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Protein

Exocyst complex component 3-like protein

Gene

EXOC3L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

As part of the exocyst, may play a role in regulated exocytosis of insulin granules.By similarity

GO - Molecular functioni

  • SNARE binding Source: GO_Central

GO - Biological processi

  • exocyst localization Source: GO_Central
  • exocytosis Source: UniProtKB
  • peptide hormone secretion Source: UniProtKB

Keywordsi

Biological processExocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 3-like protein
Alternative name(s):
Protein Jiangli
Gene namesi
Name:EXOC3L1
Synonyms:EXOC3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000179044.15
HGNCiHGNC:27540 EXOC3L1
MIMi614117 gene
neXtProtiNX_Q86VI1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179044
PharmGKBiPA147031724

Polymorphism and mutation databases

BioMutaiEXOC3L1
DMDMi223590205

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003094741 – 746Exocyst complex component 3-like proteinAdd BLAST746

Proteomic databases

PaxDbiQ86VI1
PeptideAtlasiQ86VI1
PRIDEiQ86VI1
ProteomicsDBi70022

PTM databases

iPTMnetiQ86VI1
PhosphoSitePlusiQ86VI1

Expressioni

Gene expression databases

BgeeiENSG00000179044 Expressed in 87 organ(s), highest expression level in spleen
CleanExiHS_EXOC3L
ExpressionAtlasiQ86VI1 baseline and differential
GenevisibleiQ86VI1 HS

Organism-specific databases

HPAiHPA029574

Interactioni

Subunit structurei

Interacts with EXOC2, EXOC4 and EXOC5; may be part of the exocyst.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ86VI1, 8 interactors
STRINGi9606.ENSP00000325674

Structurei

3D structure databases

ProteinModelPortaliQ86VI1
SMRiQ86VI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 370Mediates interaction with EXOC2, EXOC4 and EXOC5By similarityAdd BLAST370

Sequence similaritiesi

Belongs to the SEC6 family.Curated

Phylogenomic databases

eggNOGiKOG2286 Eukaryota
COG5173 LUCA
GeneTreeiENSGT00530000062934
HOVERGENiHBG098199
InParanoidiQ86VI1
KOiK19987
OMAiMQGRLVC
OrthoDBiEOG091G02T2
PhylomeDBiQ86VI1
TreeFamiTF314979

Family and domain databases

InterProiView protein in InterPro
IPR010326 EXOC3/Sec6
PANTHERiPTHR21292 PTHR21292, 1 hit
PfamiView protein in Pfam
PF06046 Sec6, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q86VI1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSAAKDEMQ PALSPGPEWP EQERAEQLAR GAALKWASGI FYRPEQLARL
60 70 80 90 100
GQYRSREVQR TCSLESRLKS VMQSYLEGVQ TGVWQLAQAI EVVQGTREAL
110 120 130 140 150
SQARGLLQGM SQALQTLEPL RERVAQHKQL QALSHLLPRL RAVPAAVSHT
160 170 180 190 200
QTLIDGQQFL EAYVSLRELE QLREDTWAPL GGLELPVFQG LDLLFEALGQ
210 220 230 240 250
AVEAAAGAAG KLAREDPALL VAAVRVAEVE TGRTTPLGQV PRDWRQRCLR
260 270 280 290 300
ALQEGLEQAH FGSPLLPAPG ALPGWLEALR VALPVELATA EALVAPCCPP
310 320 330 340 350
QYNVVQLWAH TLHSGLRRSL QNLLAGPELE AADAFALLHW ALHVYLGQEM
360 370 380 390 400
MGSLELGPEA DVSQLEPLLT LENIEQLEAT FVANIQASVS QWLQNALDGE
410 420 430 440 450
VAEWGREHGP NTDPSGSYYS PMPAIVLQIL EENIRVASLV SESLQQRVHG
460 470 480 490 500
MALSELGTFL RSFSDALIRF SRDHFRGKSM APHYVPYLLA ALNHKSALSS
510 520 530 540 550
SVSVLQLDGA PSGALAPVEA ALDELQRRIY RLVLEALQAE LQPLFADLPS
560 570 580 590 600
RQWLSSPELL QSVCERTGRF CRDFWRVRNP TVQLLLAEAE RAVVLQYLSA
610 620 630 640 650
LMQGRLVCRG ADERTQAAER LRHDAAQLQQ LFLSLGLEEN AHCAPVLLAL
660 670 680 690 700
RELLNLRDPA LLGLEVAGLR QQFPDVSEDH VSALLGLRGD LSREQHLAAL
710 720 730 740
SSLQAALPPS PRASRRVLFS LVPAPALAPA SCLPSGSCAR ALLLAE
Length:746
Mass (Da):81,678
Last modified:February 10, 2009 - v2
Checksum:iC762DE3E63D782C9
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H4W1F5H4W1_HUMAN
Exocyst complex component 3-like pr...
EXOC3L1
679Annotation score:
H3BPA4H3BPA4_HUMAN
Exocyst complex component 3-like pr...
EXOC3L1
684Annotation score:
H3BTH9H3BTH9_HUMAN
Exocyst complex component 3-like pr...
EXOC3L1
181Annotation score:
H3BRW6H3BRW6_HUMAN
Exocyst complex component 3-like pr...
EXOC3L1
80Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187V → F in BAB84916 (PubMed:12693554).Curated1
Sequence conflicti499S → G in AAP12545 (Ref. 1) Curated1
Sequence conflicti499S → G in BAB84916 (PubMed:12693554).Curated1
Sequence conflicti701 – 707Missing in BAC03991 (PubMed:14702039).Curated7

