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UniProtKB - Q86VL8 (S47A2_HUMAN)

Entry version 123 (13 Feb 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Multidrug and toxin extrusion protein 2

Gene

SLC47A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.3 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.76 mM for TEA2 Publications
  2. KM=0.11 mM for MPP2 Publications
  3. KM=0.12 mM for cimetidine2 Publications
  4. KM=1.98 mM for metformin2 Publications
  5. KM=4.2 mM for guanidine2 Publications
  6. KM=1.58 mM for procainamide2 Publications
  7. KM=0.06 mM for topotecan2 Publications
  8. KM=0.85 mM for estrone sulfate2 Publications
  9. KM=4.32 mM for acyclovir2 Publications
  10. KM=4.28 mM for ganciclovir2 Publications
  1. Vmax=0.88 nmol/min/mg enzyme toward TEA2 Publications
  2. Vmax=0.575 nmol/min/mg enzyme toward MPP2 Publications
  3. Vmax=0.115 nmol/min/mg enzyme toward cimetidine2 Publications
  4. Vmax=0.845 nmol/min/mg enzyme toward metformin2 Publications
  5. Vmax=0.58 nmol/min/mg enzyme toward guanidine2 Publications
  6. Vmax=3.385 nmol/min/mg enzyme toward procainamide2 Publications
  7. Vmax=0.13 nmol/min/mg enzyme toward topotecan2 Publications
  8. Vmax=0.425 nmol/min/mg enzyme toward estrone sulfate2 Publications
  9. Vmax=0.945 nmol/min/mg enzyme toward acyclovir2 Publications
  10. Vmax=0.805 nmol/min/mg enzyme toward ganciclovir2 Publications

pH dependencei

Optimum pH is 9.0. Active from pH 6 to 9.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • drug:proton antiporter activity Source: Reactome
  • drug transmembrane transporter activity Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.66.1.20 the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multidrug and toxin extrusion protein 2
Short name:
MATE-2
Short name:
hMATE-2
Alternative name(s):
Kidney-specific H(+)/organic cation antiporter
Solute carrier family 47 member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC47A2
Synonyms:MATE2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000180638.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:26439 SLC47A2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609833 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86VL8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 66ExtracellularSequence analysisAdd BLAST12
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Topological domaini88 – 119CytoplasmicSequence analysisAdd BLAST32
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 153ExtracellularSequence analysisAdd BLAST13
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 219CytoplasmicSequence analysisAdd BLAST45
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Topological domaini241 – 248ExtracellularSequence analysis8
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 289CytoplasmicSequence analysisAdd BLAST20
Transmembranei290 – 309HelicalSequence analysisAdd BLAST20
Topological domaini310 – 327ExtracellularSequence analysisAdd BLAST18
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Topological domaini349 – 368CytoplasmicSequence analysisAdd BLAST20
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21
Topological domaini390 – 402ExtracellularSequence analysisAdd BLAST13
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 442CytoplasmicSequence analysisAdd BLAST19
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Topological domaini464 – 466ExtracellularSequence analysis3
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Topological domaini488 – 578CytoplasmicSequence analysisAdd BLAST91
Transmembranei579 – 599HelicalSequence analysisAdd BLAST21
Topological domaini600 – 602ExtracellularSequence analysis3

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		146802

Open Targets

More...OpenTargetsi		ENSG00000180638

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162403847

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1743127

Drug and drug target database

More...DrugBanki		DB00787 Aciclovir

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1217

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC47A2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74727585

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003119521 – 602Multidrug and toxin extrusion protein 2Add BLAST602

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86VL8

PeptideAtlas

More...PeptideAtlasi		Q86VL8

PRoteomics IDEntifications database

More...PRIDEi		Q86VL8

ProteomicsDB human proteome resource

More...ProteomicsDBi		70034
70035 [Q86VL8-2]
70036 [Q86VL8-3]
70037 [Q86VL8-4]
70038 [Q86VL8-5]
70039 [Q86VL8-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86VL8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86VL8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000180638 Expressed in 99 organ(s), highest expression level in kidney epithelium

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86VL8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86VL8 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000326671

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q86VL8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q86VL8

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi508 – 511Poly-Gln4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1347 Eukaryota
COG0534 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163062

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000060313

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG056043

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86VL8

KEGG Orthology (KO)

More...KOi		K03327

Identification of Orthologs from Complete Genome Data

More...OMAi		RMVSGRW

Database of Orthologous Groups

More...OrthoDBi		743037at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86VL8

