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Entry version 162 (13 Feb 2019)
Sequence version 2 (07 Jun 2005)
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Protein

Cullin-associated NEDD8-dissociated protein 1

Gene

CAND1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.6 Publications

Miscellaneous

A model has been proposed to explain the mechanisms of cullin-RING E3 ubiquitin ligase complexes assembly. According to this hypothesis, cullin-RING E3 ubiquitin ligase complexes exist in a 'stable' active state when saturated with substrate, occluding access to deneddylation by the COP9 signalosome (CSN) complex. The neddylation-conjugated cullin-RING E3 ubiquitin ligase complexes mediate ubiquitination of substrates and can recruit downstream factors involved in substrate degradation. Depletion of the substrate promotes the ability of CSN to bind the cullin-RING E3 ubiquitin ligase complex and mediate deneddylation. In this 'intermediate' deneddylated state, the complex can bind CAND1 and enter the 'exchange' state, resulting in high increase in dissociation rate of the substrate-recognition subunit. The resulting CAND1-cullin-RING complex rapidly assembles with another available substrate-recognition subunit to form an unstable ternary intermediate and yield a new cullin-RING E3 ubiquitin ligase complex. Subsequent neddylation of the cullin, which is stabilized by substrate, completes the cycle (PubMed:23453757).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation
R-HSA-8951664 Neddylation
R-HSA-917937 Iron uptake and transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cullin-associated NEDD8-dissociated protein 1
Alternative name(s):
Cullin-associated and neddylation-dissociated protein 1
TBP-interacting protein of 120 kDa A
Short name:
TBP-interacting protein 120A
p120 CAND1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAND1
Synonyms:KIAA0829, TIP120, TIP120A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000111530.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30688 CAND1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607727 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86VP6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55832

Open Targets

More...
OpenTargetsi
ENSG00000111530

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672207

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CAND1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
67460541

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000892932 – 1230Cullin-associated NEDD8-dissociated protein 1Add BLAST1229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources2 Publications1
Modified residuei55N6-acetyllysineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei558PhosphoserineCombined sources1
Modified residuei971N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86VP6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q86VP6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86VP6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q86VP6

PeptideAtlas

More...
PeptideAtlasi
Q86VP6

PRoteomics IDEntifications database

More...
PRIDEi
Q86VP6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70051
70052 [Q86VP6-2]
70053 [Q86VP6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86VP6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q86VP6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q86VP6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Repressed by miR-148a.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111530 Expressed in 231 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q86VP6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86VP6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA055748
HPA062833
HPA069053

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TBP (By similarity). Part of a complex that contains CUL1 and RBX1. Interacts with unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5. Does not bind neddylated CUL1. Interaction with cullins is abolished in presence of COMMD1, which antagonizes with CAND1 for interacting with cullins. Interacts with DCUN1D3.By similarity9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120937, 728 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q86VP6

Database of interacting proteins

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DIPi
DIP-31608N

Protein interaction database and analysis system

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IntActi
Q86VP6, 35 interactors

Molecular INTeraction database

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MINTi
Q86VP6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299218