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03700275Y → N in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs117403380Ensembl.1
Natural variantiVAR_037003514A → D in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs142958191Ensembl.1
Natural variantiVAR_036959561Q → E. Corresponds to variant dbSNP:rs9939768Ensembl.1
Natural variantiVAR_036960634S → G. Corresponds to variant dbSNP:rs16957212Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY255669 mRNA Translation: AAP12545.1
AK092858 mRNA Translation: BAC03991.1
AK292004 mRNA Translation: BAF84693.1
AC040160 Genomic DNA No translation available.
AC074143 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83092.1
AK074090 mRNA Translation: BAB84916.1
CCDSiCCDS10832.1
RefSeqiNP_848611.2, NM_178516.3
UniGeneiHs.647356

Genome annotation databases

EnsembliENST00000314586; ENSP00000325674; ENSG00000179044
GeneIDi283849
KEGGihsa:283849
UCSCiuc002erx.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY255669 mRNA Translation: AAP12545.1
AK092858 mRNA Translation: BAC03991.1
AK292004 mRNA Translation: BAF84693.1
AC040160 Genomic DNA No translation available.
AC074143 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83092.1
AK074090 mRNA Translation: BAB84916.1
CCDSiCCDS10832.1
RefSeqiNP_848611.2, NM_178516.3
UniGeneiHs.647356

3D structure databases

ProteinModelPortaliQ86VI1
SMRiQ86VI1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ86VI1, 8 interactors
STRINGi9606.ENSP00000325674

PTM databases

iPTMnetiQ86VI1
PhosphoSitePlusiQ86VI1

Polymorphism and mutation databases

BioMutaiEXOC3L1
DMDMi223590205

Proteomic databases

PaxDbiQ86VI1
PeptideAtlasiQ86VI1
PRIDEiQ86VI1
ProteomicsDBi70022

Protocols and materials databases

DNASUi283849
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314586; ENSP00000325674; ENSG00000179044
GeneIDi283849
KEGGihsa:283849
UCSCiuc002erx.1 human

Organism-specific databases

CTDi283849
EuPathDBiHostDB:ENSG00000179044.15
GeneCardsiEXOC3L1
H-InvDBiHIX0079826
HGNCiHGNC:27540 EXOC3L1
HPAiHPA029574
MIMi614117 gene
neXtProtiNX_Q86VI1
OpenTargetsiENSG00000179044
PharmGKBiPA147031724
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2286 Eukaryota
COG5173 LUCA
GeneTreeiENSGT00530000062934
HOVERGENiHBG098199
InParanoidiQ86VI1
KOiK19987
OMAiMQGRLVC
OrthoDBiEOG091G02T2
PhylomeDBiQ86VI1
TreeFamiTF314979

Miscellaneous databases

GeneWikiiEXOC3L
GenomeRNAii283849
PROiPR:Q86VI1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179044 Expressed in 87 organ(s), highest expression level in spleen
CleanExiHS_EXOC3L
ExpressionAtlasiQ86VI1 baseline and differential
GenevisibleiQ86VI1 HS

Family and domain databases

InterProiView protein in InterPro
IPR010326 EXOC3/Sec6
PANTHERiPTHR21292 PTHR21292, 1 hit
PfamiView protein in Pfam
PF06046 Sec6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEX3L1_HUMAN
AccessioniPrimary (citable) accession number: Q86VI1
Secondary accession number(s): A8K7I9, Q8NAD2, Q8TEN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: February 10, 2009
Last modified: September 12, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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