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Entry version 114 (08 May 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Glucocorticoid-induced transcript 1 protein

Gene

GLCCI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glucocorticoid-induced transcript 1 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GLCCI1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18713 GLCCI1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614283 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86VQ1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
113263

MalaCards human disease database

More...
MalaCardsi
GLCCI1
MIMi614400 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000106415

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38657

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GLCCI1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74727602

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002561281 – 547Glucocorticoid-induced transcript 1 proteinAdd BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei20PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1
Modified residuei107PhosphoserineBy similarity1
Modified residuei108PhosphoserineCombined sources1
Modified residuei110PhosphothreonineBy similarity1
Modified residuei171PhosphoserineCombined sources1
Modified residuei172PhosphoserineCombined sources1
Modified residuei175PhosphothreonineCombined sources1
Modified residuei177PhosphothreonineCombined sources1
Modified residuei223PhosphoserineCombined sources1
Modified residuei258PhosphoserineCombined sources1
Modified residuei266PhosphothreonineCombined sources1
Modified residuei303PhosphoserineCombined sources1
Modified residuei343PhosphothreonineCombined sources1
Modified residuei345PhosphoserineCombined sources1
Modified residuei350PhosphothreonineBy similarity1
Modified residuei394PhosphoserineBy similarity1
Modified residuei398PhosphoserineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei412PhosphoserineBy similarity1
Modified residuei480PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86VQ1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86VQ1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86VQ1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86VQ1

PeptideAtlas

More...
PeptideAtlasi
Q86VQ1

PRoteomics IDEntifications database

More...
PRIDEi
Q86VQ1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70055

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86VQ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86VQ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in lung, spleen, thymus and testis and, at lower levels, in brain, bone marrow, peripheral leukocytes, skin and trachea.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000106415 Expressed in 200 organ(s), highest expression level in thymus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86VQ1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86VQ1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA001674
HPA005987

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125239, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q86VQ1, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000223145

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili225 – 254Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5 – 13Poly-Ser9
Compositional biasi38 – 50Poly-GlyAdd BLAST13
Compositional biasi86 – 90Poly-Ala5
Compositional biasi113 – 118Poly-Ala6
Compositional biasi525 – 528Poly-Gln4

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEAU Eukaryota
ENOG4111PY2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183046

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000252927

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86VQ1

Identification of Orthologs from Complete Genome Data

More...
OMAi
SPCISPF

Database of Orthologous Groups

More...
OrthoDBi
1132072at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86VQ1

TreeFam database of animal gene trees

More...
TreeFami
TF333159

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026639 Glcci1
IPR026642 Glcci1/FAM117

The PANTHER Classification System

More...
PANTHERi
PTHR14972 PTHR14972, 1 hit
PTHR14972:SF3 PTHR14972:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15388 FAM117, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q86VQ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTASSSSSS SSSQTPHPPS QRMRRSAAGS PPAVAAAGSG NGAGGGGGVG
60 70 80 90 100
CAPAAGAGRL LQPIRATVPY QLLRGSQHSP TRPPVAAAAA SLGSLPGPGA
110 120 130 140 150
ARGPSPSSPT PPAAAAPAEQ APRAKGRPRR SPESHRRSSS PERRSPGSPV
160 170 180 190 200
CRADKAKSQQ VRTSSTIRRT SSLDTITGPY LTGQWPRDPH VHYPSCMKDK
210 220 230 240 250
ATQTPSCWAE EGAEKRSHQR SASWGSADQL KEQIAKLRQQ LQRSKQSSRH
260 270 280 290 300
SKEKDRQSPL HGNHITISHT QATGSRSVPM PLSNISVPKS SVSRVPCNVE
310 320 330 340 350
GISPELEKVF IKENNGKEEV SKPLDIPDGR RAPLPAHYRS SSTRSIDTQT
360 370 380 390 400
PSVQERSSSC SSHSPCVSPF CPPESQDGSP CSTEDLLYDR DKDSGSSSPL
410 420 430 440 450
PKYASSPKPN NSYMFKREPP EGCERVKVFE EMASRQPISA PLFSCPDKNK
460 470 480 490 500
VNFIPTGSAF CPVKLLGPLL PASDLMLKNS PNSGQSSALA TLTVEQLSSR
510 520 530 540
VSFTSLSDDT STAGSMEASV QQPSQQQQLL QELQGEDHIS AQNYVII
Length:547
Mass (Da):58,024
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51B6AF7788E8800D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C0B2H7C0B2_HUMAN
Glucocorticoid-induced transcript 1...
GLCCI1
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0Q2H7C0Q2_HUMAN
Glucocorticoid-induced transcript 1...
GLCCI1
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2L5H7C2L5_HUMAN
Glucocorticoid-induced transcript 1...
GLCCI1
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Polymorphisms dbSNP:rs37972 and dbSNP:rs37973, located in GLCCI1 promoter region, are associated with a decreased response to glucorticoid treatment [MIMi:614400] in asthma patients (PubMed:21991891), as well as in chronic obstructive pulmonary disease patients (PubMed:22187997). The mean increase in forced expiratory volume in 1 second in glucorticoid treated subjects who are homozygous for the mutant (G) rs37973 allele is only about one-third of that seen in similarly treated subjects who are homozygous for the wild-type allele (A) (PubMed:21991891). These polymorphisms affect GLCCI1 transcription level.2 Publications

