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Entry version 127 (11 Dec 2019)
Sequence version 1 (01 Jun 2003)
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Protein

WD repeat-containing protein 5B

Gene

WDR5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • histone binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q86VZ2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein 5B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR5B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000196981.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17826 WDR5B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86VZ2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54554

Open Targets

More...
OpenTargetsi
ENSG00000196981

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38248

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86VZ2 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WDR5B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762455

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002784611 – 330WD repeat-containing protein 5BAdd BLAST330

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86VZ2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86VZ2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86VZ2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86VZ2

PeptideAtlas

More...
PeptideAtlasi
Q86VZ2

PRoteomics IDEntifications database

More...
PRIDEi
Q86VZ2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70093

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86VZ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86VZ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196981 Expressed in 173 organ(s), highest expression level in right uterine tube

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86VZ2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042994

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probable part of a cullin-RING E3 protein ligase complex containing CUL4B-DDB1 and a substrate-recruiting component (DCAF).

Interacts with CUL4B and DDB1 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120039, 21 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q86VZ2

Protein interaction database and analysis system

More...
IntActi
Q86VZ2, 24 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000330381

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86VZ2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86VZ2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati39 – 78WD 1Add BLAST40
Repeati81 – 122WD 2Add BLAST42
Repeati124 – 164WD 3Add BLAST41
Repeati165 – 204WD 4Add BLAST40
Repeati208 – 249WD 5Add BLAST42
Repeati252 – 292WD 6Add BLAST41
Repeati295 – 330WD 7Add BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi188 – 192DDB1-binding motif5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat WDR5/wds family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0266 Eukaryota
ENOG410XP3K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154143

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000091642

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86VZ2

KEGG Orthology (KO)

More...
KOi
K14963

Identification of Orthologs from Complete Genome Data

More...
OMAi
NYALKCT

Database of Orthologous Groups

More...
OrthoDBi
957291at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86VZ2

TreeFam database of animal gene trees

More...
TreeFami
TF314125

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR037866 Swd3/WDR5
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22847:SF516 PTHR22847:SF516, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 7 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00320 GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 4 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q86VZ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATKESRDAK AQLALSSSAN QSKEVPENPN YALKCTLVGH TEAVSSVKFS
60 70 80 90 100
PNGEWLASSS ADRLIIIWGA YDGKYEKTLY GHNLEISDVA WSSDSSRLVS
110 120 130 140 150
ASDDKTLKLW DVRSGKCLKT LKGHSNYVFC CNFNPPSNLI ISGSFDETVK
160 170 180 190 200
IWEVKTGKCL KTLSAHSDPV SAVHFNCSGS LIVSGSYDGL CRIWDAASGQ
210 220 230 240 250
CLKTLVDDDN PPVSFVKFSP NGKYILTATL DNTLKLWDYS RGRCLKTYTG
260 270 280 290 300
HKNEKYCIFA NFSVTGGKWI VSGSEDNLVY IWNLQTKEIV QKLQGHTDVV
310 320 330
ISAACHPTEN LIASAALEND KTIKLWMSNH
Length:330
Mass (Da):36,338
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC2C47476F24716D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti251H → Q in BAA92110 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK002149 mRNA Translation: BAA92110.1
AK315186 mRNA Translation: BAG37626.1
CR457279 mRNA Translation: CAG33560.1
CH471052 Genomic DNA Translation: EAW79485.1
BC043494 mRNA Translation: AAH43494.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3012.1

NCBI Reference Sequences

More...
RefSeqi
NP_061942.2, NM_019069.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000330689; ENSP00000330381; ENSG00000196981

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54554

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54554

UCSC genome browser

More...
UCSCi
uc003efa.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002149 mRNA Translation: BAA92110.1
AK315186 mRNA Translation: BAG37626.1
CR457279 mRNA Translation: CAG33560.1
CH471052 Genomic DNA Translation: EAW79485.1
BC043494 mRNA Translation: AAH43494.1
CCDSiCCDS3012.1
RefSeqiNP_061942.2, NM_019069.3

3D structure databases

SMRiQ86VZ2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120039, 21 interactors
CORUMiQ86VZ2
IntActiQ86VZ2, 24 interactors
STRINGi9606.ENSP00000330381

PTM databases

iPTMnetiQ86VZ2
PhosphoSitePlusiQ86VZ2

Polymorphism and mutation databases

BioMutaiWDR5B
DMDMi74762455

Proteomic databases

jPOSTiQ86VZ2
MassIVEiQ86VZ2
MaxQBiQ86VZ2
PaxDbiQ86VZ2
PeptideAtlasiQ86VZ2
PRIDEiQ86VZ2
ProteomicsDBi70093

Genome annotation databases

EnsembliENST00000330689; ENSP00000330381; ENSG00000196981
GeneIDi54554
KEGGihsa:54554
UCSCiuc003efa.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54554
DisGeNETi54554
EuPathDBiHostDB:ENSG00000196981.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WDR5B
HGNCiHGNC:17826 WDR5B
HPAiHPA042994
neXtProtiNX_Q86VZ2
OpenTargetsiENSG00000196981
PharmGKBiPA38248

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0266 Eukaryota
ENOG410XP3K LUCA
GeneTreeiENSGT00940000154143
HOGENOMiHOG000091642
InParanoidiQ86VZ2
KOiK14963
OMAiNYALKCT
OrthoDBi957291at2759
PhylomeDBiQ86VZ2
TreeFamiTF314125

Enzyme and pathway databases

SignaLinkiQ86VZ2

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54554
PharosiQ86VZ2 Tdark

Protein Ontology

More...
PROi
PR:Q86VZ2
RNActiQ86VZ2 protein

Gene expression databases

BgeeiENSG00000196981 Expressed in 173 organ(s), highest expression level in right uterine tube
GenevisibleiQ86VZ2 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR037866 Swd3/WDR5
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR22847:SF516 PTHR22847:SF516, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 7 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 4 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR5B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86VZ2
Secondary accession number(s): B2RCM9, Q9NUL4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: June 1, 2003
Last modified: December 11, 2019
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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