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Protein

Cytochrome P450 4Z1

Gene

CYP4Z1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi452Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4Z1 (EC:1.14.14.1)
Alternative name(s):
CYPIVZ1
Gene namesi
Name:CYP4Z1
ORF Names:UNQ3060/PRO9882
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000186160.4
HGNCiHGNC:20583 CYP4Z1
neXtProtiNX_Q86W10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini31 – 505LumenalSequence analysisAdd BLAST475

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi199974
OpenTargetsiENSG00000186160
PharmGKBiPA134941057

Polymorphism and mutation databases

BioMutaiCYP4Z1
DMDMi48428052

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000518641 – 505Cytochrome P450 4Z1Add BLAST505

Proteomic databases

EPDiQ86W10
PaxDbiQ86W10
PeptideAtlasiQ86W10
PRIDEiQ86W10
ProteomicsDBi70100

PTM databases

iPTMnetiQ86W10
PhosphoSitePlusiQ86W10

Expressioni

Tissue specificityi

Preferentially detected in breast carcinoma tissue and mammary gland, whereas only marginal expression is found in all other tested tissues.1 Publication

Gene expression databases

BgeeiENSG00000186160 Expressed in 96 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_CYP4Z1
GenevisibleiQ86W10 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334246

Structurei

3D structure databases

ProteinModelPortaliQ86W10
SMRiQ86W10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140829
HOGENOMiHOG000233833
HOVERGENiHBG000182
InParanoidiQ86W10
KOiK07429
OMAiKWEEHIA
OrthoDBiEOG091G06KN
PhylomeDBiQ86W10
TreeFamiTF105088

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q86W10-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPSWLQELM AHPFLLLILL CMSLLLFQVI RLYQRRRWMI RALHLFPAPP
60 70 80 90 100
AHWFYGHKEF YPVKEFEVYH KLMEKYPCAV PLWVGPFTMF FSVHDPDYAK
110 120 130 140 150
ILLKRQDPKS AVSHKILESW VGRGLVTLDG SKWKKHRQIV KPGFNISILK
160 170 180 190 200
IFITMMSESV RMMLNKWEEH IAQNSRLELF QHVSLMTLDS IMKCAFSHQG
210 220 230 240 250
SIQLDSTLDS YLKAVFNLSK ISNQRMNNFL HHNDLVFKFS SQGQIFSKFN
260 270 280 290 300
QELHQFTEKV IQDRKESLKD KLKQDTTQKR RWDFLDILLS AKSENTKDFS
310 320 330 340 350
EADLQAEVKT FMFAGHDTTS SAISWILYCL AKYPEHQQRC RDEIRELLGD
360 370 380 390 400
GSSITWEHLS QMPYTTMCIK ECLRLYAPVV NISRLLDKPI TFPDGRSLPA
410 420 430 440 450
GITVFINIWA LHHNPYFWED PQVFNPLRFS RENSEKIHPY AFIPFSAGLR
460 470 480 490 500
NCIGQHFAII ECKVAVALTL LRFKLAPDHS RPPQPVRQVV LKSKNGIHVF

AKKVC
Length:505
Mass (Da):59,086
Last modified:June 1, 2003 - v1
Checksum:iCF23D96739402E86
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048461393P → L. Corresponds to variant dbSNP:rs28463559Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262056 mRNA Translation: AAO89257.1
AY358631 mRNA Translation: AAQ88994.1
AK292175 mRNA Translation: BAF84864.1
AL450996, AL135960 Genomic DNA Translation: CAH71036.1
AL135960, AL450996 Genomic DNA Translation: CAI19734.1
CCDSiCCDS545.1
RefSeqiNP_835235.1, NM_178134.2
UniGeneiHs.176588

Genome annotation databases

EnsembliENST00000334194; ENSP00000334246; ENSG00000186160
GeneIDi199974
KEGGihsa:199974
UCSCiuc001cqu.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262056 mRNA Translation: AAO89257.1
AY358631 mRNA Translation: AAQ88994.1
AK292175 mRNA Translation: BAF84864.1
AL450996, AL135960 Genomic DNA Translation: CAH71036.1
AL135960, AL450996 Genomic DNA Translation: CAI19734.1
CCDSiCCDS545.1
RefSeqiNP_835235.1, NM_178134.2
UniGeneiHs.176588

3D structure databases

ProteinModelPortaliQ86W10
SMRiQ86W10
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000334246

PTM databases

iPTMnetiQ86W10
PhosphoSitePlusiQ86W10

Polymorphism and mutation databases

BioMutaiCYP4Z1
DMDMi48428052

Proteomic databases

EPDiQ86W10
PaxDbiQ86W10
PeptideAtlasiQ86W10
PRIDEiQ86W10
ProteomicsDBi70100

Protocols and materials databases

DNASUi199974
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334194; ENSP00000334246; ENSG00000186160
GeneIDi199974
KEGGihsa:199974
UCSCiuc001cqu.2 human

Organism-specific databases

CTDi199974
DisGeNETi199974
EuPathDBiHostDB:ENSG00000186160.4
GeneCardsiCYP4Z1
H-InvDBiHIX0000557
HGNCiHGNC:20583 CYP4Z1
neXtProtiNX_Q86W10
OpenTargetsiENSG00000186160
PharmGKBiPA134941057
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140829
HOGENOMiHOG000233833
HOVERGENiHBG000182
InParanoidiQ86W10
KOiK07429
OMAiKWEEHIA
OrthoDBiEOG091G06KN
PhylomeDBiQ86W10
TreeFamiTF105088

Miscellaneous databases

GeneWikiiCYP4Z1
GenomeRNAii199974
PROiPR:Q86W10

Gene expression databases

BgeeiENSG00000186160 Expressed in 96 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_CYP4Z1
GenevisibleiQ86W10 HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP4Z1_HUMAN
AccessioniPrimary (citable) accession number: Q86W10
Secondary accession number(s): Q5VVE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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