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Protein

Transmembrane protein 200A

Gene

TMEM200A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 200A
Gene namesi
Name:TMEM200A
Synonyms:KIAA1913
ORF Names:HBE61
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000164484.11
HGNCiHGNC:21075 TMEM200A
neXtProtiNX_Q86VY9

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 61CytoplasmicSequence analysisAdd BLAST61
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 126ExtracellularSequence analysisAdd BLAST44
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Topological domaini148 – 491CytoplasmicSequence analysisAdd BLAST344

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi114801
OpenTargetsiENSG00000164484
PharmGKBiPA162406349

Polymorphism and mutation databases

BioMutaiTMEM200A
DMDMi74750476

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002943401 – 491Transmembrane protein 200AAdd BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei350PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ86VY9
PaxDbiQ86VY9
PeptideAtlasiQ86VY9
PRIDEiQ86VY9
ProteomicsDBi70091

PTM databases

iPTMnetiQ86VY9
PhosphoSitePlusiQ86VY9

Expressioni

Tissue specificityi

Expressed in cerebellum.1 Publication

Gene expression databases

BgeeiENSG00000164484 Expressed in 159 organ(s), highest expression level in secondary oocyte
CleanExiHS_TMEM200A
ExpressionAtlasiQ86VY9 baseline and differential
GenevisibleiQ86VY9 HS

Organism-specific databases

HPAiHPA014396

Interactioni

Protein-protein interaction databases

BioGridi125362, 12 interactors
IntActiQ86VY9, 3 interactors
MINTiQ86VY9

Structurei

3D structure databases

ProteinModelPortaliQ86VY9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM200 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4823 Eukaryota
ENOG41106JF LUCA
GeneTreeiENSGT00530000063698
HOGENOMiHOG000013037
HOVERGENiHBG102357
InParanoidiQ86VY9
OMAiDSARSQH
OrthoDBiEOG091G05JS
PhylomeDBiQ86VY9
TreeFamiTF332635

Family and domain databases

InterProiView protein in InterPro
IPR018787 DUF2371_TMEM200
PANTHERiPTHR31815 PTHR31815, 1 hit
PfamiView protein in Pfam
PF10177 DUF2371, 1 hit

Sequencei

Sequence statusi: Complete.

Q86VY9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIATGGVITG LAALKRQDSA RSQQHVNLSP SPATQEKKPI RRRPRADVVV
60 70 80 90 100
VRGKIRLYSP SGFFLILGVL ISIIGIAMAV LGYWPQKEHF IDAETTLSTN
110 120 130 140 150
ETQVIRNEGG VVVRFFEQHL HSDKMKMLGP FTMGIGIFIF ICANAILHEN
160 170 180 190 200
RDKETKIIHM RDIYSTVIDI HTLRIKEQRQ MNGMYTGLMG ETEVKQNGSS
210 220 230 240 250
CASRLAANTI ASFSGFRSSF RMDSSVEEDE LMLNEGKSSG HLMPPLLSDS
260 270 280 290 300
SVSVFGLYPP PSKTTDDKTS GSKKCETKSI VSSSISAFTL PVIKLNNCVI
310 320 330 340 350
DEPSIDNITE DADNLKSRSR NLSMDSLVVP LPNTSESFQP VSTVLPRNNS
360 370 380 390 400
IGESLSSQYK SSMALGPGAG QLLSPGAARR QFGSNTSLHL LSSHSKSLDL
410 420 430 440 450
DRGPSTLTVQ AEQRKHPSWP RLDRNNSKGY MKLENKEDPM DRLLVPQVAI
460 470 480 490
KKDFTNKEKL LMISRSHNNL SFEHDEFLSN NLKRGTSETR F
Length:491
Mass (Da):54,356
Last modified:June 1, 2003 - v1
Checksum:iEEFFF8CDAC4DB610
GO

