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Entry version 163 (07 Oct 2020)
Sequence version 4 (30 Nov 2010)
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Protein

Thioredoxin domain-containing protein 2

Gene

TXNDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q86VQ3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thioredoxin domain-containing protein 2
Alternative name(s):
Spermatid-specific thioredoxin-1
Short name:
Sptrx-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TXNDC2
Synonyms:SPTRX, SPTRX1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000168454.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16470, TXNDC2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617790, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86VQ3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84203

Open Targets

More...
OpenTargetsi
ENSG00000168454

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38147

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86VQ3, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TXNDC2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104290

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001201531 – 553Thioredoxin domain-containing protein 2Add BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei362PhosphoserineBy similarity1
Modified residuei392PhosphoserineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi480 ↔ 483Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86VQ3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86VQ3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86VQ3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86VQ3

PeptideAtlas

More...
PeptideAtlasi
Q86VQ3

PRoteomics IDEntifications database

More...
PRIDEi
Q86VQ3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70057 [Q86VQ3-1]
70058 [Q86VQ3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86VQ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86VQ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis-specific. Only expressed during spermiogenesis, prominently in round and elongating spermatids.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168454, Expressed in right testis and 78 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86VQ3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86VQ3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000168454, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123944, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q86VQ3, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000304908

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86VQ3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86VQ3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati113 – 1271Add BLAST15
Repeati128 – 1422Add BLAST15
Repeati143 – 1573Add BLAST15
Repeati158 – 1724Add BLAST15
Repeati173 – 1875Add BLAST15
Repeati188 – 2026Add BLAST15
Repeati203 – 2177Add BLAST15
Repeati218 – 2328Add BLAST15
Repeati233 – 2479Add BLAST15
Repeati248 – 26210Add BLAST15
Repeati263 – 27711Add BLAST15
Repeati278 – 29212Add BLAST15
Repeati293 – 30713Add BLAST15
Repeati308 – 32214Add BLAST15
Repeati323 – 33715Add BLAST15
Repeati338 – 35216Add BLAST15
Repeati353 – 36717Add BLAST15
Repeati368 – 38218Add BLAST15
Repeati383 – 39719Add BLAST15
Repeati398 – 41220Add BLAST15
Repeati413 – 42721Add BLAST15
Repeati428 – 44222Add BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini429 – 553ThioredoxinPROSITE-ProRule annotationAdd BLAST125

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni113 – 44222 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-IAdd BLAST330

Keywords - Domaini

Redox-active center, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0907, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163147

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_045129_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86VQ3

Identification of Orthologs from Complete Genome Data

More...
OMAi
KTIPPKQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86VQ3

TreeFam database of animal gene trees

More...
TreeFami
TF106377

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036249, Thioredoxin-like_sf
IPR013766, Thioredoxin_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00085, Thioredoxin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52833, SSF52833, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51352, THIOREDOXIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86VQ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVDKELGME SVKAGASGKP EMRLGTQEET SEGDANESSL LVLSSNVPLL
60 70 80 90 100
ALEFLEIAQA KEKAFLPMVS HTFHMRTEES DASQEGDDLP KSSANTSHPK
110 120 130 140 150
QDDSPKSSEE TIQPKEGDIP KAPEETIQSK KEDLPKSSEK AIQPKESNIP
160 170 180 190 200
KSSAKPIQPK LGNIPKASVK PSQPKEGDIP KAPEETIQSK KEDLPKSSEE
210 220 230 240 250
AIQPKEGDIP KSSAKPIQPK LGNIAKTSVK PSQPKESDIP KSPEETIQPK
260 270 280 290 300
EGDIPKSSAK PIQPKLGNIP KASVKPSQPK EGDISKSPEE AIQPKEGDLP
310 320 330 340 350
KSLEEAIQPK EGDIPKSPEE AIQPKEGDIP KSLEEAIQPK EGDIPKSPEE
360 370 380 390 400
TIQPKKGDIP KSPEEAIQPK EGDIPKSPKQ AIQPKEGDIP KSLEEAIPPK
410 420 430 440 450
EIDIPKSPEE TIQPKEDDSP KSLEEATPSK EGDILKPEEE TMEFPEGDKV
460 470 480 490 500
KVILSKEDFE ASLKEAGERL VAVDFSATWC GPCRTIRPFF HALSVKHEDV
510 520 530 540 550
VFLEVDADNC EEVVRECAIM CVPTFQFYKK EEKVDELCGA LKEKLEAVIA

ELK
Length:553
Mass (Da):60,404
Last modified:November 30, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74EE3210BA5EBCF1
GO
Isoform 2 (identifier: Q86VQ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.

Show »
Length:486
Mass (Da):53,271
Checksum:iC9C7056E2E8D4BAF
GO
Isoform 3 (identifier: Q86VQ3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-318: Missing.

