UniProtKB - Q86VK4 (ZN410_HUMAN)
Protein
Zinc finger protein 410
Gene
ZNF410
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 219 – 243 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 249 – 273 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 279 – 303 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 309 – 333 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 339 – 362 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription coregulator activity Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q86VK4 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 410Alternative name(s): Another partner for ARF 1 Zinc finger protein APA-1 |
Gene namesi | Name:ZNF410 Synonyms:APA1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20144, ZNF410 |
neXtProti | NX_Q86VK4 |
VEuPathDBi | HostDB:ENSG00000119725.17 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 57862 |
PharmGKBi | PA134958929 |
Miscellaneous databases
Pharosi | Q86VK4, Tbio |
Genetic variation databases
BioMutai | ZNF410 |
DMDMi | 37538029 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047571 | 1 – 478 | Zinc finger protein 410Add BLAST | 478 |
Post-translational modificationi
Sumoylated. Sumoylation increases its half-life, possibly by blocking ubiquitin-mediated degradation.1 Publication
Keywords - PTMi
Ubl conjugationProteomic databases
MassIVEi | Q86VK4 |
MaxQBi | Q86VK4 |
PaxDbi | Q86VK4 |
PeptideAtlasi | Q86VK4 |
PRIDEi | Q86VK4 |
ProteomicsDBi | 70028 [Q86VK4-1] 70029 [Q86VK4-2] 70030 [Q86VK4-3] 70031 [Q86VK4-4] 70032 [Q86VK4-5] |
PTM databases
iPTMneti | Q86VK4 |
PhosphoSitePlusi | Q86VK4 |
Expressioni
Tissue specificityi
Widely expressed.1 Publication
Inductioni
During fibroblast senescence.1 Publication
Gene expression databases
Bgeei | ENSG00000119725, Expressed in kidney and 112 other tissues |
ExpressionAtlasi | Q86VK4, baseline and differential |
Genevisiblei | Q86VK4, HS |
Organism-specific databases
HPAi | ENSG00000119725, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with CDKN2A/p14ARF.
1 PublicationBinary interactionsi
Q86VK4
Isoform 3 [Q86VK4-3]
Protein-protein interaction databases
BioGRIDi | 121792, 54 interactors |
IntActi | Q86VK4, 66 interactors |
MINTi | Q86VK4 |
STRINGi | 9606.ENSP00000407130 |
Miscellaneous databases
RNActi | Q86VK4, protein |
Family & Domainsi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 219 – 243 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 249 – 273 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 279 – 303 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 309 – 333 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 339 – 362 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158098 |
HOGENOMi | CLU_043629_1_0_1 |
InParanoidi | Q86VK4 |
OMAi | PAEPLMG |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q86VK4 |
TreeFami | TF333498 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q86VK4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLSDELESKP ELLVQFVQNT SIPLGQGLVE SEAKDITCLS LLPVTEASEC
60 70 80 90 100
SRLMLPDDTT NHSNSSKEVP SSAVLRSLRV NVGPDGEETR AQTVQKSPEF
110 120 130 140 150
LSTSESSSLL QDLQPSDSTS FILLNLTRAG LGSSAEHLVF VQDEAEDSGN
160 170 180 190 200
DFLSSESTDS SIPWFLRVQE LAHDSLIAAT RAQLAKNAKT SSNGENVHLG
210 220 230 240 250
