UniProtKB - Q86VR2 (RETR3_HUMAN)

BLAST

>sp|Q86VR2|RETR3_HUMAN Reticulophagy regulator 3 OS=Homo sapiens OX=9606 GN=RETREG3 PE=1 SV=1
MAEAEGVPTTPGPASGSTFRGRRDVSGSWERDQQVEAAQRALVEVLGPYEPLLSRVQAAL
VWERPARSALWCLGLNAAFWFFALTSLRLVFLLAFGLMIIVCIDQWKNKIWPEIKVPRPD
ALDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNVLLFKKQNPGKFCLLSCGILTFL
AVLGRYVPGLLLSYLMLVTVMMWPLAVYHRLWDRAYVRLKPALQRLDFSVRGYMMSKQRE
RQLRRRALHPERAMDNHSDSEEELAAFCPQLDDSTVARELAITDSEHSDAEVSCTDNGTF
NLSRGQTPLTEGSEDLDGHSDPEESFARDLPDFPSINMDPAGLDDEDDTSIGMPSLMYRS
PPGAEEPQAPPASRDEAALPELLLGALPVGSNLTSNLASLVSQGMIQLALSGASQPGPSG
APAQRATRGFLRSPSSDLDTDAEGDDFELLDQSELSQLDPASSRSH

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History
Entry version 105 (12 Sep 2018)
Sequence version 1 (01 Jun 2003)
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Protein

Reticulophagy regulator 3

Gene

RETREG3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Mediates NRF1-enhanced neurite outgrowth.1 Publication

GO - Biological processⁱ

positive regulation of neuron projection development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23939472

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Reticulophagy regulator 3
Gene namesⁱ	Name:RETREG3Imported Synonyms:FAM134C
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000141699.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:27258 RETREG3
MIMⁱ	616498 gene
neXtProtⁱ	NX_Q86VR2

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	81 – 101	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	164 – 184	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	187 – 207	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000141699
PharmGKBⁱ	PA162386207

Polymorphism and mutation databases

BioMutaⁱ	FAM134C
DMDMⁱ	74727607

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000288469	2 – 466	Reticulophagy regulator 3Add BLAST		465

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	10	PhosphothreonineCombined sources	1
Modified residueⁱ	26	PhosphoserineCombined sources	1
Modified residueⁱ	258	PhosphoserineCombined sources	1
Modified residueⁱ	260	PhosphoserineCombined sources	1
Modified residueⁱ	283	PhosphothreonineCombined sources	1
Modified residueⁱ	285	PhosphoserineCombined sources	1
Modified residueⁱ	288	PhosphoserineBy similarity	1
Modified residueⁱ	293	PhosphoserineBy similarity	1
Modified residueⁱ	303	PhosphoserineBy similarity	1
Modified residueⁱ	307	PhosphothreonineCombined sources	1
Modified residueⁱ	310	PhosphothreonineCombined sources	1
Modified residueⁱ	313	PhosphoserineCombined sources	1
Modified residueⁱ	320	PhosphoserineCombined sources	1
Modified residueⁱ	360	PhosphoserineCombined sources	1
Modified residueⁱ	440	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q86VR2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q86VR2
PaxDbⁱ	Q86VR2
PeptideAtlas More...PeptideAtlasⁱ	Q86VR2
PRIDEⁱ	Q86VR2
ProteomicsDBⁱ	70060

PTM databases

iPTMnetⁱ	Q86VR2
PhosphoSitePlusⁱ	Q86VR2
SwissPalmⁱ	Q86VR2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000141699 Expressed in 239 organ(s), highest expression level in prostate gland
CleanExⁱ	HS_FAM134C
ExpressionAtlasⁱ	Q86VR2 baseline and differential
Genevisibleⁱ	Q86VR2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA016492

HPAⁱ

HPA016492

Interactionⁱ

Subunit structureⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ABHD16A	O95870	5	EBI-10192441,EBI-348517
ARL6IP1	Q15041	5	EBI-10192441,EBI-714543
GABARAPL1	Q9H0R8	6	EBI-10192441,EBI-746969
MAP1LC3A	Q9H492	5	EBI-10192441,EBI-720768
STAP1	Q9ULZ2	5	EBI-10192441,EBI-6083058

Protein-protein interaction databases

BioGridⁱ	127817, 70 interactors
Database of interacting proteins More...DIPⁱ	DIP-61578N
IntActⁱ	Q86VR2, 98 interactors
Molecular INTeraction database More...MINTⁱ	Q86VR2
STRINGⁱ	9606.ENSP00000309432

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q86VR2
SMRⁱ	Q86VR2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	445 – 450	LIR motif1 Publication		6

