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UniProtKB - Q86VK4 (ZN410_HUMAN)

Entry version 152 (29 Sep 2021)
Sequence version 2 (03 Oct 2003)
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Protein

Zinc finger protein 410

Gene

ZNF410

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3' in regulatory elements and modulates transcription of target genes (PubMed:12370286, PubMed:30078215, PubMed:33301730).

Indirectly represses transcription of HBG1 and HBG2, hemoglobin subunits gamma-1 and gamma-2, in erythroid cells, via direct transcriptional activation of the chromodomain protein CHD4, a component of the NuRD complex (PubMed:33301730).

Activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (PubMed:12370286).

Activates transcription of the gap junction gene GJC1, perhaps in response to increasing glucose (PubMed:30078215).

3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi221Zinc 1; structuralCombined sources1 Publication1
Metal bindingi226Zinc 1; structuralCombined sources1 Publication1
Metal bindingi239Zinc 1; via tele nitrogen; structuralCombined sources1 Publication1
Metal bindingi243Zinc 1; via tele nitrogen; structuralCombined sources1 Publication1
Metal bindingi251Zinc 2; structuralCombined sources1 Publication1
Metal bindingi256Zinc 2; structuralCombined sources1 Publication1
Metal bindingi269Zinc 2; via tele nitrogen; structuralCombined sources1 Publication1
Metal bindingi273Zinc 2; via tele nitrogen; structuralCombined sources1 Publication1
Metal bindingi281Zinc 3; structuralCombined sources1 Publication1
Metal bindingi286Zinc 3; structuralCombined sources1 Publication1
Metal bindingi299Zinc 3; via tele nitrogen; structuralCombined sources1 Publication1
Metal bindingi303Zinc 3; via tele nitrogen; structuralCombined sources1 Publication1
Metal bindingi311Zinc 4; structuralCombined sources1 Publication1
Metal bindingi316Zinc 4; structuralCombined sources1 Publication1
Metal bindingi329Zinc 4; via tele nitrogen; structuralCombined sources1 Publication1
Metal bindingi333Zinc 4; via tele nitrogen; structuralCombined sources1 Publication1
Metal bindingi341Zinc 5; structuralCombined sources1 Publication1
Metal bindingi344Zinc 5; structuralCombined sources1 Publication1
Metal bindingi357Zinc 5; via tele nitrogen; structuralCombined sources1 Publication1
Metal bindingi361Zinc 5; via tele nitrogen; structuralCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri219 – 243C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri249 – 273C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri279 – 303C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri309 – 333C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri339 – 362C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86VK4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 410
Alternative name(s):
Another partner for ARF 1
Zinc finger protein APA-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF410
Synonyms:APA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20144, ZNF410

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86VK4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000119725

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57862

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134958929

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86VK4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF410

Domain mapping of disease mutations (DMDM)

More...DMDMi		37538029

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475711 – 478Zinc finger protein 410Add BLAST478

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated (PubMed:12370286). Sumoylation increases its half-life, possibly by blocking ubiquitin-mediated degradation (PubMed:12370286).1 Publication
O-glycosylated (PubMed:30078215). O-GlcNAcylation may occur in response to increasing glucose levels and affect transcription factor activity (PubMed:30078215).1 Publication

Keywords - PTMi

Glycoprotein, Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86VK4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86VK4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86VK4

PeptideAtlas

More...PeptideAtlasi		Q86VK4

PRoteomics IDEntifications database

More...PRIDEi		Q86VK4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70028 [Q86VK4-1]
70029 [Q86VK4-2]
70030 [Q86VK4-3]
70031 [Q86VK4-4]
70032 [Q86VK4-5]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q86VK4, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86VK4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86VK4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

