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Protein

Four-jointed box protein 1

Gene

FJX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as an inhibitor of dendrite extension and branching.By similarity

GO - Biological processi

  • cell-cell signaling Source: GO_Central
  • retina layer formation Source: Ensembl

Names & Taxonomyi

Protein namesi
Recommended name:
Four-jointed box protein 1
Alternative name(s):
Four-jointed protein homolog
Gene namesi
Name:FJX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000179431.6
HGNCiHGNC:17166 FJX1
MIMi612206 gene
neXtProtiNX_Q86VR8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi24147
OpenTargetsiENSG00000179431
PharmGKBiPA28151

Polymorphism and mutation databases

BioMutaiFJX1
DMDMi74727610

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000033304525 – 437Four-jointed box protein 1Add BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.By similarity
Undergoes proteolytic cleavage.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86VR8
PeptideAtlasiQ86VR8
PRIDEiQ86VR8
ProteomicsDBi70063

PTM databases

iPTMnetiQ86VR8
PhosphoSitePlusiQ86VR8

Expressioni

Gene expression databases

BgeeiENSG00000179431 Expressed in 164 organ(s), highest expression level in neocortex
CleanExiHS_FJX1
GenevisibleiQ86VR8 HS

Organism-specific databases

HPAiHPA059220

Interactioni

Protein-protein interaction databases

BioGridi117297, 2 interactors
IntActiQ86VR8, 2 interactors
STRINGi9606.ENSP00000400223

Structurei

3D structure databases

ProteinModelPortaliQ86VR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi31 – 67Pro-richAdd BLAST37

Sequence similaritiesi

Belongs to the FJX1/FJ family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHNI Eukaryota
ENOG410XSE2 LUCA
GeneTreeiENSGT00390000016768
HOGENOMiHOG000112598
HOVERGENiHBG098046
InParanoidiQ86VR8
KOiK16674
OMAiMERDTNN
OrthoDBiEOG091G0L1D
PhylomeDBiQ86VR8
TreeFamiTF324767

Family and domain databases

InterProiView protein in InterPro
IPR024868 FJX1/FJ
PANTHERiPTHR13147 PTHR13147, 1 hit
PRINTSiPR02072 4JOINTEDBOX1

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86VR8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRRMRGAAA TAGLWLLALG SLLALWGGLL PPRTELPASR PPEDRLPRRP
60 70 80 90 100
ARSGGPAPAP RFPLPPPLAW DARGGSLKTF RALLTLAAGA DGPPRQSRSE
110 120 130 140 150
PRWHVSARQP RPEESAAVHG GVFWSRGLEE QVPPGFSEAQ AAAWLEAARG
160 170 180 190 200
ARMVALERGG CGRSSNRLAR FADGTRACVR YGINPEQIQG EALSYYLARL
210 220 230 240 250
LGLQRHVPPL ALARVEARGA QWAQVQEELR AAHWTEGSVV SLTRWLPNLT
260 270 280 290 300
DVVVPAPWRS EDGRLRPLRD AGGELANLSQ AELVDLVQWT DLILFDYLTA
310 320 330 340 350
NFDRLVSNLF SLQWDPRVMQ RATSNLHRGP GGALVFLDNE AGLVHGYRVA
360 370 380 390 400
GMWDKYNEPL LQSVCVFRER TARRVLELHR GQDAAARLLR LYRRHEPRFP
410 420 430
ELAALADPHA QLLQRRLDFL AKHILHCKAK YGRRSGT
Length:437
Mass (Da):48,507
Last modified:June 1, 2003 - v1
Checksum:i3E2B8D3977722639
GO

Sequence cautioni

The sequence CAB53246 differs from that shown. Reason: Frameshift at position 436.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58P → R in CAB53246 (PubMed:10568747).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043117153M → L. Corresponds to variant dbSNP:rs12792700Ensembl.1
Natural variantiVAR_062233415R → H. Corresponds to variant dbSNP:rs12286850Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245599 mRNA Translation: CAB53246.1 Frameshift.
AK315015 mRNA Translation: BAG37506.1
CH471064 Genomic DNA Translation: EAW68138.1
BC049171 mRNA Translation: AAH49171.1
BC071898 mRNA Translation: AAH71898.1
CCDSiCCDS44570.1
RefSeqiNP_055159.2, NM_014344.3
UniGeneiHs.39384

Genome annotation databases

EnsembliENST00000317811; ENSP00000400223; ENSG00000179431
GeneIDi24147
KEGGihsa:24147
UCSCiuc001mwh.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245599 mRNA Translation: CAB53246.1 Frameshift.
AK315015 mRNA Translation: BAG37506.1
CH471064 Genomic DNA Translation: EAW68138.1
BC049171 mRNA Translation: AAH49171.1
BC071898 mRNA Translation: AAH71898.1
CCDSiCCDS44570.1
RefSeqiNP_055159.2, NM_014344.3
UniGeneiHs.39384

3D structure databases

ProteinModelPortaliQ86VR8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117297, 2 interactors
IntActiQ86VR8, 2 interactors
STRINGi9606.ENSP00000400223

PTM databases

iPTMnetiQ86VR8
PhosphoSitePlusiQ86VR8

Polymorphism and mutation databases

BioMutaiFJX1
DMDMi74727610

Proteomic databases

PaxDbiQ86VR8
PeptideAtlasiQ86VR8
PRIDEiQ86VR8
ProteomicsDBi70063

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317811; ENSP00000400223; ENSG00000179431
GeneIDi24147
KEGGihsa:24147
UCSCiuc001mwh.4 human

Organism-specific databases

CTDi24147
DisGeNETi24147
EuPathDBiHostDB:ENSG00000179431.6
GeneCardsiFJX1
HGNCiHGNC:17166 FJX1
HPAiHPA059220
MIMi612206 gene
neXtProtiNX_Q86VR8
OpenTargetsiENSG00000179431
PharmGKBiPA28151
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHNI Eukaryota
ENOG410XSE2 LUCA
GeneTreeiENSGT00390000016768
HOGENOMiHOG000112598
HOVERGENiHBG098046
InParanoidiQ86VR8
KOiK16674
OMAiMERDTNN
OrthoDBiEOG091G0L1D
PhylomeDBiQ86VR8
TreeFamiTF324767

Miscellaneous databases

ChiTaRSiFJX1 human
GenomeRNAii24147
PROiPR:Q86VR8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179431 Expressed in 164 organ(s), highest expression level in neocortex
CleanExiHS_FJX1
GenevisibleiQ86VR8 HS

Family and domain databases

InterProiView protein in InterPro
IPR024868 FJX1/FJ
PANTHERiPTHR13147 PTHR13147, 1 hit
PRINTSiPR02072 4JOINTEDBOX1
ProtoNetiSearch...

Entry informationi

Entry nameiFJX1_HUMAN
AccessioniPrimary (citable) accession number: Q86VR8
Secondary accession number(s): B2RCA9, Q9UGK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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