SGDGQSKDSG PLPQVEKKLK CTVEGCDRTF VWPAHFKYHL KTHRNDRSFI
260 270 280 290 300
CPAEGCGKSF YVLQRLKVHM RTHNGEKPFM CHESGCGKQF TTAGNLKNHR
310 320 330 340 350
RIHTGEKPFL CEAQGCGRSF AEYSSLRKHL VVHSGEKPHQ CQVCGKTFSQ
360 370 380 390 400
SGSRNVHMRK HHLQLGAAGS QEQEQTAEPL MGSSLLEEAS VPSKNLVSMN
410 420 430 440 450
SQPSLGGESL NLPNTNSILG VDDEVLAEGS PRSLSSVPDV THHLVTMQSG
460 470
RQSYEVSVLT AVNPQELLNQ GDLTERRT
Isoform 2 (identifier: Q86VK4-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
245-272: NDRSFICPAEGCGKSFYVLQRLKVHMRT → RLWEKLLCAAEAEGAHEDPQWREALYVP
273-478: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KNQ6 | J3KNQ6_HUMAN | Zinc finger protein 410 | ZNF410 | 425 | Annotation score: | ||
G3V4H7 | G3V4H7_HUMAN | Zinc finger protein 410 | ZNF410 | 378 | Annotation score: | ||
G3V2C2 | G3V2C2_HUMAN | Zinc finger protein 410 | ZNF410 | 127 | Annotation score: | ||
G3V2V5 | G3V2V5_HUMAN | Zinc finger protein 410 | ZNF410 | 110 | Annotation score: | ||
G3V369 | G3V369_HUMAN | Zinc finger protein 410 | ZNF410 | 167 | Annotation score: | ||
G3V4W2 | G3V4W2_HUMAN | Zinc finger protein 410 | ZNF410 | 125 | Annotation score: | ||
H0YJI7 | H0YJI7_HUMAN | Zinc finger protein 410 | ZNF410 | 169 | Annotation score: | ||
G3V3W2 | G3V3W2_HUMAN | Zinc finger protein 410 | ZNF410 | 74 | Annotation score: | ||
G3V4E6 | G3V4E6_HUMAN | Zinc finger protein 410 | ZNF410 | 94 | Annotation score: | ||
A0A1W2PNT4 | A0A1W2PNT4_HUMAN | Zinc finger protein 410 | ZNF410 | 312 | Annotation score: | ||
There are more potential isoformsShow all |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042424 | 57 – 129 | Missing in isoform 4. 1 PublicationAdd BLAST | 73 | |
Alternative sequenceiVSP_043417 | 57 | D → EPVPWREEDGKSGCSDLN in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_008485 | 245 – 272 | NDRSF…VHMRT → RLWEKLLCAAEAEGAHEDPQ WREALYVP in isoform 2. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_008486 | 273 – 478 | Missing in isoform 2. 1 PublicationAdd BLAST | 206 | |
Alternative sequenceiVSP_008487 | 377 – 423 | Missing in isoform 3. 1 PublicationAdd BLAST | 47 | |
Alternative sequenceiVSP_043418 | 467 – 478 | LLNQG…TERRT → SLAPLPRLECSGAFSAHCNL CLPGSSDSPASAS in isoform 5. 1 PublicationAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U90919 mRNA Translation: AAB51059.1 AK293350 mRNA Translation: BAG56866.1 AK299138 mRNA Translation: BAG61190.1 AC005480 Genomic DNA No translation available. AC005520 Genomic DNA No translation available. BC000330 mRNA No translation available. BC004357 mRNA No translation available. BC050683 mRNA Translation: AAH50683.1 |
CCDSi | CCDS55929.1 [Q86VK4-5] CCDS55930.1 [Q86VK4-3] CCDS55931.1 [Q86VK4-4] CCDS9821.1 [Q86VK4-1] |
RefSeqi | NP_001229853.1, NM_001242924.1 [Q86VK4-5] NP_001229855.1, NM_001242926.1 [Q86VK4-3] NP_001229856.1, NM_001242927.1 [Q86VK4-4] NP_067011.1, NM_021188.2 [Q86VK4-1] |
Genome annotation databases
Ensembli | ENST00000324593; ENSP00000323293; ENSG00000119725 [Q86VK4-3] ENST00000398139; ENSP00000381208; ENSG00000119725 [Q86VK4-2] ENST00000442160; ENSP00000407130; ENSG00000119725 [Q86VK4-5] ENST00000540593; ENSP00000442228; ENSG00000119725 [Q86VK4-4] ENST00000555044; ENSP00000451763; ENSG00000119725 [Q86VK4-1] ENST00000615736; ENSP00000483073; ENSG00000119725 [Q86VK4-5] |