TreeFam database of animal gene trees

More...TreeFami		TF324441

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002528 MATE_fam

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01554 MatE, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00797 matE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86VL8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSLQDTVAL DHGGCCPALS RLVPRGFGTE MWTLFALSGP LFLFQVLTFM 
        60         70         80         90        100
IYIVSTVFCG HLGKVELASV TLAVAFVNVC GVSVGVGLSS ACDTLMSQSF 
       110        120        130        140        150
GSPNKKHVGV ILQRGALVLL LCCLPCWALF LNTQHILLLF RQDPDVSRLT 
       160        170        180        190        200
QDYVMIFIPG LPVIFLYNLL AKYLQNQGWL KGQEEESPFQ TPGLSILHPS 
       210        220        230        240        250
HSHLSRASFH LFQKITWPQV LSGVVGNCVN GVANYALVSV LNLGVRGSAY 
       260        270        280        290        300
ANIISQFAQT VFLLLYIVLK KLHLETWAGW SSQCLQDWGP FFSLAVPSML 
       310        320        330        340        350
MICVEWWAYE IGSFLMGLLS VVDLSAQAVI YEVATVTYMI PLGLSIGVCV 
       360        370        380        390        400
RVGMALGAAD TVQAKRSAVS GVLSIVGISL VLGTLISILK NQLGHIFTND 
       410        420        430        440        450
EDVIALVSQV LPVYSVFHVF EAICCVYGGV LRGTGKQAFG AAVNAITYYI 
       460        470        480        490        500
IGLPLGILLT FVVRMRIMGL WLGMLACVFL ATAAFVAYTA RLDWKLAAEE 
       510        520        530        540        550
AKKHSGRQQQ QRAESTATRP GPEKAVLSSV ATGSSPGITL TTYSRSECHV 
       560        570        580        590        600
DFFRTPEEAH ALSAPTSRLS VKQLVIRRGA ALGAASATLM VGLTVRILAT 

RH
Length:602
Mass (Da):65,085
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i88EB90286AE701D1
GO
Isoform 2 (identifier: Q86VL8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.
     178-213: Missing.
     376-381: VGISLV → EMSLPW
     382-602: Missing.

Note: No experimental confirmation available.
Show »
Length:296
Mass (Da):32,120
Checksum:iA8233F83A55432EC
GO
Isoform 3 (identifier: Q86VL8-3) [UniParc]FASTAAdd to basket
Also known as: MATE2-K

The sequence of this isoform differs from the canonical sequence as follows:
     178-213: Missing.

Note: No experimental confirmation available.
Show »
Length:566
Mass (Da):61,016
Checksum:iA3D0B0E578E0B8C2
GO
Isoform 4 (identifier: Q86VL8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-213: Missing.
     339-339: M → MRHSHRLAYAAHVTR

Note: No experimental confirmation available.
Show »
Length:580
Mass (Da):62,673
Checksum:i848F216F93C7F1C7
GO
Isoform 5 (identifier: Q86VL8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-213: Missing.
     317-398: GLLSVVDLSA...LKNQLGHIFT → EHAQCGGSLC...EKSAGAYFYQ
     399-602: Missing.

Note: No experimental confirmation available.
Show »
Length:362
Mass (Da):39,287
Checksum:i35A2CE7A78E3E19D
GO
Isoform 6 (identifier: Q86VL8-6) [UniParc]FASTAAdd to basket
Also known as: MATE2-B

The sequence of this isoform differs from the canonical sequence as follows:
     178-219: GWLKGQEEES...HLFQKITWPQ → AGERLCVPAS...VHPPSISLTP
     220-602: Missing.

Note: Inactive. No experimental confirmation available.
Show »
Length:219
Mass (Da):23,344
Checksum:i40D6F1AA297DAA91
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JAE6C9JAE6_HUMAN
Multidrug and toxin extrusion prote...
SLC47A2
363Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6D → E in BAF37007 (PubMed:16807400).Curated1
Sequence conflicti23V → A in AK055758 (PubMed:14702039).Curated1
Sequence conflicti93D → G in AK055758 (PubMed:14702039).Curated1
Sequence conflicti284C → Y in CAH56154 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037358429G → R. Corresponds to variant dbSNP:rs34399035Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0296561 – 49Missing in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_029657178 – 219GWLKG…ITWPQ → AGERLCVPASSNSSTGMAEG AGGGVPIPNPGFVHPPSISL TP in isoform 6. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_029658178 – 213Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 4 PublicationsAdd BLAST36
Alternative sequenceiVSP_029659220 – 602Missing in isoform 6. 1 PublicationAdd BLAST383
Alternative sequenceiVSP_029660317 – 398GLLSV…GHIFT → EHAQCGGSLCPGCHLGGHCD LHDSLGAQHRGLCPSGDGSG GRGYCAGQALGRLGRAQHSW HFPGPGHPDKHPEKSAGAYF YQ in isoform 5. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_029662339M → MRHSHRLAYAAHVTR in isoform 4. 1 Publication1
Alternative sequenceiVSP_029663376 – 381VGISLV → EMSLPW in isoform 2. 1 Publication6
Alternative sequenceiVSP_029664382 – 602Missing in isoform 2. 1 PublicationAdd BLAST221
Alternative sequenceiVSP_029661399 – 602Missing in isoform 5. 1 PublicationAdd BLAST204

