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Protein

Zinc finger protein 410

Gene

ZNF410

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri219 – 243C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri249 – 273C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri279 – 303C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri309 – 333C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri339 – 362C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 410
Alternative name(s):
Another partner for ARF 1
Zinc finger protein APA-1
Gene namesi
Name:ZNF410
Synonyms:APA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000119725.17
HGNCiHGNC:20144 ZNF410
neXtProtiNX_Q86VK4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57862
PharmGKBiPA134958929

Polymorphism and mutation databases

BioMutaiZNF410
DMDMi37538029

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475711 – 478Zinc finger protein 410Add BLAST478

Post-translational modificationi

Sumoylated. Sumoylation increases its half-life, possibly by blocking ubiquitin-mediated degradation.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ86VK4
MaxQBiQ86VK4
PaxDbiQ86VK4
PeptideAtlasiQ86VK4
PRIDEiQ86VK4
ProteomicsDBi70028
70029 [Q86VK4-2]
70030 [Q86VK4-3]
70031 [Q86VK4-4]
70032 [Q86VK4-5]

PTM databases

iPTMnetiQ86VK4
PhosphoSitePlusiQ86VK4

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Inductioni

During fibroblast senescence.1 Publication

Gene expression databases

BgeeiENSG00000119725 Expressed in 87 organ(s), highest expression level in kidney
CleanExiHS_ZNF410
ExpressionAtlasiQ86VK4 baseline and differential
GenevisibleiQ86VK4 HS

Organism-specific databases

HPAiHPA002871

Interactioni

Subunit structurei

Interacts with CDKN2A/p14ARF.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi121792, 13 interactors
IntActiQ86VK4, 57 interactors
MINTiQ86VK4
STRINGi9606.ENSP00000407130

Structurei

3D structure databases

ProteinModelPortaliQ86VK4
SMRiQ86VK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri219 – 243C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri249 – 273C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri279 – 303C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri309 – 333C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri339 – 362C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144040
HOGENOMiHOG000069877
HOVERGENiHBG055280
InParanoidiQ86VK4
OMAiPESSCGK
OrthoDBiEOG091G06YO
PhylomeDBiQ86VK4
TreeFamiTF333498

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86VK4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSDELESKP ELLVQFVQNT SIPLGQGLVE SEAKDITCLS LLPVTEASEC
60 70 80 90 100
SRLMLPDDTT NHSNSSKEVP SSAVLRSLRV NVGPDGEETR AQTVQKSPEF
110 120 130 140 150
LSTSESSSLL QDLQPSDSTS FILLNLTRAG LGSSAEHLVF VQDEAEDSGN
160 170 180 190 200
DFLSSESTDS SIPWFLRVQE LAHDSLIAAT RAQLAKNAKT SSNGENVHLG
210 220 230 240 250
SGDGQSKDSG PLPQVEKKLK CTVEGCDRTF VWPAHFKYHL KTHRNDRSFI
260 270 280 290 300
CPAEGCGKSF YVLQRLKVHM RTHNGEKPFM CHESGCGKQF TTAGNLKNHR
310 320 330 340 350
RIHTGEKPFL CEAQGCGRSF AEYSSLRKHL VVHSGEKPHQ CQVCGKTFSQ
360 370 380 390 400
SGSRNVHMRK HHLQLGAAGS QEQEQTAEPL MGSSLLEEAS VPSKNLVSMN
410 420 430 440 450
SQPSLGGESL NLPNTNSILG VDDEVLAEGS PRSLSSVPDV THHLVTMQSG
460 470
RQSYEVSVLT AVNPQELLNQ GDLTERRT
Length:478
Mass (Da):52,113
Last modified:October 3, 2003 - v2
Checksum:i1D7F7E139618F863
GO
Isoform 2 (identifier: Q86VK4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-272: NDRSFICPAEGCGKSFYVLQRLKVHMRT → RLWEKLLCAAEAEGAHEDPQWREALYVP
     273-478: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:272
Mass (Da):29,761
Checksum:iB3A06732DA0C01F8
GO
Isoform 3 (identifier: Q86VK4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     377-423: Missing.

