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Protein

Lysosomal-associated transmembrane protein 4B

Gene

LAPTM4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ceramide binding Source: UniProtKB
  • kinase binding Source: UniProtKB
  • phosphatidylinositol bisphosphate binding Source: UniProtKB
  • ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.74.1.3 the 4 tms multidrug endosomal transporter (met) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysosomal-associated transmembrane protein 4BCurated
Alternative name(s):
Lysosome-associated transmembrane protein 4-beta1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAPTM4BImported
ORF Names:PSEC0001
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000104341.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13646 LAPTM4B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613296 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86VI4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cell projection, Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi296P → A: Abolishes binding to NEDD4; when associated with A-312. Increases localization to cell membrane; when associated with A-312. Retains association with HGS and enhances PIP5K1C interaction; when associated with A-312. Does not affect EGFR degradation; when associated with A-312. 2 Publications1
Mutagenesisi312P → A: Abolishes binding to NEDD4; when associated with A-296. Increases localization to cell membrane; when associated with A-296. Retains association with HGS and enhances PIP5K1C interaction; when associated with A-296. Does not affect EGFR degradation; when associated with A-296. 2 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
55353

Open Targets

More...
OpenTargetsi
ENSG00000104341

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128395785

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LAPTM4B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74714056

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002497211 – 317Lysosomal-associated transmembrane protein 4BAdd BLAST317

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Undergoes proteolytic cleavage following delivery to the lysosomes.1 Publication
Ubiquitinated by NEDD4.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86VI4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86VI4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86VI4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86VI4

PeptideAtlas

More...
PeptideAtlasi
Q86VI4

PRoteomics IDEntifications database

More...
PRIDEi
Q86VI4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70024
70025 [Q86VI4-2]
70026 [Q86VI4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86VI4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86VI4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104341 Expressed in 238 organ(s), highest expression level in metanephros

CleanEx database of gene expression profiles

More...
CleanExi
HS_LAPTM4B

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86VI4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86VI4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB020782
HPA068830

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer; upon reaching the lysosomes (PubMed:21224396). Interacts with MCOLN1 (PubMed:21224396). Interacts with NEDD4; may play a role in the lysosomal sorting of LAPTM4B; enhances HGS association with NEDD4; mediates inhibition of EGFR degradation (PubMed:22096579, PubMed:25588945). Interacts with PIP5K1C; promotes SNX5 association with LAPTM4B; kinase activity of PIP5K1C is required; interaction is regulated by phosphatidylinositol 4,5-bisphosphate generated by PIP5K1C (PubMed:25588945). Interacts with HGS; promotes HGS ubiquitination (PubMed:25588945). Interacts with SNX5 (PubMed:25588945). Interacts with SLC3A2 AND SLC7A5; recruits SLC3A2 and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (PubMed:25998567). Interacts with LRRC32; decreases TGFB1 production in regulatory T cells (PubMed:26126825). Interacts with BECN1; competes with EGFR for LAPTM4B binding; regulates EGFR activity (PubMed:28479384). Interacts with EGFR; positively correlates with EGFR activation (PubMed:28479384).6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120633, 19 interactors

Protein interaction database and analysis system

More...
IntActi
Q86VI4, 19 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000402301

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q86VI4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni205 – 221Required for NEDD4 interaction1 PublicationAdd BLAST17

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LAPTM4/LAPTM5 transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGWG Eukaryota
ENOG4111K1Z LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153446

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007698

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000908

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86VI4

KEGG Orthology (KO)

More...
KOi
K12387

Identification of Orthologs from Complete Genome Data

More...
OMAi
TEVLVYV

Database of Orthologous Groups

More...
OrthoDBi
1145926at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86VI4

TreeFam database of animal gene trees

More...
TreeFami
TF330843

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004687 LAPTM4/5
IPR018401 Lysosomal-assoc_TM_prot4B

The PANTHER Classification System

More...
PANTHERi
PTHR12479:SF6 PTHR12479:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03821 Mtp, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86VI4-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSRTRVTWP SPPRPLPVPA AAAVAFGAKG TDPAEARSSR GIEEAGPRAH
60 70 80 90 100
GRAGREPERR RSRQQRRGGL QARRSTLLKT CARARATAPG AMKMVAPWTR
110 120 130 140 150
FYSNSCCLCC HVRTGTILLG VWYLIINAVV LLILLSALAD PDQYNFSSSE
160 170 180 190 200
LGGDFEFMDD ANMCIAIAIS LLMILICAMA TYGAYKQRAA WIIPFFCYQI
210 220 230 240 250
FDFALNMLVA ITVLIYPNSI QEYIRQLPPN FPYRDDVMSV NPTCLVLIIL
260 270 280 290 300
LFISIILTFK GYLISCVWNC YRYINGRNSS DVLVYVTSND TTVLLPPYDD
310
ATVNGAAKEP PPPYVSA
Length:317
Mass (Da):35,123
Last modified:October 10, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E93093E066BE948
GO
Isoform 2 (identifier: Q86VI4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: Missing.

