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Protein

Reticulophagy regulator 3

Gene

RETREG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates NRF1-enhanced neurite outgrowth.1 Publication

GO - Biological processi

  • positive regulation of neuron projection development Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulophagy regulator 3
Gene namesi
Name:RETREG3Imported
Synonyms:FAM134C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141699.10
HGNCiHGNC:27258 RETREG3
MIMi616498 gene
neXtProtiNX_Q86VR2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000141699
PharmGKBiPA162386207

Polymorphism and mutation databases

BioMutaiFAM134C
DMDMi74727607

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002884692 – 466Reticulophagy regulator 3Add BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei10PhosphothreonineCombined sources1
Modified residuei26PhosphoserineCombined sources1
Modified residuei258PhosphoserineCombined sources1
Modified residuei260PhosphoserineCombined sources1
Modified residuei283PhosphothreonineCombined sources1
Modified residuei285PhosphoserineCombined sources1
Modified residuei288PhosphoserineBy similarity1
Modified residuei293PhosphoserineBy similarity1
Modified residuei303PhosphoserineBy similarity1
Modified residuei307PhosphothreonineCombined sources1
Modified residuei310PhosphothreonineCombined sources1
Modified residuei313PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Modified residuei360PhosphoserineCombined sources1
Modified residuei440PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ86VR2
MaxQBiQ86VR2
PaxDbiQ86VR2
PeptideAtlasiQ86VR2
PRIDEiQ86VR2
ProteomicsDBi70060

PTM databases

iPTMnetiQ86VR2
PhosphoSitePlusiQ86VR2
SwissPalmiQ86VR2

Expressioni

Gene expression databases

BgeeiENSG00000141699 Expressed in 239 organ(s), highest expression level in prostate gland
CleanExiHS_FAM134C
ExpressionAtlasiQ86VR2 baseline and differential
GenevisibleiQ86VR2 HS

Organism-specific databases

HPAiHPA016492

Interactioni

Subunit structurei

Interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi127817, 70 interactors
DIPiDIP-61578N
IntActiQ86VR2, 98 interactors
MINTiQ86VR2
STRINGi9606.ENSP00000309432

Structurei

3D structure databases

ProteinModelPortaliQ86VR2
SMRiQ86VR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi445 – 450LIR motif1 Publication6

Domaini

The LIR motif interacts with ATG8 family proteins.1 Publication

Sequence similaritiesi

Belongs to the RETREG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHB8 Eukaryota
ENOG4110GB7 LUCA
GeneTreeiENSGT00530000063240
HOGENOMiHOG000050246
HOVERGENiHBG096339
InParanoidiQ86VR2
OMAiWPLAVYH
OrthoDBiEOG091G08S3
PhylomeDBiQ86VR2
TreeFamiTF329111

Family and domain databases

InterProiView protein in InterPro
IPR033361 RETREG3
PANTHERiPTHR28659:SF1 PTHR28659:SF1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86VR2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEAEGVPTT PGPASGSTFR GRRDVSGSWE RDQQVEAAQR ALVEVLGPYE
60 70 80 90 100
PLLSRVQAAL VWERPARSAL WCLGLNAAFW FFALTSLRLV FLLAFGLMII
110 120 130 140 150
VCIDQWKNKI WPEIKVPRPD ALDNESWGFV HPRLLSVPEL CHHVAEVWVS
160 170 180 190 200
GTIFIRNVLL FKKQNPGKFC LLSCGILTFL AVLGRYVPGL LLSYLMLVTV
210 220 230 240 250
MMWPLAVYHR LWDRAYVRLK PALQRLDFSV RGYMMSKQRE RQLRRRALHP
260 270 280 290 300
ERAMDNHSDS EEELAAFCPQ LDDSTVAREL AITDSEHSDA EVSCTDNGTF
310 320 330 340 350
NLSRGQTPLT EGSEDLDGHS DPEESFARDL PDFPSINMDP AGLDDEDDTS
360 370 380 390 400
IGMPSLMYRS PPGAEEPQAP PASRDEAALP ELLLGALPVG SNLTSNLASL
410 420 430 440 450
VSQGMIQLAL SGASQPGPSG APAQRATRGF LRSPSSDLDT DAEGDDFELL
460
DQSELSQLDP ASSRSH
Length:466
Mass (Da):51,396
Last modified:June 1, 2003 - v1
Checksum:iF9D468353C13A14B
GO
Isoform 2 (identifier: Q86VR2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-195: Missing.

