UniProtKB - Q86VZ1 (P2RY8_HUMAN)
Protein
P2Y purinoceptor 8
Gene
P2RY8
Organism
Homo sapiens (Human)
Status
Functioni
Probable receptor for purines coupled to G-proteins.
Miscellaneous
The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
GO - Molecular functioni
- G protein-coupled purinergic nucleotide receptor activity Source: InterPro
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: GO_Central
- positive regulation of Rho protein signal transduction Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q86VZ1 |
Names & Taxonomyi
Protein namesi | Recommended name: P2Y purinoceptor 8Short name: P2Y8 |
Gene namesi | Name:P2RY8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15524, P2RY8 |
MIMi | 300525, gene |
neXtProti | NX_Q86VZ1 |
VEuPathDBi | HostDB:ENSG00000182162.10 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 19 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 20 – 40 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 41 – 57 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 58 – 78 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 79 – 88 | ExtracellularSequence analysis | 10 | |
Transmembranei | 89 – 109 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 110 – 138 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 139 – 159 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 160 – 187 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 188 – 208 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 209 – 237 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 238 – 258 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 259 – 275 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 276 – 296 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 297 – 359 | CytoplasmicSequence analysisAdd BLAST | 63 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 286530 |
OpenTargetsi | ENSG00000182162 |
PharmGKBi | PA32873 |
Miscellaneous databases
Pharosi | Q86VZ1, Tbio |
Chemistry databases
DrugBanki | DB01069, Promethazine |
Genetic variation databases
BioMutai | P2RY8 |
DMDMi | 74762454 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070031 | 1 – 359 | P2Y purinoceptor 8Add BLAST | 359 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 11 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q86VZ1 |
jPOSTi | Q86VZ1 |
MassIVEi | Q86VZ1 |
MaxQBi | Q86VZ1 |
PaxDbi | Q86VZ1 |
PeptideAtlasi | Q86VZ1 |
PRIDEi | Q86VZ1 |
ProteomicsDBi | 70092 |
PTM databases
GlyGeni | Q86VZ1, 2 sites |
iPTMneti | Q86VZ1 |
PhosphoSitePlusi | Q86VZ1 |
Expressioni
Tissue specificityi
Barely detectable in normal blood leukocytes. Weaker expression was seen in heart, kidney and lung. Not detected in brain.2 Publications
Inductioni
Down-regulated during granulocytic regulation.
Gene expression databases
Bgeei | ENSG00000182162, Expressed in buccal mucosa cell and 144 other tissues |
ExpressionAtlasi | Q86VZ1, baseline and differential |
Genevisiblei | Q86VZ1, HS |
Organism-specific databases
HPAi | ENSG00000182162, Tissue enhanced (blood, lymphoid tissue) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 130402, 30 interactors |
IntActi | Q86VZ1, 18 interactors |
STRINGi | 9606.ENSP00000370697 |
Miscellaneous databases
RNActi | Q86VZ1, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 133 – 138 | Poly-Arg | 6 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QW5Q, Eukaryota |
GeneTreei | ENSGT01010000222428 |
HOGENOMi | CLU_009579_8_2_1 |
InParanoidi | Q86VZ1 |
OMAi | GIVTCFD |
OrthoDBi | 794310at2759 |
PhylomeDBi | Q86VZ1 |
TreeFami | TF330775 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR027669, P2Y8_rcpt |
PANTHERi | PTHR24232:SF25, PTHR24232:SF25, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q86VZ1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQVPNSTGPD NATLQMLRNP AIAVALPVVY SLVAAVSIPG NLFSLWVLCR
