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UniProtKB - Q86VR2 (RETR3_HUMAN)
Protein
Reticulophagy regulator 3
Gene
RETREG3
Organism
Homo sapiens (Human)
Status
Functioni
Mediates NRF1-enhanced neurite outgrowth.
1 PublicationGO - Biological processi
- positive regulation of neuron projection development Source: UniProtKB
- reticulophagy Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q86VR2 |
SignaLinki | Q86VR2 |
SIGNORi | Q86VR2 |
Names & Taxonomyi
Protein namesi | Recommended name: Reticulophagy regulator 3 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27258, RETREG3 |
MIMi | 616498, gene |
neXtProti | NX_Q86VR2 |
VEuPathDBi | HostDB:ENSG00000141699 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
- protein-containing complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 81 – 101 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 164 – 184 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 187 – 207 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 162427 |
OpenTargetsi | ENSG00000141699 |
PharmGKBi | PA162386207 |
Miscellaneous databases
Pharosi | Q86VR2, Tdark |
Genetic variation databases
BioMutai | RETREG3 |
DMDMi | 74727607 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000288469 | 2 – 466 | Reticulophagy regulator 3Add BLAST | 465 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 10 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 26 | PhosphoserineCombined sources | 1 | |
Modified residuei | 258 | PhosphoserineCombined sources | 1 | |
Modified residuei | 260 | PhosphoserineCombined sources | 1 | |
Modified residuei | 283 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 285 | PhosphoserineCombined sources | 1 | |
Modified residuei | 288 | PhosphoserineBy similarity | 1 | |
Modified residuei | 293 | PhosphoserineBy similarity | 1 | |
Modified residuei | 303 | PhosphoserineBy similarity | 1 | |
Modified residuei | 307 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 310 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 313 | PhosphoserineCombined sources | 1 | |
Modified residuei | 320 | PhosphoserineCombined sources | 1 | |
Modified residuei | 360 | PhosphoserineCombined sources | 1 | |
Modified residuei | 440 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q86VR2 |
jPOSTi | Q86VR2 |
MassIVEi | Q86VR2 |
MaxQBi | Q86VR2 |
PaxDbi | Q86VR2 |
PeptideAtlasi | Q86VR2 |
PRIDEi | Q86VR2 |
ProteomicsDBi | 3584 70060 [Q86VR2-1] |
PTM databases
iPTMneti | Q86VR2 |
PhosphoSitePlusi | Q86VR2 |
SwissPalmi | Q86VR2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000141699, Expressed in prostate gland and 250 other tissues |
ExpressionAtlasi | Q86VR2, baseline and differential |
Genevisiblei | Q86VR2, HS |
Organism-specific databases
HPAi | ENSG00000141699, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1.
1 PublicationBinary interactionsi
Q86VR2
Protein-protein interaction databases
BioGRIDi | 127817, 231 interactors |
DIPi | DIP-61578N |
IntActi | Q86VR2, 160 interactors |
MINTi | Q86VR2 |
STRINGi | 9606.ENSP00000309432 |
Miscellaneous databases
RNActi | Q86VR2, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q86VR2 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 28 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 284 – 374 | DisorderedSequence analysisAdd BLAST | 91 | |
Regioni | 412 – 466 | DisorderedSequence analysisAdd BLAST | 55 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 445 – 450 | LIR motif1 Publication | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 292 – 310 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 314 – 328 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Domaini
The LIR motif interacts with ATG8 family proteins.1 Publication
Sequence similaritiesi
Belongs to the RETREG family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QPTN, Eukaryota |
GeneTreei | ENSGT00940000161349 |
HOGENOMi | CLU_036265_0_0_1 |
InParanoidi | Q86VR2 |
OMAi | HIAEAWV |
OrthoDBi | 901531at2759 |
PhylomeDBi | Q86VR2 |
TreeFami | TF329111 |
Family and domain databases
InterProi | View protein in InterPro IPR043384, RETREG1/3 IPR033361, RETREG3 |
PANTHERi | PTHR28659, PTHR28659, 1 hit PTHR28659:SF1, PTHR28659:SF1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q86VR2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEAEGVPTT PGPASGSTFR GRRDVSGSWE RDQQVEAAQR ALVEVLGPYE
60 70 80 90 100
PLLSRVQAAL VWERPARSAL WCLGLNAAFW FFALTSLRLV FLLAFGLMII
110 120 130 140 150
VCIDQWKNKI WPEIKVPRPD ALDNESWGFV HPRLLSVPEL CHHVAEVWVS
160 170 180 190 200
GTIFIRNVLL FKKQNPGKFC LLSCGILTFL AVLGRYVPGL LLSYLMLVTV
210 220 230 240 250
