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Protein

Tax1-binding protein 1

Gene

TAX1BP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri725 – 754UBZ-type 1Add BLAST30
Zinc fingeri755 – 789UBZ-type 2Add BLAST35

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
SIGNORiQ86VP1

Protein family/group databases

MoonDBiQ86VP1 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Tax1-binding protein 1
Alternative name(s):
TRAF6-binding protein
Gene namesi
Name:TAX1BP1
Synonyms:T6BP
ORF Names:PRO0105
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106052.13
HGNCiHGNC:11575 TAX1BP1
MIMi605326 gene
neXtProtiNX_Q86VP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi771Q → A: Normal affinity for ubiquitin. 1 Publication1
Mutagenesisi774E → A: Reduced affinity for ubiquitin. 1 Publication1
Mutagenesisi775R → A: Normal affinity for ubiquitin. 1 Publication1
Mutagenesisi777V → S: Reduced affinity for ubiquitin. 1 Publication1
Mutagenesisi778Q → A: Reduced affinity for ubiquitin. 1 Publication1
Mutagenesisi781F → A: Reduced affinity for ubiquitin. 1 Publication1

Organism-specific databases

DisGeNETi8887
OpenTargetsiENSG00000106052
PharmGKBiPA36339

Polymorphism and mutation databases

BioMutaiTAX1BP1
DMDMi97202549

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345541 – 789Tax1-binding protein 1Add BLAST789

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphoserineBy similarity1
Modified residuei138PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei593Phosphoserine; by IKKA1 Publication1
Modified residuei609PhosphoserineBy similarity1
Modified residuei666Phosphoserine; by IKKACombined sources1 Publication1

Post-translational modificationi

Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86VP1
MaxQBiQ86VP1
PaxDbiQ86VP1
PeptideAtlasiQ86VP1
PRIDEiQ86VP1
ProteomicsDBi70045
70046 [Q86VP1-2]
70047 [Q86VP1-3]

PTM databases

iPTMnetiQ86VP1
PhosphoSitePlusiQ86VP1

Expressioni

Tissue specificityi

Expressed in all tissues tested.

Gene expression databases

BgeeiENSG00000106052 Expressed in 242 organ(s), highest expression level in secondary oocyte
CleanExiHS_TAX1BP1
ExpressionAtlasiQ86VP1 baseline and differential
GenevisibleiQ86VP1 HS

Organism-specific databases

HPAiHPA024432

Interactioni

Subunit structurei

Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLV-1 protein Tax-1.4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114405, 81 interactors
DIPiDIP-33010N
IntActiQ86VP1, 101 interactors
MINTiQ86VP1
STRINGi9606.ENSP00000379612

Structurei

Secondary structure

1789
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ86VP1
SMRiQ86VP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni320 – 420OligomerizationAdd BLAST101

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili144 – 599Sequence analysisAdd BLAST456

Domaini

The C-terminal UBZ-type zinc fingers function as ubiquitin-binding domains.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri725 – 754UBZ-type 1Add BLAST30
Zinc fingeri755 – 789UBZ-type 2Add BLAST35

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGMS Eukaryota
ENOG410XQDF LUCA
GeneTreeiENSGT00530000063216
HOGENOMiHOG000271638
HOVERGENiHBG053034
InParanoidiQ86VP1
KOiK21347
PhylomeDBiQ86VP1
TreeFamiTF329501

Family and domain databases

InterProiView protein in InterPro
IPR012852 CALCOCO1-like
PfamiView protein in Pfam
PF07888 CALCOCO1, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86VP1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV
60 70 80 90 100
GIFKVGWSTA RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY
110 120 130 140 150
QFCYVTHKGE IRGASTPFQF RASSPVEELL TMEDEGNSDM LVVTTKAGLL
160 170 180 190 200
ELKIEKTMKE KEELLKLIAV LEKETAQLRE QVGRMERELN HEKERCDQLQ
210 220 230 240 250
AEQKGLTEVT QSLKMENEEF KKRFSDATSK AHQLEEDIVS VTHKAIEKET
260 270 280 290 300
ELDSLKDKLK KAQHEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLMSE
310 320 330 340 350
VQTLKNLDGN KESVITHFKE EIGRLQLCLA EKENLQRTFL LTTSSKEDTC
360 370 380 390 400
FLKEQLRKAE EQVQATRQEV VFLAKELSDA VNVRDRTMAD LHTARLENEK
410 420 430 440 450
VKKQLADAVA ELKLNAMKKD QDKTDTLEHE LRREVEDLKL RLQMAADHYK
460 470 480 490 500
EKFKECQRLQ KQINKLSDQS ANNNNVFTKK TGNQQKVNDA SVNTDPATSA
510 520 530 540 550
STVDVKPSPS AAEADFDIVT KGQVCEMTKE IADKTEKYNK CKQLLQDEKA
560 570 580 590 600
KCNKYADELA KMELKWKEQV KIAENVKLEL AEVQDNYKEL KRSLENPAER
610 620 630 640 650
KMEGQNSQSP QCFKTCSEQN GYVLTLSNAQ PVLQYGNPYA SQETRDGADG
660 670 680 690 700
AFYPDEIQRP PVRVPSWGLE DNVVCSQPAR NFSRPDGLED SEDSKEDENV
710 720 730 740 750
PTAPDPPSQH LRGHGTGFCF DSSFDVHKKC PLCELMFPPN YDQSKFEEHV
760 770 780
ESHWKVCPMC SEQFPPDYDQ QVFERHVQTH FDQNVLNFD
Length:789
Mass (Da):90,877
Last modified:May 16, 2006 - v2
Checksum:iDE8460DAA6712125
GO
Isoform 2 (identifier: Q86VP1-2) [UniParc]FASTAAdd to basket
Also known as: TXBP151-L

