Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SEC14 domain and spectrin repeat-containing protein 1

Gene

SESTD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1.1 Publication

Miscellaneous

Called SOLO because the encoded protein is related to but shorter than DUO and TRIO.

GO - Molecular functioni

GO - Biological processi

  • negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Source: UniProtKB

Chemistry databases

SwissLipidsiSLP:000001538

Names & Taxonomyi

Protein namesi
Recommended name:
SEC14 domain and spectrin repeat-containing protein 1
Alternative name(s):
Huntingtin-interacting protein-like protein
Protein Solo
Gene namesi
Name:SESTD1
Synonyms:SOLO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000187231.13
HGNCiHGNC:18379 SESTD1
neXtProtiNX_Q86VW0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi91404
OpenTargetsiENSG00000187231
PharmGKBiPA38534

Polymorphism and mutation databases

BioMutaiSESTD1
DMDMi160358740

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003094791 – 696SEC14 domain and spectrin repeat-containing protein 1Add BLAST696

Proteomic databases

EPDiQ86VW0
MaxQBiQ86VW0
PaxDbiQ86VW0
PeptideAtlasiQ86VW0
PRIDEiQ86VW0
ProteomicsDBi70078

PTM databases

iPTMnetiQ86VW0
PhosphoSitePlusiQ86VW0

Expressioni

Tissue specificityi

Broad expression. High expression in thalamus and brain. Significantly expressed in vasculature.1 Publication

Gene expression databases

BgeeiENSG00000187231 Expressed in 205 organ(s), highest expression level in corpus callosum
CleanExiHS_SESTD1
ExpressionAtlasiQ86VW0 baseline and differential
GenevisibleiQ86VW0 HS

Organism-specific databases

HPAiHPA058236
HPA077408

Interactioni

Subunit structurei

Interacts (via the spectrin 1 repeat) with TRPC4 and TRPC5 (via CIRB domain). Interacts with CTNNB1.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi124826, 18 interactors
IntActiQ86VW0, 15 interactors
STRINGi9606.ENSP00000415332

Structurei

3D structure databases

ProteinModelPortaliQ86VW0
SMRiQ86VW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 153CRAL-TRIOPROSITE-ProRule annotationAdd BLAST153
Repeati275 – 378Spectrin 1Add BLAST104
Repeati381 – 494Spectrin 2Add BLAST114
Repeati500 – 602Spectrin 3Add BLAST103

Sequence similaritiesi

Belongs to the SOLO family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4240 Eukaryota
ENOG410XPZN LUCA
GeneTreeiENSGT00730000111148
HOGENOMiHOG000072717
HOVERGENiHBG104429
InParanoidiQ86VW0
OMAiCTTRSSG
OrthoDBiEOG091G03F6
PhylomeDBiQ86VW0
TreeFamiTF332003

Family and domain databases

CDDicd00170 SEC14, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
PfamiView protein in Pfam
PF13716 CRAL_TRIO_2, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q86VW0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEASVILPIL KKKLAFLSGG KDRRSGLILT IPLCLEQTNM DELSVTLDYL
60 70 80 90 100
LSIPSEKCKA RGFTVIVDGR KSQWNVVKTV VVMLQNVVPA EVSLVCVVKP
110 120 130 140 150
DEFWDKKVTH FCFWKEKDRL GFEVILVSAN KLTRYIEPCQ LTEDFGGSLT
160 170 180 190 200
YDHMDWLNKR LVFEKFTKES TSLLDELALI NNGSDKGNQQ EKERSVDLNF
210 220 230 240 250
LPSVDPETVL QTGHELLSEL QQRRFNGSDG GVSWSPMDDE LLAQPQVMKL
260 270 280 290 300
LDSLREQYTR YQEVCRQRSK RTQLEEIQQK VMQVVNWLEG PGSEQLRAQW
310 320 330 340 350
GIGDSIRASQ ALQQKHEEIE SQHSEWFAVY VELNQQIAAL LNAGDEEDLV
360 370 380 390 400
ELKSLQQQLS DVCYRQASQL EFRQNLLQAA LEFHGVAQDL SQQLDGLLGM
410 420 430 440 450
LCVDVAPADG ASIQQTLKLL EEKLKSVDVG LQGLREKGQG LLDQISNQAS
460 470 480 490 500
WAYGKDVTIE NKENVDHIQG VMEDMQLRKQ RCEDMVDVRR LKMLQMVQLF
510 520 530 540 550
KCEEDAAQAV EWLSELLDAL LKTHIRLGDD AQETKVLLEK HRKFVDVAQS
560 570 580 590 600
TYDYGRQLLQ ATVVLCQSLR CTSRSSGDTL PRLNRVWKQF TIASEERVHR
610 620 630 640 650
LEMAIAFHSN AEKILQDCPE EPEAINDEEQ FDEIEAVGKS LLDRLTVPVV
660 670 680 690
YPDGTEQYFG SPSDMASTAE NIRDRMKLVN LKRQQLRHPE MVTTES
Length:696
Mass (Da):79,348
Last modified:November 13, 2007 - v2
Checksum:i5C5C80EB57A7303A
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J4X8C9J4X8_HUMAN
SEC14 domain and spectrin repeat-co...
SESTD1
143Annotation score:
C9JHW6C9JHW6_HUMAN
SEC14 domain and spectrin repeat-co...
SESTD1
146Annotation score:
H0Y774H0Y774_HUMAN
SEC14 domain and spectrin repeat-co...
SESTD1
210Annotation score:
H7BXT9H7BXT9_HUMAN
SEC14 domain and spectrin repeat-co...
SESTD1
106Annotation score:
H7BZR8H7BZR8_HUMAN
SEC14 domain and spectrin repeat-co...
SESTD1
225Annotation score:
F8WFB2F8WFB2_HUMAN
SEC14 domain and spectrin repeat-co...
SESTD1
93Annotation score:

Sequence cautioni

The sequence BAB71618 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti508Q → H in AAP47744 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03696349Y → F1 PublicationCorresponds to variant dbSNP:rs17854501Ensembl.1
Natural variantiVAR_051919563V → A. Corresponds to variant dbSNP:rs1047994Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY209190 mRNA Translation: AAP47744.1
AC016755 Genomic DNA Translation: AAY24323.1
AC093911 Genomic DNA Translation: AAY24093.1
BC029744 mRNA Translation: AAH29744.1
BC047578 mRNA Translation: AAH47578.1
AK057944 mRNA Translation: BAB71618.1 Different initiation.
CCDSiCCDS33338.1
PIRiT34530
RefSeqiNP_835224.3, NM_178123.4
XP_011510441.1, XM_011512139.2
UniGeneiHs.30977

Genome annotation databases

EnsembliENST00000428443; ENSP00000415332; ENSG00000187231
GeneIDi91404
KEGGihsa:91404
UCSCiuc002uni.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY209190 mRNA Translation: AAP47744.1
AC016755 Genomic DNA Translation: AAY24323.1
AC093911 Genomic DNA Translation: AAY24093.1
BC029744 mRNA Translation: AAH29744.1
BC047578 mRNA Translation: AAH47578.1
AK057944 mRNA Translation: BAB71618.1 Different initiation.
CCDSiCCDS33338.1
PIRiT34530
RefSeqiNP_835224.3, NM_178123.4
XP_011510441.1, XM_011512139.2
UniGeneiHs.30977

3D structure databases

ProteinModelPortaliQ86VW0
SMRiQ86VW0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124826, 18 interactors
IntActiQ86VW0, 15 interactors
STRINGi9606.ENSP00000415332

Chemistry databases

SwissLipidsiSLP:000001538

PTM databases

iPTMnetiQ86VW0
PhosphoSitePlusiQ86VW0

Polymorphism and mutation databases

BioMutaiSESTD1
DMDMi160358740

Proteomic databases

EPDiQ86VW0
MaxQBiQ86VW0
PaxDbiQ86VW0
PeptideAtlasiQ86VW0
PRIDEiQ86VW0
ProteomicsDBi70078

Protocols and materials databases

DNASUi91404
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000428443; ENSP00000415332; ENSG00000187231
GeneIDi91404
KEGGihsa:91404
UCSCiuc002uni.5 human

Organism-specific databases

CTDi91404
DisGeNETi91404
EuPathDBiHostDB:ENSG00000187231.13
GeneCardsiSESTD1
H-InvDBiHIX0002639
HGNCiHGNC:18379 SESTD1
HPAiHPA058236
HPA077408
neXtProtiNX_Q86VW0
OpenTargetsiENSG00000187231
PharmGKBiPA38534
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4240 Eukaryota
ENOG410XPZN LUCA
GeneTreeiENSGT00730000111148
HOGENOMiHOG000072717
HOVERGENiHBG104429
InParanoidiQ86VW0
OMAiCTTRSSG
OrthoDBiEOG091G03F6
PhylomeDBiQ86VW0
TreeFamiTF332003

Miscellaneous databases

ChiTaRSiSESTD1 human
GeneWikiiSESTD1
GenomeRNAii91404
PROiPR:Q86VW0

Gene expression databases

BgeeiENSG00000187231 Expressed in 205 organ(s), highest expression level in corpus callosum
CleanExiHS_SESTD1
ExpressionAtlasiQ86VW0 baseline and differential
GenevisibleiQ86VW0 HS

Family and domain databases

CDDicd00170 SEC14, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
PfamiView protein in Pfam
PF13716 CRAL_TRIO_2, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSESD1_HUMAN
AccessioniPrimary (citable) accession number: Q86VW0
Secondary accession number(s): Q53R38
, Q53SP3, Q5GM69, Q8N6M1, Q96LQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: September 12, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again