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Entry version 138 (11 Dec 2019)
Sequence version 2 (24 Nov 2009)
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Protein

Zinc finger CCCH domain-containing protein 18

Gene

ZC3H18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri219 – 245C3H1-typePROSITE-ProRule annotationAdd BLAST27

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 18
Alternative name(s):
Nuclear protein NHN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZC3H18
Synonyms:NHN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000158545.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25091 ZC3H18

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86VM9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000158545

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162409533

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86VM9 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZC3H18

Domain mapping of disease mutations (DMDM)

More...
DMDMi
269849528

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003112421 – 953Zinc finger CCCH domain-containing protein 18Add BLAST953

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei46PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei59PhosphoserineBy similarity1
Modified residuei67PhosphoserineCombined sources1
Modified residuei74PhosphoserineCombined sources1
Modified residuei78PhosphoserineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Modified residuei95PhosphoserineBy similarity1
Modified residuei109PhosphothreonineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei118PhosphoserineCombined sources1
Modified residuei162PhosphothreonineCombined sources1
Modified residuei173PhosphoserineCombined sources1
Modified residuei179PhosphoserineCombined sources1
Modified residuei487PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki510Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei532PhosphoserineCombined sources1
Modified residuei534PhosphoserineCombined sources1
Modified residuei536PhosphoserineCombined sources1
Cross-linki622Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki661Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki766Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei814N6-acetyllysineBy similarity1
Cross-linki817Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei842PhosphoserineCombined sources1
Modified residuei852PhosphoserineBy similarity1
Modified residuei868PhosphoserineCombined sources1
Modified residuei893PhosphoserineCombined sources1
Modified residuei896PhosphoserineCombined sources1
Cross-linki908Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86VM9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86VM9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86VM9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86VM9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86VM9

PeptideAtlas

More...
PeptideAtlasi
Q86VM9

PRoteomics IDEntifications database

More...
PRIDEi
Q86VM9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70041 [Q86VM9-1]
70042 [Q86VM9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86VM9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86VM9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000158545 Expressed in 192 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86VM9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86VM9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040847
HPA041327

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ZFC3H1 in a RNase-insensitive manner.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q155542EBI-1045965,EBI-706637

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125858, 158 interactors

Protein interaction database and analysis system

More...
IntActi
Q86VM9, 231 interactors

Molecular INTeraction database

More...
MINTi
Q86VM9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000416951

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86VM9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86VM9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili105 – 134Sequence analysisAdd BLAST30
Coiled coili399 – 464Sequence analysisAdd BLAST66
Coiled coili921 – 950Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi201 – 204Poly-Asp4
Compositional biasi259 – 296Pro-richAdd BLAST38
Compositional biasi532 – 746Ser-richAdd BLAST215

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri219 – 245C3H1-typePROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ7N Eukaryota
ENOG4111IXQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111190

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000155765

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86VM9

KEGG Orthology (KO)

More...
KOi
K13092

Database of Orthologous Groups

More...
OrthoDBi
618568at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86VM9

TreeFam database of animal gene trees

More...
TreeFami
TF327301

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041367 Znf-CCCH_4
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18044 zf-CCCH_4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00356 ZnF_C3H1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF90229 SSF90229, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50103 ZF_C3H1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86VM9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVAESPERD PHSPEDEEQP QGLSDDDILR DSGSDQDLDG AGVRASDLED
60 70 80 90 100
EESAARGPSQ EEEDNHSDEE DRASEPKSQD QDSEVNELSR GPTSSPCEEE
110 120 130 140 150
GDEGEEDRTS DLRDEASSVT RELDEHELDY DEEVPEEPAP AVQEDEAEKA
160 170 180 190 200
GAEDDEEKGE GTPREEGKAG VQSVGEKESL EAAKEKKKED DDGEIDDGEI
210 220 230 240 250
DDDDLEEGEV KDPSDRKVRP RPTCRFFMKG NCTWGMNCRF IHPGVNDKGN
260 270 280 290 300
YSLITKADPF PPNGAPPLGP HPLMPANPWG GPVVDEILPP PPPEPPTESA
310 320 330 340 350
WERGLRHAKE VLKKATIRKE QEPDFEEKRF TVTIGEDERE FDKENEVFRD
360 370 380 390 400
WNSRIPRDVR DTVLEPYADP YYDYEIERFW RGGQYENFRV QYTETEPYHN
410 420 430 440 450
YRERERERER ENRQRERERE RERDRERERR QRERERERER ERDKERQRRK
460 470 480 490 500
EEWERERAKR DEKDRQHRDR DREKEREKEK GKPKPRSPQP PSRQAEPPKK
510 520 530 540 550
EAATTGPQVK RADEWKDPWR RSKSPKKKLG VSVSPSRARR RRKTSASSAS
560 570 580 590 600
ASNSSRSSSR SSSYSGSGSS RSRSRSSSYS SYSSRSSRHS SFSGSRSRSR
610 620 630 640 650
SFSSSPSPSP TPSPHRPSIR TKGEPAPPPG KAGEKSVKKP APPPAPPQAT
660 670 680 690 700
KTTAPVPEPT KPGDPREARR KERPARTPPR RRTLSGSGSG SGSSYSGSSS
710 720 730 740 750
RSRSLSVSSV SSVSSATSSS SSAHSVDSED MYADLASPVS SASSRSPAPA
760 770 780 790 800
QTRKEKGKSK KEDGVKEEKR KRDSSTQPPK SAKPPAGGKS SQQPSTPQQA
810 820 830 840 850
PPGQPQQGTF VAHKEIKLTL LNKAADKGSR KRYEPSDKDR QSPPPAKRPN
860 870 880 890 900
TSPDRGSRDR KSGGRLGSPK PERQRGQNSK APAAPADRKR QLSPQSKSSS
910 920 930 940 950
KVTSVPGKAS DPGAASTKSG KASTLSRREE LLKQLKAVED AIARKRAKIP