Show »
Length:538
Mass (Da):58,784
Checksum:i2A675984F81D0834
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H6S7F5H6S7_HUMAN
Thioredoxin domain-containing prote...
TXNDC2
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QSG5J3QSG5_HUMAN
Thioredoxin domain-containing prote...
TXNDC2
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057351225A → P. Corresponds to variant dbSNP:rs11662946Ensembl.1
Natural variantiVAR_057352314I → L. Corresponds to variant dbSNP:rs2240909Ensembl.1
Natural variantiVAR_022762341E → K3 PublicationsCorresponds to variant dbSNP:rs11081510Ensembl.1
Natural variantiVAR_022763357G → D2 PublicationsCorresponds to variant dbSNP:rs2240906Ensembl.1
Natural variantiVAR_022764461A → T1 PublicationCorresponds to variant dbSNP:rs17732496Ensembl.1
Natural variantiVAR_022765487R → T1 PublicationCorresponds to variant dbSNP:rs17805544Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0143281 – 67Missing in isoform 2. 2 PublicationsAdd BLAST67
Alternative sequenceiVSP_053684304 – 318Missing in isoform 3. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF080095 mRNA Translation: AAK94950.1
EF560747 mRNA Translation: ABQ59057.1
AK097656 mRNA Translation: BAC05133.1
AC006238 Genomic DNA No translation available.
BC050132 mRNA Translation: AAH50132.1
AL136742 mRNA Translation: CAB66676.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11846.1 [Q86VQ3-2]
CCDS42414.1 [Q86VQ3-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001091999.1, NM_001098529.1 [Q86VQ3-1]
NP_115619.4, NM_032243.5 [Q86VQ3-2]
XP_016881530.1, XM_017026041.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000306084; ENSP00000304908; ENSG00000168454 [Q86VQ3-1]
ENST00000357775; ENSP00000350419; ENSG00000168454 [Q86VQ3-2]
ENST00000611534; ENSP00000483261; ENSG00000168454 [Q86VQ3-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84203

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84203

UCSC genome browser

More...
UCSCi
uc002koh.5, human [Q86VQ3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080095 mRNA Translation: AAK94950.1
EF560747 mRNA Translation: ABQ59057.1
AK097656 mRNA Translation: BAC05133.1
AC006238 Genomic DNA No translation available.
BC050132 mRNA Translation: AAH50132.1
AL136742 mRNA Translation: CAB66676.2
CCDSiCCDS11846.1 [Q86VQ3-2]
CCDS42414.1 [Q86VQ3-1]
RefSeqiNP_001091999.1, NM_001098529.1 [Q86VQ3-1]
NP_115619.4, NM_032243.5 [Q86VQ3-2]
XP_016881530.1, XM_017026041.1

3D structure databases

SMRiQ86VQ3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123944, 3 interactors
IntActiQ86VQ3, 2 interactors
STRINGi9606.ENSP00000304908

PTM databases

iPTMnetiQ86VQ3
PhosphoSitePlusiQ86VQ3

Polymorphism and mutation databases

BioMutaiTXNDC2
DMDMi313104290

Proteomic databases

jPOSTiQ86VQ3
MassIVEiQ86VQ3
MaxQBiQ86VQ3
PaxDbiQ86VQ3
PeptideAtlasiQ86VQ3
PRIDEiQ86VQ3
ProteomicsDBi70057 [Q86VQ3-1]
70058 [Q86VQ3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
6577, 27 antibodies

The DNASU plasmid repository

More...
DNASUi
84203

Genome annotation databases

EnsembliENST00000306084; ENSP00000304908; ENSG00000168454 [Q86VQ3-1]
ENST00000357775; ENSP00000350419; ENSG00000168454 [Q86VQ3-2]
ENST00000611534; ENSP00000483261; ENSG00000168454 [Q86VQ3-3]
GeneIDi84203
KEGGihsa:84203
UCSCiuc002koh.5, human [Q86VQ3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84203
DisGeNETi84203
EuPathDBiHostDB:ENSG00000168454.11

GeneCards: human genes, protein and diseases

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GeneCardsi
TXNDC2
HGNCiHGNC:16470, TXNDC2
HPAiENSG00000168454, Tissue enriched (testis)
MIMi617790, gene
neXtProtiNX_Q86VQ3
OpenTargetsiENSG00000168454
PharmGKBiPA38147

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0907, Eukaryota
GeneTreeiENSGT00940000163147
HOGENOMiCLU_045129_0_0_1
InParanoidiQ86VQ3
OMAiKTIPPKQ
PhylomeDBiQ86VQ3
TreeFamiTF106377

Enzyme and pathway databases

PathwayCommonsiQ86VQ3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84203, 3 hits in 874 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TXNDC2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84203
PharosiQ86VQ3, Tbio

Protein Ontology

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PROi
PR:Q86VQ3
RNActiQ86VQ3, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000168454, Expressed in right testis and 78 other tissues
ExpressionAtlasiQ86VQ3, baseline and differential
GenevisibleiQ86VQ3, HS

Family and domain databases

Gene3Di3.40.30.10, 1 hit
InterProiView protein in InterPro
IPR036249, Thioredoxin-like_sf
IPR013766, Thioredoxin_domain
PfamiView protein in Pfam
PF00085, Thioredoxin, 1 hit
SUPFAMiSSF52833, SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51352, THIOREDOXIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTXND2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86VQ3
Secondary accession number(s): A5YM73
, Q8N7U4, Q96RX3, Q9H0L8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 30, 2010
Last modified: October 7, 2020
This is version 163 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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