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Entry version 144 (26 Feb 2020)
Sequence version 1 (01 Jun 2003)
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Protein

NACHT, LRR and PYD domains-containing protein 14

Gene

NLRP14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in inflammation and spermatogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi183 – 190ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NACHT, LRR and PYD domains-containing protein 14
Alternative name(s):
Nucleotide-binding oligomerization domain protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NLRP14
Synonyms:NALP14, NOD5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22939 NLRP14

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609665 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86W24

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi84L → R: Increased thermal stability of the Pyrin domain. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
338323

Open Targets

More...
OpenTargetsi
ENSG00000158077

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162397917

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86W24 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NLRP14

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38372322

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809011 – 1093NACHT, LRR and PYD domains-containing protein 14Add BLAST1093

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86W24

PeptideAtlas

More...
PeptideAtlasi
Q86W24

PRoteomics IDEntifications database

More...
PRIDEi
Q86W24

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70103

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86W24

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86W24

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis-specific.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In the testis, expressed mainly in A dark spermatogonia, mid and late spermatocytes and spermatids but not in mitotically active A pale and B spermatogonia.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000158077 Expressed in oocyte and 19 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86W24 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039477

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
130710, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q86W24, 2 interactors

Molecular INTeraction database

More...
MINTi
Q86W24

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299481

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86W24 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11093
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86W24

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 97PyrinPROSITE-ProRule annotationAdd BLAST97
Domaini177 – 499NACHTPROSITE-ProRule annotationAdd BLAST323
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati730 – 750LRR 1Add BLAST21
Repeati759 – 780LRR 2Add BLAST22
Repeati787 – 807LRR 3Add BLAST21
Repeati816 – 836LRR 4Add BLAST21
Repeati844 – 864LRR 5Add BLAST21
Repeati873 – 894LRR 6Add BLAST22
Repeati901 – 921LRR 7Add BLAST21
Repeati930 – 951LRR 8Add BLAST22
Repeati958 – 978LRR 9Add BLAST21
Repeati987 – 1008LRR 10Add BLAST22
Repeati1015 – 1035LRR 11Add BLAST21

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Upon heterologous expression, a small proportion of the isolated Pyrin domain forms homodimers and higher oligomers.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NLRP family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4308 Eukaryota
ENOG410ZBX3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162005

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002274_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86W24

KEGG Orthology (KO)

More...
KOi
K22666

Identification of Orthologs from Complete Genome Data

More...
OMAi
DWTQVHP

Database of Orthologous Groups

More...
OrthoDBi
114368at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86W24