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11230
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U6GX-ray3.10C1-1230[»]
4A0CX-ray3.80A/B1-1230[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q86VP6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86VP6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q86VP6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati2 – 39HEAT 1Add BLAST38
Repeati44 – 81HEAT 2Add BLAST38
Repeati83 – 119HEAT 3Add BLAST37
Repeati131 – 165HEAT 4Add BLAST35
Repeati171 – 208HEAT 5Add BLAST38
Repeati210 – 247HEAT 6Add BLAST38
Repeati248 – 282HEAT 7Add BLAST35
Repeati289 – 366HEAT 8Add BLAST78
Repeati370 – 407HEAT 9Add BLAST38
Repeati424 – 467HEAT 10Add BLAST44
Repeati471 – 510HEAT 11Add BLAST40
Repeati515 – 552HEAT 12Add BLAST38
Repeati563 – 602HEAT 13Add BLAST40
Repeati606 – 643HEAT 14Add BLAST38
Repeati646 – 683HEAT 15Add BLAST38
Repeati688 – 725HEAT 16Add BLAST38
Repeati729 – 768HEAT 17Add BLAST40
Repeati770 – 808HEAT 18Add BLAST39
Repeati809 – 845HEAT 19Add BLAST37
Repeati852 – 889HEAT 20Add BLAST38
Repeati890 – 927HEAT 21Add BLAST38
Repeati928 – 960HEAT 22Add BLAST33
Repeati961 – 998HEAT 23Add BLAST38
Repeati1002 – 1039HEAT 24Add BLAST38
Repeati1043 – 1097HEAT 25Add BLAST55
Repeati1099 – 1133HEAT 26Add BLAST35
Repeati1140 – 1189HEAT 27Add BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi314 – 344Asp-richAdd BLAST31

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAND family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1824 Eukaryota
ENOG410XPK4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017740

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053467

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86VP6

KEGG Orthology (KO)

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KOi
K17263

Identification of Orthologs from Complete Genome Data

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OMAi
MASHQYH

Database of Orthologous Groups

More...
OrthoDBi
194023at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86VP6

TreeFam database of animal gene trees

More...
TreeFami
TF300355

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039852 CAND1/CAND2
IPR013932 TATA-bd_TIP120

The PANTHER Classification System

More...
PANTHERi
PTHR12696 PTHR12696, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08623 TIP120, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86VP6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASASYHISN LLEKMTSSDK DFRFMATNDL MTELQKDSIK LDDDSERKVV
60 70 80 90 100
KMILKLLEDK NGEVQNLAVK CLGPLVSKVK EYQVETIVDT LCTNMLSDKE
110 120 130 140 150
QLRDISSIGL KTVIGELPPA SSGSALAANV CKKITGRLTS AIAKQEDVSV
160 170 180 190 200
QLEALDIMAD MLSRQGGLLV NFHPSILTCL LPQLTSPRLA VRKRTIIALG
210 220 230 240 250
HLVMSCGNIV FVDLIEHLLS ELSKNDSMST TRTYIQCIAA ISRQAGHRIG
260 270 280 290 300
EYLEKIIPLV VKFCNVDDDE LREYCIQAFE SFVRRCPKEV YPHVSTIINI
310 320 330 340 350
CLKYLTYDPN YNYDDEDEDE NAMDADGGDD DDQGSDDEYS DDDDMSWKVR
360 370 380 390 400
RAAAKCLDAV VSTRHEMLPE FYKTVSPALI SRFKEREENV KADVFHAYLS
410 420 430 440 450
LLKQTRPVQS WLCDPDAMEQ GETPLTMLQS QVPNIVKALH KQMKEKSVKT
460 470 480 490 500
RQCCFNMLTE LVNVLPGALT QHIPVLVPGI IFSLNDKSSS SNLKIDALSC
510 520 530 540 550
LYVILCNHSP QVFHPHVQAL VPPVVACVGD PFYKITSEAL LVTQQLVKVI
560 570 580 590 600
RPLDQPSSFD ATPYIKDLFT CTIKRLKAAD IDQEVKERAI SCMGQIICNL
610 620 630 640 650
GDNLGSDLPN TLQIFLERLK NEITRLTTVK ALTLIAGSPL KIDLRPVLGE
660 670 680 690 700
GVPILASFLR KNQRALKLGT LSALDILIKN YSDSLTAAMI DAVLDELPPL
710 720 730 740 750
ISESDMHVSQ MAISFLTTLA KVYPSSLSKI SGSILNELIG LVRSPLLQGG
760 770 780 790 800
ALSAMLDFFQ ALVVTGTNNL GYMDLLRMLT GPVYSQSTAL THKQSYYSIA
810 820 830 840 850
KCVAALTRAC PKEGPAVVGQ FIQDVKNSRS TDSIRLLALL SLGEVGHHID
860 870 880 890 900
LSGQLELKSV ILEAFSSPSE EVKSAASYAL GSISVGNLPE YLPFVLQEIT
910 920 930 940 950
SQPKRQYLLL HSLKEIISSA SVVGLKPYVE NIWALLLKHC ECAEEGTRNV
960 970 980 990 1000
VAECLGKLTL IDPETLLPRL KGYLISGSSY ARSSVVTAVK FTISDHPQPI
1010 1020 1030 1040 1050
DPLLKNCIGD FLKTLEDPDL NVRRVALVTF NSAAHNKPSL IRDLLDTVLP
1060 1070 1080 1090 1100
HLYNETKVRK ELIREVEMGP FKHTVDDGLD IRKAAFECMY TLLDSCLDRL
1110 1120 1130 1140 1150
DIFEFLNHVE DGLKDHYDIK MLTFLMLVRL STLCPSAVLQ RLDRLVEPLR
1160 1170 1180 1190 1200
ATCTTKVKAN SVKQEFEKQD ELKRSAMRAV AALLTIPEAE KSPLMSEFQS
1210 1220 1230
QISSNPELAA IFESIQKDSS STNLESMDTS
Length:1,230
Mass (Da):136,376
Last modified:June 7, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE344558F72D79D8
GO
Isoform 2 (identifier: Q86VP6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-625: Missing.

