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Entry version 126 (11 Dec 2019)
Sequence version 2 (24 Nov 2009)
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Protein

IQ domain-containing protein H

Gene

IQCH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a regulatory role in spermatogenesis.1 Publication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
IQ domain-containing protein H
Alternative name(s):
Testis development protein NYD-SP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IQCH
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000103599.19

Human Gene Nomenclature Database

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HGNCi
HGNC:25721 IQCH

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612523 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86VS3

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64799

Open Targets

More...
OpenTargetsi
ENSG00000103599

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671654

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86VS3 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IQCH

Domain mapping of disease mutations (DMDM)

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DMDMi
269849608

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002825651 – 1027IQ domain-containing protein HAdd BLAST1027

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q86VS3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q86VS3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86VS3

PeptideAtlas

More...
PeptideAtlasi
Q86VS3

PRoteomics IDEntifications database

More...
PRIDEi
Q86VS3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
15070
70064 [Q86VS3-1]
70065 [Q86VS3-2]
70066 [Q86VS3-3]
70067 [Q86VS3-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86VS3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q86VS3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in fetal and adult testis, in germ cells but not somatic cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000103599 Expressed in 111 organ(s), highest expression level in buccal mucosa cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86VS3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86VS3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040845

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122305, 2 interactors

Protein interaction database and analysis system

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IntActi
Q86VS3, 3 interactors

Molecular INTeraction database

More...
MINTi
Q86VS3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000336861

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86VS3 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini369 – 398IQPROSITE-ProRule annotationAdd BLAST30

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ65 Eukaryota
ENOG410YTWX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008908

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168550

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86VS3

Identification of Orthologs from Complete Genome Data

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OMAi
VNIFPKH

Database of Orthologous Groups

More...
OrthoDBi
203701at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86VS3

TreeFam database of animal gene trees

More...
TreeFami
TF328488

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR038752 IQCH

The PANTHER Classification System

More...
PANTHERi
PTHR14465 PTHR14465, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86VS3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQNTENHDP VGSILIQIHE DLYQLKEKLT KFSPEEKGET LDIQSLETAI
60 70 80 90 100
KRTEVGLRIH IEKYLNVVNQ NVLTTSVNDE SLYTPQASKW LLPTVIDQKS
110 120 130 140 150
FIFPQESEGT FWQPQRQHSS SLPVFPRAKI KVSKLIKGSN ISSLTVLPSS
160 170 180 190 200
HCTDPYFTPI PVLQADAHKG ILSMIERGLI PPTARITFQN PPITPRAAPL
210 220 230 240 250
HSFDEARKIP TVATFTIPRE PPPSPAEVKF FPKKQRSKGK SRRSRGHHDR
260 270 280 290 300
KAMKVKTPLR ALKSLWDYDF LIYDGVIDNT APDFLAFKEH FSLAWGGIFS
310 320 330 340 350
LLEHVEKFLR NYAIPEVKIK GNNLVALLPE FELTNKLTRY DLLSVLEDPA
360 370 380 390 400
HVQMLINLPG QRYKGQDGNS EAAMKIQATW KCYKARKFFL FYRQQKWASG
410 420 430 440 450
VIAIAWLLYC HKTRLKKILK ESRQRHLENF RIRAKHLAAN WNRIRTSRRT
460 470 480 490 500
IIHIPSLGYS QPVREHIADF NTQQNMQLGR LCDILDANVN VIYICSHHMN
510 520 530 540 550
DELVLYYKKI LSLHAAVKSG NLEDRSDLQD RFKIITPEAV NIFPKHHMCL
560 570 580 590 600
ATHLMYSPKA IKRIKNLIRG TEAYIVSGLL HRDDLAVADM LDIPILGSEP
610 620 630 640 650
ELAHLYSTKS GGKRVFDSAN VAVPPGIYDI YSQQQMIEQL SQLITDHLQI
660 670 680 690 700
QRWLFKMDSE FRGNGTAFCD IPSYLKCYKW VLKESSRYGL EDWRKKWAQE
710 720 730 740 750
PALVKISEEL AGILAQHAQP VNEKRFPTWR KFLQTFLSQG GVIEAFPPAD
760 770 780 790 800
NVTNLTVDML IEPNGKISVL STGDQLHAES PFISSGTTVP QTSVDPQVLT
810 820 830 840 850
YLCLQIGKAC RMRDVVGYFS IDLVTFIDPS TLEQQVWATG LNLAYSDQLA
860 870 880 890 900
LTQLTLYLTN GHLDCSLSTL EVPRFVPKER KKTKCMSALS MPMLATSRYA
910 920 930 940 950
VMTTQLRHSN LSLVFHYVFL QICRAHGIGY DVEERQGTVF ILYEHLKRHK
960 970 980 990 1000
LGMLTIGEDL QGVLMTFARH LFIIHQEISA PNMQGETNFK TTIADIETIL
1010 1020
RVTKENKMRF EEEQQSKDDK NLSKPKK
Length:1,027
Mass (Da):117,349
Last modified:November 24, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB36D504EE4E303E6
GO
Isoform 2 (identifier: Q86VS3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-252: Missing.
     545-635: Missing.

