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Protein

Solute carrier family 22 member 16

Gene

SLC22A16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Ion transport, Spermatogenesis, Transport

Enzyme and pathway databases

ReactomeiR-HSA-549127 Organic cation transport

Protein family/group databases

TCDBi2.A.1.19.12 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 16
Alternative name(s):
Carnitine transporter 2
Short name:
CT2
Fly-like putative transporter 2
Short name:
FLIPT2
Short name:
Flipt 2
Organic cation transporter OKB1
Organic cation/carnitine transporter 6
Gene namesi
Name:SLC22A16
Synonyms:OCT6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000004809.13
HGNCiHGNC:20302 SLC22A16
MIMi608276 gene
neXtProtiNX_Q86VW1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Transmembranei359 – 379HelicalSequence analysisAdd BLAST21
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Transmembranei476 – 496HelicalSequence analysisAdd BLAST21
Transmembranei501 – 521HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi85413
OpenTargetsiENSG00000004809
PharmGKBiPA134911502

Chemistry databases

ChEMBLiCHEMBL2073722
DrugBankiDB00997 Doxorubicin
DB00583 L-Carnitine

Polymorphism and mutation databases

BioMutaiSLC22A16
DMDMi74750474

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003189911 – 577Solute carrier family 22 member 16Add BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi345N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi352N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi546N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi558N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86VW1
PeptideAtlasiQ86VW1
PRIDEiQ86VW1
ProteomicsDBi70079
70080 [Q86VW1-2]
70081 [Q86VW1-3]

PTM databases

iPTMnetiQ86VW1
PhosphoSitePlusiQ86VW1

Expressioni

Tissue specificityi

Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney. Expressed in testis and epididymis (at protein level). Expressed at lower levels in bone marrow and fetal liver. Expressed in hematopoietic cells, including CD34+ leukocytes and leukemia cells. Abundantly expressed in ovarian cancer clear-cell adenocarcinoma. Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase.6 Publications

Gene expression databases

BgeeiENSG00000004809 Expressed in 88 organ(s), highest expression level in trabecular bone tissue
CleanExiHS_SLC22A16
ExpressionAtlasiQ86VW1 baseline and differential
GenevisibleiQ86VW1 HS

Organism-specific databases

HPAiHPA036902

Interactioni

Protein-protein interaction databases

BioGridi124519, 35 interactors
STRINGi9606.ENSP00000357915

Chemistry databases

BindingDBiQ86VW1

Structurei

3D structure databases

ProteinModelPortaliQ86VW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRIC Eukaryota
ENOG410YUFN LUCA
GeneTreeiENSGT00760000118852
HOVERGENiHBG108436
InParanoidiQ86VW1
KOiK08212
OMAiGMKSRTW
OrthoDBiEOG091G03V1
PhylomeDBiQ86VW1
TreeFamiTF315847

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86VW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSRHFEGIY DHVGHFGRFQ RVLYFICAFQ NISCGIHYLA SVFMGVTPHH
60 70 80 90 100
VCRPPGNVSQ VVFHNHSNWS LEDTGALLSS GQKDYVTVQL QNGEIWELSR
110 120 130 140 150
CSRNKRENTS SLGYEYTGSK KEFPCVDGYI YDQNTWKSTA VTQWNLVCDR
160 170 180 190 200
KWLAMLIQPL FMFGVLLGSV TFGYFSDRLG RRVVLWATSS SMFLFGIAAA
210 220 230 240 250
FAVDYYTFMA ARFFLAMVAS GYLVVGFVYV MEFIGMKSRT WASVHLHSFF
260 270 280 290 300
AVGTLLVALT GYLVRTWWLY QMILSTVTVP FILCCWVLPE TPFWLLSEGR
310 320 330 340 350
YEEAQKIVDI MAKWNRASSC KLSELLSLDL QGPVSNSPTE VQKHNLSYLF
360 370 380 390 400
YNWSITKRTL TVWLIWFTGS LGFYSFSLNS VNLGGNEYLN LFLLGVVEIP
410 420 430 440 450
AYTFVCIAMD KVGRRTVLAY SLFCSALACG VVMVIPQKHY ILGVVTAMVG
460 470 480 490 500
KFAIGAAFGL IYLYTAELYP TIVRSLAVGS GSMVCRLASI LAPFSVDLSS
510 520 530 540 550
IWIFIPQLFV GTMALLSGVL TLKLPETLGK RLATTWEEAA KLESENESKS
560 570
SKLLLTTNNS GLEKTEAITP RDSGLGE
Length:577
Mass (Da):64,614
Last modified:June 1, 2003 - v1
Checksum:iEA4ABBED0AE99632
GO
Isoform 2 (identifier: Q86VW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MGSRHFEGIYDHVGHFG → MRTLHAVSHPYSNSM
     58-89: Missing.