During fibroblast senescence.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000119725, Expressed in kidney and 113 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86VK4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86VK4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000119725, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDKN2A/p14ARF.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q86VK4
With#Exp.IntAct
BLZF1 [Q9H2G9]4EBI-720304,EBI-2548012
CEP70 [Q8NHQ1]3EBI-720304,EBI-739624
FAM9B [Q8IZU0]3EBI-720304,EBI-10175124
FSD2 [A1L4K1]3EBI-720304,EBI-5661036
GOLGA2 [Q08379]3EBI-720304,EBI-618309
MTUS2 [Q5JR59]3EBI-720304,EBI-742948
RAB3IP [Q96QF0]3EBI-720304,EBI-747844
SERTAD1 [Q53GC0]3EBI-720304,EBI-2826300
TRAF2 [Q12933]3EBI-720304,EBI-355744
TSGA10 [Q9BZW7]3EBI-720304,EBI-744794
ZNF397 [Q8NF99]3EBI-720304,EBI-10213894
Isoform 3 [Q86VK4-3]
With#Exp.IntAct
ABHD8 [Q96I13]3EBI-11741890,EBI-17180442
AGR2 [O95994]3EBI-11741890,EBI-712648
ARHGEF9 [O43307]3EBI-11741890,EBI-3447299
BANP - isoform 2 [Q8N9N5-2]3EBI-11741890,EBI-11524452
BLZF1 [Q9H2G9]7EBI-11741890,EBI-2548012
CAPN3 - isoform IV [P20807-4]3EBI-11741890,EBI-11532021
COL10A1 [Q03692]3EBI-11741890,EBI-2528309
CSNK2B [P67870]3EBI-11741890,EBI-348169
DDIT4L [Q96D03]5EBI-11741890,EBI-742054
DPEP2NB [A0A0U1RQF7]3EBI-11741890,EBI-18398199
FHL2 [Q14192]3EBI-11741890,EBI-701903
FSD2 [A1L4K1]3EBI-11741890,EBI-5661036
GFAP [P14136]3EBI-11741890,EBI-744302
GLRX3 [O76003]3EBI-11741890,EBI-374781
GOLGA6L9 [A6NEM1]3EBI-11741890,EBI-5916454
HOXB2 [P14652]3EBI-11741890,EBI-5329558
IQUB [Q8NA54]3EBI-11741890,EBI-10220600
IRAK1BP1 [Q5VVH5]3EBI-11741890,EBI-9658404
KRT40 [Q6A162]3EBI-11741890,EBI-10171697
LIMS1 - isoform 3 [P48059-3]3EBI-11741890,EBI-12864460
LMO2 - isoform 3 [P25791-3]5EBI-11741890,EBI-11959475
LMO4 [P61968]3EBI-11741890,EBI-2798728
LRIF1 [Q5T3J3]3EBI-11741890,EBI-473196
MEOX1 [P50221]3EBI-11741890,EBI-2864512
MEOX2 [Q6FHY5]3EBI-11741890,EBI-16439278
MID2 - isoform 2 [Q9UJV3-2]3EBI-11741890,EBI-10172526
NDUFAB1 [O14561]3EBI-11741890,EBI-1246261
NDUFV2 [P19404]3EBI-11741890,EBI-713665
NOSIP [Q9Y314]3EBI-11741890,EBI-1051889
PAX6 [P26367]3EBI-11741890,EBI-747278
PDE4DIP - isoform 2 [Q5VU43-2]3EBI-11741890,EBI-9640281
PICK1 [Q9NRD5]3EBI-11741890,EBI-79165
POGZ [Q7Z3K3]3EBI-11741890,EBI-1389308
POLR2G [P62487]3EBI-11741890,EBI-347928
POU6F2 [P78424]3EBI-11741890,EBI-12029004
PPM1K [Q8N3J5]3EBI-11741890,EBI-3923368
PPP1R16B [Q96T49]3EBI-11741890,EBI-10293968
PRKAR1B [P31321]3EBI-11741890,EBI-2805516
RAB3IP - isoform 7 [Q96QF0-7]3EBI-11741890,EBI-11984839
RASSF3 [Q86WH2]3EBI-11741890,EBI-2845202
RCN1 [Q15293]3EBI-11741890,EBI-948278
RPRD1A - isoform 2 [Q96P16-3]3EBI-11741890,EBI-12840198
SERTAD1 [Q9UHV2]3EBI-11741890,EBI-748601
STAT5B [P51692]3EBI-11741890,EBI-1186119
TRAF2 [Q12933]3EBI-11741890,EBI-355744
TRIM35 - isoform 2 [Q9UPQ4-2]3EBI-11741890,EBI-17716262
TSGA10 [Q9BZW7]3EBI-11741890,EBI-744794
TTC23 - isoform 3 [Q5W5X9-3]3EBI-11741890,EBI-9090990
UHRF2 - isoform 2 [Q96PU4-2]3EBI-11741890,EBI-12878912
VBP1 [P61758]3EBI-11741890,EBI-357430
ZNF24 [P17028]3EBI-11741890,EBI-707773
Q8N5D43EBI-11741890,EBI-10266435

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121792, 54 interactors

Protein interaction database and analysis system

More...IntActi		Q86VK4, 66 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000407130

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86VK4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1478
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q86VK4

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni187 – 213DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi187 – 203Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The five zinc finger domains are necessary and sufficient to bind to DNA.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri219 – 243C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri249 – 273C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri279 – 303C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri309 – 333C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri339 – 362C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158098

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_043629_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86VK4