Show »
Length:684
Mass (Da):78,870
Checksum:i08E301B6C5E803DF
GO
Isoform 3 (identifier: Q86VS3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: Missing.
     459-478: YSQPVREHIADFNTQQNMQL → ITLLPANLSATSITHHIMAP
     479-1027: Missing.

Show »
Length:305
Mass (Da):35,202
Checksum:iCEB9769DFB7FB70A
GO
Isoform 4 (identifier: Q86VS3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-248: Missing.
     249-250: DR → MT
     545-635: Missing.
     934-960: ERQGTVFILYEHLKRHKLGMLTIGEDL → NNRRGSPGGPHDLCSPSLHHPSRNIST
     961-1027: Missing.

Show »
Length:621
Mass (Da):71,182
Checksum:iE16F73A2B29B8763
GO
Isoform 5 (identifier: Q86VS3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-168: IKVSKLIKGS...PIPVLQADAH → RKIGLNVKIL...LPYINQRKAC
     169-1027: Missing.

Show »
Length:168
Mass (Da):19,245
Checksum:iAAC9494B3E43591C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BRL4H3BRL4_HUMAN
IQ domain-containing protein H
IQCH
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BU17H3BU17_HUMAN
IQ domain-containing protein H
IQCH
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4E2J4B4E2J4_HUMAN
IQ domain-containing protein H
IQCH
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGG0D6RGG0_HUMAN
IQ domain-containing protein H
IQCH
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMH8H3BMH8_HUMAN
IQ domain-containing protein H
IQCH
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMU5H0YMU5_HUMAN
IQ domain-containing protein H
IQCH
19Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti33S → T in AAK27307 (PubMed:15897968).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051077932V → L5 PublicationsCorresponds to variant dbSNP:rs3985641Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0241881 – 252Missing in isoform 2. 1 PublicationAdd BLAST252
Alternative sequenceiVSP_0241891 – 248Missing in isoform 4. 1 PublicationAdd BLAST248
Alternative sequenceiVSP_0241901 – 173Missing in isoform 3. 1 PublicationAdd BLAST173
Alternative sequenceiVSP_045251130 – 168IKVSK…QADAH → RKIGLNVKILQDPENIHHRA AVNANYGISLPYINQRKAC in isoform 5. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_045252169 – 1027Missing in isoform 5. 1 PublicationAdd BLAST859
Alternative sequenceiVSP_024191249 – 250DR → MT in isoform 4. 1 Publication2
Alternative sequenceiVSP_024192459 – 478YSQPV…QNMQL → ITLLPANLSATSITHHIMAP in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_024193479 – 1027Missing in isoform 3. 1 PublicationAdd BLAST549
Alternative sequenceiVSP_024194545 – 635Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST91
Alternative sequenceiVSP_024195934 – 960ERQGT…IGEDL → NNRRGSPGGPHDLCSPSLHH PSRNIST in isoform 4. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_024196961 – 1027Missing in isoform 4. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY014282 mRNA Translation: AAK27307.2
AK022538 mRNA Translation: BAB14087.1
AK292478 mRNA Translation: BAF85167.1
AC012568 Genomic DNA No translation available.
AC016355 Genomic DNA No translation available.
AC106000 Genomic DNA No translation available.
AC110292 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77796.1
BC031041 mRNA Translation: AAH31041.2
BC039292 mRNA Translation: AAH39292.1
BC039463 mRNA No translation available.
BC048964 mRNA Translation: AAH48964.1
AL133556 mRNA Translation: CAB63711.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10223.2 [Q86VS3-5]
CCDS32273.1 [Q86VS3-1]
CCDS61680.1 [Q86VS3-4]
CCDS61681.1 [Q86VS3-2]
CCDS76772.1 [Q86VS3-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
T43438