The sequence of this isoform differs from the canonical sequence as follows:
     604-645: Missing.

Show »
Length:747
Mass (Da):86,257
Checksum:i93EEDFF29106CE1C
GO
Isoform 3 (identifier: Q86VP1-3) [UniParc]FASTAAdd to basket
Also known as: TXBP151-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: Missing.
     604-645: Missing.

Show »
Length:563
Mass (Da):65,112
Checksum:iEFA52B16B4408B9C
GO
Isoform 4 (identifier: Q86VP1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.
     604-645: Missing.

Note: No experimental confirmation available.
Show »
Length:590
Mass (Da):68,277
Checksum:iF65F3BC653A80234
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZD4B8ZZD4_HUMAN
Tax1-binding protein 1
TAX1BP1
813Annotation score:
H7C3L5H7C3L5_HUMAN
Tax1-binding protein 1
TAX1BP1
326Annotation score:
C9J7J4C9J7J4_HUMAN
Tax1-binding protein 1
TAX1BP1
138Annotation score:
C9JBZ7C9JBZ7_HUMAN
Tax1-binding protein 1
TAX1BP1
98Annotation score:
F8WBU9F8WBU9_HUMAN
Tax1-binding protein 1
TAX1BP1
91Annotation score:
V9GZ06V9GZ06_HUMAN
Tax1-binding protein 1
TAX1BP1
142Annotation score:

Sequence cautioni

The sequence AAC13359 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti199L → P in BAG59309 (PubMed:14702039).Curated1
Sequence conflicti233 – 234QL → HV in AAA75595 (PubMed:10435631).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05141558S → N. Corresponds to variant dbSNP:rs7809260Ensembl.1
Natural variantiVAR_026286307L → I1 PublicationCorresponds to variant dbSNP:rs11540483Ensembl.1
Natural variantiVAR_035665457Q → R in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0183541 – 184Missing in isoform 3. CuratedAdd BLAST184
Alternative sequenceiVSP_0459211 – 157Missing in isoform 4. 1 PublicationAdd BLAST157
Alternative sequenceiVSP_018355604 – 645Missing in isoform 2, isoform 3 and isoform 4. 5 PublicationsAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33821 mRNA Translation: AAA75595.2
AF268075 mRNA Translation: AAG03025.1
AL136586 mRNA Translation: CAB66521.1
AF090891 mRNA Translation: AAF24016.1
CR457056 mRNA Translation: CAG33337.1
AK296720 mRNA Translation: BAG59309.1
AK314292 mRNA Translation: BAG36949.1
CR533556 mRNA Translation: CAG38587.1
AC004549 Genomic DNA Translation: AAC13359.2 Sequence problems.
AC005091 Genomic DNA Translation: AAD15412.1
CH236948 Genomic DNA Translation: EAL24213.1
CH471073 Genomic DNA Translation: EAW93901.1
CH471073 Genomic DNA Translation: EAW93904.1
BC050358 mRNA Translation: AAH50358.1
CCDSiCCDS43561.1 [Q86VP1-2]
CCDS5415.1 [Q86VP1-1]
CCDS56471.1 [Q86VP1-4]
PIRiG02043
RefSeqiNP_001073333.1, NM_001079864.2 [Q86VP1-2]
NP_001193830.1, NM_001206901.1 [Q86VP1-2]
NP_001193831.1, NM_001206902.1 [Q86VP1-4]
NP_006015.4, NM_006024.6 [Q86VP1-1]
UniGeneiHs.34576