Note: No experimental confirmation available.
Show »
Length:1,062
Mass (Da):117,889
Checksum:i2045EBFCEE84468B
GO
Isoform 3 (identifier: Q86VP6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.
     549-560: VIRPLDQPSSFD → AHHMPEAQWLRL
     561-1230: Missing.

Note: No experimental confirmation available.
Show »
Length:403
Mass (Da):45,539
Checksum:i4EC2B75A93D82663
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGH5A0A0C4DGH5_HUMAN
Cullin-associated NEDD8-dissociated...
CAND1
770Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H6I6F5H6I6_HUMAN
Cullin-associated NEDD8-dissociated...
CAND1
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YH27H0YH27_HUMAN
Cullin-associated NEDD8-dissociated...
CAND1
442Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA74852 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB55090 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti272R → K in BAB55365 (PubMed:14702039).Curated1
Sequence conflicti457M → I in BAB55090 (PubMed:14702039).Curated1
Sequence conflicti606S → P in AAF67492 (PubMed:10931946).Curated1
Sequence conflicti609P → S in AAF67492 (PubMed:10931946).Curated1
Sequence conflicti1047T → S in AAF67492 (PubMed:10931946).Curated1
Sequence conflicti1177M → T in BAB55090 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054041803V → A. Corresponds to variant dbSNP:rs12580996Ensembl.1
Natural variantiVAR_025327952A → V1 PublicationCorresponds to variant dbSNP:rs17854618Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0139471 – 157Missing in isoform 3. 1 PublicationAdd BLAST157
Alternative sequenceiVSP_013948458 – 625Missing in isoform 2. 1 PublicationAdd BLAST168
Alternative sequenceiVSP_013949549 – 560VIRPL…PSSFD → AHHMPEAQWLRL in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_013950561 – 1230Missing in isoform 3. 1 PublicationAdd BLAST670

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB020636 mRNA Translation: BAA74852.2 Different initiation.
AF157326 mRNA Translation: AAF67492.1
AL133560 mRNA Translation: CAB63714.1
AL136810 mRNA Translation: CAB66744.1
AL833880 mRNA Translation: CAD38737.1
CH471054 Genomic DNA Translation: EAW97172.1
BC004232 mRNA Translation: AAH04232.1
BC026220 mRNA Translation: AAH26220.1
BC050341 mRNA Translation: AAH50341.1
AK027404 mRNA Translation: BAB55090.1 Different initiation.
AK027783 mRNA Translation: BAB55365.1
AK314358 mRNA Translation: BAG36990.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS8977.1 [Q86VP6-1]

