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UniProtKB - Q86VR2 (RETR3_HUMAN)

Entry version 126 (25 May 2022)
Sequence version 1 (01 Jun 2003)
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Protein

Reticulophagy regulator 3

Gene

RETREG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates NRF1-enhanced neurite outgrowth.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • positive regulation of neuron projection development Source: UniProtKB
  • reticulophagy Source: InterPro
Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86VR2

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q86VR2

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q86VR2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reticulophagy regulator 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RETREG3Imported
Synonyms:FAM134C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:27258, RETREG3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616498, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86VR2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000141699

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		162427

Open Targets

More...OpenTargetsi		ENSG00000141699

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162386207

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86VR2, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RETREG3

Domain mapping of disease mutations (DMDM)

More...DMDMi		74727607

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002884692 – 466Reticulophagy regulator 3Add BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei10PhosphothreonineCombined sources1
Modified residuei26PhosphoserineCombined sources1
Modified residuei258PhosphoserineCombined sources1
Modified residuei260PhosphoserineCombined sources1
Modified residuei283PhosphothreonineCombined sources1
Modified residuei285PhosphoserineCombined sources1
Modified residuei288PhosphoserineBy similarity1
Modified residuei293PhosphoserineBy similarity1
Modified residuei303PhosphoserineBy similarity1
Modified residuei307PhosphothreonineCombined sources1
Modified residuei310PhosphothreonineCombined sources1
Modified residuei313PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Modified residuei360PhosphoserineCombined sources1
Modified residuei440PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q86VR2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q86VR2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86VR2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86VR2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86VR2

PeptideAtlas

More...PeptideAtlasi		Q86VR2

PRoteomics IDEntifications database

More...PRIDEi		Q86VR2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		3584
70060 [Q86VR2-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86VR2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86VR2