Domainⁱ

Sequence similaritiesⁱ

Belongs to the RETREG family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IHB8 Eukaryota ENOG4110GB7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063240
HOGENOMⁱ	HOG000050246
HOVERGENⁱ	HBG096339
InParanoidⁱ	Q86VR2
OMAⁱ	WPLAVYH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08S3
PhylomeDBⁱ	Q86VR2
TreeFamⁱ	TF329111

Family and domain databases

InterProⁱ	View protein in InterPro IPR033361 RETREG3
PANTHERⁱ	PTHR28659:SF1 PTHR28659:SF1, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q86VR2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAEGVPTT PGPASGSTFR GRRDVSGSWE RDQQVEAAQR ALVEVLGPYE 
        60         70         80         90        100
PLLSRVQAAL VWERPARSAL WCLGLNAAFW FFALTSLRLV FLLAFGLMII 
       110        120        130        140        150
VCIDQWKNKI WPEIKVPRPD ALDNESWGFV HPRLLSVPEL CHHVAEVWVS 
       160        170        180        190        200
GTIFIRNVLL FKKQNPGKFC LLSCGILTFL AVLGRYVPGL LLSYLMLVTV 
       210        220        230        240        250
MMWPLAVYHR LWDRAYVRLK PALQRLDFSV RGYMMSKQRE RQLRRRALHP 
       260        270        280        290        300
ERAMDNHSDS EEELAAFCPQ LDDSTVAREL AITDSEHSDA EVSCTDNGTF 
       310        320        330        340        350
NLSRGQTPLT EGSEDLDGHS DPEESFARDL PDFPSINMDP AGLDDEDDTS 
       360        370        380        390        400
IGMPSLMYRS PPGAEEPQAP PASRDEAALP ELLLGALPVG SNLTSNLASL 
       410        420        430        440        450
VSQGMIQLAL SGASQPGPSG APAQRATRGF LRSPSSDLDT DAEGDDFELL 
       460 
DQSELSQLDP ASSRSH

Length:466

Mass (Da):51,396

Last modified:June 1, 2003 - v1

Checksum:ⁱF9D468353C13A14B

Isoform 2 (identifier: Q86VR2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-195: Missing.

« Hide

        10         20         30         40         50
MLVTVMMWPL AVYHRLWDRA YVRLKPALQR LDFSVRGYMM SKQRERQLRR 
        60         70         80         90        100
RALHPERAMD NHSDSEEELA AFCPQLDDST VARELAITDS EHSDAEVSCT 
       110        120        130        140        150
DNGTFNLSRG QTPLTEGSED LDGHSDPEES FARDLPDFPS INMDPAGLDD 
       160        170        180        190        200
EDDTSIGMPS LMYRSPPGAE EPQAPPASRD EAALPELLLG ALPVGSNLTS 
       210        220        230        240        250
NLASLVSQGM IQLALSGASQ PGPSGAPAQR ATRGFLRSPS SDLDTDAEGD 
       260        270 
DFELLDQSEL SQLDPASSRS H

Note: No experimental confirmation available.

Show »

Length:271

Mass (Da):29,582

Checksum:ⁱ7361F5A0294F76BC

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EQI9	K7EQI9_HUMAN	Reticulophagy regulator 3 Reticulophagy regulator 3	RETREG3	369	Annotation score:
K7EJ34	K7EJ34_HUMAN	Reticulophagy regulator 3 Reticulophagy regulator 3	RETREG3	129	Annotation score:
K7ENF4	K7ENF4_HUMAN	Reticulophagy regulator 3 Reticulophagy regulator 3	RETREG3	133	Annotation score:
K7EPD0	K7EPD0_HUMAN	Reticulophagy regulator 3 Reticulophagy regulator 3	RETREG3	109	Annotation score:
K7EJ42	K7EJ42_HUMAN	Reticulophagy regulator 3 Reticulophagy regulator 3	RETREG3	120	Annotation score:
K7EMF4	K7EMF4_HUMAN	Reticulophagy regulator 3 Reticulophagy regulator 3	RETREG3	81	Annotation score:
K7ENZ6	K7ENZ6_HUMAN	Reticulophagy regulator 3 Reticulophagy regulator 3	RETREG3	80	Annotation score:
K7ELM8	K7ELM8_HUMAN	Reticulophagy regulator 3 Reticulophagy regulator 3	RETREG3	83	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056991	1 – 195	Missing in isoform 2. 1 PublicationAdd BLAST		195

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK091125 mRNA Translation: BAG52287.1 AK294791 mRNA Translation: BAG57914.1 AC067852 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60851.1 BC049370 mRNA Translation: AAH49370.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11432.1 [Q86VR2-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_835227.1, NM_178126.3 [Q86VR2-1]
UniGeneⁱ	Hs.632262

