEGDQVL SFAMENTILF SMCRVPVVCW
410 420 430 440 450
MVCSGLKQQM ERGNNLTQSC PNATSVFVRY ISSLFPTRAE NFSRKIHQAQ
460 470 480 490 500
LEGLCHLAAD SMWHRKWVLG KEDLEEAKLD QTGVTAFLGM SILRRIAGEE
510 520 530 540 550
DHYVFTLVTF QEFFAALFYV LCFPQRLKNF HVLSHVNIQR LIASPRGSKS
560 570 580 590 600
YLSHMGLFLF GFLNEACASA VEQSFQCKVS FGNKRKLLKV IPLLHKCDPP
610 620 630 640 650
SPGSGVPQLF YCLHEIREEA FVSQALNDYH KVVLRIGNNK EVQVSAFCLK
660 670 680 690 700
RCQYLHEVEL TVTLNFMNVW KLSSSSHPGS EAPESNGLHR WWQDLCSVFA
710 720 730 740 750
TNDKLEVLTM TNSVLGPPFL KALAAALRHP QCKLQKLLLR RVNSTMLNQD
760 770 780 790 800
LIGVLTGNQH LRYLEIQHVE VESKAVKLLC RVLRSPRCRL QCLRLEDCLA
810 820 830 840 850
TPRIWTDLGN NLQGNGHLKT LILRKNSLEN CGAYYLSVAQ LERLSIENCN
860 870 880 890 900
LTQLTCESLA SCLRQSKMLT HLSLAENALK DEGAKHIWNA LPHLRCPLQR
910 920 930 940 950
LVLRKCDLTF NCCQDMISAL CKNKTLKSLD LSFNSLKDDG VILLCEALKN
960 970 980 990 1000
PDCTLQILEL ENCLFTSICC QAMASMLRKN QHLRHLDLSK NAIGVYGILT
1010 1020 1030 1040
LCEAFSSQKK REEVIFCIPA WTRITSFSPT PHPPDFTGKS DCLSQINP
Length:1,048
Mass (Da):119,430
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE429B78960FF746
GO
Isoform 2 (identifier: Q86W28-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     846-864: Missing.

Show »
Length:1,029
Mass (Da):117,336
Checksum:i7F8CEC14577303BA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03145225P → L. Corresponds to variant dbSNP:rs306507Ensembl.1
Natural variantiVAR_031453116V → L. Corresponds to variant dbSNP:rs306506Ensembl.1
Natural variantiVAR_036383126P → R in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs61739987Ensembl.1
Natural variantiVAR_031454234A → T. Corresponds to variant dbSNP:rs11880691Ensembl.1
Natural variantiVAR_031455268Q → R. Corresponds to variant dbSNP:rs7259764Ensembl.1
Natural variantiVAR_031456367Q → E. Corresponds to variant dbSNP:rs11880748Ensembl.1
Natural variantiVAR_036384375E → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_053618543A → V. Corresponds to variant dbSNP:rs41391053Ensembl.1
Natural variantiVAR_053619651R → W. Corresponds to variant dbSNP:rs41481648Ensembl.1
Natural variantiVAR_031457782V → A. Corresponds to variant dbSNP:rs306496Ensembl.1
Natural variantiVAR_031458937K → R. Corresponds to variant dbSNP:rs306481Ensembl.1
Natural variantiVAR_0363851045Q → L in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024274846 – 864Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY154463 mRNA Translation: AAO18159.1
BK001109 mRNA Translation: DAA01242.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12937.1 [Q86W28-1]
CCDS82402.1 [Q86W28-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001303929.1, NM_001317000.1 [Q86W28-2]
NP_789781.2, NM_176811.2 [Q86W28-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000291971; ENSP00000291971; ENSG00000179709 [Q86W28-1]
ENST00000590542; ENSP00000468121; ENSG00000179709 [Q86W28-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
126205

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:126205

UCSC genome browser

More...
UCSCi
uc002qmh.3 human [Q86W28-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY154463 mRNA Translation: AAO18159.1
BK001109 mRNA Translation: DAA01242.1
CCDSiCCDS12937.1 [Q86W28-1]
CCDS82402.1 [Q86W28-2]
RefSeqiNP_001303929.1, NM_001317000.1 [Q86W28-2]
NP_789781.2, NM_176811.2 [Q86W28-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000291971

PTM databases

iPTMnetiQ86W28
PhosphoSitePlusiQ86W28

Polymorphism and mutation databases

BioMutaiNLRP8
DMDMi143355070

Proteomic databases

PaxDbiQ86W28
PeptideAtlasiQ86W28
PRIDEiQ86W28
ProteomicsDBi70106 [Q86W28-1]
70107 [Q86W28-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
126205

Genome annotation databases

EnsembliENST00000291971; ENSP00000291971; ENSG00000179709 [Q86W28-1]
ENST00000590542; ENSP00000468121; ENSG00000179709 [Q86W28-2]
GeneIDi126205
KEGGihsa:126205
UCSCiuc002qmh.3 human [Q86W28-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
126205
DisGeNETi126205

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NLRP8
HGNCiHGNC:22940 NLRP8
HPAiHPA056989
MIMi609659 gene
neXtProtiNX_Q86W28
OpenTargetsiENSG00000179709
PharmGKBiPA162398028

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJVQ Eukaryota
ENOG410Y5EC LUCA
GeneTreeiENSGT00940000163909
HOGENOMiCLU_002274_2_1_1
InParanoidiQ86W28
KOiK22662
OMAiDIFAKMN
OrthoDBi114368at2759
PhylomeDBiQ86W28

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NLRP8 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NLRP8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
126205
PharosiQ86W28 Tdark

Protein Ontology

More...
PROi
PR:Q86W28
RNActiQ86W28 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000179709 Expressed in secondary oocyte and 3 other tissues
GenevisibleiQ86W28 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR041267 NLRC_HD2
IPR041075 NOD2_WH
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF13516 LRR_6, 3 hits
PF05729 NACHT, 1 hit
PF17776 NLRC4_HD2, 1 hit
PF17779 NOD2_WH, 1 hit
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
PS50837 NACHT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNALP8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86W28
Secondary accession number(s): Q7RTR4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: February 26, 2020
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again