Show »
Length:543
Mass (Da):60,870
Checksum:i0751FA836E63CCB3
GO
Isoform 3 (identifier: Q86VW1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     509-577: FVGTMALLSG...ITPRDSGLGE → LGQHLQE

Show »
Length:515
Mass (Da):58,061
Checksum:i8AA05929FA585BF9
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JTF8C9JTF8_HUMAN
Solute carrier family 22 member 16
SLC22A16
267Annotation score:
C9JGT0C9JGT0_HUMAN
Solute carrier family 22 member 16
SLC22A16
351Annotation score:
C9JU94C9JU94_HUMAN
Solute carrier family 22 member 16
SLC22A16
174Annotation score:
X6RE50X6RE50_HUMAN
Solute carrier family 22 member 16
SLC22A16
432Annotation score:

Sequence cautioni

The sequence BAB71419 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257V → G in AAN52928 (PubMed:12372408).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03893049H → R. Corresponds to variant dbSNP:rs714368Ensembl.1
Natural variantiVAR_038931252V → A. Corresponds to variant dbSNP:rs723685Ensembl.1
Natural variantiVAR_038932409M → T4 PublicationsCorresponds to variant dbSNP:rs12210538Ensembl.1
Natural variantiVAR_038933431V → I. Corresponds to variant dbSNP:rs35948062Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0313361 – 17MGSRH…VGHFG → MRTLHAVSHPYSNSM in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_03133758 – 89Missing in isoform 2. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_031338509 – 577FVGTM…SGLGE → LGQHLQE in isoform 3. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145502 mRNA Translation: AAN52928.1
AB055798 mRNA Translation: BAC23062.1
AF268892 mRNA Translation: AAK58593.1
AC002464 Genomic DNA Translation: AAB67044.1
AL050350 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48313.1
BC047565 mRNA Translation: AAH47565.1
AK057306 mRNA Translation: BAB71419.1 Different initiation.
CCDSiCCDS5084.1 [Q86VW1-1]
RefSeqiNP_149116.2, NM_033125.3 [Q86VW1-1]
XP_011534507.1, XM_011536205.2 [Q86VW1-3]
UniGeneiHs.520319

Genome annotation databases

EnsembliENST00000330550; ENSP00000328583; ENSG00000004809 [Q86VW1-2]
ENST00000368919; ENSP00000357915; ENSG00000004809 [Q86VW1-1]
GeneIDi85413
KEGGihsa:85413
UCSCiuc003puf.5 human [Q86VW1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145502 mRNA Translation: AAN52928.1
AB055798 mRNA Translation: BAC23062.1
AF268892 mRNA Translation: AAK58593.1
AC002464 Genomic DNA Translation: AAB67044.1
AL050350 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48313.1
BC047565 mRNA Translation: AAH47565.1
AK057306 mRNA Translation: BAB71419.1 Different initiation.
CCDSiCCDS5084.1 [Q86VW1-1]
RefSeqiNP_149116.2, NM_033125.3 [Q86VW1-1]
XP_011534507.1, XM_011536205.2 [Q86VW1-3]
UniGeneiHs.520319

3D structure databases

ProteinModelPortaliQ86VW1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124519, 35 interactors
STRINGi9606.ENSP00000357915

Chemistry databases

BindingDBiQ86VW1
ChEMBLiCHEMBL2073722
DrugBankiDB00997 Doxorubicin
DB00583 L-Carnitine

Protein family/group databases

TCDBi2.A.1.19.12 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ86VW1
PhosphoSitePlusiQ86VW1

Polymorphism and mutation databases

BioMutaiSLC22A16
DMDMi74750474

Proteomic databases

PaxDbiQ86VW1
PeptideAtlasiQ86VW1
PRIDEiQ86VW1
ProteomicsDBi70079
70080 [Q86VW1-2]
70081 [Q86VW1-3]

Protocols and materials databases

DNASUi85413
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330550; ENSP00000328583; ENSG00000004809 [Q86VW1-2]
ENST00000368919; ENSP00000357915; ENSG00000004809 [Q86VW1-1]
GeneIDi85413
KEGGihsa:85413
UCSCiuc003puf.5 human [Q86VW1-1]

Organism-specific databases

CTDi85413
DisGeNETi85413
EuPathDBiHostDB:ENSG00000004809.13
GeneCardsiSLC22A16
HGNCiHGNC:20302 SLC22A16
HPAiHPA036902
MIMi608276 gene
neXtProtiNX_Q86VW1
OpenTargetsiENSG00000004809
PharmGKBiPA134911502
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRIC Eukaryota
ENOG410YUFN LUCA
GeneTreeiENSGT00760000118852
HOVERGENiHBG108436
InParanoidiQ86VW1
KOiK08212
OMAiGMKSRTW
OrthoDBiEOG091G03V1
PhylomeDBiQ86VW1
TreeFamiTF315847

Enzyme and pathway databases

ReactomeiR-HSA-549127 Organic cation transport

Miscellaneous databases

ChiTaRSiSLC22A16 human
GenomeRNAii85413
PROiPR:Q86VW1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000004809 Expressed in 88 organ(s), highest expression level in trabecular bone tissue
CleanExiHS_SLC22A16
ExpressionAtlasiQ86VW1 baseline and differential
GenevisibleiQ86VW1 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS22AG_HUMAN
AccessioniPrimary (citable) accession number: Q86VW1
Secondary accession number(s): O14567
, Q5JXM1, Q8IUG8, Q8IZD5, Q96M90, Q96RU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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