TreeFam database of animal gene trees

More...
TreeFami
TF340267

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR041267 NLRC_HD2
IPR041075 NOD2_WH
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13516 LRR_6, 4 hits
PF05729 NACHT, 1 hit
PF17776 NLRC4_HD2, 1 hit
PF17779 NOD2_WH, 1 hit
PF02758 PYRIN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01289 PYRIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986 SSF47986, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50824 DAPIN, 1 hit
PS50837 NACHT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q86W24-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADSSSSSFF PDFGLLLYLE ELNKEELNTF KLFLKETMEP EHGLTPWNEV
60 70 80 90 100
KKARREDLAN LMKKYYPGEK AWSVSLKIFG KMNLKDLCER AKEEINWSAQ
110 120 130 140 150
TIGPDDAKAG ETQEDQEAVL GDGTEYRNRI KEKFCITWDK KSLAGKPEDF
160 170 180 190 200
HHGIAEKDRK LLEHLFDVDV KTGAQPQIVV LQGAAGVGKT TLVRKAMLDW
210 220 230 240 250
AEGSLYQQRF KYVFYLNGRE INQLKERSFA QLISKDWPST EGPIEEIMYQ
260 270 280 290 300
PSSLLFIIDS FDELNFAFEE PEFALCEDWT QEHPVSFLMS SLLRKVMLPE
310 320 330 340 350
ASLLVTTRLT TSKRLKQLLK NHHYVELLGM SEDAREEYIY QFFEDKRWAM
360 370 380 390 400
KVFSSLKSNE MLFSMCQVPL VCWAACTCLK QQMEKGGDVT LTCQTTTALF
410 420 430 440 450
TCYISSLFTP VDGGSPSLPN QAQLRRLCQV AAKGIWTMTY VFYRENLRRL
460 470 480 490 500
GLTQSDVSSF MDSNIIQKDA EYENCYVFTH LHVQEFFAAM FYMLKGSWEA
510 520 530 540 550
GNPSCQPFED LKSLLQSTSY KDPHLTQMKC FLFGLLNEDR VKQLERTFNC
560 570 580 590 600
KMSLKIKSKL LQCMEVLGNS DYSPSQLGFL ELFHCLYETQ DKAFISQAMR
610 620 630 640 650
CFPKVAINIC EKIHLLVSSF CLKHCRCLRT IRLSVTVVFE KKILKTSLPT
660 670 680 690 700
NTWDGDRITH CWQDLCSVLH TNEHLRELDL YHSNLDKSAM NILHHELRHP
710 720 730 740 750
NCKLQKLLLK FITFPDGCQD ISTSLIHNKN LMHLDLKGSD IGDNGVKSLC
760 770 780 790 800
EALKHPECKL QTLRLESCNL TVFCCLNISN ALIRSQSLIF LNLSTNNLLD
810 820 830 840 850
DGVQLLCEAL RHPKCYLERL SLESCGLTEA GCEYLSLALI SNKRLTHLCL
860 870 880 890 900
ADNVLGDGGV KLMSDALQHA QCTLKSLVLR RCHFTSLSSE YLSTSLLHNK
910 920 930 940 950
SLTHLDLGSN WLQDNGVKLL CDVFRHPSCN LQDLELMGCV LTNACCLDLA
960 970 980 990 1000
SVILNNPNLR SLDLGNNDLQ DDGVKILCDA LRYPNCNIQR LGLEYCGLTS
1010 1020 1030 1040 1050
LCCQDLSSAL ICNKRLIKMN LTQNTLGYEG IVKLYKVLKS PKCKLQVLGL
1060 1070 1080 1090
CKEAFDEEAQ KLLEAVGVSN PHLIIKPDCN YHNEEDVSWW WCF
Length:1,093
Mass (Da):124,733
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i124EEACE22A11D6F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05362221E → K. Corresponds to variant dbSNP:rs11041150Ensembl.1
Natural variantiVAR_03193248N → T1 PublicationCorresponds to variant dbSNP:rs12801277Ensembl.1
Natural variantiVAR_03193355R → Q1 PublicationCorresponds to variant dbSNP:rs61063081Ensembl.1
Natural variantiVAR_03193486D → V Increased tendency to form aggregates. 3 PublicationsCorresponds to variant dbSNP:rs199735773Ensembl.1
Natural variantiVAR_03193592K → R1 PublicationCorresponds to variant dbSNP:rs16921697Ensembl.1
Natural variantiVAR_03193698S → L1 PublicationCorresponds to variant dbSNP:rs117823353Ensembl.1
Natural variantiVAR_031937375A → T1 PublicationCorresponds to variant dbSNP:rs368562565Ensembl.1
Natural variantiVAR_031938397T → I1 PublicationCorresponds to variant dbSNP:rs76670455Ensembl.1
Natural variantiVAR_031939441V → M1 PublicationCorresponds to variant dbSNP:rs147389856Ensembl.1
Natural variantiVAR_053623511L → F. Corresponds to variant dbSNP:rs11041151Ensembl.1
Natural variantiVAR_031940522D → G1 PublicationCorresponds to variant dbSNP:rs1044378174Ensembl.1
Natural variantiVAR_036387779S → C in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_024180808E → K1 PublicationCorresponds to variant dbSNP:rs10839708Ensembl.1
Natural variantiVAR_031941951S → T1 PublicationCorresponds to variant dbSNP:rs117124176Ensembl.1
Natural variantiVAR_031942954L → S1 PublicationCorresponds to variant dbSNP:rs117583918Ensembl.1
Natural variantiVAR_0319431010L → F1 PublicationCorresponds to variant dbSNP:rs17280682Ensembl.1
Natural variantiVAR_0319441019M → I1 PublicationCorresponds to variant dbSNP:rs115776642Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY154469 mRNA Translation: AAO18165.1
BK001107 mRNA Translation: DAA01240.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7776.1

NCBI Reference Sequences

More...
RefSeqi
NP_789792.1, NM_176822.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299481; ENSP00000299481; ENSG00000158077

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
338323

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:338323

UCSC genome browser

More...
UCSCi
uc001mfb.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY154469 mRNA Translation: AAO18165.1
BK001107 mRNA Translation: DAA01240.1
CCDSiCCDS7776.1
RefSeqiNP_789792.1, NM_176822.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4N1JX-ray2.60A/B/C/D1-100[»]
4N1KX-ray3.00A/B/C/D1-100[»]
4N1LX-ray1.99A1-100[»]
SMRiQ86W24
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi130710, 1 interactor
IntActiQ86W24, 2 interactors
MINTiQ86W24
STRINGi9606.ENSP00000299481

PTM databases

iPTMnetiQ86W24
PhosphoSitePlusiQ86W24

Polymorphism and mutation databases

BioMutaiNLRP14
DMDMi38372322

Proteomic databases

PaxDbiQ86W24
PeptideAtlasiQ86W24
PRIDEiQ86W24
ProteomicsDBi70103

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
338323

Genome annotation databases

EnsembliENST00000299481; ENSP00000299481; ENSG00000158077
GeneIDi338323
KEGGihsa:338323
UCSCiuc001mfb.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
338323
DisGeNETi338323

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NLRP14
HGNCiHGNC:22939 NLRP14
HPAiHPA039477
MIMi609665 gene
neXtProtiNX_Q86W24
OpenTargetsiENSG00000158077
PharmGKBiPA162397917

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4308 Eukaryota
ENOG410ZBX3 LUCA
GeneTreeiENSGT00940000162005
HOGENOMiCLU_002274_2_1_1
InParanoidiQ86W24
KOiK22666
OMAiDWTQVHP
OrthoDBi114368at2759
PhylomeDBiQ86W24
TreeFamiTF340267

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NLRP14 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NLRP14

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
338323
PharosiQ86W24 Tbio

Protein Ontology

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PROi
PR:Q86W24
RNActiQ86W24 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
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Gene expression databases

BgeeiENSG00000158077 Expressed in oocyte and 19 other tissues
GenevisibleiQ86W24 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR041267 NLRC_HD2
IPR041075 NOD2_WH
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF13516 LRR_6, 4 hits
PF05729 NACHT, 1 hit
PF17776 NLRC4_HD2, 1 hit
PF17779 NOD2_WH, 1 hit
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
PS50837 NACHT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAL14_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86W24
Secondary accession number(s): Q7RTR6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: February 26, 2020
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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