MMWPLAVYHR LWDRAYVRLK PALQRLDFSV RGYMMSKQRE RQLRRRALHP
260 270 280 290 300
ERAMDNHSDS EEELAAFCPQ LDDSTVAREL AITDSEHSDA EVSCTDNGTF
310 320 330 340 350
NLSRGQTPLT EGSEDLDGHS DPEESFARDL PDFPSINMDP AGLDDEDDTS
360 370 380 390 400
IGMPSLMYRS PPGAEEPQAP PASRDEAALP ELLLGALPVG SNLTSNLASL
410 420 430 440 450
VSQGMIQLAL SGASQPGPSG APAQRATRGF LRSPSSDLDT DAEGDDFELL
460
DQSELSQLDP ASSRSH
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EQI9 | K7EQI9_HUMAN | Reticulophagy regulator 3 | RETREG3 | 369 | Annotation score: | ||
K7EJ34 | K7EJ34_HUMAN | Reticulophagy regulator 3 | RETREG3 | 129 | Annotation score: | ||
K7ENF4 | K7ENF4_HUMAN | Reticulophagy regulator 3 | RETREG3 | 133 | Annotation score: | ||
K7EPD0 | K7EPD0_HUMAN | Reticulophagy regulator 3 | RETREG3 | 109 | Annotation score: | ||
K7EJ42 | K7EJ42_HUMAN | Reticulophagy regulator 3 | RETREG3 | 120 | Annotation score: | ||
K7ELM8 | K7ELM8_HUMAN | Reticulophagy regulator 3 | RETREG3 | 83 | Annotation score: | ||
K7ENZ6 | K7ENZ6_HUMAN | Reticulophagy regulator 3 | RETREG3 | 80 | Annotation score: | ||
K7EMF4 | K7EMF4_HUMAN | Reticulophagy regulator 3 | RETREG3 | 81 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056991 | 1 – 195 | Missing in isoform 2. 1 PublicationAdd BLAST | 195 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091125 mRNA Translation: BAG52287.1 AK294791 mRNA Translation: BAG57914.1 AC067852 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60851.1 BC049370 mRNA Translation: AAH49370.1 |
CCDSi | CCDS11432.1 [Q86VR2-1] |
RefSeqi | NP_835227.1, NM_178126.3 [Q86VR2-1] |
Genome annotation databases
Ensembli | ENST00000309428.10; ENSP00000309432.4; ENSG00000141699.11 |
GeneIDi | 162427 |
KEGGi | hsa:162427 |
MANE-Selecti | ENST00000309428.10; ENSP00000309432.4; NM_178126.4; NP_835227.1 |
UCSCi | uc060fkv.1, human [Q86VR2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091125 mRNA Translation: BAG52287.1 AK294791 mRNA Translation: BAG57914.1 AC067852 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60851.1 BC049370 mRNA Translation: AAH49370.1 |
CCDSi | CCDS11432.1 [Q86VR2-1] |
RefSeqi | NP_835227.1, NM_178126.3 [Q86VR2-1] |
3D structure databases
AlphaFoldDBi | Q86VR2 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127817, 231 interactors |
DIPi | DIP-61578N |
IntActi | Q86VR2, 160 interactors |
MINTi | Q86VR2 |
STRINGi | 9606.ENSP00000309432 |
PTM databases
iPTMneti | Q86VR2 |
PhosphoSitePlusi | Q86VR2 |
SwissPalmi | Q86VR2 |
Genetic variation databases
BioMutai | RETREG3 |
DMDMi | 74727607 |
Proteomic databases
EPDi | Q86VR2 |
jPOSTi | Q86VR2 |
MassIVEi | Q86VR2 |
MaxQBi | Q86VR2 |
PaxDbi | Q86VR2 |
PeptideAtlasi | Q86VR2 |
PRIDEi | Q86VR2 |
ProteomicsDBi | 3584 70060 [Q86VR2-1] |
Protocols and materials databases
Antibodypediai | 3087, 68 antibodies from 17 providers |
DNASUi | 162427 |
Genome annotation databases
Ensembli | ENST00000309428.10; ENSP00000309432.4; ENSG00000141699.11 |
GeneIDi | 162427 |
KEGGi | hsa:162427 |
MANE-Selecti | ENST00000309428.10; ENSP00000309432.4; NM_178126.4; NP_835227.1 |
UCSCi | uc060fkv.1, human [Q86VR2-1] |
Organism-specific databases
CTDi | 162427 |
DisGeNETi | 162427 |
GeneCardsi | RETREG3 |
HGNCi | HGNC:27258, RETREG3 |
HPAi | ENSG00000141699, Low tissue specificity |
MIMi | 616498, gene |
neXtProti | NX_Q86VR2 |
OpenTargetsi | ENSG00000141699 |
PharmGKBi | PA162386207 |
VEuPathDBi | HostDB:ENSG00000141699 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPTN, Eukaryota |
GeneTreei | ENSGT00940000161349 |
HOGENOMi | CLU_036265_0_0_1 |
InParanoidi | Q86VR2 |
OMAi | HIAEAWV |
OrthoDBi | 901531at2759 |
PhylomeDBi | Q86VR2 |
TreeFami | TF329111 |
Enzyme and pathway databases
PathwayCommonsi | Q86VR2 |
SignaLinki | Q86VR2 |
SIGNORi | Q86VR2 |
Miscellaneous databases
BioGRID-ORCSi | 162427, 21 hits in 1088 CRISPR screens |
ChiTaRSi | FAM134C, human |
GeneWikii | FAM134C |
GenomeRNAii | 162427 |
Pharosi | Q86VR2, Tdark |
PROi | PR:Q86VR2 |
RNActi | Q86VR2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000141699, Expressed in prostate gland and 250 other tissues |
ExpressionAtlasi | Q86VR2, baseline and differential |
Genevisiblei | Q86VR2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR043384, RETREG1/3 IPR033361, RETREG3 |
PANTHERi | PTHR28659, PTHR28659, 1 hit PTHR28659:SF1, PTHR28659:SF1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RETR3_HUMAN | |
Accessioni | Q86VR2Primary (citable) accession number: Q86VR2 Secondary accession number(s): B3KR75 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | June 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families