UniProtKB - Q86VM6 (Q86VM6_HUMAN)

BLAST

>tr|Q86VM6|Q86VM6_HUMAN MBNL1 protein OS=Homo sapiens OX=9606 GN=MBNL1 PE=1 SV=1
MGRCSRENCKYLHPPPHLKTQLEINGRNNLIQQKNMAMLAQQMQLANAMMPGAPLQPVPM
FSVAPSLATNASAAAFNPYLGPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAAAAAQKLM
RTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYF
HPPAHLQAKIKAAQYQVNQAAAAQAAATAAAMTQSAVKSLKRPLEATFDLGIPQAVLPPL
PKRPALEKTNGATAVFNTGIFQYQQALANMQLQQHTAFLPPGSILCMTPATSVVPMVHGA
TPATVSAATTSATSVPFAATATANQIPIISAEHLTSHKYVTQM

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History
Entry version 124 (07 Nov 2018)
Sequence version 1 (01 Jun 2003)
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Protein

Submitted name:

MBNL1 protein

Gene

MBNL1

Organism

Homo sapiens (Human)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	1 – 16	C3H1-typePROSITE-ProRule annotationAdd BLAST	16
Zinc fingerⁱ	122 – 150	C3H1-typePROSITE-ProRule annotationAdd BLAST	29
Zinc fingerⁱ	158 – 184	C3H1-typePROSITE-ProRule annotationAdd BLAST	27

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: MBNL1 proteinImported Submitted name: Muscleblind-like (Drosophila), isoform CRA_fImported Submitted name: Muscleblind-like protein 1Imported
Gene namesⁱ	Name:MBNL1Imported ORF Names:hCG_28028Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000152601.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6923 MBNL1

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000152601

OpenTargetsⁱ

ENSG00000152601

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000152601 Expressed in 247 organ(s), highest expression level in blood

Bgeeⁱ

ENSG00000152601 Expressed in 247 organ(s), highest expression level in blood

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AEN	Q8WTP8	3	EBI-10225084,EBI-8637627
AES	Q08117	3	EBI-10225084,EBI-717810
DAB1	O75553	3	EBI-10225084,EBI-7875264

Protein-protein interaction databases

IntActⁱ	Q86VM6, 3 interactors Q86VM6, 3 interactors

IntActⁱ

Q86VM6, 3 interactors
Q86VM6, 3 interactors

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 16	C3H1-typeInterPro annotationAdd BLAST	16
Domainⁱ	122 – 150	C3H1-typeInterPro annotationAdd BLAST	29
Domainⁱ	158 – 184	C3H1-typeInterPro annotationAdd BLAST	27

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	1 – 16	C3H1-typePROSITE-ProRule annotationAdd BLAST	16
Zinc fingerⁱ	122 – 150	C3H1-typePROSITE-ProRule annotationAdd BLAST	29
Zinc fingerⁱ	158 – 184	C3H1-typePROSITE-ProRule annotationAdd BLAST	27

Keywords - Domainⁱ

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG2494 Eukaryota ENOG410ZNRC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001586
HOGENOMⁱ	HOG000230928
HOVERGENⁱ	HBG006999

Family and domain databases

InterProⁱ	View protein in InterPro IPR000571 Znf_CCCH
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00642 zf-CCCH, 1 hit
SMARTⁱ	View protein in SMART SM00356 ZnF_C3H1, 2 hits
PROSITEⁱ	View protein in PROSITE PS50103 ZF_C3H1, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show all Align All

Q86VM6-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MGRCSRENCK YLHPPPHLKT QLEINGRNNL IQQKNMAMLA QQMQLANAMM 
        60         70         80         90        100
PGAPLQPVPM FSVAPSLATN ASAAAFNPYL GPVSPSLVPA EILPTAPMLV 
       110        120        130        140        150
TGNPGVPVPA AAAAAAQKLM RTDRLEVCRE YQRGNCNRGE NDCRFAHPAD 
       160        170        180        190        200
STMIDTNDNT VTVCMDYIKG RCSREKCKYF HPPAHLQAKI KAAQYQVNQA 
       210        220        230        240        250
AAAQAAATAA AMTQSAVKSL KRPLEATFDL GIPQAVLPPL PKRPALEKTN 
       260        270        280        290        300
GATAVFNTGI FQYQQALANM QLQQHTAFLP PGSILCMTPA TSVVPMVHGA 
       310        320        330        340 
TPATVSAATT SATSVPFAAT ATANQIPIIS AEHLTSHKYV TQM