Identification of Orthologs from Complete Genome Data

More...OMAi		PAEPLMG

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86VK4

TreeFam database of animal gene trees

More...TreeFami		TF333498

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86VK4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSDELESKP ELLVQFVQNT SIPLGQGLVE SEAKDITCLS LLPVTEASEC 
        60         70         80         90        100
SRLMLPDDTT NHSNSSKEVP SSAVLRSLRV NVGPDGEETR AQTVQKSPEF 
       110        120        130        140        150
LSTSESSSLL QDLQPSDSTS FILLNLTRAG LGSSAEHLVF VQDEAEDSGN 
       160        170        180        190        200
DFLSSESTDS SIPWFLRVQE LAHDSLIAAT RAQLAKNAKT SSNGENVHLG 
       210        220        230        240        250
SGDGQSKDSG PLPQVEKKLK CTVEGCDRTF VWPAHFKYHL KTHRNDRSFI 
       260        270        280        290        300
CPAEGCGKSF YVLQRLKVHM RTHNGEKPFM CHESGCGKQF TTAGNLKNHR 
       310        320        330        340        350
RIHTGEKPFL CEAQGCGRSF AEYSSLRKHL VVHSGEKPHQ CQVCGKTFSQ 
       360        370        380        390        400
SGSRNVHMRK HHLQLGAAGS QEQEQTAEPL MGSSLLEEAS VPSKNLVSMN 
       410        420        430        440        450
SQPSLGGESL NLPNTNSILG VDDEVLAEGS PRSLSSVPDV THHLVTMQSG 
       460        470 
RQSYEVSVLT AVNPQELLNQ GDLTERRT
Length:478
Mass (Da):52,113
Last modified:October 3, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1D7F7E139618F863
GO
Isoform 2 (identifier: Q86VK4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-272: NDRSFICPAEGCGKSFYVLQRLKVHMRT → RLWEKLLCAAEAEGAHEDPQWREALYVP
     273-478: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:272
Mass (Da):29,761
Checksum:iB3A06732DA0C01F8
GO
Isoform 3 (identifier: Q86VK4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     377-423: Missing.

Show »
Length:431
Mass (Da):47,318
Checksum:i92051EC28E38E1A4
GO
Isoform 4 (identifier: Q86VK4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-129: Missing.

Show »
Length:405
Mass (Da):44,254
Checksum:i99A1BF0D2CDCB18C
GO
Isoform 5 (identifier: Q86VK4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-57: D → EPVPWREEDGKSGCSDLN
     467-478: LLNQGDLTERRT → SLAPLPRLECSGAFSAHCNLCLPGSSDSPASAS

Show »
Length:516
Mass (Da):55,829
Checksum:i062D596402E5AAAA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V4H7G3V4H7_HUMAN
Zinc finger protein 410
ZNF410
378Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KNQ6J3KNQ6_HUMAN
Zinc finger protein 410
ZNF410
425Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2C2G3V2C2_HUMAN
Zinc finger protein 410
ZNF410
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2V5G3V2V5_HUMAN
Zinc finger protein 410
ZNF410
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V369G3V369_HUMAN
Zinc finger protein 410
ZNF410
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4W2G3V4W2_HUMAN
Zinc finger protein 410
ZNF410
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJI7H0YJI7_HUMAN
Zinc finger protein 410
ZNF410
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3W2G3V3W2_HUMAN
Zinc finger protein 410
ZNF410
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4E6G3V4E6_HUMAN
Zinc finger protein 410
ZNF410
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PNT4A0A1W2PNT4_HUMAN
Zinc finger protein 410
ZNF410
312Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04242457 – 129Missing in isoform 4. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_04341757D → EPVPWREEDGKSGCSDLN in isoform 5. 1 Publication1
Alternative sequenceiVSP_008485245 – 272NDRSF…VHMRT → RLWEKLLCAAEAEGAHEDPQ WREALYVP in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_008486273 – 478Missing in isoform 2. 1 PublicationAdd BLAST206
Alternative sequenceiVSP_008487377 – 423Missing in isoform 3. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_043418467 – 478LLNQG…TERRT → SLAPLPRLECSGAFSAHCNL CLPGSSDSPASAS in isoform 5. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U90919 mRNA Translation: AAB51059.1
AK293350 mRNA Translation: BAG56866.1
AK299138 mRNA Translation: BAG61190.1
AC005480 Genomic DNA No translation available.
AC005520 Genomic DNA No translation available.
BC000330 mRNA No translation available.
BC004357 mRNA No translation available.
BC050683 mRNA Translation: AAH50683.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55929.1 [Q86VK4-5]
CCDS55930.1 [Q86VK4-3]
CCDS55931.1 [Q86VK4-4]
CCDS9821.1 [Q86VK4-1]