Protein sequence database of the Protein Information Resource

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PIRi
T43441

NCBI Reference Sequences

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RefSeqi
NP_060918.2, NM_018448.4 [Q86VP6-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.546407

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000545606; ENSP00000442318; ENSG00000111530 [Q86VP6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55832

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55832

UCSC genome browser

More...
UCSCi
uc001stn.3 human [Q86VP6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020636 mRNA Translation: BAA74852.2 Different initiation.
AF157326 mRNA Translation: AAF67492.1
AL133560 mRNA Translation: CAB63714.1
AL136810 mRNA Translation: CAB66744.1
AL833880 mRNA Translation: CAD38737.1
CH471054 Genomic DNA Translation: EAW97172.1
BC004232 mRNA Translation: AAH04232.1
BC026220 mRNA Translation: AAH26220.1
BC050341 mRNA Translation: AAH50341.1
AK027404 mRNA Translation: BAB55090.1 Different initiation.
AK027783 mRNA Translation: BAB55365.1
AK314358 mRNA Translation: BAG36990.1
CCDSiCCDS8977.1 [Q86VP6-1]
PIRiT43441
RefSeqiNP_060918.2, NM_018448.4 [Q86VP6-1]
UniGeneiHs.546407

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U6GX-ray3.10C1-1230[»]
4A0CX-ray3.80A/B1-1230[»]
ProteinModelPortaliQ86VP6
SMRiQ86VP6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120937, 728 interactors
CORUMiQ86VP6
DIPiDIP-31608N
IntActiQ86VP6, 35 interactors
MINTiQ86VP6
STRINGi9606.ENSP00000299218

PTM databases

iPTMnetiQ86VP6
PhosphoSitePlusiQ86VP6
SwissPalmiQ86VP6

Polymorphism and mutation databases

BioMutaiCAND1
DMDMi67460541

Proteomic databases

EPDiQ86VP6
jPOSTiQ86VP6
MaxQBiQ86VP6
PaxDbiQ86VP6
PeptideAtlasiQ86VP6
PRIDEiQ86VP6
ProteomicsDBi70051
70052 [Q86VP6-2]
70053 [Q86VP6-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55832
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000545606; ENSP00000442318; ENSG00000111530 [Q86VP6-1]
GeneIDi55832
KEGGihsa:55832
UCSCiuc001stn.3 human [Q86VP6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55832
DisGeNETi55832
EuPathDBiHostDB:ENSG00000111530.12

GeneCards: human genes, protein and diseases

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GeneCardsi
CAND1
HGNCiHGNC:30688 CAND1
HPAiHPA055748
HPA062833
HPA069053
MIMi607727 gene
neXtProtiNX_Q86VP6
OpenTargetsiENSG00000111530
PharmGKBiPA142672207

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1824 Eukaryota
ENOG410XPK4 LUCA
GeneTreeiENSGT00390000017740
HOVERGENiHBG053467
InParanoidiQ86VP6
KOiK17263
OMAiMASHQYH
OrthoDBi194023at2759
PhylomeDBiQ86VP6
TreeFamiTF300355

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-8951664 Neddylation
R-HSA-917937 Iron uptake and transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CAND1 human
EvolutionaryTraceiQ86VP6

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CAND1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55832

Protein Ontology

More...
PROi
PR:Q86VP6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111530 Expressed in 231 organ(s), highest expression level in kidney
ExpressionAtlasiQ86VP6 baseline and differential
GenevisibleiQ86VP6 HS

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039852 CAND1/CAND2
IPR013932 TATA-bd_TIP120
PANTHERiPTHR12696 PTHR12696, 1 hit
PfamiView protein in Pfam
PF08623 TIP120, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAND1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86VP6
Secondary accession number(s): B2RAU3
, O94918, Q6PIY4, Q8NDJ4, Q96JZ9, Q96T19, Q9BTC4, Q9H0G2, Q9P0H7, Q9UF85
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: February 13, 2019
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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