Show »
Length:226
Mass (Da):25,419
Checksum:iA3156D2F2C0DCF0B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBN1H0YBN1_HUMAN
Lysosomal-associated transmembrane ...
LAPTM4B
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAO84265 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32D → R in CAB66876 (PubMed:11230166).Curated1
Sequence conflicti85R → S in AAH38117 (PubMed:15489334).Curated1
Sequence conflicti179M → T in AAH38117 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0598311 – 91Missing in isoform 2. Add BLAST91

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF527412 mRNA Translation: AAP14034.1
AY057051 mRNA Translation: AAL17908.2
AY261384 mRNA Translation: AAO84265.1 Sequence problems.
AF317417 mRNA Translation: AAK69595.1
AK075326 mRNA Translation: BAC11549.1
BC014129 mRNA Translation: AAH14129.1
BC031021 mRNA Translation: AAH31021.1
BC038117 mRNA Translation: AAH38117.1
AL136942 mRNA Translation: CAB66876.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6275.1 [Q86VI4-2]

NCBI Reference Sequences

More...
RefSeqi
NP_060877.3, NM_018407.4 [Q86VI4-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.492314

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000445593; ENSP00000402301; ENSG00000104341 [Q86VI4-3]
ENST00000521545; ENSP00000428409; ENSG00000104341 [Q86VI4-2]
ENST00000619747; ENSP00000482533; ENSG00000104341 [Q86VI4-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55353

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55353

UCSC genome browser

More...
UCSCi
uc003yia.4 human [Q86VI4-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527412 mRNA Translation: AAP14034.1
AY057051 mRNA Translation: AAL17908.2
AY261384 mRNA Translation: AAO84265.1 Sequence problems.
AF317417 mRNA Translation: AAK69595.1
AK075326 mRNA Translation: BAC11549.1
BC014129 mRNA Translation: AAH14129.1
BC031021 mRNA Translation: AAH31021.1
BC038117 mRNA Translation: AAH38117.1
AL136942 mRNA Translation: CAB66876.2
CCDSiCCDS6275.1 [Q86VI4-2]
RefSeqiNP_060877.3, NM_018407.4 [Q86VI4-2]
UniGeneiHs.492314

3D structure databases

ProteinModelPortaliQ86VI4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120633, 19 interactors
IntActiQ86VI4, 19 interactors
STRINGi9606.ENSP00000402301

Protein family/group databases

TCDBi2.A.74.1.3 the 4 tms multidrug endosomal transporter (met) family

PTM databases

iPTMnetiQ86VI4
PhosphoSitePlusiQ86VI4

Polymorphism and mutation databases

BioMutaiLAPTM4B
DMDMi74714056

Proteomic databases

EPDiQ86VI4
jPOSTiQ86VI4
MaxQBiQ86VI4
PaxDbiQ86VI4
PeptideAtlasiQ86VI4
PRIDEiQ86VI4
ProteomicsDBi70024
70025 [Q86VI4-2]
70026 [Q86VI4-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55353
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000445593; ENSP00000402301; ENSG00000104341 [Q86VI4-3]
ENST00000521545; ENSP00000428409; ENSG00000104341 [Q86VI4-2]
ENST00000619747; ENSP00000482533; ENSG00000104341 [Q86VI4-3]
GeneIDi55353
KEGGihsa:55353
UCSCiuc003yia.4 human [Q86VI4-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55353
DisGeNETi55353
EuPathDBiHostDB:ENSG00000104341.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LAPTM4B
HGNCiHGNC:13646 LAPTM4B
HPAiCAB020782
HPA068830
MIMi613296 gene
neXtProtiNX_Q86VI4
OpenTargetsiENSG00000104341
PharmGKBiPA128395785

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IGWG Eukaryota
ENOG4111K1Z LUCA
GeneTreeiENSGT00940000153446
HOGENOMiHOG000007698
HOVERGENiHBG000908
InParanoidiQ86VI4
KOiK12387
OMAiTEVLVYV
OrthoDBi1145926at2759
PhylomeDBiQ86VI4
TreeFamiTF330843

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
LAPTM4B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55353

Protein Ontology

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PROi
PR:Q86VI4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000104341 Expressed in 238 organ(s), highest expression level in metanephros
CleanExiHS_LAPTM4B
ExpressionAtlasiQ86VI4 baseline and differential
GenevisibleiQ86VI4 HS

Family and domain databases

InterProiView protein in InterPro
IPR004687 LAPTM4/5
IPR018401 Lysosomal-assoc_TM_prot4B
PANTHERiPTHR12479:SF6 PTHR12479:SF6, 1 hit
PfamiView protein in Pfam
PF03821 Mtp, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAP4B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86VI4
Secondary accession number(s): Q3ZCV5
, Q7L909, Q86VH8, Q9H060
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 10, 2018
Last modified: January 16, 2019
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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