NCBI Reference Sequences

More...RefSeqi		NP_001229853.1, NM_001242924.1 [Q86VK4-5]
NP_001229855.1, NM_001242926.1 [Q86VK4-3]
NP_001229856.1, NM_001242927.1 [Q86VK4-4]
NP_067011.1, NM_021188.2 [Q86VK4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000324593; ENSP00000323293; ENSG00000119725 [Q86VK4-3]
ENST00000398139; ENSP00000381208; ENSG00000119725 [Q86VK4-2]
ENST00000442160; ENSP00000407130; ENSG00000119725 [Q86VK4-5]
ENST00000540593; ENSP00000442228; ENSG00000119725 [Q86VK4-4]
ENST00000555044; ENSP00000451763; ENSG00000119725 [Q86VK4-1]
ENST00000615736; ENSP00000483073; ENSG00000119725 [Q86VK4-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57862

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57862

UCSC genome browser

More...UCSCi		uc001xoz.3, human [Q86VK4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90919 mRNA Translation: AAB51059.1
AK293350 mRNA Translation: BAG56866.1
AK299138 mRNA Translation: BAG61190.1
AC005480 Genomic DNA No translation available.
AC005520 Genomic DNA No translation available.
BC000330 mRNA No translation available.
BC004357 mRNA No translation available.
BC050683 mRNA Translation: AAH50683.1
CCDSiCCDS55929.1 [Q86VK4-5]
CCDS55930.1 [Q86VK4-3]
CCDS55931.1 [Q86VK4-4]
CCDS9821.1 [Q86VK4-1]
RefSeqiNP_001229853.1, NM_001242924.1 [Q86VK4-5]
NP_001229855.1, NM_001242926.1 [Q86VK4-3]
NP_001229856.1, NM_001242927.1 [Q86VK4-4]
NP_067011.1, NM_021188.2 [Q86VK4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6WMIX-ray2.75A/D217-366[»]
SMRiQ86VK4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121792, 54 interactors
IntActiQ86VK4, 66 interactors
STRINGi9606.ENSP00000407130

PTM databases

GlyGeniQ86VK4, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ86VK4
PhosphoSitePlusiQ86VK4

Genetic variation databases

BioMutaiZNF410
DMDMi37538029

Proteomic databases

MassIVEiQ86VK4
MaxQBiQ86VK4
PaxDbiQ86VK4
PeptideAtlasiQ86VK4
PRIDEiQ86VK4
ProteomicsDBi70028 [Q86VK4-1]
70029 [Q86VK4-2]
70030 [Q86VK4-3]
70031 [Q86VK4-4]
70032 [Q86VK4-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		126, 189 antibodies

The DNASU plasmid repository

More...DNASUi		57862

Genome annotation databases

EnsembliENST00000324593; ENSP00000323293; ENSG00000119725 [Q86VK4-3]
ENST00000398139; ENSP00000381208; ENSG00000119725 [Q86VK4-2]
ENST00000442160; ENSP00000407130; ENSG00000119725 [Q86VK4-5]
ENST00000540593; ENSP00000442228; ENSG00000119725 [Q86VK4-4]
ENST00000555044; ENSP00000451763; ENSG00000119725 [Q86VK4-1]
ENST00000615736; ENSP00000483073; ENSG00000119725 [Q86VK4-5]
GeneIDi57862
KEGGihsa:57862
UCSCiuc001xoz.3, human [Q86VK4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57862
DisGeNETi57862

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF410
HGNCiHGNC:20144, ZNF410
HPAiENSG00000119725, Low tissue specificity
neXtProtiNX_Q86VK4
PharmGKBiPA134958929
VEuPathDBiHostDB:ENSG00000119725

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000158098
HOGENOMiCLU_043629_1_0_1
InParanoidiQ86VK4
OMAiPAEPLMG
OrthoDBi1318335at2759
PhylomeDBiQ86VK4
TreeFamiTF333498

Enzyme and pathway databases

PathwayCommonsiQ86VK4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57862, 14 hits in 1049 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF410, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57862
PharosiQ86VK4, Tbio

Protein Ontology

More...PROi		PR:Q86VK4
RNActiQ86VK4, protein

Gene expression databases

BgeeiENSG00000119725, Expressed in kidney and 113 other tissues
ExpressionAtlasiQ86VK4, baseline and differential
GenevisibleiQ86VK4, HS

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 5 hits
SUPFAMiSSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN410_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86VK4
Secondary accession number(s): B4DDV5
, B4DR78, O00153, Q9BQ19
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 3, 2003
Last modified: September 29, 2021
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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