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH236948 Genomic DNA Translation: EAL24302.1
CH471073 Genomic DNA Translation: EAW93607.1
BC011254 mRNA Translation: AAH11254.1
BC050291 mRNA Translation: AAH50291.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34601.1

NCBI Reference Sequences

More...
RefSeqi
NP_612435.1, NM_138426.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000223145; ENSP00000223145; ENSG00000106415

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
113263

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:113263

UCSC genome browser

More...
UCSCi
uc003srk.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236948 Genomic DNA Translation: EAL24302.1
CH471073 Genomic DNA Translation: EAW93607.1
BC011254 mRNA Translation: AAH11254.1
BC050291 mRNA Translation: AAH50291.1
CCDSiCCDS34601.1
RefSeqiNP_612435.1, NM_138426.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi125239, 10 interactors
IntActiQ86VQ1, 6 interactors
STRINGi9606.ENSP00000223145

PTM databases

iPTMnetiQ86VQ1
PhosphoSitePlusiQ86VQ1

Polymorphism and mutation databases

BioMutaiGLCCI1
DMDMi74727602

Proteomic databases

EPDiQ86VQ1
jPOSTiQ86VQ1
MaxQBiQ86VQ1
PaxDbiQ86VQ1
PeptideAtlasiQ86VQ1
PRIDEiQ86VQ1
ProteomicsDBi70055

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223145; ENSP00000223145; ENSG00000106415
GeneIDi113263
KEGGihsa:113263
UCSCiuc003srk.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
113263
DisGeNETi113263

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GLCCI1
HGNCiHGNC:18713 GLCCI1
HPAiHPA001674
HPA005987
MalaCardsiGLCCI1
MIMi614283 gene
614400 phenotype
neXtProtiNX_Q86VQ1
OpenTargetsiENSG00000106415
PharmGKBiPA38657

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEAU Eukaryota
ENOG4111PY2 LUCA
GeneTreeiENSGT00950000183046
HOGENOMiHOG000252927
InParanoidiQ86VQ1
OMAiSPCISPF
OrthoDBi1132072at2759
PhylomeDBiQ86VQ1
TreeFamiTF333159

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GLCCI1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GLCCI1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
113263

Protein Ontology

More...
PROi
PR:Q86VQ1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000106415 Expressed in 200 organ(s), highest expression level in thymus
ExpressionAtlasiQ86VQ1 baseline and differential
GenevisibleiQ86VQ1 HS

Family and domain databases

InterProiView protein in InterPro
IPR026639 Glcci1
IPR026642 Glcci1/FAM117
PANTHERiPTHR14972 PTHR14972, 1 hit
PTHR14972:SF3 PTHR14972:SF3, 1 hit
PfamiView protein in Pfam
PF15388 FAM117, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLCI1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86VQ1
Secondary accession number(s): A4D103, Q96FD0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2003
Last modified: May 8, 2019
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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