NCBI Reference Sequences

More...
RefSeqi
NP_001026885.1, NM_001031715.2 [Q86VS3-1]
NP_001271276.1, NM_001284347.1 [Q86VS3-2]
NP_001271277.1, NM_001284348.1 [Q86VS3-4]
NP_001271278.1, NM_001284349.1 [Q86VS3-3]
NP_001309404.1, NM_001322475.1
NP_073621.2, NM_022784.2 [Q86VS3-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000335894; ENSP00000336861; ENSG00000103599 [Q86VS3-1]
ENST00000358767; ENSP00000351617; ENSG00000103599 [Q86VS3-4]
ENST00000512104; ENSP00000427323; ENSG00000103599 [Q86VS3-5]
ENST00000546225; ENSP00000444118; ENSG00000103599 [Q86VS3-2]
ENST00000629425; ENSP00000486970; ENSG00000103599 [Q86VS3-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64799

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64799

UCSC genome browser

More...
UCSCi
uc002aqm.4 human [Q86VS3-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014282 mRNA Translation: AAK27307.2
AK022538 mRNA Translation: BAB14087.1
AK292478 mRNA Translation: BAF85167.1
AC012568 Genomic DNA No translation available.
AC016355 Genomic DNA No translation available.
AC106000 Genomic DNA No translation available.
AC110292 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77796.1
BC031041 mRNA Translation: AAH31041.2
BC039292 mRNA Translation: AAH39292.1
BC039463 mRNA No translation available.
BC048964 mRNA Translation: AAH48964.1
AL133556 mRNA Translation: CAB63711.1
CCDSiCCDS10223.2 [Q86VS3-5]
CCDS32273.1 [Q86VS3-1]
CCDS61680.1 [Q86VS3-4]
CCDS61681.1 [Q86VS3-2]
CCDS76772.1 [Q86VS3-3]
PIRiT43438
RefSeqiNP_001026885.1, NM_001031715.2 [Q86VS3-1]
NP_001271276.1, NM_001284347.1 [Q86VS3-2]
NP_001271277.1, NM_001284348.1 [Q86VS3-4]
NP_001271278.1, NM_001284349.1 [Q86VS3-3]
NP_001309404.1, NM_001322475.1
NP_073621.2, NM_022784.2 [Q86VS3-5]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi122305, 2 interactors
IntActiQ86VS3, 3 interactors
MINTiQ86VS3
STRINGi9606.ENSP00000336861

PTM databases

iPTMnetiQ86VS3
PhosphoSitePlusiQ86VS3

Polymorphism and mutation databases

BioMutaiIQCH
DMDMi269849608

Proteomic databases

jPOSTiQ86VS3
MassIVEiQ86VS3
PaxDbiQ86VS3
PeptideAtlasiQ86VS3
PRIDEiQ86VS3
ProteomicsDBi15070
70064 [Q86VS3-1]
70065 [Q86VS3-2]
70066 [Q86VS3-3]
70067 [Q86VS3-4]

Genome annotation databases

EnsembliENST00000335894; ENSP00000336861; ENSG00000103599 [Q86VS3-1]
ENST00000358767; ENSP00000351617; ENSG00000103599 [Q86VS3-4]
ENST00000512104; ENSP00000427323; ENSG00000103599 [Q86VS3-5]
ENST00000546225; ENSP00000444118; ENSG00000103599 [Q86VS3-2]
ENST00000629425; ENSP00000486970; ENSG00000103599 [Q86VS3-3]
GeneIDi64799
KEGGihsa:64799
UCSCiuc002aqm.4 human [Q86VS3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64799
DisGeNETi64799
EuPathDBiHostDB:ENSG00000103599.19

GeneCards: human genes, protein and diseases

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GeneCardsi
IQCH
HGNCiHGNC:25721 IQCH
HPAiHPA040845
MIMi612523 gene
neXtProtiNX_Q86VS3
OpenTargetsiENSG00000103599
PharmGKBiPA142671654

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IJ65 Eukaryota
ENOG410YTWX LUCA
GeneTreeiENSGT00390000008908
HOGENOMiHOG000168550
InParanoidiQ86VS3
OMAiVNIFPKH
OrthoDBi203701at2759
PhylomeDBiQ86VS3
TreeFamiTF328488

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
IQCH human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64799
PharosiQ86VS3 Tdark

Protein Ontology

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PROi
PR:Q86VS3
RNActiQ86VS3 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000103599 Expressed in 111 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasiQ86VS3 baseline and differential
GenevisibleiQ86VS3 HS

Family and domain databases

InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR038752 IQCH
PANTHERiPTHR14465 PTHR14465, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIQCH_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86VS3
Secondary accession number(s): A8K8W3
, C9JPR6, D6RJ88, Q4G0S6, Q8NEH9, Q9BWX2, Q9H9Y1, Q9UF88
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 24, 2009
Last modified: December 11, 2019
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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