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Entry version 144 (13 Nov 2019)
Sequence version 2 (16 May 2006)
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Protein

Tax1-binding protein 1

Gene

TAX1BP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri727 – 753UBZ1-type 1PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri754 – 780UBZ1-type 2PROSITE-ProRule annotationAdd BLAST27

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q86VP1

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
Q86VP1 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tax1-binding protein 1
Alternative name(s):
TRAF6-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAX1BP1
Synonyms:T6BP
ORF Names:PRO0105
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11575 TAX1BP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605326 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86VP1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi771Q → A: Normal affinity for ubiquitin. 1 Publication1
Mutagenesisi774E → A: Reduced affinity for ubiquitin. 1 Publication1
Mutagenesisi775R → A: Normal affinity for ubiquitin. 1 Publication1
Mutagenesisi777V → S: Reduced affinity for ubiquitin. 1 Publication1
Mutagenesisi778Q → A: Reduced affinity for ubiquitin. 1 Publication1
Mutagenesisi781F → A: Reduced affinity for ubiquitin. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
8887

Open Targets

More...
OpenTargetsi
ENSG00000106052

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36339

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86VP1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TAX1BP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
97202549

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002345541 – 789Tax1-binding protein 1Add BLAST789

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei124PhosphoserineBy similarity1
Modified residuei138PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei593Phosphoserine; by IKKA1 Publication1
Modified residuei609PhosphoserineBy similarity1
Modified residuei666Phosphoserine; by IKKACombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86VP1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86VP1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q86VP1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86VP1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86VP1

PeptideAtlas

More...
PeptideAtlasi
Q86VP1

PRoteomics IDEntifications database

More...
PRIDEi
Q86VP1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
17229
70045 [Q86VP1-1]
70046 [Q86VP1-2]
70047 [Q86VP1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86VP1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86VP1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues tested.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000106052 Expressed in 242 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86VP1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86VP1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024432

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer.

Interacts with TRAF6 in a IL-1-dependent manner.

Interacts with TNFAIP3.

Interacts with STARD13.

Interacts with the HTLV-1 protein Tax-1.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114405, 87 interactors

Database of interacting proteins

More...
DIPi
DIP-33010N

Protein interaction database and analysis system

More...
IntActi
Q86VP1, 113 interactors

Molecular INTeraction database

More...
MINTi
Q86VP1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379612

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1789
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86VP1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni320 – 420OligomerizationAdd BLAST101

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili144 – 599Sequence analysisAdd BLAST456

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal UBZ-type zinc fingers function as ubiquitin-binding domains.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri727 – 753UBZ1-type 1PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri754 – 780UBZ1-type 2PROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGMS Eukaryota
ENOG410XQDF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183025

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000271638

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86VP1

KEGG Orthology (KO)

More...
KOi
K21347

Database of Orthologous Groups

More...
OrthoDBi
179838at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86VP1

TreeFam database of animal gene trees

More...
TreeFami
TF329501

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012852 CALCOCO1-like
IPR041641 CALCOCO1/2_Zn-C2H2
IPR041611 SKICH

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07888 CALCOCO1, 1 hit
PF17751 SKICH, 1 hit
PF18112 Zn-C2H2_12, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51905 ZF_UBZ1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86VP1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV
60 70 80 90 100
GIFKVGWSTA RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY
110 120 130 140 150
QFCYVTHKGE IRGASTPFQF RASSPVEELL TMEDEGNSDM LVVTTKAGLL
160 170 180 190 200
ELKIEKTMKE KEELLKLIAV LEKETAQLRE QVGRMERELN HEKERCDQLQ
210 220 230 240 250
AEQKGLTEVT QSLKMENEEF KKRFSDATSK AHQLEEDIVS VTHKAIEKET
260 270 280 290 300
ELDSLKDKLK KAQHEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLMSE
310 320 330 340 350
VQTLKNLDGN KESVITHFKE EIGRLQLCLA EKENLQRTFL LTTSSKEDTC
360 370 380 390 400
FLKEQLRKAE EQVQATRQEV VFLAKELSDA VNVRDRTMAD LHTARLENEK
410 420 430 440 450
VKKQLADAVA ELKLNAMKKD QDKTDTLEHE LRREVEDLKL RLQMAADHYK
460 470 480 490 500
EKFKECQRLQ KQINKLSDQS ANNNNVFTKK TGNQQKVNDA SVNTDPATSA
510 520 530 540 550
STVDVKPSPS AAEADFDIVT KGQVCEMTKE IADKTEKYNK CKQLLQDEKA
560 570 580 590 600
KCNKYADELA KMELKWKEQV KIAENVKLEL AEVQDNYKEL KRSLENPAER
610 620 630 640 650
KMEGQNSQSP QCFKTCSEQN GYVLTLSNAQ PVLQYGNPYA SQETRDGADG
660 670 680 690 700
AFYPDEIQRP PVRVPSWGLE DNVVCSQPAR NFSRPDGLED SEDSKEDENV
710 720 730 740 750
PTAPDPPSQH LRGHGTGFCF DSSFDVHKKC PLCELMFPPN YDQSKFEEHV
760 770 780
ESHWKVCPMC SEQFPPDYDQ QVFERHVQTH FDQNVLNFD
Length:789
Mass (Da):90,877
Last modified:May 16, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE8460DAA6712125
GO
Isoform 2 (identifier: Q86VP1-2) [UniParc]FASTAAdd to basket
Also known as: TXBP151-L