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q86VR2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000141699, Expressed in prostate gland and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86VR2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86VR2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000141699, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q86VR2
With#Exp.IntAct
ABHD16A [O95870]7EBI-10192441,EBI-348517
ACSL5 [Q9ULC5]5EBI-10192441,EBI-2876927
AGPAT4 [Q9NRZ5]3EBI-10192441,EBI-1754287
AGTRAP - isoform 2 [Q6RW13-2]3EBI-10192441,EBI-11522760
ANKRD46 - isoform 1 [Q86W74-2]3EBI-10192441,EBI-12109402
ARL6IP1 [Q15041]7EBI-10192441,EBI-714543
ARPC3 [O15145]5EBI-10192441,EBI-351829
ATP6V0C [P27449]3EBI-10192441,EBI-721179
BET1 [O15155]3EBI-10192441,EBI-749204
BNIP1 [Q12981]3EBI-10192441,EBI-4402847
C4orf3 - isoform 2 [Q8WVX3-2]3EBI-10192441,EBI-12003442
CCDC167 [Q9P0B6]3EBI-10192441,EBI-9083477
CCL4L2 [Q8NHW4]3EBI-10192441,EBI-10271156
CDIPT [O14735]3EBI-10192441,EBI-358858
CDS1 [Q92903]3EBI-10192441,EBI-13295305
CMTM3 [Q96MX0]3EBI-10192441,EBI-7247651
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-10192441,EBI-11522780
CMTM7 [Q96FZ5]5EBI-10192441,EBI-2807956
CSGALNACT2 [Q8N6G5]3EBI-10192441,EBI-10267100
CYB5B [O43169]3EBI-10192441,EBI-1058710
CYP4F2 [P78329]3EBI-10192441,EBI-1752413
DERL1 [Q9BUN8]3EBI-10192441,EBI-398977
DHRSX [Q8N5I4]3EBI-10192441,EBI-3923585
ERG28 [Q9UKR5]3EBI-10192441,EBI-711490
FAXDC2 [Q96IV6]3EBI-10192441,EBI-12142299
FIMP [Q96LL3]3EBI-10192441,EBI-12887376
FKBP8 [Q14318]3EBI-10192441,EBI-724839
FUNDC2 [Q9BWH2]3EBI-10192441,EBI-714482
GABARAPL1 [Q9H0R8]8EBI-10192441,EBI-746969
GABARAPL2 [P60520]3EBI-10192441,EBI-720116
GIMAP5 [Q96F15]5EBI-10192441,EBI-6166686
GOSR2 [O14653]3EBI-10192441,EBI-4401517
HMOX2 [P30519]3EBI-10192441,EBI-712096
HTATIP2 - isoform 3 [Q9BUP3-3]3EBI-10192441,EBI-12937691
IFITM3 [Q01628]3EBI-10192441,EBI-7932862
JAGN1 [Q8N5M9]3EBI-10192441,EBI-10266796
LEMD1 [Q68G75]3EBI-10192441,EBI-12268900
LPAR3 [Q9UBY5]5EBI-10192441,EBI-12033434
LPCAT2 [Q7L5N7]3EBI-10192441,EBI-4280011
LRCH4 [O75427]3EBI-10192441,EBI-718707
MAL2 [Q969L2]3EBI-10192441,EBI-944295
MALL [Q13021]3EBI-10192441,EBI-750078
MAP1LC3A [Q9H492]9EBI-10192441,EBI-720768
MCRS1 [Q96EZ8]3EBI-10192441,EBI-348259
MFF - isoform 5 [Q9GZY8-5]3EBI-10192441,EBI-11956541
MOB2 [Q70IA6]3EBI-10192441,EBI-2558739
MOSPD3 [O75425]3EBI-10192441,EBI-12179105
NRM [Q8IXM6]3EBI-10192441,EBI-10262547
OPTN [Q96CV9]3EBI-10192441,EBI-748974
ORMDL2 [Q53FV1]3EBI-10192441,EBI-11075081
ORMDL3 [Q8N138]3EBI-10192441,EBI-721750
OTULINL [Q9NUU6]3EBI-10192441,EBI-6916492
PKMYT1 - isoform 2 [Q99640-2]3EBI-10192441,EBI-12257782
PLP2 [Q04941]3EBI-10192441,EBI-608347
PLPP6 [Q8IY26]3EBI-10192441,EBI-11721828
PNLIPRP1 [P54315]3EBI-10192441,EBI-8652812
PRAF2 [O60831]3EBI-10192441,EBI-2506064
RABAC1 [Q9UI14]3EBI-10192441,EBI-712367
REEP6 - isoform 2 [Q96HR9-2]3EBI-10192441,EBI-14065960
RUSF1 [Q96GQ5]3EBI-10192441,EBI-8636004
SCD [O00767]3EBI-10192441,EBI-2684237
SEC22A [Q96IW7]5EBI-10192441,EBI-8652744
SENP2 [Q9HC62]3EBI-10192441,EBI-714881
SERP2 [Q8N6R1]3EBI-10192441,EBI-749270
SFT2D1 [Q8WV19]3EBI-10192441,EBI-2854842
SFXN3 [A0A1P0AYU5]5EBI-10192441,EBI-14193895
SLC30A3 [Q99726]3EBI-10192441,EBI-10294651
SLC39A6 - isoform 2 [Q13433-2]3EBI-10192441,EBI-12956703
SMCO4 [Q9NRQ5]3EBI-10192441,EBI-8640191
SMIM1 [B2RUZ4]3EBI-10192441,EBI-12188413
STAP1 [Q9ULZ2]8EBI-10192441,EBI-6083058
STX5 [Q13190]3EBI-10192441,EBI-714206
STX7 [O15400]3EBI-10192441,EBI-3221827
STX8 [Q9UNK0]5EBI-10192441,EBI-727240
SYNGR1 - isoform 1B [O43759-2]3EBI-10192441,EBI-12187159
TBRG4 [Q969Z0]3EBI-10192441,EBI-702328
TCEA2 [Q15560]3EBI-10192441,EBI-710310
TECR [Q9NZ01]3EBI-10192441,EBI-2877718
TMEM100 [Q9NV29]3EBI-10192441,EBI-8644968
TMEM11 [P17152]3EBI-10192441,EBI-723946
TMEM120B [A0PK00]3EBI-10192441,EBI-10171534
TMEM128 - isoform 2 [Q5BJH2-2]3EBI-10192441,EBI-10694905
TMEM176A [Q96HP8]3EBI-10192441,EBI-2800645
TMEM18 - isoform 2 [Q96B42-2]3EBI-10192441,EBI-17196383
TMEM203 [Q969S6]3EBI-10192441,EBI-12274070
TMEM218 [A2RU14]3EBI-10192441,EBI-10173151
TMEM222 [Q9H0R3]3EBI-10192441,EBI-347385
TMEM237 - isoform 2 [Q96Q45-2]3EBI-10192441,EBI-10982110
TMEM239 - isoform 2 [Q8WW34-2]3EBI-10192441,EBI-11528917
TMEM243 [Q9BU79]3EBI-10192441,EBI-12887458
TMEM254 [Q8TBM7]3EBI-10192441,EBI-11956809
TMEM42 [Q69YG0]3EBI-10192441,EBI-12038591
TMEM60 [Q9H2L4]3EBI-10192441,EBI-2852148
TMEM65 [Q6PI78]3EBI-10192441,EBI-6656213
TMPPE [Q6ZT21]3EBI-10192441,EBI-11724433
TPRG1 [Q6ZUI0]3EBI-10192441,EBI-17249488
TSNARE1 [A0AVG3]3EBI-10192441,EBI-12003468
TSPO2 [Q5TGU0]5EBI-10192441,EBI-12195249
UBIAD1 [Q9Y5Z9]3EBI-10192441,EBI-2819725
VAMP1 - isoform 2 [P23763-3]3EBI-10192441,EBI-12097582
VAMP3 [Q15836]3EBI-10192441,EBI-722343
VAMP4 [O75379]3EBI-10192441,EBI-744953
VAMP5 [O95183]3EBI-10192441,EBI-10191195
VAPA [Q9P0L0]3EBI-10192441,EBI-1059156
VAPB [O95292]3EBI-10192441,EBI-1188298
YIPF1 [Q9Y548]3EBI-10192441,EBI-7850136
YIPF6 [Q96EC8]5EBI-10192441,EBI-751210