Note: No experimental confirmation available.
Show »
Length:271
Mass (Da):29,582
Checksum:i7361F5A0294F76BC
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQI9K7EQI9_HUMAN
Reticulophagy regulator 3
RETREG3
369Annotation score:
K7EJ34K7EJ34_HUMAN
Reticulophagy regulator 3
RETREG3
129Annotation score:
K7ENF4K7ENF4_HUMAN
Reticulophagy regulator 3
RETREG3
133Annotation score:
K7EPD0K7EPD0_HUMAN
Reticulophagy regulator 3
RETREG3
109Annotation score:
K7EJ42K7EJ42_HUMAN
Reticulophagy regulator 3
RETREG3
120Annotation score:
K7EMF4K7EMF4_HUMAN
Reticulophagy regulator 3
RETREG3
81Annotation score:
K7ENZ6K7ENZ6_HUMAN
Reticulophagy regulator 3
RETREG3
80Annotation score:
K7ELM8K7ELM8_HUMAN
Reticulophagy regulator 3
RETREG3
83Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0569911 – 195Missing in isoform 2. 1 PublicationAdd BLAST195

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091125 mRNA Translation: BAG52287.1
AK294791 mRNA Translation: BAG57914.1
AC067852 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60851.1
BC049370 mRNA Translation: AAH49370.1
CCDSiCCDS11432.1 [Q86VR2-1]
RefSeqiNP_835227.1, NM_178126.3 [Q86VR2-1]
UniGeneiHs.632262

Genome annotation databases

EnsembliENST00000309428; ENSP00000309432; ENSG00000141699 [Q86VR2-1]
GeneIDi162427
KEGGihsa:162427
UCSCiuc060fkv.1 human [Q86VR2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091125 mRNA Translation: BAG52287.1
AK294791 mRNA Translation: BAG57914.1
AC067852 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60851.1
BC049370 mRNA Translation: AAH49370.1
CCDSiCCDS11432.1 [Q86VR2-1]
RefSeqiNP_835227.1, NM_178126.3 [Q86VR2-1]
UniGeneiHs.632262

3D structure databases

ProteinModelPortaliQ86VR2
SMRiQ86VR2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127817, 70 interactors
DIPiDIP-61578N
IntActiQ86VR2, 98 interactors
MINTiQ86VR2
STRINGi9606.ENSP00000309432

PTM databases

iPTMnetiQ86VR2
PhosphoSitePlusiQ86VR2
SwissPalmiQ86VR2

Polymorphism and mutation databases

BioMutaiFAM134C
DMDMi74727607

Proteomic databases

EPDiQ86VR2
MaxQBiQ86VR2
PaxDbiQ86VR2
PeptideAtlasiQ86VR2
PRIDEiQ86VR2
ProteomicsDBi70060

Protocols and materials databases

DNASUi162427
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309428; ENSP00000309432; ENSG00000141699 [Q86VR2-1]
GeneIDi162427
KEGGihsa:162427
UCSCiuc060fkv.1 human [Q86VR2-1]

Organism-specific databases

CTDi162427
EuPathDBiHostDB:ENSG00000141699.10
GeneCardsiRETREG3
H-InvDBiHIX0020377
HGNCiHGNC:27258 RETREG3
HPAiHPA016492
MIMi616498 gene
neXtProtiNX_Q86VR2
OpenTargetsiENSG00000141699
PharmGKBiPA162386207
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHB8 Eukaryota
ENOG4110GB7 LUCA
GeneTreeiENSGT00530000063240
HOGENOMiHOG000050246
HOVERGENiHBG096339
InParanoidiQ86VR2
OMAiWPLAVYH
OrthoDBiEOG091G08S3
PhylomeDBiQ86VR2
TreeFamiTF329111

Miscellaneous databases

ChiTaRSiFAM134C human
GeneWikiiFAM134C
GenomeRNAii162427
PROiPR:Q86VR2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141699 Expressed in 239 organ(s), highest expression level in prostate gland
CleanExiHS_FAM134C
ExpressionAtlasiQ86VR2 baseline and differential
GenevisibleiQ86VR2 HS

Family and domain databases

InterProiView protein in InterPro
IPR033361 RETREG3
PANTHERiPTHR28659:SF1 PTHR28659:SF1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRETR3_HUMAN
AccessioniPrimary (citable) accession number: Q86VR2
Secondary accession number(s): B3KR75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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