The sequence of this isoform differs from the canonical sequence as follows:
     604-645: Missing.

Show »
Length:747
Mass (Da):86,257
Checksum:i93EEDFF29106CE1C
GO
Isoform 3 (identifier: Q86VP1-3) [UniParc]FASTAAdd to basket
Also known as: TXBP151-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: Missing.
     604-645: Missing.

Show »
Length:563
Mass (Da):65,112
Checksum:iEFA52B16B4408B9C
GO
Isoform 4 (identifier: Q86VP1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.
     604-645: Missing.

Note: No experimental confirmation available.
Show »
Length:590
Mass (Da):68,277
Checksum:iF65F3BC653A80234
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZD4B8ZZD4_HUMAN
Tax1-binding protein 1
TAX1BP1
813Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3L5H7C3L5_HUMAN
Tax1-binding protein 1
TAX1BP1
326Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J7J4C9J7J4_HUMAN
Tax1-binding protein 1
TAX1BP1
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JBZ7C9JBZ7_HUMAN
Tax1-binding protein 1
TAX1BP1
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBU9F8WBU9_HUMAN
Tax1-binding protein 1
TAX1BP1
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GZ06V9GZ06_HUMAN
Tax1-binding protein 1
TAX1BP1
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC13359 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti199L → P in BAG59309 (PubMed:14702039).Curated1
Sequence conflicti233 – 234QL → HV in AAA75595 (PubMed:10435631).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05141558S → N. Corresponds to variant dbSNP:rs7809260Ensembl.1
Natural variantiVAR_026286307L → I1 PublicationCorresponds to variant dbSNP:rs11540483Ensembl.1
Natural variantiVAR_035665457Q → R in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0183541 – 184Missing in isoform 3. CuratedAdd BLAST184
Alternative sequenceiVSP_0459211 – 157Missing in isoform 4. 1 PublicationAdd BLAST157
Alternative sequenceiVSP_018355604 – 645Missing in isoform 2, isoform 3 and isoform 4. 5 PublicationsAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U33821 mRNA Translation: AAA75595.2
AF268075 mRNA Translation: AAG03025.1
AL136586 mRNA Translation: CAB66521.1
AF090891 mRNA Translation: AAF24016.1
CR457056 mRNA Translation: CAG33337.1
AK296720 mRNA Translation: BAG59309.1
AK314292 mRNA Translation: BAG36949.1
CR533556 mRNA Translation: CAG38587.1
AC004549 Genomic DNA Translation: AAC13359.2 Sequence problems.
AC005091 Genomic DNA Translation: AAD15412.1
CH236948 Genomic DNA Translation: EAL24213.1
CH471073 Genomic DNA Translation: EAW93901.1
CH471073 Genomic DNA Translation: EAW93904.1
BC050358 mRNA Translation: AAH50358.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43561.1 [Q86VP1-2]
CCDS5415.1 [Q86VP1-1]
CCDS56471.1 [Q86VP1-4]

Protein sequence database of the Protein Information Resource

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PIRi
G02043

NCBI Reference Sequences

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RefSeqi
NP_001073333.1, NM_001079864.2 [Q86VP1-2]
NP_001193830.1, NM_001206901.1 [Q86VP1-2]
NP_001193831.1, NM_001206902.1 [Q86VP1-4]
NP_006015.4, NM_006024.6 [Q86VP1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265393; ENSP00000265393; ENSG00000106052 [Q86VP1-2]
ENST00000396319; ENSP00000379612; ENSG00000106052 [Q86VP1-1]
ENST00000433216; ENSP00000391907; ENSG00000106052 [Q86VP1-4]
ENST00000543117; ENSP00000444811; ENSG00000106052 [Q86VP1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8887