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127817, 231 interactors

Database of interacting proteins

More...DIPi		DIP-61578N

Protein interaction database and analysis system

More...IntActi		Q86VR2, 160 interactors

Molecular INTeraction database

More...MINTi		Q86VR2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000309432

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86VR2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q86VR2

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 28DisorderedSequence analysisAdd BLAST28
Regioni284 – 374DisorderedSequence analysisAdd BLAST91
Regioni412 – 466DisorderedSequence analysisAdd BLAST55

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi445 – 450LIR motif1 Publication6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi292 – 310Polar residuesSequence analysisAdd BLAST19
Compositional biasi314 – 328Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The LIR motif interacts with ATG8 family proteins.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RETREG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QPTN, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161349

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_036265_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86VR2

Identification of Orthologs from Complete Genome Data

More...OMAi		HIAEAWV

Database of Orthologous Groups

More...OrthoDBi		901531at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86VR2

TreeFam database of animal gene trees

More...TreeFami		TF329111

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043384, RETREG1/3
IPR033361, RETREG3

The PANTHER Classification System

More...PANTHERi		PTHR28659, PTHR28659, 1 hit
PTHR28659:SF1, PTHR28659:SF1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86VR2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEAEGVPTT PGPASGSTFR GRRDVSGSWE RDQQVEAAQR ALVEVLGPYE 
        60         70         80         90        100
PLLSRVQAAL VWERPARSAL WCLGLNAAFW FFALTSLRLV FLLAFGLMII 
       110        120        130        140        150
VCIDQWKNKI WPEIKVPRPD ALDNESWGFV HPRLLSVPEL CHHVAEVWVS 
       160        170        180        190        200
GTIFIRNVLL FKKQNPGKFC LLSCGILTFL AVLGRYVPGL LLSYLMLVTV 
       210        220        230        240        250
MMWPLAVYHR LWDRAYVRLK PALQRLDFSV RGYMMSKQRE RQLRRRALHP 
       260        270        280        290        300
ERAMDNHSDS EEELAAFCPQ LDDSTVAREL AITDSEHSDA EVSCTDNGTF 
       310        320        330        340        350
NLSRGQTPLT EGSEDLDGHS DPEESFARDL PDFPSINMDP AGLDDEDDTS 
       360        370        380        390        400
IGMPSLMYRS PPGAEEPQAP PASRDEAALP ELLLGALPVG SNLTSNLASL 
       410        420        430        440        450
VSQGMIQLAL SGASQPGPSG APAQRATRGF LRSPSSDLDT DAEGDDFELL 
       460 
DQSELSQLDP ASSRSH
Length:466
Mass (Da):51,396
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF9D468353C13A14B
GO
Isoform 2 (identifier: Q86VR2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-195: Missing.

Show »
Length:271
Mass (Da):29,582
Checksum:i7361F5A0294F76BC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQI9K7EQI9_HUMAN
Reticulophagy regulator 3
RETREG3
369Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ34K7EJ34_HUMAN
Reticulophagy regulator 3
RETREG3
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENF4K7ENF4_HUMAN
Reticulophagy regulator 3
RETREG3
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPD0K7EPD0_HUMAN
Reticulophagy regulator 3
RETREG3
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ42K7EJ42_HUMAN
Reticulophagy regulator 3
RETREG3
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELM8K7ELM8_HUMAN
Reticulophagy regulator 3
RETREG3
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENZ6K7ENZ6_HUMAN
Reticulophagy regulator 3
RETREG3
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMF4K7EMF4_HUMAN
Reticulophagy regulator 3
RETREG3
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0569911 – 195Missing in isoform 2. 1 PublicationAdd BLAST195

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK091125 mRNA Translation: BAG52287.1
AK294791 mRNA Translation: BAG57914.1
AC067852 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60851.1
BC049370 mRNA Translation: AAH49370.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11432.1 [Q86VR2-1]

NCBI Reference Sequences

More...RefSeqi		NP_835227.1, NM_178126.3 [Q86VR2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000309428.10; ENSP00000309432.4; ENSG00000141699.11

Database of genes from NCBI RefSeq genomes

More...GeneIDi		162427

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:162427

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000309428.10; ENSP00000309432.4; NM_178126.4; NP_835227.1

UCSC genome browser

More...UCSCi		uc060fkv.1, human [Q86VR2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091125 mRNA Translation: BAG52287.1
AK294791 mRNA Translation: BAG57914.1
AC067852 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60851.1
BC049370 mRNA Translation: AAH49370.1
CCDSiCCDS11432.1 [Q86VR2-1]
RefSeqiNP_835227.1, NM_178126.3 [Q86VR2-1]

3D structure databases

AlphaFoldDBiQ86VR2
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi127817, 231 interactors
DIPiDIP-61578N
IntActiQ86VR2, 160 interactors
MINTiQ86VR2
STRINGi9606.ENSP00000309432

PTM databases

iPTMnetiQ86VR2
PhosphoSitePlusiQ86VR2
SwissPalmiQ86VR2

Genetic variation databases

BioMutaiRETREG3
DMDMi74727607

Proteomic databases

EPDiQ86VR2
jPOSTiQ86VR2
MassIVEiQ86VR2
MaxQBiQ86VR2
PaxDbiQ86VR2
PeptideAtlasiQ86VR2
PRIDEiQ86VR2
ProteomicsDBi3584
70060 [Q86VR2-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3087, 68 antibodies from 17 providers

The DNASU plasmid repository

More...DNASUi		162427

Genome annotation databases

EnsembliENST00000309428.10; ENSP00000309432.4; ENSG00000141699.11
GeneIDi162427
KEGGihsa:162427
MANE-SelectiENST00000309428.10; ENSP00000309432.4; NM_178126.4; NP_835227.1
UCSCiuc060fkv.1, human [Q86VR2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		162427
DisGeNETi162427

GeneCards: human genes, protein and diseases

More...GeneCardsi		RETREG3
HGNCiHGNC:27258, RETREG3
HPAiENSG00000141699, Low tissue specificity
MIMi616498, gene
neXtProtiNX_Q86VR2
OpenTargetsiENSG00000141699
PharmGKBiPA162386207
VEuPathDBiHostDB:ENSG00000141699

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QPTN, Eukaryota
GeneTreeiENSGT00940000161349
HOGENOMiCLU_036265_0_0_1
InParanoidiQ86VR2
OMAiHIAEAWV
OrthoDBi901531at2759
PhylomeDBiQ86VR2
TreeFamiTF329111

Enzyme and pathway databases

PathwayCommonsiQ86VR2
SignaLinkiQ86VR2
SIGNORiQ86VR2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		162427, 21 hits in 1088 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FAM134C, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FAM134C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		162427
PharosiQ86VR2, Tdark

Protein Ontology

More...PROi		PR:Q86VR2
RNActiQ86VR2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000141699, Expressed in prostate gland and 250 other tissues
ExpressionAtlasiQ86VR2, baseline and differential
GenevisibleiQ86VR2, HS

Family and domain databases

InterProiView protein in InterPro
IPR043384, RETREG1/3
IPR033361, RETREG3
PANTHERiPTHR28659, PTHR28659, 1 hit
PTHR28659:SF1, PTHR28659:SF1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRETR3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86VR2
Secondary accession number(s): B3KR75
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2003
Last modified: May 25, 2022
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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