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UniProtKB - Q86VZ1 (P2RY8_HUMAN)

Entry version 145 (10 Feb 2021)
Sequence version 1 (01 Jun 2003)
Previous versions | rss
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Protein

P2Y purinoceptor 8

Gene

P2RY8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable receptor for purines coupled to G-proteins.

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86VZ1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
P2Y purinoceptor 8
Short name:
P2Y8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:P2RY8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15524, P2RY8

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300525, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86VZ1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000182162.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 19ExtracellularSequence analysisAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini41 – 57CytoplasmicSequence analysisAdd BLAST17
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 88ExtracellularSequence analysis10
Transmembranei89 – 109Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini110 – 138CytoplasmicSequence analysisAdd BLAST29
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 187ExtracellularSequence analysisAdd BLAST28
Transmembranei188 – 208Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini209 – 237CytoplasmicSequence analysisAdd BLAST29
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 275ExtracellularSequence analysisAdd BLAST17
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 359CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		286530

Open Targets

More...OpenTargetsi		ENSG00000182162

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA32873

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86VZ1, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB01069, Promethazine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		P2RY8

Domain mapping of disease mutations (DMDM)

More...DMDMi		74762454

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000700311 – 359P2Y purinoceptor 8Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi5N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi11N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q86VZ1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q86VZ1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86VZ1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86VZ1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86VZ1

PeptideAtlas

More...PeptideAtlasi		Q86VZ1

PRoteomics IDEntifications database

More...PRIDEi		Q86VZ1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70092

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q86VZ1, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86VZ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86VZ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Barely detectable in normal blood leukocytes. Weaker expression was seen in heart, kidney and lung. Not detected in brain.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated during granulocytic regulation.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000182162, Expressed in buccal mucosa cell and 144 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86VZ1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86VZ1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000182162, Tissue enhanced (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		130402, 30 interactors

Protein interaction database and analysis system

More...IntActi		Q86VZ1, 18 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000370697

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86VZ1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q86VZ1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi133 – 138Poly-Arg6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QW5Q, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01010000222428

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_8_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86VZ1

Identification of Orthologs from Complete Genome Data

More...OMAi		GIVTCFD

Database of Orthologous Groups

More...OrthoDBi		794310at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86VZ1

TreeFam database of animal gene trees

More...TreeFami		TF330775

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR027669, P2Y8_rcpt

The PANTHER Classification System

More...PANTHERi		PTHR24232:SF25, PTHR24232:SF25, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237, GPCRRHODOPSN

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q86VZ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQVPNSTGPD NATLQMLRNP AIAVALPVVY SLVAAVSIPG NLFSLWVLCR 
        60         70         80         90        100
RMGPRSPSVI FMINLSVTDL MLASVLPFQI YYHCNRHHWV FGVLLCNVVT 
       110        120        130        140        150
VAFYANMYSS ILTMTCISVE RFLGVLYPLS SKRWRRRRYA VAACAGTWLL 
       160        170        180        190        200
LLTALSPLAR TDLTYPVHAL GIITCFDVLK WTMLPSVAMW AVFLFTIFIL 
       210        220        230        240        250
LFLIPFVITV ACYTATILKL LRTEEAHGRE QRRRAVGLAA VVLLAFVTCF 
       260        270        280        290        300
APNNFVLLAH IVSRLFYGKS YYHVYKLTLC LSCLNNCLDP FVYYFASREF 
       310        320        330        340        350
QLRLREYLGC RRVPRDTLDT RRESLFSART TSVRSEAGAH PEGMEGATRP 

GLQRQESVF
Length:359
Mass (Da):40,635
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i565C43660B3C0CF7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GUR3A0A1B0GUR3_HUMAN
P2Y purinoceptor 8
P2RY8
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL683870 Genomic DNA No translation available.
BC043610 mRNA Translation: AAH43610.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14115.1

NCBI Reference Sequences

More...RefSeqi		NP_835230.1, NM_178129.4
XP_005274486.1, XM_005274429.3
XP_005274835.1, XM_005274778.3
XP_011543933.1, XM_011545631.2
XP_011543934.1, XM_011545632.2
XP_011544480.1, XM_011546178.2
XP_011544481.1, XM_011546179.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000381297; ENSP00000370697; ENSG00000182162

Database of genes from NCBI RefSeq genomes

More...GeneIDi		286530

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:286530

UCSC genome browser

More...UCSCi		uc004cpz.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL683870 Genomic DNA No translation available.
BC043610 mRNA Translation: AAH43610.1
CCDSiCCDS14115.1
RefSeqiNP_835230.1, NM_178129.4
XP_005274486.1, XM_005274429.3
XP_005274835.1, XM_005274778.3
XP_011543933.1, XM_011545631.2
XP_011543934.1, XM_011545632.2
XP_011544480.1, XM_011546178.2
XP_011544481.1, XM_011546179.2

3D structure databases

SMRiQ86VZ1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi130402, 30 interactors
IntActiQ86VZ1, 18 interactors
STRINGi9606.ENSP00000370697

Chemistry databases

DrugBankiDB01069, Promethazine

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniQ86VZ1, 2 sites
iPTMnetiQ86VZ1
PhosphoSitePlusiQ86VZ1

Genetic variation databases

BioMutaiP2RY8
DMDMi74762454

Proteomic databases

EPDiQ86VZ1
jPOSTiQ86VZ1
MassIVEiQ86VZ1
MaxQBiQ86VZ1
PaxDbiQ86VZ1
PeptideAtlasiQ86VZ1
PRIDEiQ86VZ1
ProteomicsDBi70092

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		588, 215 antibodies

Genome annotation databases

EnsembliENST00000381297; ENSP00000370697; ENSG00000182162
GeneIDi286530
KEGGihsa:286530
UCSCiuc004cpz.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		286530
DisGeNETi286530

GeneCards: human genes, protein and diseases

More...GeneCardsi		P2RY8
HGNCiHGNC:15524, P2RY8
HPAiENSG00000182162, Tissue enhanced (blood, lymphoid tissue)
MIMi300525, gene
neXtProtiNX_Q86VZ1
OpenTargetsiENSG00000182162
PharmGKBiPA32873
VEuPathDBiHostDB:ENSG00000182162.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QW5Q, Eukaryota
GeneTreeiENSGT01010000222428
HOGENOMiCLU_009579_8_2_1
InParanoidiQ86VZ1
OMAiGIVTCFD
OrthoDBi794310at2759
PhylomeDBiQ86VZ1
TreeFamiTF330775

Enzyme and pathway databases

PathwayCommonsiQ86VZ1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		286530, 11 hits in 443 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		P2RY8, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		P2RY8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		286530
PharosiQ86VZ1, Tbio

Protein Ontology

More...PROi		PR:Q86VZ1
RNActiQ86VZ1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000182162, Expressed in buccal mucosa cell and 144 other tissues
ExpressionAtlasiQ86VZ1, baseline and differential
GenevisibleiQ86VZ1, HS

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR027669, P2Y8_rcpt
PANTHERiPTHR24232:SF25, PTHR24232:SF25, 1 hit
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP2RY8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86VZ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2003
Last modified: February 10, 2021
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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