60 70 80 90 100
RMGPRSPSVI FMINLSVTDL MLASVLPFQI YYHCNRHHWV FGVLLCNVVT
110 120 130 140 150
VAFYANMYSS ILTMTCISVE RFLGVLYPLS SKRWRRRRYA VAACAGTWLL
160 170 180 190 200
LLTALSPLAR TDLTYPVHAL GIITCFDVLK WTMLPSVAMW AVFLFTIFIL
210 220 230 240 250
LFLIPFVITV ACYTATILKL LRTEEAHGRE QRRRAVGLAA VVLLAFVTCF
260 270 280 290 300
APNNFVLLAH IVSRLFYGKS YYHVYKLTLC LSCLNNCLDP FVYYFASREF
310 320 330 340 350
QLRLREYLGC RRVPRDTLDT RRESLFSART TSVRSEAGAH PEGMEGATRP
GLQRQESVF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GUR3 | A0A1B0GUR3_HUMAN | P2Y purinoceptor 8 | P2RY8 | 40 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL683870 Genomic DNA No translation available. BC043610 mRNA Translation: AAH43610.1 |
CCDSi | CCDS14115.1 |
RefSeqi | NP_835230.1, NM_178129.4 XP_005274486.1, XM_005274429.3 XP_005274835.1, XM_005274778.3 XP_011543933.1, XM_011545631.2 XP_011543934.1, XM_011545632.2 XP_011544480.1, XM_011546178.2 XP_011544481.1, XM_011546179.2 |
Genome annotation databases
Ensembli | ENST00000381297; ENSP00000370697; ENSG00000182162 |
GeneIDi | 286530 |
KEGGi | hsa:286530 |
UCSCi | uc004cpz.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL683870 Genomic DNA No translation available. BC043610 mRNA Translation: AAH43610.1 |
CCDSi | CCDS14115.1 |
RefSeqi | NP_835230.1, NM_178129.4 XP_005274486.1, XM_005274429.3 XP_005274835.1, XM_005274778.3 XP_011543933.1, XM_011545631.2 XP_011543934.1, XM_011545632.2 XP_011544480.1, XM_011546178.2 XP_011544481.1, XM_011546179.2 |
3D structure databases
SMRi | Q86VZ1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 130402, 30 interactors |
IntActi | Q86VZ1, 18 interactors |
STRINGi | 9606.ENSP00000370697 |
Chemistry databases
DrugBanki | DB01069, Promethazine |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q86VZ1, 2 sites |
iPTMneti | Q86VZ1 |
PhosphoSitePlusi | Q86VZ1 |
Genetic variation databases
BioMutai | P2RY8 |
DMDMi | 74762454 |
Proteomic databases
EPDi | Q86VZ1 |
jPOSTi | Q86VZ1 |
MassIVEi | Q86VZ1 |
MaxQBi | Q86VZ1 |
PaxDbi | Q86VZ1 |
PeptideAtlasi | Q86VZ1 |
PRIDEi | Q86VZ1 |
ProteomicsDBi | 70092 |
Protocols and materials databases
Antibodypediai | 588, 215 antibodies |
Genome annotation databases
Ensembli | ENST00000381297; ENSP00000370697; ENSG00000182162 |
GeneIDi | 286530 |
KEGGi | hsa:286530 |
UCSCi | uc004cpz.3, human |
Organism-specific databases
CTDi | 286530 |
DisGeNETi | 286530 |
GeneCardsi | P2RY8 |
HGNCi | HGNC:15524, P2RY8 |
HPAi | ENSG00000182162, Tissue enhanced (blood, lymphoid tissue) |
MIMi | 300525, gene |
neXtProti | NX_Q86VZ1 |
OpenTargetsi | ENSG00000182162 |
PharmGKBi | PA32873 |
VEuPathDBi | HostDB:ENSG00000182162.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QW5Q, Eukaryota |
GeneTreei | ENSGT01010000222428 |
HOGENOMi | CLU_009579_8_2_1 |
InParanoidi | Q86VZ1 |
OMAi | GIVTCFD |
OrthoDBi | 794310at2759 |
PhylomeDBi | Q86VZ1 |
TreeFami | TF330775 |
Enzyme and pathway databases
PathwayCommonsi | Q86VZ1 |
Miscellaneous databases
BioGRID-ORCSi | 286530, 11 hits in 443 CRISPR screens |
ChiTaRSi | P2RY8, human |
GeneWikii | P2RY8 |
GenomeRNAii | 286530 |
Pharosi | Q86VZ1, Tbio |
PROi | PR:Q86VZ1 |
RNActi | Q86VZ1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182162, Expressed in buccal mucosa cell and 144 other tissues |
ExpressionAtlasi | Q86VZ1, baseline and differential |
Genevisiblei | Q86VZ1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR027669, P2Y8_rcpt |
PANTHERi | PTHR24232:SF25, PTHR24232:SF25, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | P2RY8_HUMAN | |
Accessioni | Q86VZ1Primary (citable) accession number: Q86VZ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 7, 2006 |
Last sequence update: | June 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM