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Protein

Catechol O-methyltransferase domain-containing protein 1

Gene

COMTD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative O-methyltransferase.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei108S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1
Binding sitei116S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1
Binding sitei134S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1
Binding sitei135S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei163S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei185S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1
Binding sitei187S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1
Binding sitei194S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • O-methyltransferase activity Source: InterPro
  • S-adenosylmethionine-dependent methyltransferase activity Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Catechol O-methyltransferase domain-containing protein 1 (EC:2.1.1.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COMTD1
ORF Names:UNQ766/PRO1558
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000165644.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26309 COMTD1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86VU5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 32Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000165644

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134961676

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB03923 Feruloyl Coenzyme A
DB01752 S-Adenosyl-L-Homocysteine
DB03179 Sinapoyl Coenzyme A

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
COMTD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74750472

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002332891 – 262Catechol O-methyltransferase domain-containing protein 1Add BLAST262

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86VU5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86VU5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86VU5

PeptideAtlas

More...
PeptideAtlasi
Q86VU5

PRoteomics IDEntifications database

More...
PRIDEi
Q86VU5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70070

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86VU5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86VU5

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q86VU5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165644 Expressed in 170 organ(s), highest expression level in body of pancreas

CleanEx database of gene expression profiles

More...
CleanExi
HS_COMTD1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86VU5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86VU5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042165

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN1Q9UMX0-23EBI-2836030,EBI-10173939

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125625, 65 interactors

Protein interaction database and analysis system

More...
IntActi
Q86VU5, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361616

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1262
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q86VU5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86VU5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q86VU5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni110 – 111S-adenosyl-L-methionine binding2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1663 Eukaryota
COG4122 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004409

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000016839

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG081259

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86VU5

Identification of Orthologs from Complete Genome Data

More...
OMAi
LSDNVLW

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0JQB

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86VU5

TreeFam database of animal gene trees

More...
TreeFami
TF312986

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029063 SAM-dependent_MTases
IPR002935 SAM_O-MeTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01596 Methyltransf_3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335 SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51682 SAM_OMT_I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q86VU5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTQPVPRLSV PAALALGSAA LGAAFATGLF LGRRCPPWRG RREQCLLPPE
60 70 80 90 100
DSRLWQYLLS RSMREHPALR SLRLLTLEQP QGDSMMTCEQ AQLLANLARL
110 120 130 140 150
IQAKKALDLG TFTGYSALAL ALALPADGRV VTCEVDAQPP ELGRPLWRQA
160 170 180 190 200
EAEHKIDLRL KPALETLDEL LAAGEAGTFD VAVVDADKEN CSAYYERCLQ
210 220 230 240 250
LLRPGGILAV LRVLWRGKVL QPPKGDVAAE CVRNLNERIR RDVRVYISLL
260
PLGDGLTLAF KI
Length:262
Mass (Da):28,809
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A422F32D6FBE128
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GNF4R4GNF4_HUMAN
Catechol O-methyltransferase domain...
COMTD1
260Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti84S → Y in BAB85077 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358476 mRNA Translation: AAQ88840.1
AK074421 mRNA Translation: BAB85077.1
AL390034 Genomic DNA No translation available.
BC023663 mRNA Translation: AAH23663.1
BC047774 mRNA Translation: AAH47774.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7349.1

NCBI Reference Sequences

More...
RefSeqi
NP_653190.2, NM_144589.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.355333

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372538; ENSP00000361616; ENSG00000165644

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
118881

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:118881

UCSC genome browser

More...
UCSCi
uc001jxb.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358476 mRNA Translation: AAQ88840.1
AK074421 mRNA Translation: BAB85077.1
AL390034 Genomic DNA No translation available.
BC023663 mRNA Translation: AAH23663.1
BC047774 mRNA Translation: AAH47774.1
CCDSiCCDS7349.1
RefSeqiNP_653190.2, NM_144589.2
UniGeneiHs.355333

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AVDX-ray1.70A/B36-262[»]
ProteinModelPortaliQ86VU5
SMRiQ86VU5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125625, 65 interactors
IntActiQ86VU5, 5 interactors
STRINGi9606.ENSP00000361616

Chemistry databases

DrugBankiDB03923 Feruloyl Coenzyme A
DB01752 S-Adenosyl-L-Homocysteine
DB03179 Sinapoyl Coenzyme A

PTM databases

iPTMnetiQ86VU5
PhosphoSitePlusiQ86VU5
SwissPalmiQ86VU5

Polymorphism and mutation databases

BioMutaiCOMTD1
DMDMi74750472

Proteomic databases

EPDiQ86VU5
MaxQBiQ86VU5
PaxDbiQ86VU5
PeptideAtlasiQ86VU5
PRIDEiQ86VU5
ProteomicsDBi70070

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372538; ENSP00000361616; ENSG00000165644
GeneIDi118881
KEGGihsa:118881
UCSCiuc001jxb.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
118881
EuPathDBiHostDB:ENSG00000165644.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
COMTD1
HGNCiHGNC:26309 COMTD1
HPAiHPA042165
neXtProtiNX_Q86VU5
OpenTargetsiENSG00000165644
PharmGKBiPA134961676

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1663 Eukaryota
COG4122 LUCA
GeneTreeiENSGT00390000004409
HOGENOMiHOG000016839
HOVERGENiHBG081259
InParanoidiQ86VU5
OMAiLSDNVLW
OrthoDBiEOG091G0JQB
PhylomeDBiQ86VU5
TreeFamiTF312986

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
COMTD1 human
EvolutionaryTraceiQ86VU5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
118881

Protein Ontology

More...
PROi
PR:Q86VU5

Gene expression databases

BgeeiENSG00000165644 Expressed in 170 organ(s), highest expression level in body of pancreas
CleanExiHS_COMTD1
ExpressionAtlasiQ86VU5 baseline and differential
GenevisibleiQ86VU5 HS

Family and domain databases

InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR002935 SAM_O-MeTrfase
PfamiView protein in Pfam
PF01596 Methyltransf_3, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51682 SAM_OMT_I, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCMTD1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86VU5
Secondary accession number(s): Q8TE79
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2003
Last modified: December 5, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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