Sequence cautioni

The sequence BAB67806 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052099 mRNA Translation: BAD05135.1
AB067500 mRNA Translation: BAB67806.1 Different initiation.
AL137251 Genomic DNA No translation available.
BC044246 mRNA Translation: AAH44246.1
CCDSiCCDS5140.1
RefSeqiNP_001245205.1, NM_001258276.1
NP_001245206.1, NM_001258277.1
NP_001245207.1, NM_001258278.1
NP_443145.1, NM_052913.2
XP_005266873.1, XM_005266816.2
XP_011533721.1, XM_011535419.2
XP_016865719.1, XM_017010230.1
UniGeneiHs.591341

Genome annotation databases

EnsembliENST00000296978; ENSP00000296978; ENSG00000164484
ENST00000392429; ENSP00000376224; ENSG00000164484
ENST00000545622; ENSP00000438928; ENSG00000164484
ENST00000617887; ENSP00000480294; ENSG00000164484
GeneIDi114801
KEGGihsa:114801
UCSCiuc003qca.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052099 mRNA Translation: BAD05135.1
AB067500 mRNA Translation: BAB67806.1 Different initiation.
AL137251 Genomic DNA No translation available.
BC044246 mRNA Translation: AAH44246.1
CCDSiCCDS5140.1
RefSeqiNP_001245205.1, NM_001258276.1
NP_001245206.1, NM_001258277.1
NP_001245207.1, NM_001258278.1
NP_443145.1, NM_052913.2
XP_005266873.1, XM_005266816.2
XP_011533721.1, XM_011535419.2
XP_016865719.1, XM_017010230.1
UniGeneiHs.591341

3D structure databases

ProteinModelPortaliQ86VY9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125362, 12 interactors
IntActiQ86VY9, 3 interactors
MINTiQ86VY9

PTM databases

iPTMnetiQ86VY9
PhosphoSitePlusiQ86VY9

Polymorphism and mutation databases

BioMutaiTMEM200A
DMDMi74750476

Proteomic databases

EPDiQ86VY9
PaxDbiQ86VY9
PeptideAtlasiQ86VY9
PRIDEiQ86VY9
ProteomicsDBi70091

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296978; ENSP00000296978; ENSG00000164484
ENST00000392429; ENSP00000376224; ENSG00000164484
ENST00000545622; ENSP00000438928; ENSG00000164484
ENST00000617887; ENSP00000480294; ENSG00000164484
GeneIDi114801
KEGGihsa:114801
UCSCiuc003qca.5 human

Organism-specific databases

CTDi114801
DisGeNETi114801
EuPathDBiHostDB:ENSG00000164484.11
GeneCardsiTMEM200A
HGNCiHGNC:21075 TMEM200A
HPAiHPA014396
neXtProtiNX_Q86VY9
OpenTargetsiENSG00000164484
PharmGKBiPA162406349
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4823 Eukaryota
ENOG41106JF LUCA
GeneTreeiENSGT00530000063698
HOGENOMiHOG000013037
HOVERGENiHBG102357
InParanoidiQ86VY9
OMAiDSARSQH
OrthoDBiEOG091G05JS
PhylomeDBiQ86VY9
TreeFamiTF332635

Miscellaneous databases

ChiTaRSiTMEM200A human
GenomeRNAii114801
PROiPR:Q86VY9

Gene expression databases

BgeeiENSG00000164484 Expressed in 159 organ(s), highest expression level in secondary oocyte
CleanExiHS_TMEM200A
ExpressionAtlasiQ86VY9 baseline and differential
GenevisibleiQ86VY9 HS

Family and domain databases

InterProiView protein in InterPro
IPR018787 DUF2371_TMEM200
PANTHERiPTHR31815 PTHR31815, 1 hit
PfamiView protein in Pfam
PF10177 DUF2371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT200A_HUMAN
AccessioniPrimary (citable) accession number: Q86VY9
Secondary accession number(s): Q96PX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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