Genome annotation databases

EnsembliENST00000265393; ENSP00000265393; ENSG00000106052 [Q86VP1-2]
ENST00000396319; ENSP00000379612; ENSG00000106052 [Q86VP1-1]
ENST00000433216; ENSP00000391907; ENSG00000106052 [Q86VP1-4]
ENST00000543117; ENSP00000444811; ENSG00000106052 [Q86VP1-2]
GeneIDi8887
KEGGihsa:8887
UCSCiuc003szk.4 human [Q86VP1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33821 mRNA Translation: AAA75595.2
AF268075 mRNA Translation: AAG03025.1
AL136586 mRNA Translation: CAB66521.1
AF090891 mRNA Translation: AAF24016.1
CR457056 mRNA Translation: CAG33337.1
AK296720 mRNA Translation: BAG59309.1
AK314292 mRNA Translation: BAG36949.1
CR533556 mRNA Translation: CAG38587.1
AC004549 Genomic DNA Translation: AAC13359.2 Sequence problems.
AC005091 Genomic DNA Translation: AAD15412.1
CH236948 Genomic DNA Translation: EAL24213.1
CH471073 Genomic DNA Translation: EAW93901.1
CH471073 Genomic DNA Translation: EAW93904.1
BC050358 mRNA Translation: AAH50358.1
CCDSiCCDS43561.1 [Q86VP1-2]
CCDS5415.1 [Q86VP1-1]
CCDS56471.1 [Q86VP1-4]
PIRiG02043
RefSeqiNP_001073333.1, NM_001079864.2 [Q86VP1-2]
NP_001193830.1, NM_001206901.1 [Q86VP1-2]
NP_001193831.1, NM_001206902.1 [Q86VP1-4]
NP_006015.4, NM_006024.6 [Q86VP1-1]
UniGeneiHs.34576

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M7QNMR-A725-789[»]
4BMJX-ray2.75A/B/C/D/E/F/G/H/I/J/K725-789[»]
4NLHX-ray1.90A/B15-147[»]
4Z4KX-ray2.80A/B725-781[»]
4Z4MX-ray2.15A/B755-781[»]
5AASNMR-A722-784[»]
5YT6X-ray1.50B/D/F/H754-787[»]
ProteinModelPortaliQ86VP1
SMRiQ86VP1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114405, 81 interactors
DIPiDIP-33010N
IntActiQ86VP1, 101 interactors
MINTiQ86VP1
STRINGi9606.ENSP00000379612

Protein family/group databases

MoonDBiQ86VP1 Predicted

PTM databases

iPTMnetiQ86VP1
PhosphoSitePlusiQ86VP1

Polymorphism and mutation databases

BioMutaiTAX1BP1
DMDMi97202549

Proteomic databases

EPDiQ86VP1
MaxQBiQ86VP1
PaxDbiQ86VP1
PeptideAtlasiQ86VP1
PRIDEiQ86VP1
ProteomicsDBi70045
70046 [Q86VP1-2]
70047 [Q86VP1-3]

Protocols and materials databases

DNASUi8887
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265393; ENSP00000265393; ENSG00000106052 [Q86VP1-2]
ENST00000396319; ENSP00000379612; ENSG00000106052 [Q86VP1-1]
ENST00000433216; ENSP00000391907; ENSG00000106052 [Q86VP1-4]
ENST00000543117; ENSP00000444811; ENSG00000106052 [Q86VP1-2]
GeneIDi8887
KEGGihsa:8887
UCSCiuc003szk.4 human [Q86VP1-1]

Organism-specific databases

CTDi8887
DisGeNETi8887
EuPathDBiHostDB:ENSG00000106052.13
GeneCardsiTAX1BP1
HGNCiHGNC:11575 TAX1BP1
HPAiHPA024432
MIMi605326 gene
neXtProtiNX_Q86VP1
OpenTargetsiENSG00000106052
PharmGKBiPA36339
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGMS Eukaryota
ENOG410XQDF LUCA
GeneTreeiENSGT00530000063216
HOGENOMiHOG000271638
HOVERGENiHBG053034
InParanoidiQ86VP1
KOiK21347
PhylomeDBiQ86VP1
TreeFamiTF329501

Enzyme and pathway databases

ReactomeiR-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
SIGNORiQ86VP1

Miscellaneous databases

ChiTaRSiTAX1BP1 human
GeneWikiiTAX1BP1
GenomeRNAii8887
PROiPR:Q86VP1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106052 Expressed in 242 organ(s), highest expression level in secondary oocyte
CleanExiHS_TAX1BP1
ExpressionAtlasiQ86VP1 baseline and differential
GenevisibleiQ86VP1 HS

Family and domain databases

InterProiView protein in InterPro
IPR012852 CALCOCO1-like
PfamiView protein in Pfam
PF07888 CALCOCO1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAXB1_HUMAN
AccessioniPrimary (citable) accession number: Q86VP1
Secondary accession number(s): A4D196
, B4DKU7, E7ENV2, O60398, O95770, Q13311, Q9BQG5, Q9UI88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: November 7, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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