Genome annotation databases

Ensemblⁱ	ENST00000309428; ENSP00000309432; ENSG00000141699 [Q86VR2-1]
GeneIDⁱ	162427
KEGGⁱ	hsa:162427
UCSC genome browser More...UCSCⁱ	uc060fkv.1 human [Q86VR2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q86VR2	Uncharacterized protein		PANPA		466	UniRef100_Q86VR2
Reticulophagy regulator 3		HUMAN		80
RETREG3 isoform 8		PANTR		80
Q86VR2-2	Reticulophagy regulator 3		HUMAN		369	UniRef100_K7EQI9
Reticulophagy regulator family member 3		GORGO		466
RETREG3 isoform 3 (Fragment)		PONAB		120
RETREG3 isoform 3 (Fragment)		PANTR		120
Reticulophagy regulator 3 (Fragment)		HUMAN		120
+1

Protein	Similar proteins		Species	Score	Length	Source
Q86VR2	Reticulophagy regulator 3		MOUSE		466	UniRef90_Q86VR2
Uncharacterized protein		PANPA		466
Reticulophagy regulator 3		HUMAN		80
RETREG3 isoform 8		PANTR		80
Reticulophagy regulator family member 3		AILME		471
+140

Protein	Similar proteins		Species	Score	Length	Source
Q86VR2	Reticulophagy regulator 3		MOUSE		466	UniRef50_Q86VR2
Uncharacterized protein		PANPA		466
Reticulophagy regulator 3		HUMAN		80
RETREG3 isoform 8		PANTR		80
Reticulophagy regulator family member 3		AILME		471
+217

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK091125 mRNA Translation: BAG52287.1 AK294791 mRNA Translation: BAG57914.1 AC067852 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60851.1 BC049370 mRNA Translation: AAH49370.1
CCDSⁱ	CCDS11432.1 [Q86VR2-1]
RefSeqⁱ	NP_835227.1, NM_178126.3 [Q86VR2-1]
UniGeneⁱ	Hs.632262

3D structure databases

ProteinModelPortalⁱ	Q86VR2
SMRⁱ	Q86VR2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127817, 70 interactors
DIPⁱ	DIP-61578N
IntActⁱ	Q86VR2, 98 interactors
MINTⁱ	Q86VR2
STRINGⁱ	9606.ENSP00000309432

PTM databases

iPTMnetⁱ	Q86VR2
PhosphoSitePlusⁱ	Q86VR2
SwissPalmⁱ	Q86VR2

Polymorphism and mutation databases

BioMutaⁱ	FAM134C
DMDMⁱ	74727607

Proteomic databases

EPDⁱ	Q86VR2
MaxQBⁱ	Q86VR2
PaxDbⁱ	Q86VR2
PeptideAtlasⁱ	Q86VR2
PRIDEⁱ	Q86VR2
ProteomicsDBⁱ	70060

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	162427
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000309428; ENSP00000309432; ENSG00000141699 [Q86VR2-1]
GeneIDⁱ	162427
KEGGⁱ	hsa:162427
UCSCⁱ	uc060fkv.1 human [Q86VR2-1]

Organism-specific databases

CTDⁱ	162427
EuPathDBⁱ	HostDB:ENSG00000141699.10
GeneCardsⁱ	RETREG3
H-InvDBⁱ	HIX0020377
HGNCⁱ	HGNC:27258 RETREG3
HPAⁱ	HPA016492
MIMⁱ	616498 gene
neXtProtⁱ	NX_Q86VR2
OpenTargetsⁱ	ENSG00000141699
PharmGKBⁱ	PA162386207
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHB8 Eukaryota ENOG4110GB7 LUCA
GeneTreeⁱ	ENSGT00530000063240
HOGENOMⁱ	HOG000050246
HOVERGENⁱ	HBG096339
InParanoidⁱ	Q86VR2
OMAⁱ	WPLAVYH
OrthoDBⁱ	EOG091G08S3
PhylomeDBⁱ	Q86VR2
TreeFamⁱ	TF329111

Miscellaneous databases

ChiTaRSⁱ	FAM134C human
GeneWikiⁱ	FAM134C
GenomeRNAiⁱ	162427
Protein Ontology More...PROⁱ	PR:Q86VR2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000141699 Expressed in 239 organ(s), highest expression level in prostate gland
CleanExⁱ	HS_FAM134C
ExpressionAtlasⁱ	Q86VR2 baseline and differential
Genevisibleⁱ	Q86VR2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR033361 RETREG3
PANTHERⁱ	PTHR28659:SF1 PTHR28659:SF1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RETR3_HUMAN
Accessionⁱ	Q86VR2Primary (citable) accession number: Q86VR2 Secondary accession number(s): B3KR75
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
	Last sequence update:	June 1, 2003
	Last modified:	September 12, 2018
	This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q86VR2 (RETR3_HUMAN)

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Reticulophagy regulator 3

RETREG3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