GeneIDi | 57862 |
KEGGi | hsa:57862 |
UCSCi | uc001xoz.3, human [Q86VK4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U90919 mRNA Translation: AAB51059.1 AK293350 mRNA Translation: BAG56866.1 AK299138 mRNA Translation: BAG61190.1 AC005480 Genomic DNA No translation available. AC005520 Genomic DNA No translation available. BC000330 mRNA No translation available. BC004357 mRNA No translation available. BC050683 mRNA Translation: AAH50683.1 |
CCDSi | CCDS55929.1 [Q86VK4-5] CCDS55930.1 [Q86VK4-3] CCDS55931.1 [Q86VK4-4] CCDS9821.1 [Q86VK4-1] |
RefSeqi | NP_001229853.1, NM_001242924.1 [Q86VK4-5] NP_001229855.1, NM_001242926.1 [Q86VK4-3] NP_001229856.1, NM_001242927.1 [Q86VK4-4] NP_067011.1, NM_021188.2 [Q86VK4-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6WMI | X-ray | 2.75 | A/D | 217-366 | [»] | |
SMRi | Q86VK4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121792, 54 interactors |
IntActi | Q86VK4, 66 interactors |
MINTi | Q86VK4 |
STRINGi | 9606.ENSP00000407130 |
PTM databases
iPTMneti | Q86VK4 |
PhosphoSitePlusi | Q86VK4 |
Genetic variation databases
BioMutai | ZNF410 |
DMDMi | 37538029 |
Proteomic databases
MassIVEi | Q86VK4 |
MaxQBi | Q86VK4 |
PaxDbi | Q86VK4 |
PeptideAtlasi | Q86VK4 |
PRIDEi | Q86VK4 |
ProteomicsDBi | 70028 [Q86VK4-1] 70029 [Q86VK4-2] 70030 [Q86VK4-3] 70031 [Q86VK4-4] 70032 [Q86VK4-5] |
Protocols and materials databases
Antibodypediai | 126, 185 antibodies |
DNASUi | 57862 |
Genome annotation databases
Ensembli | ENST00000324593; ENSP00000323293; ENSG00000119725 [Q86VK4-3] ENST00000398139; ENSP00000381208; ENSG00000119725 [Q86VK4-2] ENST00000442160; ENSP00000407130; ENSG00000119725 [Q86VK4-5] ENST00000540593; ENSP00000442228; ENSG00000119725 [Q86VK4-4] ENST00000555044; ENSP00000451763; ENSG00000119725 [Q86VK4-1] ENST00000615736; ENSP00000483073; ENSG00000119725 [Q86VK4-5] |
GeneIDi | 57862 |
KEGGi | hsa:57862 |
UCSCi | uc001xoz.3, human [Q86VK4-1] |
Organism-specific databases
CTDi | 57862 |
DisGeNETi | 57862 |
GeneCardsi | ZNF410 |
HGNCi | HGNC:20144, ZNF410 |
HPAi | ENSG00000119725, Low tissue specificity |
neXtProti | NX_Q86VK4 |
PharmGKBi | PA134958929 |
VEuPathDBi | HostDB:ENSG00000119725.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158098 |
HOGENOMi | CLU_043629_1_0_1 |
InParanoidi | Q86VK4 |
OMAi | PAEPLMG |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q86VK4 |
TreeFami | TF333498 |
Enzyme and pathway databases
PathwayCommonsi | Q86VK4 |
Miscellaneous databases
BioGRID-ORCSi | 57862, 13 hits in 1027 CRISPR screens |
ChiTaRSi | ZNF410, human |
GenomeRNAii | 57862 |
Pharosi | Q86VK4, Tbio |
PROi | PR:Q86VK4 |
RNActi | Q86VK4, protein |
Gene expression databases
Bgeei | ENSG00000119725, Expressed in kidney and 112 other tissues |
ExpressionAtlasi | Q86VK4, baseline and differential |
Genevisiblei | Q86VK4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN410_HUMAN | |
Accessioni | Q86VK4Primary (citable) accession number: Q86VK4 Secondary accession number(s): B4DDV5 Q9BQ19 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2003 |
Last sequence update: | October 3, 2003 | |
Last modified: | April 7, 2021 | |
This is version 150 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - PDB cross-references
Index of Protein Data Bank (PDB) cross-references