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB250364 mRNA Translation: BAF36847.1
AB250701 mRNA Translation: BAF37007.1
AK055758 mRNA No translation available.
BX648861 mRNA Translation: CAH56154.1
CH471212 Genomic DNA Translation: EAW50902.1
CH471212 Genomic DNA Translation: EAW50904.1
CH471212 Genomic DNA Translation: EAW50905.1
BC035288 mRNA Translation: AAH35288.1
BC050578 mRNA Translation: AAH50578.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11211.1 [Q86VL8-1]
CCDS58530.1 [Q86VL8-4]

NCBI Reference Sequences

More...RefSeqi		NP_001093116.1, NM_001099646.1 [Q86VL8-3]
NP_001243592.1, NM_001256663.1 [Q86VL8-4]
NP_690872.2, NM_152908.3 [Q86VL8-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.126830

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000325411; ENSP00000326671; ENSG00000180638 [Q86VL8-1]
ENST00000350657; ENSP00000338084; ENSG00000180638 [Q86VL8-4]
ENST00000574239; ENSP00000458694; ENSG00000180638 [Q86VL8-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		146802

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:146802

UCSC genome browser

More...UCSCi		uc002gwe.5 human [Q86VL8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB250364 mRNA Translation: BAF36847.1
AB250701 mRNA Translation: BAF37007.1
AK055758 mRNA No translation available.
BX648861 mRNA Translation: CAH56154.1
CH471212 Genomic DNA Translation: EAW50902.1
CH471212 Genomic DNA Translation: EAW50904.1
CH471212 Genomic DNA Translation: EAW50905.1
BC035288 mRNA Translation: AAH35288.1
BC050578 mRNA Translation: AAH50578.1
CCDSiCCDS11211.1 [Q86VL8-1]
CCDS58530.1 [Q86VL8-4]
RefSeqiNP_001093116.1, NM_001099646.1 [Q86VL8-3]
NP_001243592.1, NM_001256663.1 [Q86VL8-4]
NP_690872.2, NM_152908.3 [Q86VL8-1]
UniGeneiHs.126830

3D structure databases

ProteinModelPortaliQ86VL8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000326671

Chemistry databases

BindingDBiQ86VL8
ChEMBLiCHEMBL1743127
DrugBankiDB00787 Aciclovir
GuidetoPHARMACOLOGYi1217

Protein family/group databases

TCDBi2.A.66.1.20 the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily

PTM databases

iPTMnetiQ86VL8
PhosphoSitePlusiQ86VL8

Polymorphism and mutation databases

BioMutaiSLC47A2
DMDMi74727585

Proteomic databases

PaxDbiQ86VL8
PeptideAtlasiQ86VL8
PRIDEiQ86VL8
ProteomicsDBi70034
70035 [Q86VL8-2]
70036 [Q86VL8-3]
70037 [Q86VL8-4]
70038 [Q86VL8-5]
70039 [Q86VL8-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325411; ENSP00000326671; ENSG00000180638 [Q86VL8-1]
ENST00000350657; ENSP00000338084; ENSG00000180638 [Q86VL8-4]
ENST00000574239; ENSP00000458694; ENSG00000180638 [Q86VL8-6]
GeneIDi146802
KEGGihsa:146802
UCSCiuc002gwe.5 human [Q86VL8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		146802
DisGeNETi146802
EuPathDBiHostDB:ENSG00000180638.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC47A2

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0039367
HGNCiHGNC:26439 SLC47A2
MIMi609833 gene
neXtProtiNX_Q86VL8
OpenTargetsiENSG00000180638
PharmGKBiPA162403847

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1347 Eukaryota
COG0534 LUCA
GeneTreeiENSGT00940000163062
HOGENOMiHOG000060313
HOVERGENiHBG056043
InParanoidiQ86VL8
KOiK03327
OMAiRMVSGRW
OrthoDBi743037at2759
PhylomeDBiQ86VL8
TreeFamiTF324441

Enzyme and pathway databases

ReactomeiR-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SLC47A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		146802

Protein Ontology

More...PROi		PR:Q86VL8

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000180638 Expressed in 99 organ(s), highest expression level in kidney epithelium
ExpressionAtlasiQ86VL8 baseline and differential
GenevisibleiQ86VL8 HS

Family and domain databases

InterProiView protein in InterPro
IPR002528 MATE_fam
PfamiView protein in Pfam
PF01554 MatE, 2 hits
TIGRFAMsiTIGR00797 matE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS47A2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86VL8
Secondary accession number(s): A0JBX9
, A0P8Z7, Q63HJ9, Q8IV44, Q96NA1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 2003
Last modified: February 13, 2019
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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