Length:343

Mass (Da):36,551

Last modified:June 1, 2003 - v1

Checksum:ⁱ7F9CE984EB6FB72E

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q9NR56	MBNL1_HUMAN	Muscleblind-like protein 1 Muscleblind-like protein 1 (Triplet-expansion RNA-binding protein)	MBNL1 EXP, KIAA0428, MBNL	388	Annotation score:
C9JP00	C9JP00_HUMAN	Muscleblind-like protein 1 Muscleblind-like protein 1	MBNL1	348	Annotation score:
A0A0A0MQX8	A0A0A0MQX8_HUMAN	Muscleblind-like protein 1 Muscleblind-like protein 1	MBNL1	400	Annotation score:
H7C4Y1	H7C4Y1_HUMAN	Muscleblind-like protein 1 Muscleblind-like protein 1	MBNL1	210	Annotation score:
C9JCX1	C9JCX1_HUMAN	Muscleblind-like protein 1 Muscleblind-like protein 1	MBNL1	155	Annotation score:
H7C4T5	H7C4T5_HUMAN	Muscleblind-like protein 1 Muscleblind-like protein 1	MBNL1	329	Annotation score:
C9J7P7	C9J7P7_HUMAN	Muscleblind-like protein 1 Muscleblind-like protein 1	MBNL1	90	Annotation score:
C9J4T8	C9J4T8_HUMAN	Muscleblind-like protein 1 Muscleblind-like protein 1	MBNL1	58	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC026347 Genomic DNA No translation available. AC106722 Genomic DNA No translation available. BC050535 mRNA Translation: AAH50535.1 CH471052 Genomic DNA Translation: EAW78780.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001300986.1, NM_001314057.1 NP_997178.1, NM_207295.1 NP_997179.1, NM_207296.1 NP_997180.1, NM_207297.1
UniGeneⁱ	Hs.201858 Hs.725347

Genome annotation databases

Ensemblⁱ	ENST00000493459; ENSP00000419347; ENSG00000152601
GeneIDⁱ	4154
UCSC genome browser More...UCSCⁱ	uc003ezj.4 human

Protein	Similar proteins		Species	Score	Length	Source
Q86VM6	MBNL1 isoform 11		PANTR		343	UniRef100_Q86VM6
Uncharacterized protein		PANPA		343
Muscleblind like splicing regulator 1		GORGO		343

Protein	Similar proteins		Species	Score	Length	Source
Q86VM6	MBNL1 isoform 11		PANTR		343	UniRef90_Q86VM6
Uncharacterized protein		PANPA		343
Muscleblind like splicing regulator 1		GORGO		343
Uncharacterized protein		Cebus capucinus imitator		343
Uncharacterized protein		PIG		343
+42

Protein	Similar proteins		Species	Score	Length	Source
Q86VM6	Muscleblind-like protein 1		MOUSE		341	UniRef50_Q9JKP5
Uncharacterized protein		FELCA		384
muscleblind-like protein 1 isoform X4		DIPOR		359
Muscleblind-like protein 1		HUMAN		348
MBNL1 isoform 10		PANTR		348
+596

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC026347 Genomic DNA No translation available. AC106722 Genomic DNA No translation available. BC050535 mRNA Translation: AAH50535.1 CH471052 Genomic DNA Translation: EAW78780.1
RefSeqⁱ	NP_001300986.1, NM_001314057.1 NP_997178.1, NM_207295.1 NP_997179.1, NM_207296.1 NP_997180.1, NM_207297.1
UniGeneⁱ	Hs.201858 Hs.725347

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q86VM6, 3 interactors Q86VM6, 3 interactors

IntActⁱ

Q86VM6, 3 interactors
Q86VM6, 3 interactors

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000493459; ENSP00000419347; ENSG00000152601
GeneIDⁱ	4154
UCSCⁱ	uc003ezj.4 human

Organism-specific databases

CTDⁱ	4154
EuPathDBⁱ	HostDB:ENSG00000152601.17
HGNCⁱ	HGNC:6923 MBNL1
OpenTargetsⁱ	ENSG00000152601
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2494 Eukaryota ENOG410ZNRC LUCA
GeneTreeⁱ	ENSGT00390000001586
HOGENOMⁱ	HOG000230928
HOVERGENⁱ	HBG006999

Miscellaneous databases

ChiTaRSⁱ	MBNL1 human

ChiTaRSⁱ

MBNL1 human

Gene expression databases

Bgeeⁱ	ENSG00000152601 Expressed in 247 organ(s), highest expression level in blood

Bgeeⁱ

ENSG00000152601 Expressed in 247 organ(s), highest expression level in blood

Family and domain databases

InterProⁱ	View protein in InterPro IPR000571 Znf_CCCH
Pfamⁱ	View protein in Pfam PF00642 zf-CCCH, 1 hit
SMARTⁱ	View protein in SMART SM00356 ZnF_C3H1, 2 hits
PROSITEⁱ	View protein in PROSITE PS50103 ZF_C3H1, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q86VM6_HUMAN
Accessionⁱ	Q86VM6Primary (citable) accession number: Q86VM6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 1, 2003
	Last sequence update:	June 1, 2003
	Last modified:	November 7, 2018
	This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q86VM6 (Q86VM6_HUMAN)

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MBNL1 protein

MBNL1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