Note: No experimental confirmation available.
Show »
Length:431
Mass (Da):47,318
Checksum:i92051EC28E38E1A4
GO
Isoform 4 (identifier: Q86VK4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-129: Missing.

Note: No experimental confirmation available.
Show »
Length:405
Mass (Da):44,254
Checksum:i99A1BF0D2CDCB18C
GO
Isoform 5 (identifier: Q86VK4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-57: D → EPVPWREEDGKSGCSDLN
     467-478: LLNQGDLTERRT → SLAPLPRLECSGAFSAHCNLCLPGSSDSPASAS

Note: No experimental confirmation available.
Show »
Length:516
Mass (Da):55,829
Checksum:i062D596402E5AAAA
GO

Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KNQ6J3KNQ6_HUMAN
Zinc finger protein 410
ZNF410
425Annotation score:
G3V4E6G3V4E6_HUMAN
Zinc finger protein 410
ZNF410
94Annotation score:
H0YJI7H0YJI7_HUMAN
Zinc finger protein 410
ZNF410
169Annotation score:
A0A1W2PNT4A0A1W2PNT4_HUMAN
Zinc finger protein 410
ZNF410
312Annotation score:
G3V4H7G3V4H7_HUMAN
Zinc finger protein 410
ZNF410
86Annotation score:
G3V369G3V369_HUMAN
Zinc finger protein 410
ZNF410
167Annotation score:
G3V565G3V565_HUMAN
Zinc finger protein 410
ZNF410
129Annotation score:
G3V2V5G3V2V5_HUMAN
Zinc finger protein 410
ZNF410
110Annotation score:
G3V4W2G3V4W2_HUMAN
Zinc finger protein 410
ZNF410
125Annotation score:
G3V2C2G3V2C2_HUMAN
Zinc finger protein 410
ZNF410
127Annotation score:
There are more potential isoformsShow all

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04242457 – 129Missing in isoform 4. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_04341757D → EPVPWREEDGKSGCSDLN in isoform 5. 1 Publication1
Alternative sequenceiVSP_008485245 – 272NDRSF…VHMRT → RLWEKLLCAAEAEGAHEDPQ WREALYVP in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_008486273 – 478Missing in isoform 2. 1 PublicationAdd BLAST206
Alternative sequenceiVSP_008487377 – 423Missing in isoform 3. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_043418467 – 478LLNQG…TERRT → SLAPLPRLECSGAFSAHCNL CLPGSSDSPASAS in isoform 5. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90919 mRNA Translation: AAB51059.1
AK293350 mRNA Translation: BAG56866.1
AK299138 mRNA Translation: BAG61190.1
AC005480 Genomic DNA No translation available.
AC005520 Genomic DNA No translation available.
BC000330 mRNA No translation available.
BC004357 mRNA No translation available.
BC050683 mRNA Translation: AAH50683.1
CCDSiCCDS55929.1 [Q86VK4-5]
CCDS55930.1 [Q86VK4-3]
CCDS55931.1 [Q86VK4-4]
CCDS9821.1 [Q86VK4-1]
RefSeqiNP_001229853.1, NM_001242924.1 [Q86VK4-5]
NP_001229855.1, NM_001242926.1 [Q86VK4-3]
NP_001229856.1, NM_001242927.1 [Q86VK4-4]
NP_067011.1, NM_021188.2 [Q86VK4-1]
UniGeneiHs.270869