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8887

UCSC genome browser

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UCSCi
uc003szk.4 human [Q86VP1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33821 mRNA Translation: AAA75595.2
AF268075 mRNA Translation: AAG03025.1
AL136586 mRNA Translation: CAB66521.1
AF090891 mRNA Translation: AAF24016.1
CR457056 mRNA Translation: CAG33337.1
AK296720 mRNA Translation: BAG59309.1
AK314292 mRNA Translation: BAG36949.1
CR533556 mRNA Translation: CAG38587.1
AC004549 Genomic DNA Translation: AAC13359.2 Sequence problems.
AC005091 Genomic DNA Translation: AAD15412.1
CH236948 Genomic DNA Translation: EAL24213.1
CH471073 Genomic DNA Translation: EAW93901.1
CH471073 Genomic DNA Translation: EAW93904.1
BC050358 mRNA Translation: AAH50358.1
CCDSiCCDS43561.1 [Q86VP1-2]
CCDS5415.1 [Q86VP1-1]
CCDS56471.1 [Q86VP1-4]
PIRiG02043
RefSeqiNP_001073333.1, NM_001079864.2 [Q86VP1-2]
NP_001193830.1, NM_001206901.1 [Q86VP1-2]
NP_001193831.1, NM_001206902.1 [Q86VP1-4]
NP_006015.4, NM_006024.6 [Q86VP1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M7QNMR-A725-789[»]
4BMJX-ray2.75A/B/C/D/E/F/G/H/I/J/K725-789[»]
4NLHX-ray1.90A/B15-147[»]
4Z4KX-ray2.80A/B725-781[»]
4Z4MX-ray2.15A/B755-781[»]
5AASNMR-A722-784[»]
5YT6X-ray1.50B/D/F/H754-787[»]
5Z7GX-ray2.30A/B1-121[»]
SMRiQ86VP1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi114405, 87 interactors
DIPiDIP-33010N
IntActiQ86VP1, 113 interactors
MINTiQ86VP1
STRINGi9606.ENSP00000379612

Protein family/group databases

MoonDBiQ86VP1 Predicted

PTM databases

iPTMnetiQ86VP1
PhosphoSitePlusiQ86VP1

Polymorphism and mutation databases

BioMutaiTAX1BP1
DMDMi97202549

Proteomic databases

EPDiQ86VP1
jPOSTiQ86VP1
MassIVEiQ86VP1
MaxQBiQ86VP1
PaxDbiQ86VP1
PeptideAtlasiQ86VP1
PRIDEiQ86VP1
ProteomicsDBi17229
70045 [Q86VP1-1]
70046 [Q86VP1-2]
70047 [Q86VP1-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8887

Genome annotation databases

EnsembliENST00000265393; ENSP00000265393; ENSG00000106052 [Q86VP1-2]
ENST00000396319; ENSP00000379612; ENSG00000106052 [Q86VP1-1]
ENST00000433216; ENSP00000391907; ENSG00000106052 [Q86VP1-4]
ENST00000543117; ENSP00000444811; ENSG00000106052 [Q86VP1-2]
GeneIDi8887
KEGGihsa:8887
UCSCiuc003szk.4 human [Q86VP1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8887
DisGeNETi8887

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TAX1BP1
HGNCiHGNC:11575 TAX1BP1
HPAiHPA024432
MIMi605326 gene
neXtProtiNX_Q86VP1
OpenTargetsiENSG00000106052
PharmGKBiPA36339

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGMS Eukaryota
ENOG410XQDF LUCA
GeneTreeiENSGT00950000183025
HOGENOMiHOG000271638
InParanoidiQ86VP1
KOiK21347
OrthoDBi179838at2759
PhylomeDBiQ86VP1
TreeFamiTF329501

Enzyme and pathway databases

ReactomeiR-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
SIGNORiQ86VP1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TAX1BP1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TAX1BP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8887
PharosiQ86VP1

Protein Ontology

More...
PROi
PR:Q86VP1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000106052 Expressed in 242 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ86VP1 baseline and differential
GenevisibleiQ86VP1 HS

Family and domain databases

InterProiView protein in InterPro
IPR012852 CALCOCO1-like
IPR041641 CALCOCO1/2_Zn-C2H2
IPR041611 SKICH
PfamiView protein in Pfam
PF07888 CALCOCO1, 1 hit
PF17751 SKICH, 1 hit
PF18112 Zn-C2H2_12, 2 hits
PROSITEiView protein in PROSITE
PS51905 ZF_UBZ1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAXB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86VP1
Secondary accession number(s): A4D196
, B4DKU7, E7ENV2, O60398, O95770, Q13311, Q9BQG5, Q9UI88
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: November 13, 2019
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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