GKA
Length:953
Mass (Da):106,378
Last modified:November 24, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF12E87B342E1F892
GO
Isoform 2 (identifier: Q86VM9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     228-228: M → MKDVVTPLSTLLPPISNSIPFRGQV
     412-469: NRQRERERERERDRERERRQRERERERERERDKERQRRKEEWERERAKRDEKDRQHRD → RE
     683-953: TLSGSGSGSG...RKRAKIPGKA → LIKEAGSAMN...PARCLGGRSC

Show »
Length:757
Mass (Da):84,100
Checksum:i883B3D5A20DCBC4F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ERS3E7ERS3_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H18
977Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPD0H3BPD0_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H18
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BP01H3BP01_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H18
238Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRH3H3BRH3_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H18
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRN6H3BRN6_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H18
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti251Y → H in BAB71237 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037188368A → T. Corresponds to variant dbSNP:rs34808360Ensembl.1
Natural variantiVAR_037189440R → H1 PublicationCorresponds to variant dbSNP:rs17855686Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029453228M → MKDVVTPLSTLLPPISNSIP FRGQV in isoform 2. 1 Publication1
Alternative sequenceiVSP_029454412 – 469NRQRE…RQHRD → RE in isoform 2. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_029455683 – 953TLSGS…IPGKA → LIKEAGSAMNHQTRTGRALL QPSGPTHPQTEVLGTGSQVG DWAPRSQSGREARTPKPLQP RLTGSASCHPSPRAPARSRA CPAKPRIPAPPAPNQGRPAR CLGGRSC in isoform 2. 1 PublicationAdd BLAST271

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK056632 mRNA Translation: BAB71237.1
AC116552 Genomic DNA No translation available.
BC001584 mRNA Translation: AAH01584.1
BC050463 mRNA Translation: AAH50463.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10967.1 [Q86VM9-1]

NCBI Reference Sequences

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RefSeqi
NP_001281269.1, NM_001294340.1
NP_653205.3, NM_144604.3 [Q86VM9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000301011; ENSP00000301011; ENSG00000158545 [Q86VM9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
124245

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:124245

UCSC genome browser

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UCSCi
uc002fky.4 human [Q86VM9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056632 mRNA Translation: BAB71237.1
AC116552 Genomic DNA No translation available.
BC001584 mRNA Translation: AAH01584.1
BC050463 mRNA Translation: AAH50463.1
CCDSiCCDS10967.1 [Q86VM9-1]
RefSeqiNP_001281269.1, NM_001294340.1
NP_653205.3, NM_144604.3 [Q86VM9-1]

3D structure databases

SMRiQ86VM9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125858, 158 interactors
IntActiQ86VM9, 231 interactors
MINTiQ86VM9
STRINGi9606.ENSP00000416951

PTM databases

iPTMnetiQ86VM9
PhosphoSitePlusiQ86VM9

Polymorphism and mutation databases

BioMutaiZC3H18
DMDMi269849528

Proteomic databases

EPDiQ86VM9
jPOSTiQ86VM9
MassIVEiQ86VM9
MaxQBiQ86VM9
PaxDbiQ86VM9
PeptideAtlasiQ86VM9
PRIDEiQ86VM9
ProteomicsDBi70041 [Q86VM9-1]
70042 [Q86VM9-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
124245

Genome annotation databases

EnsembliENST00000301011; ENSP00000301011; ENSG00000158545 [Q86VM9-1]
GeneIDi124245
KEGGihsa:124245
UCSCiuc002fky.4 human [Q86VM9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
124245
EuPathDBiHostDB:ENSG00000158545.15

GeneCards: human genes, protein and diseases

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GeneCardsi
ZC3H18
HGNCiHGNC:25091 ZC3H18
HPAiHPA040847
HPA041327
neXtProtiNX_Q86VM9
OpenTargetsiENSG00000158545
PharmGKBiPA162409533

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IJ7N Eukaryota
ENOG4111IXQ LUCA
GeneTreeiENSGT00730000111190
HOGENOMiHOG000155765
InParanoidiQ86VM9
KOiK13092
OrthoDBi618568at2759
PhylomeDBiQ86VM9
TreeFamiTF327301

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZC3H18 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
124245
PharosiQ86VM9 Tdark

Protein Ontology

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PROi
PR:Q86VM9
RNActiQ86VM9 protein

Gene expression databases

BgeeiENSG00000158545 Expressed in 192 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ86VM9 baseline and differential
GenevisibleiQ86VM9 HS

Family and domain databases

InterProiView protein in InterPro
IPR041367 Znf-CCCH_4
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PfamiView protein in Pfam
PF18044 zf-CCCH_4, 1 hit
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 1 hit
SUPFAMiSSF90229 SSF90229, 1 hit
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZCH18_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86VM9
Secondary accession number(s): Q96DG4, Q96MP7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 24, 2009
Last modified: December 11, 2019
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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