Genome annotation databases

EnsembliENST00000324593; ENSP00000323293; ENSG00000119725 [Q86VK4-3]
ENST00000398139; ENSP00000381208; ENSG00000119725 [Q86VK4-2]
ENST00000442160; ENSP00000407130; ENSG00000119725 [Q86VK4-5]
ENST00000540593; ENSP00000442228; ENSG00000119725 [Q86VK4-4]
ENST00000555044; ENSP00000451763; ENSG00000119725 [Q86VK4-1]
ENST00000615736; ENSP00000483073; ENSG00000119725 [Q86VK4-5]
GeneIDi57862
KEGGihsa:57862
UCSCiuc001xoz.3 human [Q86VK4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90919 mRNA Translation: AAB51059.1
AK293350 mRNA Translation: BAG56866.1
AK299138 mRNA Translation: BAG61190.1
AC005480 Genomic DNA No translation available.
AC005520 Genomic DNA No translation available.
BC000330 mRNA No translation available.
BC004357 mRNA No translation available.
BC050683 mRNA Translation: AAH50683.1
CCDSiCCDS55929.1 [Q86VK4-5]
CCDS55930.1 [Q86VK4-3]
CCDS55931.1 [Q86VK4-4]
CCDS9821.1 [Q86VK4-1]
RefSeqiNP_001229853.1, NM_001242924.1 [Q86VK4-5]
NP_001229855.1, NM_001242926.1 [Q86VK4-3]
NP_001229856.1, NM_001242927.1 [Q86VK4-4]
NP_067011.1, NM_021188.2 [Q86VK4-1]
UniGeneiHs.270869

3D structure databases

ProteinModelPortaliQ86VK4
SMRiQ86VK4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121792, 13 interactors
IntActiQ86VK4, 57 interactors
MINTiQ86VK4
STRINGi9606.ENSP00000407130

PTM databases

iPTMnetiQ86VK4
PhosphoSitePlusiQ86VK4

Polymorphism and mutation databases

BioMutaiZNF410
DMDMi37538029

Proteomic databases

EPDiQ86VK4
MaxQBiQ86VK4
PaxDbiQ86VK4
PeptideAtlasiQ86VK4
PRIDEiQ86VK4
ProteomicsDBi70028
70029 [Q86VK4-2]
70030 [Q86VK4-3]
70031 [Q86VK4-4]
70032 [Q86VK4-5]

Protocols and materials databases

DNASUi57862
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324593; ENSP00000323293; ENSG00000119725 [Q86VK4-3]
ENST00000398139; ENSP00000381208; ENSG00000119725 [Q86VK4-2]
ENST00000442160; ENSP00000407130; ENSG00000119725 [Q86VK4-5]
ENST00000540593; ENSP00000442228; ENSG00000119725 [Q86VK4-4]
ENST00000555044; ENSP00000451763; ENSG00000119725 [Q86VK4-1]
ENST00000615736; ENSP00000483073; ENSG00000119725 [Q86VK4-5]
GeneIDi57862
KEGGihsa:57862
UCSCiuc001xoz.3 human [Q86VK4-1]

Organism-specific databases

CTDi57862
DisGeNETi57862
EuPathDBiHostDB:ENSG00000119725.17
GeneCardsiZNF410
HGNCiHGNC:20144 ZNF410
HPAiHPA002871
neXtProtiNX_Q86VK4
PharmGKBiPA134958929
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144040
HOGENOMiHOG000069877
HOVERGENiHBG055280
InParanoidiQ86VK4
OMAiPESSCGK
OrthoDBiEOG091G06YO
PhylomeDBiQ86VK4
TreeFamiTF333498

Miscellaneous databases

ChiTaRSiZNF410 human
GenomeRNAii57862
PROiPR:Q86VK4

Gene expression databases

BgeeiENSG00000119725 Expressed in 87 organ(s), highest expression level in kidney
CleanExiHS_ZNF410
ExpressionAtlasiQ86VK4 baseline and differential
GenevisibleiQ86VK4 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN410_HUMAN
AccessioniPrimary (citable) accession number: Q86VK4
Secondary accession number(s): B4DDV5
, B4DR78, O00153, Q9BQ19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 3, 2003
Last modified: October 10, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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